[Acute and subacute toxicity studies on netilmicin (author's transl)].
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Many strains of cefazolin (CEZ)-resistant Staphylococcus aureus of recent clinical isolates were also resistant to gentamicin (GM). In addition, the antibacterial activity of NTL was found to be stronger than that of GM and stronger than that of CEZ for those resistant strains and especially for those moderately resistant to GM.
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A study of 283 isolates of gram-negative bacilli revealed a good correlation (r = -0.74) between disk diffusion zones of inhibition and agar dilution minimal inhibitory concentrations. Regression analysis suggested that strains with zone sizes =/<11 mm should be considered resistant, but 34 of 45 strains resistant by minimal inhibitory concentration (including 27 strains of Pseudomonas aeruginosa) would have been called susceptible using this break point.