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Adenosine deaminase levels in construction workers with asbestos contact dermatitis.

Adenosine deaminase (ADA) activity was measured in the lymphocytes, red blood cells and plasma of twelve construction workers with cutaneous hypersensitivity reactions to asbestos. Lymphocyte ADA activity was significantly greater in exposed individuals than a control population (p less than 0.0001), whereas erythrocyte and plasma enzyme activity did not differ from control determinations. ADA catalyzes the conversion of adenosine to inosine. Since increased adenosine concentrations in tissue culture inhibit the growth of lymphoblastic cell lines, it has been postulated that decreased ADA activity can result in suppression of the immune response by the inhibition of cell division. Our results indicate that the converse also applies, such that an increase in lymphocyte ADA activity may reflect an increased immune response.

Adenosine Deaminase↗

Surgical glove related contact dermatitis.

With increased emphasis on infection control in the dental office has come an increase in complaints of adverse reactions to surgical gloves. A review of the literature reveals latex allergy problems not to be confined to gloves, but to involve articles of clothing, rubber dam material, and other latex-containing products. Life-threatening cases have been reported. The dental profession may be faced with compromising reactive possibilities in patients who have been previously sensitized. There is a need for development of alternative protective products for the dental office.

Dental Staff↗

Cosmetics and contact dermatitis.

A complete work-up of most patients with cosmetic allergies can be performed satisfactorily in a dermatologist's office without expensive equipment. After taking a complete history and performing a thorough examination, a biopsy is seldom required. Examine all the patient's cosmetics, eliminate the strong irritants, and proceed with product patch testing. Patch testing with the AAD allergen test tray at the same time is frequently helpful. When results are doubtful or do not fit with the information obtained from the history and examination, supplemental provocative use tests often clarify what information is clinically relevant. Patch testing with ingredients that dermatologists have obtained from cosmetic manufacturers or other sources often provides a helpful, definitive answer for the patient. Always provide the patient with information about cross-reactions and the official name of the allergen as it will appear on a cosmetic label to prevent recurrences.

Cosmetics↗

[Allergic contact dermatitis: the evaluation of positivity in skin tests in the workers of an animal feed plant].

Patch tests were performed on 43 workers employed in an animal fodder plant, a typical dust-laden environment. The aim of the study was to establish and assess the incidence of preclinical sensitization to the substances used, some of which are well known allergens, and identify which of these were mostly responsible. On the whole, the tests did not reveal any major reaction to the allergens used, nor polysensitization. However, an unexpected number of cases was sensitized to phenothiazine, a substance that had not been use for the preceding two years. This observation is of interest since phenothiazine is scarcely allergenic and skin eruptions occur only after photosensitization.

Adult↗

[Contact dermatitis caused by heterologous proteins].

A patient (gastronomic employee) presented a sharp dermatosis of eczema type in both hands. Patch-test confirmed sensitivity to heterologous proteins contained in the squid, which he was accustomed to handling. Although the levels of the IgE were elevated, the final diagnostic was dermatitis by allergic heterologous proteins.

Adult↗