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Conservative management of degenerative temporomandibular joint disease in the elderly.

Degenerative arthropathy and rheumatoid disease produce significant morbidity in elderly dental patients. Clinical and radiographic examination usually indicates the nature and extent of the disease in the temporomandibular joints and provides the basis for graduated treatment. Conservative measures are generally more acceptable and most successful in the elderly patient with pain, limitation of opening and grating of the joint. Acute-onset arthritis is relieved by local anaesthetics, non-steroidal anti-inflammatory drugs and occlusal adjustment. Occasionally, intra-articular steroids are needed; these provide prolonged relief from pain and stiffness. Remedial exercises, in conjunction with physical therapy, should be continued after resolution of the acute attack or used as primary treatment for chronic arthropathy. A small proportion of cases remain resistant to conservative treatment; blind condylotomy (surgical sectioning) of the affected condylar neck is a safe, effective procedure for refractory cases which do not respond to the conservative regimen described. This procedure may be used for degenerative arthropathy and also for chronic dislocation which has failed to respond to peri-articular injection of sclerosing agents. Rheumatoid disease in the jaw should be treated in conjunction with the medical therapist when other joints are involved.

Adrenal Cortex Hormones↗

Topical NSAIDs for joint disease.

Over 20 proprietary topical preparations of non-steroidal anti-inflammatory drugs (NSAIDs) are now available, both 'over the counter' and on prescription. They are licensed for the treatment of pain due to 'non-serious' arthritic conditions and/or soft tissue injuries. In the early 1990s, we could find little evidence to support the use of these products rather than simple analgesics or oral NSAIDs for acute soft tissue injuries, and even less for chronic inflammatory and degenerative joint diseases. Here, we reconsider the place of topical NSAIDs, concentrating on their use in chronic arthritic conditions.

Administration, Topical↗

Cell-mediated immune response in the diseased joints in patients with reactive arthritis.

To evaluate the level of lymphocyte activation in reactive and rheumatoid arthritis, density gradient-isolated, synovial fluid mononuclear cells were stained with a panel of antisera directed at lymphocyte activation markers using an avidin-biotin-peroxidase complex (ABC) method. More specifically, we studied the expression of immune response-associated class II HLA antigen (Ia), of receptors for interleukin 2 (Tac) and transferrin (T9), as well as of gp 40/80 glycoprotein (4F2). Although Ia+ cells formed about 60% of all the synovial fluid mononuclear cells in both disease conditions, the proportion of Tac+ (33 +/- 4% vs 3 +/- 1%, P less than 0.001), T9+ (34 +/- 4% vs 5 +/- 2%, P less than 0.001), and 4F2+ (48 +/- 6% vs 3 +/- 2%, P less than 0.001) cells was high only in reactive arthritis. All the patients who had reactive arthritis followed a favourable clinical course during the 4-month-long prospective follow-up, whereas disease activity was stable in patients with rheumatoid arthritis. These findings suggest that the diseased joints in reactive arthritis are a site for an active, but normally down-regulated, cell-mediated immune response.

Antibodies, Monoclonal↗

Correlation of synovial fluid interleukin 6 (IL-6) activities with IgG concentrations in patients with inflammatory joint disease and osteoarthritis.

Synovial fluids of patients with rheumatoid arthritis, osteoarthritis, psoriatic arthritis, reactive arthritis and Reiter's syndrome were examined for their concentrations of interleukin 6 (IL-6) in a proliferation assay with the IL-6 dependent hybridoma cell line B13.29 (subclone B9). IL-6 activity was significantly higher in the synovial fluids of patients with rheumatoid arthritis and psoriatic arthritis than in patients with osteoarthritis. Significant correlations were shown between the concentrations of synovial fluid IL-6 and IgG. These findings may contribute to the understanding of the enhanced immunoglobulin production by synovial mononuclear cells in patients with inflammatory joint disease.

Adult↗