[Reaction of 2-halogenomethyl-4-phenylquinazoline-3-oxides with hydroxylamine].
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The combined use of 1H NMR spectroscopy with theoretical calculations of chemical shifts (GIAO) and coupling constants (B3LYP/6-311 ++G**) of a 5-hydroxy-5-trifluoromethyl-Delta2-isoxazoline has enabled solving the problem of the assignments of the diastereotopic protons in this compound. This result has been extended to 5-hydroxy-5-trifluoromethyl-Delta2-pyrazolines and the corresponding 5-trichloromethyl derivatives.
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N-Nitroso-O,N-Diethylhydroxylamine was given orally to male SD rats 100 mg/kg twice a week. 25 out of 28 evaluable animals developped after 276 plus or minus 15 days multiple carcinoma of paranasal sinus, lung and stomach.
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In a solution of transition metal ions with or without kaolin not only amino acids but also their oligomers were formed. The maximum ratio of amino acids after to before acid hydrolysis 5 6.
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