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At least 631 records · Page 35Linked to original sources
PubMed2002

Genetic polymorphisms of the interleukin-4 receptor alpha gene are associated with an increasing risk and a poor prognosis of sporadic renal cell carcinoma in a Japanese population.

PURPOSE: It has been suggested that the immune system of the host may be capable of modulating the clinical course of renal cell carcinoma (RCC) patients. In fact, the amount of Th2 cytokines such as interleukin (IL)-4 and IL-10 in the serum of patients has been found to be an important predictor of poor prognosis. Recently, it was reported that genetic polymorphisms of the IL-4 receptor alpha (IL-4Ralpha) gene affect the strength of signaling through the receptor. In addition, these same polymorphisms were found to be associated with an increased risk of atopy by causing Th2-dominated responses of the host. The significance of the polymorphisms on the incidence and prognosis in sporadic RCC patients were examined to clarify the role of IL-4 as well as that of the Th1/Th2 immune system in this disease. EXPERIMENTAL DESIGN: A case-control study was performed with 143 sporadic RCCs in a Japanese population and 205 Japanese controls. Logistic regression models were also used to assess the genetic effects on prognosis. RESULTS: The frequencies of variant alleles that enhance signaling of IL-4 were significantly related to an increased risk of RCC. Furthermore, multivariate regression analysis showed that the genotype of the IL-4R gene was an independent prognostic factor for cause-specific survival (P = 0.018) together with M classification (P = 0.0002) and histopathological grade (P = 0.044). CONCLUSIONS: The present findings show that the preferential Th2-type response to tumors was associated with a poorer prognosis and suggest that polymorphisms of the IL-4Ralpha gene may serve as useful genetic markers for assessing the risk of the development and progression of RCC.

Adult↗
PubMed2002

[Prognosis of non-small cell lung cancer patients with microscopic residual disease at bronchial stump after lung resection].

OBJECTIVE: To investigate the prognosis of patients of non-small cell lung cancer (NSCLC) receiving lobectomy or pneumonectomy with microscopic residual disease (MRD) at the bronchial resection margin postoperatively and analyze the factors influencing prognosis. METHODS: The data of 1 218 patients who under went lobectomy or pneumonectomy for NSCLC 1965 approximately 1995 were retrospectively studied. Staging was done according to the TNM and UICC classifications. The factors influencing survival were analysed with Likelihood Ratio method. RESULTS: Of the 1 218 patients, 62 suffered form MRD (5.1%) at the bronchial margin postoperatively, including 21 MMRD cases and 41 EMRD cases, with a median survival time of 44 months and a five-year survival rate of 33.9%. Forty-two patients received adjuvant chemotherapy after operation. According to pTNM classification,the five-year survival rate was 51.4% for stage I,16.7% for stage II,and 6.7% for stage III a respectively, being significantly higher for stage I than for stage II and III a (P = 0.001 1). The 5-year survival rate in the MMRD group was 57.1%, significantly higher than that in the EMRD group (22.0%, P = 0.0078). The five-year survival rate in the MRD patients who received adjuvant therapy postoperatively was 42.86%, significantly higher than that in those without postoperative therapy (15%, P = 0.002). CONCLUSION: The factors influencing the prognosis of MRD patients receiving lobectomy or pneumonectomy for NSCLC include the pathological stage and the type of infiltration of MRD. Chemotherapy after operation improves the prognosis in those patients.

Adult↗
PubMed2002

[Prognosis and prognostic factors of sarcoidosis in Japan].

Sarcoidosis is a systemic granulomatous disease that primarily affects the lung and lymphatic systems. Sarcoidosis patients commonly have spontaneous remission and good prognosis. But some patients show chronic, progressive and life-threatening conditions. Determination of prognosis based on the initial clinical presentation is important for the treatment. In this article, we review natural history, prognosis and the factors related prognosis of sarcoidosis patients in Japan. Shadows on chest radiograph were cleared in 76% of patients for 10 years. Approximately 15% of patients had severe organ dysfunction. In 60% of the sarcoidosis autopsy cases, the causes of death were attributed to organ involvement of sarcoidosis. Adverse prognostic factors are advanced age at onset, the presence of symptoms, extrathoracic involvement and treatment of corticosteroids.

