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Conversion of plaque-area measurements to plaque index scores. An assessment of variation and discriminatory power.

Plaque areas recorded graphically or photographically provide a permanent record of plaque accumulations on teeth at a moment in time. As such, these records could be re-evaluated and converted into other index scores. The purpose of this study was to determine the reproducibility of scoring a plaque index from previously recorded plaque areas and to compare such scores with the original scores of the same index. A randomised blind, crossover study comparing 5 treatments for plaque inhibition scored by plaque area and index was chosen. 2 examiners, the original scorer PRH and another, NC, 2x scored the plaque area tooth charts according to the criteria of the plaque index system used in the original study. Standard deviations of the differences showed intra-examiner repeatability to be high particularly for the original examiner. Inter-examiner reproducibility for the original index scores was considered good but less than for intra-examiner repeatability. Correlation coefficients were complimentary to the differences analysis, being very high within examiners and less high for between examiners and original and rescored index. Separation between distributions of plaque area measurements for consecutive values of the index were particular good for scores 2 versus 3 and 3 versus 4 and less good for 1 versus 2 and 4 versus 5. Reanalysis of the study for treatment differences using rescored data revealed a similar level of significance as using the original data. Rescored index had similar discriminatory power for the study as plaque area and original plaque index when both were derived from the same buccal tooth surfaces. However, discriminatory power was less by comparison with original plaque index derived from the buccal surfaces of all teeth. It is concluded that plaque area provides a permanent record of plaque distribution which can be converted into index data at a later date. Such data collection could make possible comparisons between studies using different indices.

Cross-Over Studies↗

A new morphologic index for the evaluation of renal biopsies in lupus nephritis.

BACKGROUND: Various morphologic indices for the evaluation of renal biopsies in lupus nephritis have been developed, of which the most successful have been the NIH Activity Index (AI) and Chronicity Index (CI). We wished to develop a biopsy index from standard light and immunofluorescence (IF) material that would correlate yet more closely with clinical and outcome parameters than the current indices, and be applicable to both treated and untreated cases. METHODS: A cohort of 71 patients with lupus nephritis who had initial renal biopsies (Bx1) with systematic second biopsies (Bx2) at six months after induction therapy was studied, with a large number of light microscopic and IF variables evaluated. These were examined statistically to choose the combinations of variables with the highest overall correlations with clinical and outcome parameters. RESULTS: The adopted biopsy index comprised four elements: Glomerular Activity Index (GAI), a modification of the standard AI with the addition of glomerular monocytes and elimination of interstitial inflammation; Tubulointerstitial Activity Index (TIAI), evaluating several tubular epithelial and inflammatory components, including interstitial inflammation, but excluding tubular atrophy; Chronic Lesions Index, a modification of the standard CI, with the addition of glomerular scars; IF Index (IFI), a semiquantitative index of IF staining for six standard antisera for glomerular capillary, mesangial, tubulointerstitial, and vascular elements. The Biopsy Index showed a statistically higher correlation with clinical and outcome parameters than the NIH AI (P = 0.0170), the NIH CI (P = 0.0009), or their combination (P = 0.0444). At Bx1, comparisons between correlation coefficients for the appropriate AI or CI value and for the Biopsy Index, were: anti-DNA antibodies (0.30 vs. 045), serum creatinine (SCr; 0.33 vs. 0.48), proteinuria (0.22 vs. 0.36), hemoglobin (-0.21 vs. -0.45), and final renal function (0.22 vs. 0.40). Spearman rank correlations showed similar superiority for outcome parameters: doubling of SCr (0.1810 vs. 0.3018) and end-stage renal disease (0.0529 vs. 0.1925). The same improvement of correlations was seen at Bx2 for most parameters, particularly doubling of SCr (0.2716 vs. 0.4753). CONCLUSIONS: The Biopsy Index and/or its components show better correlations with clinical and outcome parameters than the standard AI and CI and other similar indices.

Adult↗

Body-mass index and mortality in a prospective cohort of U.S. adults.

