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PubMed1997

[Development of a geographical information system and its application to Escherichia coli O-157 patient distribution].

The so called Geographical Information System (GIS) is one of the basic tools for wide range of public health applications. We had developed a general purpose GIS and applied it to represent geographical distribution of patients of the bacterium E. coli O-157 which bursted out in Japan last early summer particularly at Sakai City in Osaka Prefecture. The patient record have been supplied from the Food Safety Office of the Ministry of Health and Welfare. These records were handled by EXCEL. The basic geographical data was constructed from the map data provided by Japan Geographical Survey Institute, and ArcView 2 was used as the map system. The maps were converted to Graphics Interchange Format (GIF) files and put on our Web server.

Computer Communication Networks↗
PubMed2004

New approach to association testing in case-parent designs under informative parental missingness.

The transmission/disequilibrium test (TDT) and related methods using genotype data on diseased probands and their both parents (triads) have been popular for testing linkage or association between a disease and a candidate gene. The usefulness of the TDT-type approaches lies mainly in their robustness, in the sense that they are valid under population stratification, arbitrary parental genotype distribution, and "informative" parental missingness where the parental missingness may depend on parental genotypes. Recently, a variety of extended TDTs were developed to accommodate parental missingness and to allow for using incomplete triads, including single-offspring-single-parent families (dyads) and single offspring with no parents (monads). However, these methods usually do not preserve the full robustness of the original TDT. In this paper, we propose a new TDT-type approach based on the conditional likelihood of the proband's genotype given the number and, if any, genotypes of the available parents, as well as the proband's phenotype. This new proposal keeps the full robust property of the original TDT. In addition, the new method is very easy to implement, without the need to specify models on parental mating-type probabilities and on parental missingness.

Genetic Linkage↗
PubMed2005

On-line communities: helping "senior surfers" find health information on the Web.

Currently, it is estimated that approximately 10 million older adults use Internet communities to gain information on any health issue. It is nearly impossible to police all of the sites available to make sure correct information is distributed. A short website review demonstrates factors that create an unsafe or safe health environment. The ability of a facilitator to properly manage an online community and the problems that may be encountered in this setting are issues that warrant attention. Discussion forums provide information through threaded discussion boards, and frequently the information is inaccurate. Research is needed to determine if on-line health communities are a bane or a boon to the elderly population.

Aged↗
PubMed2001

Evaluating auditory performance limits: II. One-parameter discrimination with random-level variation.

Previous studies have combined analytical models of stochastic neural responses with signal detection theory (SDT) to predict psychophysical performance limits; however, these studies have typically been limited to simple models and simple psychophysical tasks. A companion article in this issue ("Evaluating Auditory Performance Limits: I") describes an extension of the SDT approach to allow the use of computational models that provide more accurate descriptions of neural responses. This article describes an extension to more complex psychophysical tasks. A general method is presented for evaluating psychophysical performance limits for discrimination tasks in which one stimulus parameter is randomly varied. Psychophysical experiments often randomly vary a single parameter in order to restrict the cues that are available to the subject. The method is demonstrated for the auditory task of random-level frequency discrimination using a computational auditory nerve (AN) model. Performance limits based on AN discharge times (all-information) are compared to performance limits based only on discharge counts (rate place). Both decision models are successful in predicting that random-level variation has no effect on performance in quiet, which is the typical result in psychophysical tasks with random-level variation. The distribution of information across the AN population provides insight into how different types of AN information can be used to avoid the influence of random-level variation. The rate-place model relies on comparisons between fibers above and below the tone frequency (i.e., the population response), while the all-information model does not require such across-fiber comparisons. Frequency discrimination with random-level variation in the presence of high-frequency noise is also simulated. No effect is predicted for all-information, consistent with the small effect in human performance; however, a large effect is predicted for rate-place in noise with random-level variation.

Animals↗
PubMed1984

Radiation oncology--the misunderstood specialty.

