[Patch test in eczema of the legs. (Comparative study with the results in other dermatoses)].
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BACKGROUND: Housekeepers are exposed to irritants and allergens in their work and are at significant risk for developing occupationally induced contact dermatitis. OBJECTIVE: We studied housekeepers at the Hershey Medical Center to determine the cause and frequency of contact dermatitis and contact urticaria in these workers. METHODS: All housekeepers were examined. Those with hand dermatitis had an extensive history, patch testing, and latex RAST testing. RESULTS: Eight of 130 had hand dermatitis. None had a relevant positive patch test or positive RAST test. CONCLUSIONS: Of our housekeepers, 6.2% had occupationally induced irritant contact dermatitis. None had allergic contact dermatitis or contact urticaria to latex.
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The histologic localization of fibronectin (FN) in normal human skin, granulation tissue, hypertrophic scar, mature scar, progressive systemic sclerotic skin, and tissue of other fibrotic disorders was investigated by an indirect immunofluorescence technique using specific antiserum prepared in rabbits against purified human plasma FN. In granulation tissue that developed just after traumatic wounding, FN seemed to increase remarkably in the wound as a fibrillar network. In the hypertrophic scar, one to five years after wounding, FN was detected in a linear or curling arrangement throughout the dermis. On the contrary, FN gradually decreased in the wound of the mature scar five to 20 years after wounding. There were some interesting observations among other diseases. In the skin of patients with progressive systemic sclerosis and morphea, FN was found to be localized faintly on the dermoepidermal junction and papillary dermis. In the involved skin of dermatofibroma, FN was observed in a curling arrangement throughout the dermis.
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