BACKGROUND: Body-mass index (the weight in kilograms divided by the square of the height in meters) is known to be associated with overall mortality. We investigated the effects of age, race, sex, smoking status, and history of disease on the relation between body-mass index and mortality. METHODS: In a prospective study of more than 1 million adults in the United States (457,785 men and 588,369 women), 201,622 deaths occurred during 14 years of follow-up. We examined the relation between body-mass index and the risk of death from all causes in four subgroups categorized according to smoking status and history of disease. In healthy people who had never smoked, we further examined whether the relation varied according to race, cause of death, or age. The relative risk was used to assess the relation between mortality and body-mass index. RESULTS: The association between body-mass index and the risk of death was substantially modified by smoking status and the presence of disease. In healthy people who had never smoked, the nadir of the curve for body-mass index and mortality was found at a body-mass index of 23.5 to 24.9 in men and 22.0 to 23.4 in women. Among subjects with the highest body-mass indexes, white men and women had a relative risk of death of 2.58 and 2.00, respectively, as compared with those with a body-mass index of 23.5 to 24.9. Black men and women with the highest body-mass indexes had much lower risks of death (1.35 and 1.21), which did not differ significantly from 1.00. A high body-mass index was most predictive of death from cardiovascular disease, especially in men (relative risk, 2.90; 95 percent confidence interval, 2.37 to 3.56). Heavier men and women in all age groups had an increased risk of death. CONCLUSIONS: The risk of death from all causes, cardiovascular disease, cancer, or other diseases increases throughout the range of moderate and severe overweight for both men and women in all age groups. The risk associated with a high body-mass index is greater for whites than for blacks.

Adult↗

Impact of prepregnant body mass index and maternal weight gain on the risk of pregnancy complications in Japanese women.

BACKGROUND: To analyze the association of pregnancy complications with prepregnant body mass index and weight gain during pregnancy in Japanese women. METHODS: A retrospective cohort study was conducted with 21,718 Japanese women with a singleton pregnancy. Pregnant women were grouped by prepregnant body mass index and evaluated for association with pregnancy complications using multivariate logistic regression analysis. The women in each body mass index group were then divided into groups by weight gain during pregnancy using intervals of 0.05 kg/week to analyze the relationship between the weight gain and pregnancy complications by multivariate logistic regression association analysis. RESULTS: In both nulliparous and parous women, the least pregnancy complications were found among women with medium prepregnant body mass indexes (18-23.9). Significant risks of pregnancy complications were associated with low (< 18) and high (> or = 24) prepregnant body mass indexes, particularly high prepregnant body mass indexes. In nulliparous women, the optimal weight gain was 0.25-0.4 kg/week for low (< 18) prepregnant body mass index, 0.20-0.30 kg/week for medium (18-23.9) prepregnant body mass index, and > or = 0.05 kg/week for high (> or = 24) prepregnant body mass index. In parous women, the corresponding values were > or = 0.20, 0.20-0.30, and 0.05-0.30 kg/week. CONCLUSIONS: Japanese women with prepregnant body mass indexes from 18 to 23.9 are least associated with pregnancy complications, although there is a broad range of prepregnant body mass indexes associated with few pregnancy complications. Optimal weight gain is roughly inversely related to prepregnant body mass index.

Adult↗

Improving risk indexes for Alzheimer's disease and related dementias for use in midlife.

Knowledge of a person's risk for Alzheimer's disease and related dementias (ADRDs) is required to triage candidates for preventive interventions, surveillance, and treatment trials. ADRD risk indexes exist for this purpose, but each includes only a subset of known risk factors. Information missing from published indexes could improve risk prediction. In the Dunedin Study of a population-representative New Zealand-based birth cohort followed to midlife (N&#x2009;=&#x2009;938, 49.5% female), we compared associations of four leading risk indexes with midlife antecedents of ADRD against a novel benchmark index comprised of nearly all known ADRD risk factors, the Dunedin ADRD Risk Benchmark (DunedinARB). Existing indexes included the Cardiovascular Risk Factors, Aging, and Dementia index (CAIDE), LIfestyle for BRAin health index (LIBRA), Australian National University Alzheimer's Disease Risk Index (ANU-ADRI), and risks selected by the Lancet Commission on Dementia. The Dunedin benchmark was comprised of 48 separate indicators of risk organized into 10 conceptually distinct risk domains. Midlife antecedents of ADRD treated as outcome measures included age-45 measures of brain structural integrity [magnetic resonance imaging-assessed: (i) machine-learning-algorithm-estimated brain age, (ii) log-transformed volume of white matter hyperintensities, and (iii) mean grey matter volume of the hippocampus] and measures of brain functional integrity [(i) objective cognitive function assessed via the Wechsler Adult Intelligence Scale-IV, (ii) subjective problems in everyday cognitive function, and (iii) objective cognitive decline measured as residualized change in cognitive scores from childhood to midlife on matched Weschler Intelligence scales]. All indexes were quantitatively distributed and proved informative about midlife antecedents of ADRD, including algorithm-estimated brain age (&#x3b2;'s from 0.16 to 0.22), white matter hyperintensities volume (&#x3b2;'s from 0.16 to 0.19), hippocampal volume (&#x3b2;'s from -0.08 to -0.11), tested cognitive deficits (&#x3b2;'s from -0.36 to -0.49), everyday cognitive problems (&#x3b2;'s from 0.14 to 0.38), and longitudinal cognitive decline (&#x3b2;'s from -0.18 to -0.26). Existing indexes compared favourably to the comprehensive benchmark in their association with the brain structural integrity measures but were outperformed in their association with the functional integrity measures, particularly subjective cognitive problems and tested cognitive decline. Results indicated that existing indexes could be improved with targeted additions, particularly of measures assessing socioeconomic status, physical and sensory function, epigenetic aging, and subjective overall health. Existing premorbid ADRD risk indexes perform well in identifying linear gradients of risk among members of the general population at midlife, even when they include only a small subset of potential risk factors. They could be improved, however, with targeted additions to more holistically capture the different facets of risk for this multiply determined, age-related disease.

