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PubMed2006

Evolving medical knowledge: moving toward efficiently answering questions and keeping current.

The information needs of clinicians are many and varied; however, these information needs remain largely unmet. This likely diminishes the quality of patient care. Although it is important that physicians be proficient in critically evaluating the medical literature, it is more important that they become proficient in the "applied science of information management." Clinicians must learn the techniques and skills to find, evaluate, and use relevant and valid information both in the care of patients and in their careers of lifelong learning. Clinicians need sources for rapid retrieval of valid information at the point of care.

Education, Medical, Continuing↗

PubMed2001

Health and safety issues pertaining to genetically modified foods.

Genetic modification involves the insertion of genes from other organisms (within or between species) into host cells to select for desirable qualities. Potential benefits of GM foods include increased nutritional value; reduced allergenicity; pest and disease-resistance; and enhanced processing value. Possible detrimental outcomes include producing foods with novel toxins, allergens or reduced nutritional value, and development of antibiotic resistance or herbicide-resistant weeds. Benefits to individuals or populations need to be weighed against adverse health and environmental risks, and may differ between developing and Westernised countries. Whether testing and monitoring should exceed requirements for conventional foods is under debate. While not necessarily scientifically justifiable, consumer concerns have resulted in Australian and New Zealand requirements to label foods containing GM-produced proteins. Dissatisfied consumer advocacy groups are calling for all foods involving GM technology to be labelled, irrelevant of whether the final product contains novel protein. Goals to improve the quantity, quality and safety of foods are laudable; however, the primary aim of the bio-food industry is financial gain. GM foods may be as safe as conventional foods but public distrust runs high. It is important that discussion is informed by science and that claims of both benefits and risks are evidence-based, to ensure that the process is driven neither by the vested interest of the bio-technical multinational companies on the one hand, nor ill-informed public fears on the other.

Attitude to Health↗

PubMed1991

The Human Genome Project: a paradigm for information management in the life sciences.

The major product of the Human Genome Project will be a series of linked data sets containing the genetic and physical location of all genes on each chromosome, plus the complete nucleotide sequence of the genome for humans and several model organisms. Here we summarize the current status of attempts to collect, analyze, and distribute this information in an electronically accessible form. Although formidable problems remain to be solved in the acquisition and adequate representation of the genetic, physical, and biological data, this project is a model for the rapid dissemination of genome and related information in biology and medicine.

Base Sequence↗

PubMed1991

[Model for estimating costs per student at the medical sciences campus].

The information about cost is considered at present essential for decision making in institutions of higher education. The way this information is collected, and the determination of the variables and cost objectives to be considered on the model depend on the particular characteristics and the objectives of the institution. This article describes the model developed for estimating costs per student and per year of study in the program, in the Medical Sciences Campus of the University of Puerto Rico. The information about costs is never completely precise yet, the model presented has tried to consider, whenever possible, all the cost elements that contribute to approximate the estimates to the real costs.

Costs and Cost Analysis↗

PubMedDate not supplied

["In all homes, the moral comfort of science and of art": the Revista Nacional de Educação and scientific dissemination in Brazil (1932-34)].

Between 1932 and 1934, the journal Revista Nacional de Educação was published by Rio de Janeiro's National Museum, under the auspices of hte Brazilian Ministry of Education and Public Health and under the direction of Roquette-Pinto. Its main goal was to disseminate information on science, history, and art among a wide-ranging Brazilian public. The articles were written by the intellectuals of the day, many of whom were scientists at the Museu Nacional. The Revista also published translations of excerpts by a number of travelers. Every issue was published at a low cost, with a significant number of copies. The journal was touted as the initiative of a renewed Republic, part of a broader strategy of inaugurating new relations between government and a population to be educated. It defined itself as "a spiritual milestone in the Brazilian nationality" in tune with the ideal of a State whose educational initiatives were meant to constitute a people and a nation.

Brazil↗

PubMed2003

The current status of the anatomical sciences curriculum in U.S. and Canadian dental schools.

