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PubMed1976

Regulation and metabolic background of polyketide formation. I. Effects of (-)-hydroxycitrate and metabolic roles of citrate and malate in fatty acid and polyketide formations.

The effects of (-)-hydroxycitrate on fatty acid and alternariol syntheses from glucose and acetate in Alternaria alternata were investigated. Fatty acid synthesis from glucose and acetate was inhibited by (-)-hydroxycitrate. The inhibition could partly be removed by the addition of malate or isocitrate. Alternariol synthesis from glucose was also inhibited by (-)-hydroxycitrate. This inhibition was not influenced to the same extent by malate addition as was that of fatty acid synthesis. It is shown that ATP -citrate lyase is essential not only for the production of cytoplasmic acetyl-CoA but also for the production of NADPH by supplying malate via oxaloacetate.

Acetates↗
PubMed2003

New vessel formation after surgical brain injury in the rat's cerebral cortex II. Formation of the blood vessels distal to the surgical injury.

We investigated the features of newly formed blood vessels after surgical brain injury of the rat's cerebral cortex distal to the operated region. We document the process of split mature blood vessels by an endothelial bridge and morphological features of newly formed vessels. We did not observe a disruption of brain parenchyma. The endothelial lining in vessels was complete. The morphological features of the endothelial cells and basement membrane show that non-sprouting angiogenesis takes place distally to the surgical injury.

Animals↗