Alzheimer&#x2019;s disease↗

Relation between birth weight and the insulin sensitivity index in a population sample of 331 young, healthy Caucasians.

The objective was to study the association between birth weight and the insulin sensitivity index. Altogether, 331 unrelated Caucasian subjects aged 18-32 years with measures of the insulin sensitivity index and insulin secretion during a combined intravenous glucose and tolbutamide tolerance test were included in the study. The data on birth weight and length were obtained from the midwife records. The study took place in Copenhagen, Denmark, during 1992-1993. Univariately, a significant positive association between birth weight and the insulin sensitivity index was found in women (p = 0.045), but not in men (p = 0.23). In multivariate analysis, controlling for age, gender, body mass index, waist circumference, maximal aerobic capacity, and use of oral contraceptives, no significant interaction between birth weight and gender that considered the insulin sensitivity index was found. The insulin sensitivity index was significantly associated with birth weight (p = 0.0012), corresponding to an increase of 1.7% (95% confidence interval 0.7-2.7%) in the insulin sensitivity index for each 100-g increases in birth weight. In comparison, an increase in body mass index of 1 kg/m2 (a weight gain of 2.9 kg in a man 1.70 m tall) corresponds to a decrease in the insulin sensitivity index of 3.8% (95% confidence interval 0.7-6.8%), an increase in waist circumference of 1 cm corresponds to a decrease in the insulin sensitivity index of 2.1% (95% confidence interval 0.9-3.1%), and use of oral contraceptives corresponds to a decrease in the insulin sensitivity index of 26.7% (95% confidence interval 12.2-38.1%). Thus, the impact of birth weight on the insulin sensitivity index was of minor importance.

Adult↗

A new ventilation inhomogeneity index from multiple breath indicator gas washout tests in mechanically ventilated patients.

OBJECTIVES: a) To determine the validity of a new method to analyze indicator gas washout tests on mechanically ventilated patients. This method takes into account the difference between the end-expiratory gas fraction and the mean gas fraction in the lung and provides the end-expiratory lung volume and a new index of ventilation inhomogeneity called volumes regression index. b) To determine the validity of this index as a predictor of chronic obstructive pulmonary disease. c) To compare this index with the moment ratio index and Becklake index. DESIGN: Prospective study of diagnostic test. Criterium standards: Closed-circuit indicator gas dilution technique and Tiffeneau index. SETTING: Surgical intensive care unit of a university hospital. PATIENTS: A total of 38 mechanically ventilated postoperative patients, divided into two groups: the obstructive group (n = 21) and the nonobstructive group (n = 17), based on their preoperative lung function. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: a) The mean coefficient of variation of all lung volume measurements in a group of nine healthy volunteers was 5%, and the difference between this technique and the closed-circuit helium dilution measurements was -2 +/- 5%. In patients, the mean coefficient of variation of the lung volume measurements was 3.5%. The volumes regression index was measured as 0.02 +/- 0.04 in a dummy lung, 0.37 +/- 0.08 in the healthy volunteers, 0.64 +/- 0.23 in the nonobstructive patients, and 1.1 +/- 0.3 in the obstructive patients. The volumes regression index provided a better correlation (r2 = .46) with preoperatively determined Tiffeneau index than the Becklake index (r2 = .11) or the moment ratio index (r2 = .18). CONCLUSION: The proposed technique provides a means for accurate measurement of the end-expiratory lung volume and the amount of ventilation inhomogeneity in mechanically ventilated intensive care unit patients.