A shortage of radiation oncologists has been a problem in both Canada and the United States of America. The fundamental step to rectify this situation is the recruitment of interested medical students. A mail-in survey was sent to 214 third- and fourth-year medical students at the University of British Columbia to evaluate attitudes to and the level of understanding of radiation oncology. The response rate was 59%. Seventy-five percent of the students were planning postgraduate training in clinically orientated specialties with good lifestyle and availability of job opportunities. However, only 18% of the respondents considered radiation oncology as a possible specialty. This survey suggests that this lack of interest is the result of misconceptions about training in the practice of radiotherapy. To better inform the medical students, teaching clinics providing them with direct contact with radiation oncologists and their patients, are invaluable. In order to generate the correct image of the specialty and the types of patients encountered, teaching in an ambulatory care setting is not to be neglected. Distribution of information pamphlets describing the radiation oncology program and the nature of radiation oncology practice is also suggested as an efficient means of informing medical students.

Attitude of Health Personnel↗
PubMed1995

An integrated approach for mobile information processing in hospitals.

Computer-based mobile information processing in hospitals is at a turning point of becoming a substantial and integral part of hospital information systems. Its necessity and potential require a comprehensive systematic approach to support the needs of health care professionals and thus to contribute to high quality patient care and medical research. From the authors' point of view, standardized digital documents could become an appropriate basis for distributed mobile information processing in hospitals. An architecture for the integrated co-operative use of conventional, stationary, and mobile information tools is a major research topic at Heidelberg University. The objective of this paper is to present a departmental prototype design to establish mobile information processing as an integral part of hospital information systems through the use of standardized digital documents.

Computer Communication Networks↗
PubMed1994

Medical office automation integrated into the distributed architecture of a hospital information system.

Patient histories, discharge summaries, and medical consultant reports are made up of written texts. Therefore, the gathering and archiving of these texts in machine-readable form has many characteristics of computer-based medical records. In Geneva, approximately 1,540 PCs are connected to the Hospital Information System DIOGENE 2, with the possibility of accessing all the functions offered by the system without losing any of their MS-DOS word processing capabilities. The UNIDOC system, presented in this paper, takes all these features into account, a real marriage of technologies between the MS-DOS environment and the distributed client-server architecture. The INGRES database management system supports the entire archiving process of the medical patient texts, structured by prelabelled paragraphs and automatically indexed. Both the quality and accessibility of the records are enhanced, while the archiving capacity is neither too limited nor too expensive.

Archives↗
PubMed1996

Structural plasticity of identified glomeruli in the antennal lobes of the adult worker honey bee.

Adult worker honey bees alter their behaviour with age but retain a strong reliance on sensory information from the antennae. The antennae house a diverse array of receptors, including mechanoreceptors, hygroreceptors, olfactory receptors, and contact chemoreceptors, which relay information to the brain. Antennal sensory neurons that project to the antennal lobes of the brain converge onto second-order interneurones to form discrete spheres of neuropil, called glomeruli. The spatial organisation of glomeruli in the antennal lobes of the honey bee is constant, but the central distribution of information from receptors tuned to different sensory modalities is unknown. Here we show that the glomerular neuropil of the antennal lobes undergoes constant modification during the lifetime of the adult worker bee. Changes in morphology are site specific and highly predictable. The total volume of the glomerular neuropil of the antennal lobe increased significantly during the first 4 days of adult life. Each of the five readily identifiable glomeruli examined in this study exhibited a unique pattern of growth. The growth of two of the five glomeruli changed dramatically with the shift to foraging duties. Furthermore, significant differences were identified between the antennal lobes of bees performing nectar- and pollen-foraging tasks. The highly compartmentalized nature of the antennal lobes, the ease with which specific glomeruli can be identified, and the predictability of changes to the antennal lobe neuropil make this an ideal system for examining the mechanisms and behavioural consequences of structural plasticity in primary sensory centres of the brain.

Aging↗
PubMed1995

The Jupiter approach to interoperability with healthcare legacy systems.

This paper describes a novel approach to supporting interoperability between autonomous healthcare information systems. The approach, which has been implemented in the Jupiter system, is founded on the development of a formal model of legacy systems that are used as the basis for the definition of a language to support interoperability. Jupiter gives users a uniform, integrated view of heterogeneous, distributed, independent information systems. The target domain of Jupiter is healthcare, although the solution is sufficiently generic to be applicable elsewhere.

Computer Systems↗
PubMed1996

PAH Mutation Analysis Consortium Database: a database for disease-producing and other allelic variation at the human PAH locus.