Cause of Death↗
PubMed2002

[Therapeutic results and changes in prognosis in patients with multiple myeloma in central and northern Moravia over the past 40 years].

OBJECTIVE: The objective of the investigation is evaluation of therapeutic results and the development of the prognosis of patients with multiple myeloma (MM) as a result of consecutive changes of therapeutic procedures in patients of central and northern Moravia in the course of the last 40 years. METHODS AND RESULTS: The analyzed group of 562 patients with MM was concentrated at the Ist and IIIrd Medical Clinic of the Faculty Hospital Olomouc in 1959 - 2000, median age 63 (28-91) male/female ratio 1.1: 1.0. From analysis of Kaplan-Meier survival curves and the results of statistical analysis (log rank test p = 0.0000) ensued that during the evaulated period a very substantial change of prognosis occurred with improvement of theraupeutic results and a significant prolongation of survival in general. The first " turning point" was the introduction of chemotheraphy with alkylating substances with Prednisone (1963-1975), leading as compared with the period of symptomatic treatment alone (1959-1063) to a significant prolongation of the media value of general survival (M) from 8 to 19 months (p = 0.0031) and 3-year survival from 4 to 23 % patients, whereby 10-year survival was only 0 % and 1 %. The second "turning point" was the period from 1976 - 1980 with introduction of systematic chemotherapy using conventional doses of polychemotherapeutic (CP) regimes with better opportunities of supporting treatment (M = 40 months, p = 0.0000; 3-year and 10-year survival 55% and 5.5% patients). The therapeutic results acheived during the subsequent 15 years were however an unsatisfactory advance. During the interval between 1976-1995 in a group of 295 patients divided into 5-year sub-periods remission was acheived (R = < 25 % of the baseline value of M-protein) in 10-24 % patients, an inadequate response (NR) = persistence in > 50 % M-protein) in 55-28 %, prolongation of the median of total survival in 232 of the accessble patients for 44 months and long-term survival of 5 - 10 years after establisment of the diagnosis increased from 25 to 36 % and from 5.5 to 16.5 % patients. The third "turning point" was 1996 characterized by the introduction of high-dosage chemotheraphy with transplantation of autologuos peripheral haematopoietic cells ("HD" therapy with ASCT) leading ina group of so far only 33, assessable patients under 65 years to acheived remission in 71 %, to decline of NR in 10 % only and 5 -year suvival so far in 91 % patients ( p = 0.0037). Improvement of therapeutic results and prognosis of the disease as compared with 1976 - 1995 occurred in the whole group of patients also in 1996 - 2000 (CP and "HD"-therapy with ASCT) characterized by remission in 36 %, NR IN 33 % and 5 -year survival in 57 % (p = 0.030). It was reveled that the application of "HD" theraphy with ASCT led in 1995-2000 to the acheivement of more favorable therapeutic results (R - 71 % NR - 10 %. 5-year survival after the interval which elapsed so far 91 %), as compared with 2 similar groups of subjects under 65 years meeting the criteria of "HD" theraphy with ASCT, but treated only by conventional polychemotheraphy (1991 - 1995 and 1996 - 2000: R - 24 and 32 %, NR - 42 and 23 %, 5-year survival 46 and 68 % of the patients). In the group of 148 patients from the period of 1991-2000 the patients had as regards remission (R) more favourable results as compared with patients with NR concerning the prognosis [M 63 vs.22 months, 5-year and 10-year survival 53 vs. 17 % and 17 vs. 0 % of patients (p = 0.0000)]. CONCLUSION: From the submitted analysis ensured that during the period form 1959 - 2000 in patients with mutiple myeloma in central and northern Moravia as a result of the application of modern methods of chemotheraphy and supporting treatment a significant improvements of results of conventional treatment occurred with a more than 5 fold prolongation of so far assessable median values of survival (8 - 44 months) and long-term 10-year survival of almost one sixth of the patients. The real asset of "HD" theraphy with transplantation of ASCT will be revealed by analyses made after a longer time interval.