Adult↗

A pilot study of contextual UMLS indexing to improve the precision of concept-based representation in XML-structured clinical radiology reports.

OBJECTIVE: Despite the advantages of structured data entry, much of the patient record is still stored as unstructured or semistructured narrative text. The issue of representing clinical document content remains problematic. The authors' prior work using an automated UMLS document indexing system has been encouraging but has been affected by the generally low indexing precision of such systems. In an effort to improve precision, the authors have developed a context-sensitive document indexing model to calculate the optimal subset of UMLS source vocabularies used to index each document section. This pilot study was performed to evaluate the utility of this indexing approach on a set of clinical radiology reports. DESIGN: A set of clinical radiology reports that had been indexed manually using UMLS concept descriptors was indexed automatically by the SAPHIRE indexing engine. Using the data generated by this process the authors developed a system that simulated indexing, at the document section level, of the same document set using many permutations of a subset of the UMLS constituent vocabularies. MEASUREMENTS: The precision and recall scores generated by simulated indexing for each permutation of two or three UMLS constituent vocabularies were determined. RESULTS: While there was considerable variation in precision and recall values across the different subtypes of radiology reports, the overall effect of this indexing strategy using the best combination of two or three UMLS constituent vocabularies was an improvement in precision without significant impact of recall. CONCLUSION: In this pilot study a contextual indexing strategy improved overall precision in a set of clinical radiology reports.

Abstracting and Indexing↗

Applicability of the International Index for aggressive lymphomas to patients with low-grade lymphoma.

PURPOSE: Variables used to build up the International Index for aggressive lymphomas (age, performance status, stage, extranodal involvement, and lactic dehydrogenase [LDH]) are also important in low-grade lymphoma. To assess the prognostic value of this index in low-grade lymphoma, we have applied it to a series of 125 patients. PATIENTS AND METHODS: One hundred twenty-five patients with low-grade lymphoma who were diagnosed at a single institution over a 20-year period and treated with standard chemotherapy were studied. End points of the study were response to therapy and survival according to the International Index. In addition to the International Index, main initial and evolutive variables were evaluated. Univariate and multivariate methods were used. RESULTS: After applying the International Index, the patients divided into four risk groups: low (36% of cases), low-intermediate (32%), high-intermediate (20.8%), and high (11.2%), with complete response (CR) rates in the four groups being 60%, 35%, 23%, and 21%, respectively. Ten-year overall survival rates for the risk groups were as follows: low, 73.6%; low-intermediate, 45.2%; high-intermediate, 53.5%; and high, 0% (P < .001). When the International Index was included in a multivariate analysis, along with the main initial variables, International Index (P < .001) and sex (male, worse) (P = .038) were the only parameters related to survival. When response to therapy was also included, achievement of CR (P < .0001) and International Index (P < .001) were the most important factors. In patients who achieved a CR, the International Index was the only parameter related to survival (P = .051). The results were the same when the International Index was applied to the subset of 107 patients with follicular lymphoma. CONCLUSION: In this study, the International Index has been found to be an important prognostic tool in low-grade lymphomas. Such an index could be used to predict prognosis not only in aggressive, but also in low-grade lymphomas.

Actuarial Analysis↗

Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention.

