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PubMed1976

Glimpses into the social world of middle age.

This paper describes briefly the two cohorts recently followed up in the long term longitudinal research program at the Institute of Human Development at Berkeley, and notes the characteristics of those members who remain under study. It then presents a few findings on the occupational carreers and work orientations of both men and women, notes certain personality correlates of career patterns in the middle years, and briefly touches on marital satisfaction as related to work status.

Adolescent↗

PubMed2006

Search for microbial signatures within human and microbial calcifications using soft x-ray spectromicroscopy.

BACKGROUND: The origin of advanced arterial and renal calcification remains poorly understood. Self-replicating, calcifying entities have been detected and isolated from calcified human tissues, including blood vessels and kidney stones, and are referred to as nanobacteria. However, the microbiologic nature of putative nanobacteria continues to be debated, in part because of the difficulty in discriminating biomineralized microbes from minerals nucleated on anything else (eg, macromolecules, cell membranes). To address this controversy, the use of techniques capable of characterizing the organic and mineral content of these self-replicated structures at the submicrometer scale would be beneficial. METHODS: Calcifying gram-negative bacteria (Caulobacter crescentus, Ramlibacter tataouinensis) used as references and self-replicating calcified nanoparticles cultured from human samples of calcified aneurysms were examined using a scanning transmission x-ray microscope (STXM) at the Advanced Light Source at Lawrence Berkeley National Laboratory. This microscope uses a monochromated and focused synchrotron x-ray beam (80-2,200 eV) to yield microscopic and spectroscopic information on both organic compounds and minerals at the 25 nm scale. RESULTS: High-spatial and energy resolution near-edge x-ray absorption fine structure (NEXAFS) spectra indicative of elemental speciation acquired at the C K-edge, N K-edge, and Ca L(2,3)-edge on a single-cell scale from calcified C. crescentus and R. tataouinensis displayed unique spectral signatures different from that of nonbiologic hydroxyapatite (Ca(10)(PO(4))(6)(OH)(2)). Further, preliminary NEXAFS measurements of calcium, carbon, and nitrogen functional groups of cultured calcified nanoparticles from humans revealed evidence of organics, likely peptides or proteins, specifically associated with hydroxyapatite minerals. CONCLUSION: Using NEXAFS at the 25 nm spatial scale, it is possible to define a biochemical signature for cultured calcified bacteria, including proteins, polysaccharides, nucleic acids, and hydroxyapatite. These preliminary studies suggest that nanoparticles isolated from human samples share spectroscopic characteristics with calcified proteins.

Aneurysm↗

PubMed1993

Lipid tolerance testing in pregnancy.

OBJECTIVE: Macrosomia in the infant of the well-controlled diabetic mother suggests that a substrate other than glucose may influence fetal growth. We hypothesized that GDM alters lipid homeostasis during pregnancy. Our objective was to determine if an LTT could assist in identification of lipid abnormalities in the GDM individual. RESEARCH DESIGNS AND METHODS: The LTT consisted of bolus infusion of 1.0 mg/kg 10% Intralipid (Cutter Vitrum, Berkeley, CA) followed by measurements of plasma glucose, insulin, glycerol, total triglycerides, and triglyceride fatty acids (18:1 and 18:2), total FFAs, and total phospholipids for 30 min before and 90 min after the bolus. The study groups were composed of 8 nonpregnant, nondiabetic subjects, 8 pregnant, nondiabetic subjects, 8 GDM patients receiving insulin, and 8 GDM patients who were diet controlled. RESULTS: Plasma glucose and plasma insulin concentrations did not change significantly after the bolus. No significant difference was noted in the K2 for glycerol of the nonpregnant, nondiabetic group compared with the pregnant groups. The K2 for total triglycerides, plasma triglyceride 18:1, and plasma triglyceride 18:2 indicated increased rates of disappearance of these substrates for the nonpregnant nondiabetic group compared with all pregnant groups. No significant differences were observed among the pregnant groups for any of these parameters. CONCLUSIONS: Pregnancy may be associated with a decreased rate of triglyceride lipolysis compared with nonpregnancy. No differences in lipid metabolism were noted among normal pregnant and relatively well-controlled GDM patients.

Adult↗

PubMed2002

Adjectives, phrases, and sentences: intracorrelation of three five-factor personality inventories.

