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A self-administered health questionnaire for the preoperative risk stratification of patients undergoing cataract surgery.

PURPOSE: To determine if a self-administered health status questionnaire completed by candidates for cataract surgery is beneficial for identifying medical comorbidities and patients at risk for adverse intraoperative and postoperative medical events. DESIGN: Prospective cohort study. METHODS: Data were obtained from a large, randomized clinical trial of 19,250 cataract surgeries performed between June 1, 1995, and June 30, 1997. Preoperative data were obtained from a standardized, self-administered patient health questionnaire and a history and physical form completed by the patient's physician. A record of adverse medical events on the day of surgery and through the first 7 postoperative days was recorded. RESULTS: Responses to 21 questions on the questionnaire were highly specific for 12 comorbid conditions identified by the physician history and physical, ranging from 100% specificity for arrhythmia to 91.3% specificity for coronary artery disease. Comorbid conditions identified by the questionnaire were associated with similar relative risks of adverse events as those identified by the physician history and physical. Patients who had no comorbidities identified by the questionnaire had adverse medical event rates indistinguishable from patients with no comorbid conditions identified by the health provider history and physical. CONCLUSIONS: The self-administered questionnaire showed a high degree of specificity for 12 common comorbid conditions in cataract patients. A questionnaire such as this may be useful in preoperative risk stratification.

Aged↗

CK-MB isoforms for early risk stratification of emergency department patients.

The potential clinical utility of single sample CK-MB isoforms measurement for early risk stratification of Emergency Department (ED) patients with possible myocardial ischemia was evaluated among 405 patients presenting to two urban EDs. Clinical and serologic data were prospectively collected and the occurrence of adverse events (AEs) and myocardial infarction (MI) during the 14-day outcome period was recorded and utilized to calculate and compare relative risks (RR) and predictive values of isoforms and CK-MB alone. Among the 405 patients, 67 accrued 105 AEs. Both isoforms and CK-MB alone were predictive of AEs with RR of 3.32 (2.09, 5.27) and 6.28 (4.64, 8.52), respectively. Isoforms had higher sensitivity for AEs compared to CK-MB (65.7% [54.3, 77.0] vs. 14.9% [6.4, 23.5]; p<0. 01) but lower specificity (69.2% [64.3, 74.2] vs. 99.7% [99.1,100. 0]; p<0.01). Isoforms' superior sensitivity allowed identification of many high risk patients missed by CK-MB alone. Further, for the prediction of MI, isoforms had superior diagnostic sensitivity and equivalent specificity. This investigation supports the emergency department use of early, single sample CK-MB isoform testing.

Adult↗

Cardiac markers and risk stratification: an integrated approach.

Risk stratification of patients with acute coronary syndromes (ACS) is pivotal for correct allocation of health resources and for maximizing the benefit of available treatment modalities. However, clinical and electrocardiographic indicators of high risk lack sufficient sensitivity for the detection of major cardiac events. The complementary information provided by the measurement of different biomarkers is believed to be very useful. Specifically, elevations of cardiac troponin I (cTnI) and T (cTnT) are strongly associated with a high-risk profile both at short- and long-term. This has been definitely demonstrated in many studies as well as in cumulative meta-analysis. The role of different biomarkers, such as those reflecting activation of hemostasis and the presence of inflammation, is however less defined. At the moment, no study has prospectively evaluated these biomarkers in the whole spectrum of unselected patients with ACS. It is also unclear whether these biomarkers add independent prognostic value to the clinical and electrocardiographic indicators of adverse outcome and whether they offer additional information when compared to each other. The Early Prognostic Value of Biochemical Markers of Myocardial Damage, Activation of Hemostatic Mechanism and Inflammation in Acute Ischemic Syndromes (EMAI) study has been prospectively designed to solve these issues. In this study, we have evaluated the prognostic value of cTnI and cTnT, D-dimer, prothrombin fragment 1+2 (F1+2), thrombin-antithrombin complex (TAT) and C-reactive protein (CRP) in patients with ACS at the time of admission. We have enrolled in 31 Italian Coronary Care Units 1971 patients with rest anginal pain within 12 h from admission and electrocardiographic evidence of myocardial ischemia. Of these, 730 patients resulted to have ST-segment elevation myocardial infarction eligible for a reperfusion strategy and 1241, an acute coronary syndrome without persisting ST-segment elevation. Primary outcome measure of the study is the composite of death and non-fatal MI within 30 days from admission, which has occurred in 8.9% of the study population.

Animals↗

C-Reactive Protein and cardiac troponin for early risk stratification in patients with acute coronary syndromes.

An increasing body of evidence demonstrates that the acute coronary syndromes share a common pathophysiological background. New biochemical markers, and in particular cardiac troponins, are now available for risk stratification also in patients with minor myocardial damage. There is a linear relationship between the serum level of troponins and the risk of major cardiac events. However, in patients with normal cardiac troponins, the measurement of C-Reactive Protein (CRP) may add further information: in fact, an increased CRP is associated with an adverse outcome independent of an increased troponin. The time course of CRP and cardiac troponin elevation after the onset of myocardial damage may be one of the reasons of the independent prognostic value of the two markers.