Adult↗
PubMed2002

[Surgical margin to direct the treatment and predict the prognosis of laryngeal carcinoma after partial laryngectomy].

BACKGROUND & OBJECTIVE: The surgical margin is very important for laryngeal carcinoma treatment. To preserve more laryngeal tissue can give patients good function, however, which increase the rate of positive surgical margin and recurrence. The correct surgical margin is benefit for laryngeal carcinoma patients' prognosis. This study was designed to investigate the value of surgical margin to direct the treatment of laryngeal carcinoma after partial laryngectomy and to evaluate the prognosis of laryngeal carcinoma. METHODS: The authors studied 115 cases of laryngeal carcinoma in which surgical margin samples were harvested during partial laryngectomy. The recurrence rate and survival curve of the positive and negative margin group were compared; The survival curve between the groups with and without postoperative radiotherapy both in negative margin group and positive margin group were also compared. RESULTS: The results of the negative group were better than that of the positive group: recurrence rate was higher (28.0% Vs 7.8% P = 0.006), the survival curve was better(P = 0.0241); The survival curve of those with positive surgical margin, at the same time, treated by postoperative radiotherapy was better than that of those without postoperative radiotherapy (P = 0.0046); but in negative group, the survival curve of those who treated with or without postoperative radiotherapy or not was different insignificantly (P = 0.0829). CONCLUSIONS: The prognosis of the positive margin group of laryngeal carcinoma was waster than that of the negative group, but it can be improved partially by postoperative radiotherapy. The best way to improve the prognosis was dissect entirely; There is not necessary to treat negative group by postoperative radiotherapy.

Adult↗
PubMed2002

[Diagnosis and prognosis of ovarian epithelial tumor with morphometry].

BACKGROUND & OBJECTIVE: Morphometry for diagnosis and prognosis of tumor becomes important. This study was designed to evaluate the efficiency of morphometry for diagnosis and prognosis of the patients with ovarian epithelial tumor. METHODS: A total of 110 patients with ovarian epithelial tumor were studied by three morphometrical methods (image analysis, determination of DNA content, and quantitative analysis of AgNOR). Nuclear area (NA), nuclear perimeter (NP), nuclear form factor (NFF), DNA content (DC), DNA index (DI), percentage of DNA multiploid (P > 4c), and percentage of G0/G1 phases (P2c) were determined by morphometrical instrument. AgNOR was counted under light microscope. RESULTS: (1) The results in these three groups of benign, borderline, and malignant ovarian epithelial tumors: the differences of all parameters (NA, NP, NFF, DC, DI, AgNOR counts) among these groups have a extremely significant statistical difference (P < 0.01 and P < 0.001). (2) A study on prognosis: NA, NP, and NFF between two groups of patients (survival > or = 5 years and < 5 years) with ovarian epithelial carcinoma have a significant difference(P < 0.05 and P < 0.01), this means different results of image analysis indicate different survival. AgNOR counts have a close correlation with month of the survivors (r = -0.73, P < 0.001). The P > 4c had a relation to month of survivors (r = -0.75, P < 0.001). CONCLUSIONS: Morphometry can provide reliable parameters for diagnosis and prognosis of the patients with different kinds of ovarian epithelial tumors.

Female↗
PubMed2003

[Correlation between expression of p53 and prognosis of laryngeal squamous carcinoma].

BACKGROUND & OBJECTIVE: p53 expression was a marker to predict the poor prognosis of laryngeal cancer. Detection of p53 in the pathological negative margin can be used to find more patients with poor prognosis. The aim of this study was to reveal the correlation between p53 expression and prognosis in primary cancer and surgical margin of laryngeal squamous cell carcinoma (SCC). METHODS: The clinical data of 67 laryngeal SCC with pathological negative margin were analyzed retrospectively. The expression of p53 protein in the margin and primary cancer was detected by immunohistochemistry. The survival rates and the recurrent rates were compared between p53 positive and negative group both in surgical margin and primary cancer. RESULTS: (1) The positive rates of p53 in surgical margin and primary cancer were 19.4% (13/67) and 50.7% (34/67), respectively. (2) The recurrent rate of positive margin group was higher than that of negative margin group (69.2% vs. 33.3%, P = 0.018). The survival rate of positive margin group was lower than that of negative margin group (24.62% vs. 75.69%, P = 0.0012). The recurrent rate of p53 positive primary cancer was higher than that of p53 negative primary cancer (64.7% vs. 15.2%, P = 0.0000). The survival rate of p53 positive primary cancer was lower than that of p53 negative primary cancer (42.86% vs. 90.86%, P = 0.0000). CONCLUSION: The prognosis of those with p53 protein positive in the pathological margin or the primary cancer were worse than that of the negative group.

