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Anaphase promoting complex or cyclosome?

The anaphase promoting complex/cyclosome (APC/C) was initially described as a multi-subunit protein complex that ubiquitinates anaphase inhibitors thus targeting them for destruction by proteasomes to initiate loss of sister chromatid cohesion. However, recent studies have identified important new functions of the APC/C. Moreover, sister centromere separation can occur in the absence of APC/C activity in mammals, indicating that anaphase onset might be triggered by multiple factors. Here we discuss whether the APC/C functions primarily as the anaphase trigger, or whether it has more general properties, relevant for cell cycle control at multiple developmental and cell cycle stages. Additionally, we discuss the validity of the APC-dependent model for sister segregation in mammals.

Anaphase↗

[Abdominal tuberculosis].

Abdominal tuberculosis develops according to a non-specific clinical picture, with a difficult differential diagnosis with respect to other entities of similar semiology. We present the case of a male who was admitted because of abdominal pain, progressive and notable loss of body weight and a fever of two months evolution. The culture from the colon biopsy showed the presence of Koch bacilli.

Abdominal Pain↗

To survive, to become: our way of life (Presidential address).

Occupational therapy's domain consists of a carefully compounded alchemy of a great vision, transforming the "poetry of the commonplace" into a vital sustainer and prolonger of precious life. Through the judicious application of an unique technology--human occupation--cautiously blended with timeless values and beliefs, we will inevitably succeed where others have failed. The grand tasks of occupational therapy abide and endure: to attend to the multiple, complex, interrelated, and critical human activities of not just living, but living well. Through the habits of attention and interest, we engage the human in regaining the harmony of functions that ensure survival, retaining those characteristics that facilitate and push balanced growth and development, and attaining those interdependent meanings of a purposeful, fulfilled life within the context of a personal and social order.

Adult↗

Impurity and danger: the need for new barriers and bridges in the prevention of sexually-transmitted disease in the Tari Basin, Papua New Guinea.

The Huli of the Tari Basin have a serious problem with the spread of STDs following the opening of the Highlands Highway from Mendi in the early 1980s. Huli territory is now the site of huge mineral exploration and development and fears are held by health officers that the diseases may soon become an epidemic. The likelihood of AIDS entering the area in the near future provides a further need for all available barriers to be erected against the diseases and new bridges constructed to better health practices. Traditional teaching among the Huli emphasized the polluting effects of sexual contact. Missionary activity and the increasing commercialization of Huli culture have combined to weaken deterrents to premarital and extramarital sexual experiences. Traditionally, men believed that dangers of pollution came from two sources; women and outsiders. Only the Huli elders held these beliefs in the 1990s and little heed is paid to their warnings. Travel for work or pleasure has greatly increased among Huli men who no longer fear the outside world but rather wish to be part of it. Thus the traditional barriers which minimized infectious diseases have been demolished. The traditional Huli health-belief model is discussed and the possibility of harnessing traditional taboos in the fight against the spread of STDs is explored.

Adult↗

[Scientific languages and the science of complexity].

For centuries the goal of galileian and newtonian science has been the discovery of the universal laws of nature governing all natural phenomena. But, starting with the sixties of this century, advanced research has concentrated on the study of the characteristic aspects of irregular and unrepeatable evolutionary processes. Signs of this change are the rediscovery of Poincaré's results on the dynamics of non linear systems, and the extraordinary development of evolutionary thinking. Three properties characterize complex systems: the multiplicity of their levels of organization, the presence of self-referential loops of internal communication, and the irreducible nature of their past history to structural properties. The traditional cartesian gap between mind and body therefore falls down, as argued at length by the works of Gregory Bateson. His arguments are further strengthened by the neurologist Antonio Damasio in his book on reason, emotion and human brain, whose title is L'errore di Cartesio (The error of Descartes), where the negative consequences of this error on the development of science in general and on contemporary medicine in particular, are illustrated.

Biological Evolution↗

[The epicrisis].

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Cultural Evolution↗

[Not Available].

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Anthropology↗