The anatomical sciences form one of the major building blocks of the basic medical sciences in the professional training of dentists. This paper defines the courses and classifies the formats of teaching for each course within the anatomical sciences curriculum. Information was gathered from the Internet, specifically the American Dental Education Association (ADEA) website links to U.S. and Canadian dental schools and their online catalogues or bulletins as well as online course syllabi. The results demonstrate the distribution of schools in the United States and Canada teaching anatomical sciences in the following categories: stand-alone, sequential, and multifaceted courses for gross anatomy; stand-alone and integrated courses for histology; stand-alone, integrated, incorporated, and no course for neuroanatomy; and stand-alone, incorporated, and no course in embryology. This paper concludes with the proposition that a survey of the usage of anatomical knowledge in use in a typical dental general practice needs to be conducted. The results of such a survey need to be evaluated with the intention of determining what should be taught in a dental clinical anatomical sciences curriculum.

Anatomy↗

PubMed2002

Use of animals in research: a science - society controversy? The European perspective.

The use of animals for research and testing purposes has decreased substantially during the last two decades but is now increasing again, mainly because of the increased use of transgenic animal models. Presently, 10-12 millions of vertebrate animals are used per year within EU Member States. Scientists who are using animals in research are frequently criticised by animal protection groups and blamed that they do not respect the integrity of an animal's life. The European Science Foundation (ESF) is recognising that legislation cannot be the only answer to those worries in society and that it is essential to take a stand and to clearly explain what the Foundation's position with regard to the use of animals is. In a recently published position paper, ESF has discussed its views and has adopted guidelines for the use of animals in research. The document explicitly states that laboratory animals have an intrinsic value, which must be respected. The consequences of recognising the intrinsic value have been elaborated in the position paper and include, among others, strong endorsement of the replacement, reduction, refinement principles. It is stated that, prior to the performance of an animal experiment, the protocol should be subjected to independent expert review including the weighing of the likely benefit versus the likely animal suffering. Also, the development and organisation of accredited courses on laboratory animal science, including information on animal alternatives, welfare and ethics are encouraged. The guidelines, as formulated in the position paper, can be seen as reinforcement of developments that have already been started in several countries, but have not always received full support from the scientific community. With this document, the association of 70 leading national science organisations in Europe has taken a position that, in several aspects, exceeds current European legislative regulations. For bridging the science - society controversy, it is essential to continue this initiative by promoting the implementation of the guidelines at all levels of the scientific community. This requires commitment and scientific leadership.

Animal Testing Alternatives↗

PubMed2002

New perspectives on the use of Geographical Information Systems (GIS) in environmental health sciences.

At first glance, the domain of health is no typical area to applicate Geographical Information Systems (GIS). Nevertheless, the recent development clearly shows that also within the domains of environmental health, disease ecology and public health GIS have become an indispensable tool for processing, analysing and visualising spatial data. In the field of geographical epidemiology, GIS are used for drawing up disease maps and for ecological analysis. The striking advantages of GIS for the disease mapping process are the considerably simplified generation and variation of maps as well as a broader variety in terms of determining a real units. In the frame of ecological analysis, GIS can significantly assist with the assessment of the distribution of health-relevant environmental factors via interpolation and modelling. On the other hand, the GIS-supported methods for the detection of striking spatial patterns of disease distribution need to be much improved. An important topic in this respect is the integration of the time dimension. The increasing use of remote sensing as well as the integration into internet functionalities will stimulate the application of GIS in the field of Environmental Health Sciences (EHS). In future, the integration and analysis of health-relevant data in one single data system will open up many new research opportunities.

Ecology↗

PubMedDate not supplied

Brownfields: a case study in partnering with residents to develop an easy-to-read print guide.