Adult↗
PubMed1999

[Diagnosis and prognosis evaluation of primary non-Hodgkin's lymphoma of the nose].

OBJECTIVE: To Study the diagnosis of primary nasal non-Hodgkin's Lymphoma (NHL) and to find the relationship between its classification, stage and prognosis. METHOD: The data of 10 cases with primary nasal NHL documented pathologically were analysed retrospectively. RESULT: The classification and stage were related to the prognosis significantly. Following up seven cases, 5T-ML with severe systemic symptoms died 4-6 months after diagnosis and treatment. One earlier T-ML is survival till now, and another B-ML was alive for 2.5 years. CONCLUSION: Early diagnosis of NHL of nose based on pathology is very important for treatment and prognosis. Repeat biopsies will be necessary when the diagnosis is suspected. The prognosis of late T-ML is disastrous.

Adolescent↗
PubMed2002

[Relationship between the expression of E-cadherin-catenins and alpha-, beta-, gamma-catenin and the metastasis and prognosis of breast cancer].

OBJECTIVE: To investigate the relationship between E-cadherin, alpha-, beta-, gamma-catenin expression and clinicopathological features and prognosis of breast cancer. METHODS: The expression of E-cadherin and alpha-, beta-, gamma-catenin in 40 breast cancer specimens was studied by the immunohistochemical method. The relationship between E-cadherin, alpha-, beta-, gamma-catenin expression and clinicopathological characteristics or survival time was analyzed respectively. RESULTS: The abnormal expression of E-cadherin and alpha-, beta-catenin was significantly correlated with lymph nodes and distant metastasis (P < 0.01, P < 0.05). The expression of E-cadherin and beta-catenin was also strictly correlated with surival time of breast cancer patients (P < 0.01). However, when all the four proteins (E-cadherin, alpha-, beta-, gamma-catenin) were analyzed as one group, a significant association was found between the abnormal expression of two or more of these four proteins and the metastasis and prognosis of breast cancer (P < 0.05). CONCLUSION: Lower expression of E-cadherin and beta-catenin could be used as an important marker of metastasis and prognosis of breast cancer. Moreover, when all the four proteins (E-cadherin, alpha-, beta-, gamma-catenin) are considered together, the accuracy and sensitivity predicting metastasis and prognosis of breast cancer could be increased.

Adult↗
PubMed1992

[A study on the relationship between pathologic morphology and clinical prognosis of renal cell carcinoma].

One hundred and six cases of renal cell carcinoma (RCC) were studied with an objective to investigate the effects of clinical stages, histological patterns (grading), cell types, nuclear grading and tumor sizes on the postoperative survival time of the patients. The results showed that there were no statistical differences in the postoperative survival time among different histological patterns and among different cellular types, such as clear cell, granular cell and mixed cell. But those with either diffuse sarcomatoid pattern or undifferentiated cell type had poor prognosis. The patients with tumor size greater than 10 cm in diameter had poor prognosis. The prognosis-deciding factors for RCC patients were the clinical staging and nuclear grading. We suggest that the nuclear grading of RCC be noted in every pathological report, so as to provide reference for clinical evaluation of the prognosis and further treatment.

Carcinoma, Renal Cell↗
PubMed1992

[Study of prognostic factors and estimation of prognosis in patients with fungemia].