The aim of the present study was to evaluate the recently defined simple insulin sensitivity check index QUICKI (Katz et al. 2000) for insulin resistance diagnostics in common clinical and epidemiological practice. Both the QUICKI (1/log insulin + log glycemia in mg/dL) and HOMA (insulin * glycemia in micromol/L/22.5) indexes were calculated from fasting values in 259 adult healthy volunteers and patients, and in 47 healthy and obese children of prepubertal age of both sexes. In adults, a fall in the QUICKI index (mean +/- SEM in healthy subjects = 0.366 +/- 0.029) as well as an increase in the HOMA index (in healthy subjects 1.57 +/- 0.87) corresponded to metabolic and clinical manifestations of insulin resistance in various groups of outpatients. The QUICKI index had lower dispersion variances and the 95% confidence limits displayed a higher discrimination capacity. Patients with glucose intolerance or diabetes, hyperlipidemia typical for insulin resistance, or with combination of these metabolic disorders were characterized by QUICKI index values that were significantly lower than those of healthy volunteers. The QUICKI index in healthy prepubertal children indicated a higher insulin resistance compared to adults (mean 0.339 +/- 0.020); an increase in the QUICKI index in obese children with BMI over 25 was not significant, although obese children showed a significant increase of serum leptin and triglycerides and a decrease of HDL-cholesterol. Adult patients with QUICKI index below 0.357 (which is at the lower limit of 95% confidence limits in healthy persons) represented a group with typical manifestations of metabolic syndrome, differing in these parameters significantly from the group of patients of comparable age with a QUICKI index greater than 0.357. The present study suggests suitability of the QUICKI index for diagnosis of insulin resistance in clinical and epidemiological practice. However, a normal QUICKI index range needs to be established for each laboratory with an appropriate control group because of significant interlaboratory variations in insulin determinations and/or possible differences in various populations.

Adult↗

Acute pulmonary embolism: correlation of CT pulmonary artery obstruction index with blood gas values.

OBJECTIVE: The purpose of our study was to investigate the relation between the pulmonary artery obstruction index assessed with helical CT and impairment in blood gases in patients with acute pulmonary embolism. SUBJECTS AND METHODS: Helical CT pulmonary angiography was performed in 78 patients who were suspected of having acute pulmonary embolism and selected as being free of underlying cardiopulmonary disease. Findings consistent with acute pulmonary embolism were observed in 34 patients. The severity was assessed by the pulmonary artery obstruction index, defined as Sigma (n x d), where n is the number of segmental arteries occluded and d is the degree of obstruction. Spearman's rank correlation coefficients were used to assess the correlation between the index of arterial obstruction and arterial partial pressure of oxygen (Pao(2)); alveolar-arterial difference in partial pressure of oxygen (Pao(2)-Pao(2)); arterial partial pressure of carbon dioxide (Paco(2)); and arterial oxygen saturation (Sao(2)). The statistical difference of the arterial blood gas values between the two groups of patients (those with and those without pulmonary embolism) was evaluated using the Mann-Whitney U test. Blood gases were comparatively evaluated below and above different index values (from 40% to 70%) and different Paco(2) values (25, 30, and 35 mm Hg) as possible indexes of embolism severity using the same test. The level of significance was set at 95% (p = 0.05). RESULTS: The values of Pao(2), Sao(2), and Paco(2) were significantly lower (p = 0.024, p = 0.0062, and p = 0.000075, respectively) and the values of Pao(2)-Pao(2) were significantly higher (p = 0.0169) in the pulmonary embolism group than in the no-pulmonary-embolism group. A significant correlation was observed between the obstruction index and Pao(2) (r = -0.33, p = 0.05), Paco(2) (r = -0.34, p = 0.05), Pao(2)-Pao(2) (r = 0.39, p = 0.02), and Sao(2) (r = -0.35, p = 0.04). Using cutoff values for the pulmonary artery obstruction index of 40%, 50%, 60%, and 70%, we observed that Paco(2) and Pao(2)-Pao(2) differed significantly between above and below the 40% (p = 0.018 and p = 0.03), 50% (p = 0.0087 and p = 0.029), and 60% (p = 0.005 and p = 0.003) cutoffs. Pao(2) differed significantly for the cutoff values of 60% (p = 0.03) and 70% (p = 0.004). The same was observed for Sao(2) at 60% (p = 0.05) and 70% (p = 0.03). Comparisons for Paco(2) showed that a value of 30 mm Hg significantly separates levels of the pulmonary artery obstruction index (p = 0.002), with 78% sensitivity and 82% specificity indicating a pulmonary artery obstruction index greater than 50%. CONCLUSION: In patients with acute pulmonary embolism but no other underlying cardiopulmonary disease, the severity of the pulmonary arterial tree obstruction assessed using the CT obstruction index is significantly correlated to the blood gas values. The strongest correlation was observed between the index and the Pao(2)-Pao(2). Furthermore, a Paco(2) value of 30 mm Hg or less is highly suggestive of an obstruction index of more than 50% of the arterial bed.

Adult↗

Glycemic index and serum high-density lipoprotein cholesterol concentration among us adults.