The PAH Mutation Analysis Consortium (81 investigators, 26 countries) is engaged in mutation detection at the human PAH locus. Ascertainment of probands occurs largely through newborn screening for hyperphenylalaninemia. A relational database records allelic variation (disease-producing and polymorphic) at the locus. Information is distributed by Newsletter, diskette (WINPAHDB software stand-alone executable on IBM compatible hardware), and at a 'real' site on the Worldwide Web (http://www.mcgill.ca/pahdb). The database presently records (Sept. 27, 1995) 248 alleles in 798 different associations (with polymorphic haplotype, geographic region and population) along with additional information. The database, as a record of human genetic diversity, at a particular locus, contributes to the study of human evolution and demic expansion; it also has medical relevance.

Alleles↗
PubMed1993

[Concepts and attitudes of parents of adolescents in regard to suicide].

In the context of parents reacting with surprise to the suicidal tendencies of their teenage child, the authors prepared a questionnaire for 380 parents of adolescents to gauge the realism of their perceptions on the topic. The authors noted differences of opinion between fathers and mothers among parents who have experienced a variety of situations related to suicide and others who have received information on the matter. These differing points of view concern the impulsive nature of the gesture, the age of the suicidal person, the opportunity to intervene and the level of acceptance of suicide. In addition, this study underscores the importance of implementing prevention programs that go beyond the simple distribution of information.

Adolescent↗
PubMed2002

DBTSS: DataBase of human Transcriptional Start Sites and full-length cDNAs.

Although the information of cDNAs is indispensable for analyzing gene function, most of the cDNA sequences stored in current databases are imperfect in the sense that they lack the precise information of 5' end termini. To overcome this difficulty, we have developed the oligo-capping method to obtain full-length cDNAs, the information of which has been partly deposited in public databases. In this study, we further constructed human cDNA libraries enriched in clones containing the cap structure to systematically explore the 5' end structure of expressed genes. Of approximately 217 402 5' end sequences obtained, 111 382 have been matched to cDNA sequences of known genes (7889 genes) and are presented in our new database, DataBase of Transcriptional Start Sites (DBTSS; http://elmo.ims.u-tokyo.ac.jp/dbtss/). Sequence comparison between our entries and those of a reference sequence database, RefSeq, revealed that 4683 (34%) of RefSeq sequences should be extended towards the 5' ends. We also mapped each sequence on the human draft genome sequence to identify its transcriptional start site, which provides us with more detailed information on distribution patterns of transcriptional start sites and adjacent regulatory regions.

5' Flanking Region↗
PubMed2002

[Are the "elderly" living at the expense of the "young"? Remarks on the burden distribution between "generations" in an aging population from the economic perspective].

Public and scientific discussion on the effects of an aging population is often biased: aging is primarily seen as an economic burden. Increasing contribution rates in pension schemes, health and long-term care insurance are highlighted. This paper tries to provide a more balanced view. The distinction between a cross-sectional and a longitudinal view already gives different information on distributional effects. Labeling older people as "economically inactive" is a much too narrow perspective focused on the activity on the labor market only. Other types of work are neglected such as caring for children or frail elderly as well as economic activities from wealth, consumption as well as paying taxes to finance public expenditure. The approach of "generational accounting" is also narrow, focusing on public expenditure, social insurance contributions and only some types of taxes, but not dealing with private, especially intrafamily transfers. In economic terms, a comprehensive approach is needed regarding the effect of institutions and measures on the economic situation of cohorts. The role of investment in human capital is mentioned as a decisive factor for productivity in a country. Further education and retraining of older workers is one important element. An integrative approach dealing with the different fields of activities is needed when analyzing the intergenerational as well as the intragenerational distribution. This requires an elaborated and differentiated reporting of distributional effects. This important precondition, however, does not exist in Germany.

Aged↗
PubMed1990

Multiple sources of P3b associated with different types of information.

This experiment investigated how the P3a, P3b, and Slow Wave components of the event-related brain potential (ERP) respond to manipulations of the nature, timing, and extent of information delivery. There were two experiments in which the total amount of task information was distributed between pairs of successive stimuli (S1 and S2) within each trail. The task was to predict the relation between S1 and S2. In Experiment 1, the S1 could resolve no, partial, or all uncertainty with respect to the prediction outcome (correct or incorrect). Each S1 delivered three types of information: 1) outcome information--which resolved the subjects' uncertainty about the correctness of their prediction; 2) procedural information--which resolved uncertainty about how much outcome information would be delivered by S1; and 3) memory information--the identity of S1, which had to be stored for subsequent comparison with S2. In Experiment 2, the activity of these components was contrasted in two conditions in which the S1 delivered either memory information alone or both memory and procedural information. P3a and Slow Wave were sensitive only to outcome information. P3b was sensitive to all three types of information, and its scalp topography varied as a function of the type of information. The topographic variations indicate that P3b is not a unitary phenomenon but rather is a composite of activity arising from multiple intracranial sources of bioelectric activity.