INTRODUCTION: The estimation of prognosis is necessary in the treatment of fungemia because of its high mortality rate. We studied prognostic factors and estimated prognosis by scoring clinical and laboratory findings in 41 patients with fungemia treated at Tenri Hospital between 1976 and 1990. RESULTS: Although the mortality rate was low (33%) in 18 patients in whom the route of infection had been an intravenous catheter or the urinary tract, it was high (91%) in 23 patients with other or unknown route of infection. The risk of death was high in patients with disseminated intravascular coagulopathy (DIC), shock (systolic blood pressure > or = 90 mmHg), malnutrition (cholinesterase < 0.05 delta pH and albumin < or = 3.0 g/dl), renal failure (urea-N > or = 30 mg/dl and creatinine > or = 3.0 mg/dl), neutropenia (neutrophils < or = 500/microliters) or advanced age (age > or = 60 years old). Application scoring system taking into account of the presence or absence of DIC or shock, the degree of malnutrition, renal failure and neutropenia, and age (20 possible points) in 36 patients revealed that the scores of the 23 patients who died significantly different from those of the 13 survivors; score was less than 6 in every survivor (100%), while it was more than 6 in twenty-two (96%) of the patients who died. Seven of 10 patients with persistent fungal infection had greater than 15. CONCLUSION: The prognosis of patients with fungemia is adversely influenced by the presence of DIC, shock, malnutrition, renal failure, neutropenia and advanced age, and the scoring of these clinical and laboratory findings is useful in the estimation of prognosis and detection of persistent fungal infection in these patients.

Adult↗
PubMed1992

Influence of coexisting cirrhosis on long-term prognosis after surgery in patients with hepatocellular carcinoma.

BACKGROUND: As one of the reasons for the poor prognosis of patients with hepatocellular carcinoma (HCC) and cirrhosis, the influence of cirrhosis itself has not been clarified. METHODS: We compared the postoperative long-term courses of patients with HCC and cirrhosis with the courses of patients with HCC and without cirrhosis to determine how the coexisting cirrhosis affected the prognosis after surgery. The patients with HCC who underwent curative hepatic resection consisted of 142 with associated histologically confirmed cirrhosis and 48 without cirrhosis. RESULTS: The 5-, 7-, and 9-year survival rates were 44%, 32%, and 26%, respectively, in the patients with cirrhosis and 68%, 57%, and 57%, respectively, in the patients without cirrhosis. The prognosis of the group with cirrhosis was significantly worse than that of the group without cirrhosis. The main cause of death in both groups was cancer recurrence. The patients with cirrhosis had significantly lower recurrence-free survival rates at 3 years and later than had the patients without cirrhosis. A comparison of the background factors revealed no substantive disadvantages with regard to tumor-related and surgical factors in the patients with cirrhosis compared with the patients without cirrhosis. The recurrence-free survival rates after minor and major resection indicated fewer disadvantages of limited hepatectomy in the group with cirrhosis than in the group without cirrhosis. Moreover, the recurrence-free survival of the group with cirrhosis was shorter at less advanced stages than at more advanced stages when compared with that of the group without cirrhosis. CONCLUSIONS: The higher carcinogenic potential in cirrhosis could be presumed to be the most likely reason for the poorer prognosis after surgery in the patients with HCC and cirrhosis.

Carcinoma, Hepatocellular↗
PubMed1975

Prognosis of SMON patients.

The following points have become clear on prognosis of SMON through the analysis of 981 cases collected. 1) The prognosis of the old whose ages were 60 year old or over is not favorable, when compared with that of the young. However, there is no prognostic difference between male and female. 2) The cummulative death rate of SMON which was calculated by the life table method is approx twice as much as the generally expected value. 3) Approximately 80% of the patients showed some sort of improvement 7 to 12 months after the onset of the disease. The rate for 13 months or over if nearly the same. 4) The abdominal symptoms found at the time of the onset of the disease decreased markedly in the course of the disease. 5) Among neurological symptoms, the prognosis of motor disorders is more favorable. The complete recovery of sensory disturbances was extremely rare, but approx 60% showed more or less favorable in the course of the illness. Approximately 40% of the cases with visual disturbances completely recovered or showed favorable improvement, whereas 9% of them became worse. As for the prognosis of visual impairment, it is more serious than other symptoms. 6) The patients who had been administered clioquinol over long period displayed a higher rate of severe or moderate motor, sensory and visual disturbances, compared with the group with short-term administration of clioquinol. The death rate was also higher in the former group. 7) The rate of relapse as a whole was 16.7% and 68% of them was seen within 18 months after the onset. There is no difference in relapse according to sex. There was seen a high rate of relapse in the group of longterm administration of clioquinol. 8) A 10.5% of total cases were either unable to walk or in need of assistance in walking, whereas the rate of patients who cannot get dressed or who cannot defecate unassisted was lower. 9) Approximately 65% returned to the job in 12 months or more after the onset. The employment rate was not different according to sex, whereas it was lower along with the age advances. 10) Approximately 20% were not received medical treatment. The rate of non-treated patients is higher in the younger patients. The rate of hospitalized patients was higher in the older patients.