BACKGROUND: Dietary glycemic index, an indicator of the ability of the carbohydrate to raise blood glucose levels, and glycemic load, the product of glycemic index and carbohydrate intake, have been positively related to risk of coronary heart disease. However, the relationships between glycemic index and glycemic load and high-density lipoprotein cholesterol (HDL-C) concentration in the US population are unknown. METHODS: Using data from 13 907 participants aged 20 years and older in the Third National Health and Nutrition Examination Survey (1988-1994), we examined the relationships between glycemic index and glycemic load, which were determined from a food frequency questionnaire and HDL-C concentration. RESULTS: The age-adjusted mean HDL-C concentrations for increasing quintiles of glycemic index distribution were 1.38, 1.32, 1.30, 1.26, and 1.27 mmol/L (P<.001 for trend). (To convert millimoles per liter to milligrams per deciliter, divide by 0.0259.) After additional adjustment for sex, ethnicity, education, smoking status, body mass index, alcohol intake, physical activity, energy fraction from carbohydrates and fat, and total energy intake, the mean HDL-C concentrations for ascending quintiles of glycemic index were 1.36, 1.31, 1.30, 1.27, and 1.28 mmol/L (P<.001 for trend). Adjusting for the same covariates and considering glycemic index as a continuous variable, we found a change in HDL-C concentration of -0.06 mmol/L per 15-unit increase in glycemic index (P<.001). The multiple R(2) for the model was 0.23. Similarly, the multivariate-adjusted mean HDL-C concentrations for ascending quintiles of glycemic load distribution were 1.35, 1.31, 1.31, 1.30, and 1.26 mmol/L (P<.001 for linear trend). The inverse relationships between glycemic index and glycemic load and HDL-C persisted across all subgroups of participants categorized by sex or body mass index. CONCLUSIONS: These findings from a nationally representative sample of US adults suggest that high dietary glycemic index and high glycemic load are associated with a lower concentration of plasma HDL-C.

Adult↗

A performance comparison of metric scoring methods for a multimetric index for Mid-Atlantic highlands streams.

When biological metrics are combined into a multimetric index for bioassessment purposes, individual metrics must be scored as unitless numbers to be combined into a single index value. Among different multimetric indices, methods of scoring metrics may vary widely in the type of scaling used and the way in which metric expectations are established. These differences among scoring methods may influence the performance characteristics of the final index that is created by summing individual metric scores. The Macroinvertebrate Biotic Integrity Index (MBII), a multimetric index, was developed previously for first through third order streams in the Mid-Atlantic highlands of the United States. In this study, six metric scoring methods were evaluated for the MBII using measures related to site condition and index variability, including the degree of overlap between impaired and reference distributions, relationships to a stressor gradient, within-sample index variability, temporal variability, and the minimum detectable difference. Measures of index variability were affected to a greater degree than those of index responsiveness by both the type of scaling (discrete or continuous) and the method of setting expectations. A scoring method using continuous scaling and setting metric expectations using the 95th percentile of the entire distribution of sites performed the best overall for the MBII. These results showed that the method of scoring metrics affects the properties of the final index, particularly variability, and should be examined in developing a multimetric index because these properties can affect the number of condition classes (e.g., unimpaired, impaired) an index can distinguish.

Animals↗

Predicting anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones: computational approach using reformed eccentric connectivity index.

The eccentric connectivity index, which has recently been employed successfully for the development of numerous mathematical models for the prediction of biological activities of diverse nature, has been reformed to overcome its limitations caused by degeneracy and insensitivity towards heteroatoms. The reformed eccentric connectivity index, termed the eccentric connectivity topochemical index, overcomes the limitations of the eccentric connectivity index by exhibiting very low degeneracy and displaying sensitivity to both the presence and relative position of heteroatoms without compromizing the discriminating power of the eccentric connectivity index. The relationship of the eccentric connectivity topochemical index, eccentric connectivity index and Wiener's index with regard to the anti-HIV activity of 2, 3-diaryl-1, 3-thiazolidin-4-one derivatives was subsequently investigated. The values of the eccentric connectivity topochemical index, the eccentric connectivity index and Wiener's index of each of 31 analogues comprizing the data set were computed using in-house computer program. Resultant data was analyzed and suitable models developed after identification of active ranges. Subsequently, each derivative was assigned a biological activity using these models, which was then compared with the reported anti-HIV activity. The accuracy of prediction using these models was found to vary from 81 to 90%. The proposed index offers a vast potential for virtual screening of combinatorial libraries, structure property/activity studies and drug design. [figure]. Basic structure of 2,3-diaryl-1, 3-thiazoidin-4-ones.

