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At least 631 records · Page 35Linked to original sources
PubMed1981

Diagnostic value of total and differential leukocyte counts in pleural effusions.

Total and differential leukocyte counts in pleural fluid were determined prospectively in 140 consecutive patients undergoing diagnostic thoracentesis. The total number of leukocytes was higher in exudates than in transudates. Lymphocytes predominated overwhelmingly (more than 80% of all leukocytes) in 29 of the 31 effusions with verified or probable tuberculous etiology and in 18 of the 24 with malignant etiology, as well as in 20 exudative pleural effusions of other causes. The significant differences in the percentage of lymphocyte distinguished tuberculous effusions from parapneumonic (p less than 0.001), nonspecific (p less than 0.001) and rheumatoid effusions (p less than 0.005), as well as from effusions caused by undefined connective tissue disease (p less than 0.001). Eosinophilia (more than 10%) of the pleural fluid was not present in any patient with proven tuberculosis and in only one patient with malignant effusion (malignant mesothelioma) but did occur in 12 of the 26 patients with nonspecific effusion. These results show that a great lymphocytic predominance is characteristic particularly of tuberculous but also of malignant pleural effusions, although this predominance cannot be regarded as disease-specific. Eosinophilia of the pleural fluid--usually a nonspecific sign--indicates nontuberculous, nonmalignant etiology.

Adult↗
PubMed1963

NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.

Kellogg, Douglas S., Jr. (Communicable Disease Center, Atlanta, Ga.), William L. Peacock, Jr., W. E. Deacon, L. Brown, and Carl I. Pirkle. Neisseria gonorrhoeae. I. Virulence genetically linked to clonal variation. J. Bacteriol. 85:1274-1279. 1963.-One type, obtained from the purulent exudate of acute gonorrhea was maintained by 69 selective in vitro passages, at which point the organisms produced infections in human volunteers. A predominance of clonal types found in laboratory strains and a lack of ability to infect human volunteers resulted from 69 nonselective in vitro passages. Physiological and serological characteristics of the clonal types are compared. We are now in a position to study Neisseria gonorrhoeae organisms in their virulent form.

Exudates and Transudates↗