The Eysenck Personality Inventory and three short five-factor personality inventories, the NEO Five Factor Inventory, the Berkeley Personality Profile, and the SONSO Personality Inventory, were administered in pairs to six samples of college subjects. The three samples using the Eysenck inventory each contained 300 subjects, whereas the remaining three samples contained 500 subjects each. Each sample was half women and half men. The inventories appear to have corresponding scales, often with correlations of around .70 among them. Also, measures associated with Neuroticism were weakly and negatively correlated with some measures of Extraversion, Agreeableness, and Conscientiousness.

Adolescent↗

PubMed1990

An angular alignment measurement device for prosthetic fitting.

A device to measure socket/shank angular alignment in a prosthesis equipped with a Berkeley Adjustable Leg is described. Angular alignment in the sagittal plane can be measured over the entire 20-degree range with a repeatability of 1 degree. This device can be a useful prosthetics fitting, teaching, and research tool.

Amputation, Surgical↗

PubMed1994

A trans-femoral brim adapter for CAD CAM measurements.

A computer aided design/computer aided manufacture (CAD CAM) brim measurement adapter was designed for use with a Berkeley casting stand. This measurement adapter accommodates all IPOS/CANFIT-PLUS transfemoral brim sizes and shapes, allows brim positioning, provides adequate stability, and provides a substantial cost saving by using existing, functional hardware as a base.

Anthropometry↗

PubMed1996

Interindividual variation in circulating zinc concentrations among healthy adult men and women.

Circulating zinc concentrations were measured in 73 healthy adult males and females 19-52 years of age who were volunteers for eight different metabolic studies at the University of California, Berkeley. The interindividual variation in the eight studies varied from 5 to 20%; the global coefficient of variation for all studies was 12 +/- 7% (mean +/- SD). The analysis of a reference plasma sample on six different days showed a mean coefficient of variation of 3.8%. Thus, only a small portion of the intraindividual variation is due to day-to-day analytical differences. There was no relationship between circulating zinc concentrations and age, height, or body mass index. Nor were there any significant differences due to gender. Information regarding dietary zinc and protein intakes was available from three-day weighed food intake records from 44 of the subjects. Plasma zinc concentrations were unrelated to the intake of either zinc or protein in those subjects. The results of this study show that the impact of age, gender, body size and dietary zinc or protein on circulating zinc concentrations are too small to be detected in the presence of the analytical and endogenous factors that influence plasma/serum zinc concentrations. Also, within a population of healthy adults, circulating zinc concentrations may vary by as much as 15%.

Adolescent↗

PubMed2000

Community-identified alcohol issues in the Mexican American community: research design and utilization.

This article describes a community-based study, Alcohol Outlet Density and Mexican American Youth Violence, funded by the California Wellness Foundation--Violence Prevention Initiative to the prevention Research Center in Berkeley, California. The study was conducted in three northern California cities in 1993-1996. The focus is on the inclusionary planning process in designing and implementing the study. Community members were an integral part in the identification of study questions. As a result, the findings of the study are relevant to community activists in advocating alcohol-related policies. The need for more utilization-based community studies is emphasized.

Advertising↗

PubMed2026

Nephropathies Associated with Sickle Cell Trait and How to Study Them.

Sickle cell trait (SCT), which carries a single point mutation in the hemoglobin-β (HBB) gene, has long been considered a benign condition. However, epidemiological evidence challenges this assumption, revealing that individuals with SCT face an elevated risk of renal dysfunction. However, this field of study remains ill-defined as it has focused on sickle cell disease (SCD), where renal complications are severe. As SCT is more prevalent than SCD, consequences of nephropathies in this group translate into a substantial and largely unaddressed public health burden. Clinical data, primarily observational, implicate age and sex in the development of SCT-associated nephropathies. These manifestations span glomerular hyperfiltration, tubular damage, hematuria, renal papillary necrosis, renal medullary carcinoma, and progression to chronic kidney disease, all complications that cluster disproportionately in older male individuals. Despite this, the mechanistic basis of SCT nephropathy, the thresholds at which renal injury becomes clinically significant, and the optimal strategies for early identification and prevention remain inadequately defined. In vitro studies have primarily focused on SCD blood cell biology, with SCT receiving comparatively little attention. Humanized murine models (i.e., Berkeley and Townes) have recapitulated some SCT-associated renal phenotypes but need to be more fully characterized. This review aims to provide an overview of the biology of sickle cell trait nephropathies, the gaps in our knowledge, and the model systems we can use to fill those gaps.

