Moritz Kaposi: noted dermatologist.
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The Papanicolaou smear, a routine screening test for cancer of the uterine cervix, was reported in 1928, and its efficacy was proved by 1941. Since then, it has been used worldwide as a clinical tool for the early detection of cancer. Cancer of the cervix follows a predictable sequence. Precancerous changes, not visible to the naked eye, are detected readily in cells sampled by the Papanicolaou smear. The evolution from the precancerous stage to cancer is slow, and routine annual screening makes this a curable cancer and totally preventable disease. This is the story of an ambitious and brilliant man, George Papanicolaou, and his devoted wife, Andromache Mavroyenous, whose discovery of the screening test is now recognized as the most significant advance in the control of cancer in the 20th century.
The Nobel Prize in Medicine/Physiology for 1913 was awarded to Charles Richet, French physiologist, for studies of "anaphylaxis." The earliest articles on what was actually the original experimental induction of hypersensitivity were the result of collaborative studies of Paul Portier and Charles Richet. This article presents an account of the discovery based on an extensive examination of original sources with attention to the particulars of the contributions of each of the codiscoverers. An unusually complete and intimate story of the unfolding of the discovery could be pieced together from the findings in the original sources. The contributions of Paul Portier in the experiments leading to the recognition of a relationship between hypersensitivity and immunity earned him a more prominent position in the ancestry of allergy.
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The botanist and explorer, Ferdinand von Mueller, was the most distinguished of the many German scientists who made important contributions to Australian science during the nineteenth century. This article explores the background to his going to Australia and the way in which he established a scientific career there, and outlines his principal contributions as Victoria's Government Botanist for over 40 years, from 1853 to 1896.
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