At least three cultural circumstances have converged to make environmental health information critical, yet highly inaccessible, to many Americans: 1) the declining literacy levels of almost half the population, 2) the growing cultural diversity of the population, and 3) the complexity of environmental health information and science. This paper presents a case study of how literacy experts and environmental scientists partnered with a panel of inner-city residents to produce a community guide about brownfields, a process the authors refer to as "cooperative composing." The goal was to create low-barrier material (fifth-through-eight-grade reading level) that would inform people about brownfields issues so that they can meaningfully insert themselves into the process of planning for brownfields reuse and redevelopment. The authors structured an ongoing process with a panel of residents to learn with them just what types of information they wanted and what language level and graphics were appropriate. A primary motivator of this study was the belief that informed, activated residents will bring about greater equity and collaboration in environmental planning for brownfields.

City Planning↗

PubMed1997

The role of the Agency for Health Care Policy and Research (AHCPR) in improving outcomes of care.

This article describes the various outcomes programs supported by the Agency for Health Care Policy and Research (AHCPR). The mission of the agency is to generate and disseminate information that improves the delivery and quality of health care. The agency is charged with helping consumers, providers, purchasers, health plans, and policy makers meet the challenge of improving the quality of health care services while reducing spending. AHCPR has been recognized as funding the development of "gold standard" clinical practice guidelines and the source of unbiased, science-based information on what works and does not work in health care.

Cost-Benefit Analysis↗

PubMed2006

On teaching computer ethics within a computer science department.

The author has surveyed a quarter of the accredited undergraduate computer science programs in the United States. More than half of these programs offer a 'social and ethical implications of computing' course taught by a computer science faculty member, and there appears to be a trend toward teaching ethics classes within computer science departments. Although the decision to create an 'in house' computer ethics course may sometimes be a pragmatic response to pressure from the accreditation agency, this paper argues that teaching ethics within a computer science department can provide students and faculty members with numerous benefits. The paper lists topics that can be covered in a computer ethics course and offers some practical suggestions for making the course successful.

Computers↗

PubMed2004

A proposed higher education institution-based Three Rs advisory service.

The University of Oxford's Ethical Review Process (ERP) is promoting a pilot scheme for a collaborative UK higher education institution-based Three Rs advisory service. It is believed that there is scope for UK academia to make a significant contribution, through the spread of its science base and the availability of high-quality library and IT services. A collaborative approach based on the concept of the critically appraised topic is envisaged, to minimise duplication and to ensure that limited resources are used to good effect. The initial objective is to identify, research, and validate refinement and replacement alternatives, drawing on both the skills of the information professional and the analogy of evidence-based health care. The results would be disseminated among member institutions by way of web-based systems, which could also offer on-line training in search strategies. The service would provide assistance to university-based project licence applicants, and would contribute to achieving the aims of the ERP, as an initiative "leading to the widest possible application of the Three Rs". It is hoped to develop the scheme in partnership with research council initiatives now under way, as the councils play a key role as funders, not only of research, but also of research student training. Universities are uniquely positioned, as centres of scientific education and, through continuing education, of continuing professional development, to provide a base for training in good practice. A successful pilot project could provide a foundation for a similar approach to reduction strategies and experimental design.

Animal Use Alternatives↗

PubMed1988

Decree relating to health education and information on youth as well as to aid and assistance to families in areas relating to contraception and responsible parenting, 10 July 1984.

This Decree requires various organizations in the French Community of Belgium, which supply aid and information on sexuality, marriage, and the family, to furnish their personnel with a list of approved centers and documentation containing the necessary legal, technical, and medical information for couples and persons who request it in the area of contraception and responsible parenting. It also requires the personnel of such organizations, as well as hospitals, to give to women in distress the necessary technical and medical aid to deal with difficulties in using contraceptive methods. Finally, it requires educational establishments to provide, within the framework of biology and social and moral science courses, information on the legal, technical, moral, and medical problems posed by responsible parenting and contraceptives.

Ambulatory Care Facilities↗

PubMed2004

Family practice clerkship information seminars:the role of the health sciences library.

This article will describe the New Jersey Medical School (NJMS) Family Medicine clerkship's Information Seminars for thirdyear medical students, conducted by the faculty and staff of the Department of Family Medicine and by librarians at the University of Medicine and Dentistry of New Jersey's (UMDNJ) George F. Smith Library of the Health Sciences. Content of the information seminars will be briefly described, as well as the renewed focus on the library through the incorporation of evidence-based medicine concepts into practice.

