[Physiological and pharmacological actions of prostaglandins and related substances on the digestive system].
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Evaluation of the gastrointestinal system of ruminants is a logical progression of investigation and elimination. Important aspects of the animal's history pertinent to the gastrointestinal system are described. A systematic, comprehensive technique for physical examination is presented with emphasis on the digestive and lymphatic systems. Examples of potential signs of disease are provided for each body section.
The influence of the cholecystokinin (CCK)-A receptor antagonist, devazepide (DVZ), on the chicken digestive tract was investigated. The passage of food from the crops of birds treated with DVZ was not significantly different from that of the control. DVZ treatment did not inhibit the biliary flow stimulated by the CCK analogue, caerulein. Dispersed chicken pancreatic acini stimulated with CCK were treated with various concentrations of DVZ. At 10-5 M, DVZ completely inhibited amylase release; this concentration was much higher than those reported to have similar effects in mammals. The results suggest that the action DVZ as a CCK antagonist in the chicken is very weak.
Five statistical procedures were used to partial the correlation between waterborne asbestos and digestive site cancer for the putative effects of population density. These include: analysis based on a data subset with roughly homogeneous population density; standard residual analysis (partial correlation); conditional probability integral transformation; analysis based upon ranked data, and use of logarithmic transformation. Nonparametric regression graphical techniques are applied to examine the nature or shape of the asbestos-cancer dose-response curve. Evidence is presented that suggests that there is considerable difference between analyses involving nonhigh-density tracts and non-San Francisco tracts. Evidence is also presented that the modal-type nonparametric regression curve forks or bifurcates when adjustment is made for population density.
In incidence data from 10 cancer registries in Italy, cancers of digestive organs make up 20-25% of all cancers. In incidence of oral cavity, pharynx, oesophagus and colorectal cancer is higher in the North. The highest incidence rates for stomach cancer (among the highest in Europe) are in Centre-North. Liver cancer, on the contrary, is one of few cancers with the highest frequency in the South. The first observed prevalence data measured from Italian cancer registries refer to patients with colorectal cancer recorded in Varese province in 1976-87 period and followed up to 1988. Including those cases with less than 12 years from diagnosis, they were about 200 per 100,000: more than 60% aged between 60 and 80 years.