Central neurofibromas of the mandible: report of two cases.
Two cases of intramandibular neurofibromas unassociated with Von Recklinghausen's disease are presented and the literature is reviewed.
Adult↗
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[Neurofibroma with a glandular component].
A 21-year-old man had a delimited tumour of a size of a nut, which grew expansively in the subcutaneous region of the thigh. It had the structure of neurofibroma with myofibrils and with a glandular component which on electronoptic examination was cylindromatous nature. This case is the eighth one in literature and the first one documented electronoptically. A similar tumour in a 26-year-old woman was located in the subcutaneous layer of the calf but, apart from this electronoptic structure revealed a multitude of tumours cells of a tonofibril corresponding to the spinocellular epithelium. The possibility is discussed whether even this tumour may not be of neurofibromatous origin.
Adult↗
Colic in a mare caused by a colonic neurofibroma.
A 16 year old Thoroughbred mare was presented to the Ontario Veterinary College because of an acute episode of colic. An exploratory laparotomy was performed and a neurofibroma was identified and successfully removed from the small colon. The clinical and pathological features of this case are discussed.
Animals↗
[Giant neurofibroma of the occipital scalp associated with lambda defect-case report (author's transl)].
Calvarial bone defect associated with a hugh neurofibroma in the region of the lambdoid suture was reported in a 42-year-old man with v. Recklinghausen's neurofibromatosis. An enlarging occipital tumor was first noted at age 4 similar to or approximately 5, and an operation was performed at age 12. Lambda defect was noted at that time, but the operative diagnosis was, apparently, "meningocele". Available literature was reviewed, and the significance of calvarial bone defect in the region of the lambdoid suture as a manifestation of v. Recklinghausen's disease was stressed. Lambda defect witn no sclerosing margin, particularly if associated with hypoplasia of the ipsilateral mastoid cells, has been known to represent the primary nature of the bone defect due to mesodermal dysplasia. In the present case, plain radiographs of the skull revealed abnormal sclerotic change around the bone defect. It is suggested that such an osteoblastic change may well indicate the secondary nature of the bone defect due to the presence of overlying neurogenic tumor.
Adult↗
[Neurofibroma of the larynx].
During the years 1986--90 about 480 patients with tumors of the larynx were treated in Cracow Otolaryngological Clinic. In this group were two cases of neurofibroma of the larynx. These patients were treated upon by various types of surgically operations.
Adult↗
Hepatocyte growth factor is a mitogen for Schwann cells and is present in neurofibromas.
To characterize mitogens that might contribute to Schwann cell proliferation during development or in tumors, we tested the ability of hepatocyte growth factor (HGF) to stimulate Schwann cell division in vitro. HGF is a potent mitogen for purified rat Schwann cells; DNA synthesis in rat Schwann cells was stimulated 20-40-fold by 3-10 ng/ml HGF. Rat Schwann cells express c-met mRNA, encoding the HGF receptor, but not HGF mRNA, implying that HGF might act as a paracrine Schwann cell growth factor. HGF-stimulated Schwann cell proliferation differs from that of previously described Schwann cell mitogens in that its activity is abolished by forskolin and is not inhibited or potentiated by addition of transforming growth factor beta (TGF beta) or fibroblast growth factor (FGF). HGF is probably not a component of the axonal signal thought to cause Schwann cell division during development, as anti-HGF neutralizing antibodies failed to block neuron-stimulated Schwann cell proliferation. In contrast, mitogenic activity present in normal human adult nerves and in neurofibromas from patients with type 1 neurofibromatosis analyzed in the absence of forskolin is largely inhibitable by anti-HGF. Thus, HGF is a novel mitogen for Schwann cells in vitro and it is present in Schwann cell tumors, suggesting a potential role for HGF after wounding of peripheral nerves or in tumor growth.
Adolescent↗
Solitary intraosseous neurofibroma of the mandible: report of a case.
A case of solitary intraosseous neurofibroma of the mandible is reported. The tumor was located in the body of the right mandible. Segmental mandibulectomy including the surrounding tissue was performed and the mandible was reconstructed with the free scapular osteocutaneous flap. From histological examination of the resected mandible, typical findings of a tumor invading the adjacent bone along the mandibular nerve were observed. Immunohistochemical examination of the tumor showed positive staining of the tumor cells for anti-S100 protein antibodies. Numerous nerve-like fibers were also noted by Bodian stain.
Adult↗
[Neurofibroma of the lower lip].
Reporting a nervous tumor diagnosed as Neurofibroma, which owing to its localisation, on the lower lip, and its possible origin, from a salivary gland, should be considered an extraordinary rarity. The AA, make a bibliographic review of the commonest sites of the growth, the histological description and consider some possible differential diagnosis with special emphasis to the schwannoma and the Recklinghausen's disease.
Animals↗
[Lateral isolated neurofibroma of the neck].
The neurofibroma (NF) of the neck is a neurogenic tumor seldom presented. Sometimes solitary, as the case reported, or within the context of von Recklinghausen's disease. When diagnosis is doubtful either the TAC, the RMN of the PAAF show its usefulness. However the ultimate diagnosis is made through the histologic exam of the removed lump, which is the elective treatment.
Adult↗
[Myxoid neurofibroma of the renal sinus].
Presentation of one case of a 7.5 x 6 cm myxoid neurofibroma located in the left renal sinus, which is really exceptional. The finding in a 41-year-old, asymptomatic patient is casual and during a routine follow-up study with ultrasound for a Hodgkin lymphoma with a 9-year remission interval. Computerized axial tomography, intravenous urography and thin-needle puncture-aspiration cytology were performed to investigate its origin. Treatment is surgical and requires nephrectomy of the affected side.