Adult↗
PubMedDate not supplied

Discrepancy between older clients' ability to read and comprehend and the reading level of written educational materials used by occupational therapists.

OBJECTIVE: The match between the reading level of occupational therapy education materials and older clients' reading ability and comprehension was determined. The sociodemographic and literacy characteristics that influenced clients' reading ability and comprehension were investigated. METHOD: The reading level of 110 written education materials (handouts, brochures, and information leaflets), distributed to older clients (65 years of age and older) by occupational therapists working in Queensland hospitals, was analyzed using the Flesch formula. The reading ability of 214 older persons (mean age 77 years, 63% female) was assessed using the Rapid Estimate of Adult Literacy in Medicine. Participants' comprehension of information of increasing reading difficulty was measured using the Cloze procedure. RESULTS: The written materials required a mean reading level between the ninth and tenth grades. Participants' mean reading ability was seventh to eighth grade. Therefore some materials may have been too difficult for participants to read and understand. Participants with a managerial or professional or clerical background (p= 0.001) and those who perceived they read well (p= 0.001) had a significantly higher reading ability. Older age was significantly related to poorer comprehension (p = 0.018), with participants 75 years of age and over having a mean comprehension score of 25.6 compared to 30.3 for those 65 to 74 years of age. CONCLUSION: Occupational therapists must analyze the reading level of the written education materials they develop for and use with clients by applying readability formulas. There should be a match between the reading level of written materials and clients' reading ability. Clients' reading ability may be assessed informally by discussing years of education and literacy habits or formally using reading assessments. Content and design characteristics should be considered when developing written education materials for clients.

Aged↗
PubMedDate not supplied

Results of a patient education project using a touch-screen computer.

PURPOSE: The purpose of this project was to increase use of the Physician Data Query and Patient Information File services of the National Cancer Institute in a clinical setting. OVERVIEW: A patient education demonstration project was conducted at the University of Rochester Cancer Center using a touch-screen computer program called CancerHelp. Two computers were purchased, one stationed in the Patient Library at the University of Rochester Cancer Center and one circulated to three affiliated hospitals. Demographic information was asked at the beginning of the program and an evaluation was elicited at the end of the program. All information was given voluntarily; users of the system could bypass the questions if they wished. The computer program was very well received by patients and their families. The program was used 1758 times over 6 months. CLINICAL IMPLICATIONS: A touch-screen computer program can be an effective method for distributing cancer information.

Adult↗
PubMedDate not supplied

[Parameters of enzyme reactions in microcirculation].

It has been shown that time-dependent change in the concentration of enzymic reaction substrate in a microcirculatory channel cell, as well as its steady spatial distribution contain information both about the structure of the microcirculatory channel and about the reaction kinetic parameters. In terms of the hypothesis about the stationary state of the enzyme-substrate complex at selective values of hydrodynamic parameters of the substrate, enzyme, channel correlation between the change in the substrate concentration, its stationary distribution, kinetic parameters and the microcirculation cell structure were estimated.

Enzymes↗
PubMed2004

A cross-platform model for secure Electronic Health Record communication.

During the past decade, there have been many regional, national and European projects focused on the development of platforms for secure access and sharing of distributed patient information. A platform is needed because present local or enterprise-wide information systems are typically not intended for cross-organisational secure access of patient data. Most of the present secure platforms are local or regional. Commonly used platform types in the health care environment vary from secure point-to-point communication systems to internet-based portals. This paper defines an enhanced cross-security platform which makes it possible for different kinds of local, regional, and national health information systems to communicate in a secure way. The proposed evolutionary way interconnects regional or national security domains with the help of a cross-platform zone. A more revolutionary model based on peer-to-peer Grid like networks and dynamic security credentials is also discussed. The proposed evolutionary model uses cross-domain security and interoperability services to ensure secure communication and interoperability between different security domains. The platform supports both communication defined beforehand and adhoc dynamic access to distributed electronic health records (EHRs). The internet is proposed as the "glue" between different regional or national security domains.

Access to Information↗