Adult↗
PubMed2003

[Long-term prognosis in patients with acute myocardial infarct and treatment with direct coronary angioplasty].

BACKGROUND: Primary coronary angioplasty (PTCA) has a beneficial effect on the immediate prognosis for patients with acute myocardial infarction. Number of information about effects of direct PTCA on the long-term prognosis are less numerous. The aim of the work was to establish the long-term prognosis for not-selected patients treated by direct PTCA. METHODS AND RESULTS: The studied group consisted of 279 patients with acute myocardial infarction treated by direct PTCA in years 1995 to 1999 for the period of 38 +/- 12 months. Part of them were out-door patients of our clinic. The necessary data of the other patients were obtained by a questionnaire and by a telephone contact. 45 (16%) patients were lost from the follow up. The mortality rate of the study group was compared with data in the central register of Czech Republic. Positive angiographic effect of the direct PTCA (residual stenosis < 50% + flow TIMI 3) was achieved in 90% of patients. 30-day mortality was 6.8%, after excluding patients with cardiogenic shock it decreased to 3.2%. 6 patients (2.2%) had non-fatal infarction within 30 days after the first attack. From 259 patients who survived the acute infarction phase 24 died during the next period of follow up, 18 (7%) patients had a relapse of non-fatal infarction. PTCA of the infarcted artery was done in 15% of patients, PTCA of another artery in 9% of patients. The aorthocoronary bypass was indicated in 6% of patients. Almost half of relapses occurred during the first year after the hospitalisation. The risk factors of the death during the follow up were the age > 70 years, ejection fraction < 35%, impairment of 3 or more coronary artery branches, i.m. in the history, duration of ischemia > 4 hours, and diabetes mellitus. The total mortality was 11.4% in the first year, 1.4% in the second and 3.3% in the third year of the follow up. CONCLUSIONS: The beneficial prognostic effect of the direct PTCA on patients with acute infarction carries through the whole period of follow up. Prognosis of the risk patients remains critical. Next revascularization of the infarcted artery was in our cohort of patients necessary in 21% of patients.

Angioplasty, Balloon, Coronary↗
PubMed2003

[Molecular markers associated to prognosis of melanoma].

Melanoma prognosis is based on histological criteria such as tumor thickness (measured by Breslow index), level of invasion (Clarck's level), presence of ulceration and number of mitoses per mm2. However, these parameters do not provide a precise prognosis in all cases: thin melanomas may develop metastases and thick melanomas may remain focalized for many years. For these reasons, the search for other prognostic factors is still ongoing. Many molecules play a part in the invasiveness and metastatic dissemination of melanoma have now been identified. Expression of these molecules has been studied in primary melanoma and correlated with prognosis. An increase in the number of cells positive for Ki67 (detected by Mib1), cycline A, cycline D, p35, MMp-2, beta1 and beta3 integrins, osteonectin, the presence of an intense inflammatory infiltrate and capillary invasion are considered as factors of poor prognosis as well as the decrease in p16, p27, Melan A and nm23. The significance of CD44 modifications is still controversial. Only a small number of these different proteins has a prognostic value independent of tumor thickness. These results need to be confirmed on larger series of patients. Additional hope is given to new techniques such as the analysis of the genes implied in tumor progression by microarray technique in such a way as to provide a molecular map of each tumor.