Anti-HIV Agents↗

A new method for estimating preexcitation index without extrastimulus technique and its usefulness in determining the mechanism of supraventricular tachycardia.

The preexcitation index has been shown to be useful in determining the mechanism of paroxysmal supraventricular tachycardia (SVT) and the site of the accessory pathway in atrioventricular (AV) reentrant tachycardia. To test whether a preexcitation index could be computed analytically instead of by scanning the whole SVT cycle with extrastimuli, 19 patients with SVT were studied. The new index was computed using the following formula: (AV conduction time during SVT) + (ventriculoatrial conduction time during ventricular pacing at the SVT cycle length) - (SVT cycle length). There was a strong correlation between the preexcitation index determined by the extrastimulus technique and the new index in 15 patients in whom the preexcitation index could be determined (r = 0.99, p less than 0.01). The value on the new index was greater than 90 ms only in patients with dual AV nodal pathways. In the 4 patients in whom the preexcitation index could not be determined by the extrastimulus technique, the new index could differentiate AV reentrant tachycardia (index for 2 patients, 60 and 60 ms, respectively) from AV nodal reentrant tachycardia (index for 2 patients, 100 and 105 ms, respectively). In conclusion, the new index provided help in determining the mechanism of SVT, even when retrograde atrial preexcitation by a ventricular extrastimulus did not occur.

Adolescent↗

Sonographic estimation of umbilical coiling index and correlation with Doppler flow characteristics.

OBJECTIVE: To quantitate umbilical vascular coiling antenatally, and to correlate the coiling index with Doppler flow characteristics in umbilical vessels. METHODS: We studied 45 normal term fetuses within 24 hours before delivery. The umbilical coiling index was calculated using sonographic longitudinal views of cord vessels from several segments antenatally, and by dividing the total number of helices by the cord length (in centimeters) postnatally. Doppler flow velocities were obtained from umbilical arteries and vein in each cord. Flow characteristics were correlated with the umbilical coiling index. RESULTS: The mean (+/- standard deviation) umbilical coiling index was 0.44 +/- 0.11 in the antepartum period and 0.28 +/- 0.08 after birth. Regression analysis showed a significant linear trend (r = 0.71, P < .001). The correlations between sonographic coiling index and umbilical arterial Doppler flow characteristics (mean velocity, pulsatility index, resistance index, and systolic-diastolic ratio) were not significant. The sonographic coiling index was related to time-averaged velocity and flow in the umbilical vein. A good correlation was found between umbilical vein flow and the coiling index, with a significant linear trend (r = 0.59, P < .001). CONCLUSION: An intrauterine umbilical coiling index can be determined by ultrasound and correlates well with the actual index at birth. The sonographic umbilical coiling index is related to Doppler flow characteristics in the umbilical vein.

Female↗

Bispectral index monitoring quantifies depth of sedation during emergency department procedural sedation and analgesia in children.

