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At least 631 records · Page 35Linked to original sources
PubMed1978

CT biopsy of abdominal tumors: aids for lesion localization.

Computed tomographic guided fine needle aspiration biopsy of 25 consecutive patients with a variety of confirmed malignant abdominal and plevic neoplasms resulted in a 100% yield of positive tissue diagnosed, without significant complications. The principal advantage of CT guidance is the continuous direct observation of the needle tip position in relation to the target volume. Simultaneous insertion of 2 fine caliber biopsy needles (tandem needle maneuver) is a new technique developed for rapid, accurate needle repositioning for repeated aspiration attempts. CT guidance, multiple aspirates with the fine needle, and the tandem needle maneuver for precise localization all contribute to a high rate of tissue diagnoses. Because CT guidance permits more precise sampling of smaller, deeper tumors than other procedures, including ultrasonic biopsy transducer systems, it is preferred for percutaneous tissue sampling of abdominal neoplasms. Preliminary experience suggests that a large proportion of symptomatic abdominal malignancies which can be diagnosed by CT are amenable to successful percutaneous biopsy by this technique.

Abdominal Neoplasms↗
PubMed1987

Intraoperative irradiation of the canine abdominal aorta and vena cava.

The canine abdominal aorta and vena cava were examined 6 months after single doses of intraoperatively delivered electrons (IORT), fractionated external beam X rays, or a combination. The predominant pathologic change in aortas given fractionated doses was a segmental thickening of the subendothelial region of the tunica intima which was due to fibroelastic proliferation. In severe cases, the intimal proliferation caused significant narrowing of the aortic lumen. The greatest proliferation and lumen narrowing resulted from 80 Gy given in 30 fractions, whereas 60 Gy produced little response. In contrast, IORT alone or combined with fractionated doses resulted in mild subendothelial intimal proliferation at all doses. In some aortas there was focal aortic wall thinning after IORT alone or combined with fractionated doses. This response may be explained by increased intimal cell death and lost or delayed proliferative capability caused by large single doses. These studies suggest that large single doses produce structural alterations in the walls of large blood vessels that are clinically undetectable at early post-irradiation times. If these changes progress in severity they could lead to late effects such as rupture, fissure, or aneurysm that are clinically more significant than the marked intimal proliferation and lumen narrowing changes seen after fractionated doses. The aortic cell responsible for intimal fibroelastic proliferation appears to be a pluripotential stem cell capable of producing fibrous, elastic, and possibly smooth muscle tissue. There were no significant alterations in any of the irradiated vena cavas.

Abdominal Neoplasms↗