Biomarkers, Tumor↗
PubMedDate not supplied

Intraluminal irradiation for T2M0 esophageal cancer: effect of patient selection on prognosis.

The contribution of intraluminal irradiation to the prognosis of T2M0 esophageal cancer was examined with reference to patient selection. To determine the effect of patient selection, we used esophagrams to assess the potential difficulty of inserting a tube for intraluminal irradiation in 39 patients who were treated with external irradiation prior to 1982. Twenty-two patients were assessed as likely to have been able to undergo intraluminal irradiation (group 1) while 17 were assessed as unlikely to have been able to undergo the procedure (group 2). Of 36 patients treated after 1983, 19 patients were treated with a combination of intraluminal irradiation and external beam therapy (group 3) and 17 by external irradiation alone (group 4). The median survival times of groups 1, 2, 3, and 4 were 10.8, 6.4, 12.0, and 8.5 months, respectively. The prognosis of patients treated with combination therapy (group 3) was superior to that of those treated before 1982 (groups 1 + 2). However, there was no improvement in the prognosis of T2M0 esophageal cancer treated by radiotherapy after the introduction of intraluminal irradiation, and the difference between the survival curves of patients treated by combination therapy (group 3) and with a wide esophageal lumen (group 1) was not significant. Our study thus showed that the selection of patients according to the insertability of the intraluminal therapy tube affected the prognosis.

Aged↗
PubMed1992

[Correlation between karyotype and prognosis in adult lymphocytic leukemia].

Correlation between karyotype and prognosis in adults with lymphocytic leukemia are reviewed. Concerning acute lymphoblastic leukemia (ALL), patients with normal karyotype or with hyperdiploidy (greater than 50 chromosomes) show good prognosis. On the other hand, patients with structural abnormalities, such as t(8;14), t(4;11), t(11;14) or with hyperdiploidy (47 to 50 chromosomes), show poor prognosis. Above findings indicate that karyotype is a significant prognostic factor in adults as well as in children with ALL. Karyotype must be considered in designing clinical trials to improve the prognosis in patients with lymphocytic leukemia, especially in ALL.

Adult↗
PubMed2004

[Expression of DNA excision repair enzymes and lung cancer prognosis].

OBJECTIVE: To study the expression levels of three DNA damage excision repair enzymes: excision repair cross-complementing rodent repair deficiency gene 2 (ERCC2), uracil DNA glycosylase (UDG), and proliferating cell nuclear antigen (PCNA), in different lung tissues and their relationship with lung cancer prognosis. METHODS: The expression levels of ERCC2, UDG, and PCNA protein were detected using immunohistochemistry method. Cancer tissues and normal tissues adjacent to the cancer from 61 cases of lung carcinoma, and tissue samples from 18 cases of benign lung disease were studied. The relationship among ERCC2, UDG, and PCNA expression levels with lung cancer development and prognosis were studied using Ridit analysis method. RESULTS: The expression levels of all three proteins were not significantly different between cancer tissues and a normal tissues adjacent to the cancer (P > 0.05); but significantly different between cancer tissues and benign tissues, and between normal tissues adjacent to the cancer and benign tissues (P < 0.05). ERCC2 and UDG levels were higher in benign tissues than those in cancer and cancer adjacent tissues, while the PCNA level was the opposite. Only the UDG level in cancer adjacent normal tissues showed no significant difference compared to that of benign tissues (P > 0.05). There were no relationship among age, smoke, cancer metastasis, cancer type and ERCC2, UDG, PCNA expression levels. ERCC2 also showed no relationship with degree of malignancy and cancer size, while UDG and PCNA expression levels were correlated with cancer malignancy and cancer size (P < 0.05). Low UDG and high PCNA expression levels were correlated with higher malignancy and larger tumors. CONCLUSION: The expression levels of ERCC2, UDG and PCNA were significantly different in benign lung tissues, lung cancer tissues and lung cancer adjacent normal tissues. ERCC2 showed no significant relationship with lung cancer prognosis, while patients with low UDG and high PCNA expressions were more likely to have higher malignancy and larger tumors. UDG and PCNA were possible markers for evaluating lung cancer prognosis.

Adult↗