STUDY OBJECTIVE: The bispectral index monitor uses processed electroencephalogram signals to measure sedation depth on a unitless scale from 0 to 100 (0, coma; 40 to 60, general anesthesia; 60 to 90, sedated; 100, awake). It has been validated in the operating room as an objective measure of sedation depth with nondissociative general anesthesia; however, its usefulness in the pediatric emergency department (ED) for procedural sedation and analgesia has not been established. We determine the ability of the bispectral index to monitor depth of nondissociative procedural sedation and analgesia in children. METHODS: This was an observational study conducted in a children's hospital ED. Procedural sedation and analgesia was performed in the standard manner, with the addition of bispectral index monitoring and simultaneous clinical sedation scoring (modified Ramsay Sedation Scale [range 1 to 8; 1=alert, 8=unresponsive]). Paired bispectral index and Ramsay Sedation Scale scores were assigned every 5 minutes during the sedation. Ramsay Sedation Scale scores were assigned by a single study investigator blinded to the bispectral index score. An emergency physician independently administered all medications for procedural sedation and analgesia. The correlation between the paired bispectral index/Ramsay Sedation Scale scores was determined by using a repeated-measures regression analysis. Receiver operator characteristic (ROC) curves were constructed to determine the ability of the bispectral index to discriminate various thresholds of sedation depth. RESULTS: A convenience sample of 20 patients was enrolled, providing 217 paired bispectral index/Ramsay Sedation Scale measurements. Median age was 4.6 years (range 0.4 to 16.7 years). Fourteen patients received midazolam with fentanyl; the remainder received pentobarbital. Bispectral index scores ranged from 40 to 98 (mean 81.6+/-16.1). Ramsay Sedation Scale scores ranged from 1 to 8 (median 3; interquartile range 2 to 4). The simple Pearson correlation between paired bispectral index and Ramsay Sedation Scale scores was -0.78 (95% confidence interval [CI] -0.83 to -0.72; P<.001). After adjustment for the nonindependence of intrapatient data with bivariate repeated-measures analysis, the correlation was -0.67 (95% CI -0.90 to -0.43; P<.001). The linear regression coefficient between bispectral index and Ramsay Sedation Scale scores was estimated to be between -5.7 and -12.7. ROC curve analysis demonstrated moderate to high discriminatory power of bispectral index scores in predicting level of sedation throughout the sedation continuum, with areas under the curve at least 0.87 for all Ramsay Sedation Scale score thresholds. Bispectral index scores between 60 and 90 predicted with moderate accuracy traditional clinical levels of sedation typically encountered during procedural sedation and analgesia in the pediatric ED. CONCLUSION: Bispectral index monitoring correlated with clinical sedation scores and may serve as a useful, objective adjunct in quantifying depth of nondissociative procedural sedation and analgesia in children.

Adolescent↗

Tei-index in symptomatic patients with primary and secondary mitral regurgitation.

Significant mitral regurgitation (MR) may result from primary valve dysfunction or develop secondary to ischemic or dilated cardiomyopathy. The index 'isovolumic contraction time and isovolumic relaxation time divided by ejection time' (ICT + IRT/ET, 'Tei-index') is a well established measure of global cardiac function in patients with dilated cardiomyopathy and cardiac amyloidosis. We sought to define the diagnostic value of the Tei-index in patients with significant MR of various origin. Sixteen asymptomatic control subjects (8 male (m)/8 female (f), age 62+/-8 years, control group), 12 patients with primary MR (PMR) (mean grade 3.1+/-0.3, due to rupture of the chordae tendineae (n = 2), flail leaflet (n = 1), valve prolapse (n = 6) or rheumatic degeneration (n = 3), 6 m/6 f, age 58+/-18 years, NYHA class 2.5+/-0.3, PMR group) and 25 patients with secondary MR (SMR) (mean grade 3.1+/-0.3; due to ischemic (n = 14) or dilated cardiomyopathy (n = 10), 19 m/6 f, age 60+/-11 years, NYHA class 3.1+/-0.5, SMR group) underwent conventional two-dimensional (2D) and Doppler echocardiographic examination including measurement of the Tei-index. In the SMR group, left ventricular ejection fraction was reduced compared to the control and the PMR group (29+/-13% vs. 59+/-8% and 59+/-8%, p < 0.001 for both comparisons). The E/A ratio was elevated in PMR and SMR groups in comparison to the control group (1.74+/-0.44 and 1.70+/-0.45 vs. 1.09+/-0.28, p < 0.05). The Tei-index was easily and reproducibly measured in all study subjects. The mean value of the index was significantly elevated in the SMR group compared to control and PMR groups (0.87+/-0.3 vs. 0.42+/-0.07 and 0.38+/-0.05, p < 0.001). The difference between the control group and the PMR group did not reach statistical significance. In MR patients, receiver operating characteristic curve analysis for the Tei-index yielded an area under the curve of 0.96+/-0.03 for separating the PMR and the SMR group. Using a Tei-index > 0.51 as a cutpoint, SMR was identified with a sensitivity of 92% and a specificity of 88%. In MR patients, a significant correlation between left ventricular end-systolic volume and the Tei-index was observed (r = 0.71, p < 0.01). The Tei-index is a feasible and sensitive indicator of overall cardiac dysfunction in severely symptomatic patients with significant MR secondary to ischemic or dilated cardiomyopathy. The index is in the normal range in symptomatic patients with PMR and preserved systolic function. The Tei-index differentiates between patients with SMR and PMR and may be useful in the work-up of such patients.

Echocardiography, Doppler↗