Journal Article↗

PubMed2001

The oldest-old: how do they differ from the old-old?

This article reviews findings from the Berkeley Older Generation Study, a long-term longitudinal study of aging. The findings show many important differences between the oldest-old age group and other, younger-old individuals. Marked variation is demonstrated in the verbal scale of intelligence. More than half of oldest-old individuals did not decline, and some actually increased in verbal IQ. Four personality traits (i.e., agreeableness, satisfaction, intellect, extroversion) are stable. The fifth trait, energetic, may reflect responses to external circumstances, including physical health. As for social relationships, most individuals--including the oldest-old--still retain ties with important family members and friends. Individual differences are great, stressing the danger of accepting stereotypes about old individuals.

Aged↗

PubMed1996

Disability glare after excimer laser photorefractive keratectomy for myopia.

BACKGROUND: A change of corneal topography and haze after excimer laser photorefractive keratectomy (PRK) can reduce contrast sensitivity and cause glare. Both glare and contrast sensitivity can be examined in a reproducible manner with one instrument. METHODS: We have used the Berkeley Glare Test to examine 46 eyes of 32 patients before and 1, 3, 6, 9, and 12 months after excimer laser PRK for moderate to high myopia. Multiple regression analysis was used for statistical analysis. RESULTS: High contrast visual acuity showed a statistically significant deterioration during the first 6 months after PRK (p = 0.01); 1 year after treatment visual acuity returned to almost pretreatment levels (p = 0.2). High- and low contrast visual acuity under glare deteriorated significantly 3 months after PRK and had only risen slightly 1 year later (p < or = 0.0065). A similar development could be observed for the low contrast visual acuity without glare. CONCLUSION: Although high contrast visual acuity recovers by 1 year after PRK, low contrast visual acuity and glare deteriorate significantly and do not recover, even after 1 year.

Adult↗

PubMedDate not supplied

Studying the news on public health: how content analysis supports media advocacy.

OBJECTIVE: To describe how content analysis of the news assists media advocates. METHODS: A description of how findings from the Berkeley Media Studies Group's research on how 2 public health issues have been portrayed in the news has informed media advocacy. RESULTS: For media advocates, the research suggests they make themselves available to reporters, prepare spokespeople representing key stakeholders, and make data available. For reporters, the research suggests they expand sources beyond the "usual suspects," provide context in regular reporting, increase enterprise and investigative reporting, and ask better questions based on epidemiology and risk factors. CONCLUSION: Content analysis can help media advocates pinpoint areas for creating news to advance policy.

Child↗

PubMed1999

Recombinant human granulocyte-macrophage colony-stimulating factor accelerates engraftment kinetics after allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia.

BACKGROUND AND OBJECTIVE: The use of recombinant human granulocyte-macrophage stimulating factor (rhGM-CSF) has been shown to be well-tolerated and to reduce post-transplantation morbidity in adults undergoing HLA-identical allogeneic bone marrow transplantation (BMT). There is however, limited experience in children. DESIGN AND METHODS: We performed a prospective, comparative multicenter trial using rhGM-CSF after allogeneic BMT in children with acute lymphoblastic leukemia (ALL). The study comprised 24 patients with ALL who received rhGM-CSF and 22 patients with ALL who did not receive rhGM-CSF. There were no statistically significant differences in the demographic characteristics between the rhGM-CSF-treated and untreated groups. rhGM-CSF was given at a dose of 10 micrograms/kg/day infusion over 4 hours from day +1 until +28 or until the absolute neutrophil count (ANC) was > or = 1 x 10(9)/L. All patients received HLA-identical sibling marrow and cyclosporine alone for graft-versus-host disease (GvHD) prophylaxis. The number of cells infused was similar in both groups. A software program (Statview 4.0, Abacus Concept, Inc., Berkeley, CA, USA) was used for statistical analysis. RESULTS: The median of days to achieve ANC > or = 0.5 x 10(9)/L was shorter in the rhGM-CSF-treated patients (14 days vs 18.5 days; p < 0.0001). Patients who received rhGM-CSF had a lower incidence of grade III-IV mucositis. The duration of hospital stay was significantly shorter in patients who received rhGM-CSF (31 days vs 45 days; p < 0.005). No differences in GvHD severity, relapse or survival were observed. At the dose and schedule used in the present study, rhGM-CSF was well-tolerated and no side effects were observed. INTERPRETATIONS AND CONCLUSIONS: rhGM-CSF at a dose of 10 micrograms/kg/day in children with ALL undergoing allogeneic BMT is well tolerated, accelerates neutrophil and platelet engraftment, reduces the intensity and severity of mucositis and permits a more rapid discharge from hospital.