Adult↗
[Solitary neurofibroma of the larynx. Removal by a microlaryngoscopic method].
We report a case of neurofibroma of the larynx arising from the aryepiglottic fold, surgically removed by direct micro-laringoscopy. From a review of the literature the case is extremelly rare (35 cases until 1963), expecially looking to the age of the patient (3 1/2 years old), that seems to be the lowest reported until now.
Child, Preschool↗
A case of giant bathing trunk naevus with neurofibroma-like change.
It is recognized that cells of melanocytic naevi may resemble neuroid structures and the term neurotization has been used to describe this phenomenon. This may result in difficulty in the histological differentiation between naevi and neurofibromas. We report the case of a patient with a giant bathing trunk naevus which has undergone marked neurotization and in whom there had been diagnostic difficulty.
Adult↗
[Intraparotid facial neurofibroma].
A 56-year-old man with a solitary neurofibroma involving the main trunk of the intraparotid facial nerve is presented. Because its small frequency it's an unexpected tumour of which the definitive diagnosis is only established after its removal. Literature is revised.
Facial Nerve↗
A neurofibroma affecting the first right cervical sympathetic ganglion and entering the jugular foramen of the skull base.
The case of a 27 year old male patient is presented. He had been complaining for three months prior to his initial medical examination of severe pulsating headache in the right occipital region, propagating toward the right parietal and temporal regions, occasionally extending along the neck to the right shoulder. The pain subsequently spread over the right tonsil, the voice became hoarse and the patient experienced difficulties in swallowing. On admission to our Department we found: persistent attacks of headache, dysphonia, dysphagia, the palatine arch was slow during phonation. The right pharyngeal reflex was absent, there was pain on palpation over the right occipital bone and the antero-lateral region of the neck, as well as hypotrophy of the right sternocleidomastoid muscle. Selective right carotid arteriogram was performed--the A/P view revealed lateral displacement of the right internal carotid artery 3 cm above the bifurcation, while on lateral view the artery was pushed forward. Computed tomography of the neck with bolus contrast enhancement showed a space-occupying lesion which caused asymmetry of right pharyngeal valleculae. During surgery the tumor was found to have a spindleform shape, to emerge from the jugular foramen and to involve within its capsule the first cervical sympathetic ganglion. After enlarging the jugular foramen we achieved total extirpation of the tumor along with the first right sympathetic ganglion. The histological characteristics of the specimen defined it as neurofibroma and neural ganglion. The headache subsided in the postoperative period, recovery of the voice without dysphonia was also noted. A month later the fibrillar contractions of the tongue disappeared.
Adult↗
[Neurofibroma of the larynx].
Thus article has presented a late case of neurofibroma of the larynx. The attention has been directed towards diagnosis difficulties which were recognized before the histopathologic diagnosis has been established.
Biopsy↗
Plexiform neurofibroma with and without associated malignant peripheral nerve sheath tumor: a clinicopathologic and immunohistochemical analysis of 54 cases.
Plexiform neurofibroma (PNF) is an important part of the diagnostic criteria for neurofibromatosis type 1 (NF1) and is a known precursor lesion of malignant peripheral nerve sheath tumor (MPNST). We studied the clinicopathologic features of 54 cases of PNF for which the hematoxylin- and eosin-stained slides and paraffin blocks were available and adequate clinical follow-up could be obtained. In addition, in all cases, a representative section of the PNF and, when present, MPNST, was evaluated immunohistochemically with an antibody for p53 (DO7). The cohort included 28 male patients and 26 female patients, with an age range from 4 to 79 years (mean, 27 yr). Of these 54 patients, 46 (85%) met the strict diagnostic criteria for NF1. Thirty-nine patients had PNF alone; 15 patients had an MPNST arising from the PNF (PNF/MPNST). Those patients with PNF/MPNST tended to be older (38 yr vs. 22 yr) and to have larger tumors (10.5 cm mean vs. 7.4 cm mean) than those with PNF alone. In 9 patients (23%) of 39 with PNF alone, local recurrence developed, whereas in 7 patients (47%) of 15 with PNF/MPNST, recurrent MPNST developed, and metastases developed in 3 (20%) of the 15. Immunohistochemically, only 1 case (2.5%) of 39 cases of PNF alone stained for p53. On the other hand, 12 (80%) of 15 cases of PNF/MPNST showed p53 immunoreactivity in the MPNST component, 2 of which also showed staining in the PNF areas. In conclusion, we found that the vast majority of patients with PNF met the strict diagnostic criteria for NF1. The immunohistochemical detection of intranuclear p53 protein is common in the malignant areas of PNF/MPNST but is rare in the PNF regions. The rarity of p53 staining in the PNF regions precludes its use in predicting those tumors that are likely to progress to MPNST.
Adolescent↗
[Neurofibroma and neurofibrosarcoma in Recklinghausen's neurofibromatosis].
The neurofibromatosis von Recklinghausen is a systemic disease, which can cause various different changes in the body. The case report of a female patient shows all the typical signs of neurofibromatosis von Recklinghausen. These signs are café-au-lait spots, congenital tibia pseudarthrosis, abdominal plexiform neurofibromatosis and peripherical neurofibromas with sarcomatous degeneration.
Adult↗
Solitary, central neurofibroma of the mandible: a case report.
A case of Solitary Central Neurofibroma in a 53 years old female is reported. This is an apparently single primary lesion, in which physical and Radiological examination failed to reveal other bony lesions or the stigmata of multiple neurofribomatosis.
Female↗