Clinical Clerkship↗

PubMedDate not supplied

Genetic practice, education, and research: an overview for advanced practice nurses.

PURPOSE/OBJECTIVES: The purpose of this article is to describe how the new genomic era will affect advanced practice registered nurses (APRNs) patient care, education, and research. BACKGROUND/RATIONALE: Given the exponential growth of genetic information and that 9 of the top 10 leading causes of mortality have genetic components (www.cdc.gov), it is imperative to educate advanced practice nurses about this salient topic. DESCRIPTION OF THE PROCESS: Because few APRNs in practice or academia have had formal education on genetics, the first step of nursings' own gene discovery is recognizing that there is an ongoing need to understand state of the science genetic information to gain clinical and educational utility. OUTCOMES: By recognizing APRNs need to know genetics, APRNs will clamor within their workplace for continuing education about this dynamic information. It is critical knowledge for APRNs to classify risk based on family history, target individualized patient prevention and education, modify pharmacologic interventions, and refer when genetic testing is necessary. INTERPRETATION/CONCLUSION: This article stresses the timely relevance of applying genetics and genomics to practice, teaching, and research. IMPLICATIONS FOR NURSING PRACTICE: APRNs need to maintain a place at the genetic table with all healthcare providers by developing strategies to expand this nursing knowledge to their practice, teaching, and research. Nurses need to be cognizant of the keen genetic value of family histories, how risk classification will individualize prevention recommendations, and the exciting role of pharmacogenetics, given many APRNs' prescriptive authority. Our core professional belief that each human is highly unique has probably never been more accurate than with the future in genetic and genomic nursing.

Genetic Testing↗

PubMed2003

Neural connections that compute.

The UK's Foresight Cognitive Systems Project brings together researchers in the life sciences and physical sciences to see where they can learn from one another and to debate, and plan, the future of research in cognitive systems. The project, a part of the UK government's Foresight initiative, sets out to identify potential opportunities for the economy or society from new science and technology. Through a series of research reviews, the project has created 'snap shots' of research in cognitive systems. A major conference in Bristol in September will consider series of research manifestos created by interdisciplinary groups.

Cognition↗

PubMed2004

Toxicogenomics through the eyes of informatics: conference overview and recommendations.

Virginia Bioinformatics Institute, in conjunction with National Institutes of Environmental Health Sciences, hosted a conference, "Toxicogenomics through the Eyes of Informatics," in Bethesda, Maryland, USA, on 12-13 May 2003. Researchers around the world met to discuss how the application of bioinformatics tools, methodologies, and technologies will enhance our understanding of how cells and organisms respond to toxins. Conference topics included statistical methods, quantitative molecular data sets, computational algorithms for data analysis, computational modeling and simulation, challenges and opportunities in computational biology, and information technology infrastructure for data and tool management. This meeting report is a summary of conference presentations, survey results, current toxicogenomics concerns, and future directions of the toxicogenomics community. In conclusion this report discusses toxicogenomics as related to environmental agents, cell-chemical reactions, and gene-environment interactions.

Algorithms↗

PubMedDate not supplied

[Le Quercinois, Guillaume Jacob, physician and surgeon at the Montpellier School, artisan of the reform of medical sciences in Spain the the 18th century].

Guillaume Jacob born in Castelnau-Montratier at the dawn of the XVIIIth century, physician of the School of Medicine of Montpellier was attracted by Spain during the reign of Philip V grand-son of Louis XIV. Nominated Professor of Anatomy at the Royal Society of Medicine of Sevilla, later Royal Academy, he worked during seventeen years to improve Spanish medical science: he informed himself in Paris of the discoveries of French scientists, obtained modern surgical instruments, books to enrich the library, laid the foundations of a botanical garden for medical plants and established links between the Royal Society of Sevilla and various European Royal Academies in order to allow exchanges.

France↗