Adolescent↗

PubMed1990

Experts outline managed-care strategies.

Hospitals and physicians are wasting time, energy and money trying to be insurance agents when they should be trying to figure out the best setting for treating patients, says a new book edited by Peter Boland, a Berkeley, Calif., healthcare consultant.

Cost Control↗

PubMedDate not supplied

Implementing complex networking laboratory information systems in a health maintenance organization.

Kaiser Permanente, Northern California Region (KPNCR) currently consists of 17 medical centers and 28 medical office building clinical laboratories plus a large, centralized reference laboratory. Before 1977, KPNCR processed laboratory information manually. With the opening of the Kaiser Permanente Regional Laboratory in Berkeley in 1977, a card punch system was used to capture that laboratory's data. In 1985, the Regional Laboratory installed a mini-mainframe system. In 1990, KPNCR Implemented a Region-wide Integrated Laboratory Information System. The software used was manufactured by Cerner Corporation, Kansas City, Missouri. The hardware platform consisted of for DEC VAXs. The decision was based on flexibility, supportability, and well established customer base. Work on the database began in September of 1991. The first "go-live" was in August of 1992. All facilities--46 laboratories--were "live" by February of 1995. Total implementation time was 27 months.

California↗

PubMedDate not supplied

Survey of alternative health systems for business.

There is a new climate of deregulation and increasing competition in the healthcare marketplace. Until recently, methods for moderating the cost of health care have focused on inpatient care to the virtual exclusion of other delivery systems. Thus, ambulatory care has been almost totally ignored. The prominence of business/health coalitions has begun to highlight outpatient providers. Furthermore, medical group practices are beginning to negotiate directly with businesses and industries to provide an agreed upon set of outpatient services. As a part of its ongoing activities and through a grant from the Western Network for Education in Health Administration in Berkeley, California, the Center for Research has initiated a project, New Perspectives for Affordable, Quality Health Care. The research underlying this upcoming Center publication was conducted by Dr. Tynan of the University of Colorado at Denver, School of Public Administration. Dr. Tynan 's survey findings provide an excellent description of the activities of MGMA member groups in alternative arrangements for delivering medical services.

Advertising↗

PubMed1999

Ethnology as a play: a comparison of two schools of thought at the turn of the century.

The methods and theories of science are in a state of constant flux. With the perimeters of science changing so does the subject of inquiry. Ethnology, a relatively young science underwent a drastic change at the turn of the century as unillineal evolutionism of the preceding century became obsolete and gave away to diffusionism. In this paper I want to outline briefly the development of two institutes of cultural anthropology--at the University of California at Berkeley and the University of Vienna--at the turn of the century. It is not surprising that synchronous with this paradigmatic shift in ethnological inquiry the two institutes examined here found themselves in a time of great social as well as cultural upheaval. I took on the task of writing a kind of meta-ethnology, an inquiry into the socio-political and cultural forces that shape a scientific dogma, which in turn can and did change society. For my reader's as well as for my own benefit I used the metaphor of a "play" in describing such a complex process.

Anthropology, Cultural↗

PubMed2000

Becoming respectable: T. Dale Stewart and the acceptance of forensic anthropology in the academic community.

Before World War II, forensic anthropology was of peripheral interest to a few anthropologists willing to assist in investigations by law enforcement agencies. A strong bias that "police work" was unbecoming to the scholarly pursuits of academics persisted into the post-war years. Changes took place as a consequence of T. Dale Stewart's case work in the identification of human remains with the FBI from 1943 to 1969, his directorship of the National Museum of Natural History (Smithsonian Institution) beginning in 1962, and his work with the Armed Forces after 1948. This paper discusses the historic period of transition of attitudes and practices in the contexts of Stewart's contributions and the cases and teaching programs of one of his contemporaries. Theodore D. McCown at the University of California at Berkeley, during the period of 1939 to 1969. The establishment of the Physical Anthropology Section within the American Academy of Forensic Sciences in 1972 and the creation of the T. Dale Stewart award for distinguished service in forensic anthropology advanced those laboratory research programs and medical-legal investigations conducted by present-day forensic anthropologists.

Forensic Anthropology↗