Biomarkers↗

An efficient SAS program for extract stratification of person-years.

An efficient Statistical Analysis System computer program for the exact stratification of person-years is described, in order to determine the expected number of deaths or cases of diseases in a cohort for the calculation of standardized mortality ratios or standardized morbidity ratios. A comparison of this program with Macaluso's "Method B" program shows that the speed of the former is considerably faster than that of the latter, when the widths of the categories defined by all of the time factors are identical.

Age Distribution↗

Stratification of time-frequency abnormalities in the signal-averaged high-resolution ECG in postinfarction patients with and without ventricular tachycardia and congenital long QT syndrome.

Having developed sound mathematical techniques that allow precise mapping of cardiac signals in the time-frequency (TF) and time-scale planes, the next important issue is to extract from these representations information that best reflects the electrophysiologic and anatomic derangement unique to patients at risk of arrhythmias and other cardiac diseases. In this study, the authors present a new method that stratifies the magnitude of the TF transforms of abnormal cardiac signals into distinguishing features by comparing the means of the coefficients of the TF transforms of any study population to the corresponding means of a control population using a standard ANOVA technique. This results in a three-dimensional mapping of the high-resolution ECG into time, frequency, and P value components. Significant energy increases are given positive P values and depressed energies are given negative P values: these are ranked according to a color scale. The method was tested on two study populations: postmyocardial infarction patients with documented ventricular tachycardia (MI+VT, n = 23) and without (MI-VT, n = 40) and patients with congenital long QT syndrome (LQTS, n = 19). Two groups of healthy control subjects (n = 31 and n = 40) were used as a reference group matched for sex. The study results were based on the Morlet analyzing wavelets, with frequencies ranging from 40 to 250 Hz in 10 logarithmically progressing scales, and computed millisecond per millisecond over a 350-ms analyzing time window, starting from 100 ms before the onset of the QRS. The patients with MI+VT displayed significantly increased high-frequency components in the 40-250-Hz frequency range, corresponding to prolonged QRS duration and late potentials in the area from 80 to 150 ms after QRS onset. Significantly depressed energy (P < 10(-4)) was also observed for the 40-106-Hz frequency range in the first 50 ms of the QRS complex, mainly in lead Y and in the magnitude vector. In patients with LQTS, significant modifications (P < 10(-2)) were observed in the first half of the QRS and in the ST-segment, in all leads, revealing anomalies in the genesis of the ventricular depolarization and repolarization processes. In conclusion, the authors propose a new method for the stratification of abnormal TF components occurring in the signal-averaged high-resolution electrocardiogram of patients at risk of VT and fibrillation under different pathologic conditions.

Adult↗

Diagnosis and risk stratification in patients with acute coronary syndromes according to ESC guidelines.

Diagnosis and risk stratification of patients with acute coronary syndromes remain extremely important in order to avoid unnecessary hospitalizations on the one hand, and to improve prognosis of these patients on the other. For diagnosis of acute coronary syndromes, an ECG should be obtained at rest, troponin T and I should be measured on admission and again 6 to 12 h later, and myoglobin or CK-MB should be determined in patients with recent syndromes and those with recurring ischemia. Risk should be assessed upon admission and repeatedly during the hospital stay. Early risk indicators are: age, male sex, previous manifestation of coronary artery disease, history of left ventricular dysfunction or congestive heart failure and ongoing chest pain, as well as ST depression, transient ST segment elevation, and elevated levels of troponin T or I. Longer term risk assessment in unstable coronary artery disease includes rest and stress echocardiography, exercise ECG, thallium scintigraphy, as well as coronary angiography and left ventriculography. Markers of high long-term risk are old age, prior history of myocardial infarction, diabetes, elevated levels of C-reactive protein, and the extent of coronary artery disease and left ventricular dysfunction.

Acute Disease↗

Adenocarcinoma of the prostate invading the seminal vesicle: prognostic stratification based on pathologic parameters.

OBJECTIVES: To stratify the prognosis of lymph node-negative, seminal vesicle-positive tumors in men with prostate cancer after radical retropubic prostatectomy. METHODS: Sixty cases were analyzed for multiple parameters and correlated with postoperative biochemical (prostate-specific antigen) progression. Variables included Gleason score, primary Gleason pattern, percentage of Gleason pattern 4, any presence of Gleason pattern 5, method of seminal vesicle invasion (SVI), margin positivity, SVI extent, SVI bilaterality, vascular invasion, extent of extraprostatic extension, length of tumor extending along the seminal vesicles, presence of intraductal carcinoma within the prostate, bladder neck margin positivity, and tumor volume. RESULTS: We were able to stratify the prognosis based on the combination of a variation of the Gleason score and margin status and vascular invasion status. Using this stratification, a few patients had an excellent long-term prognosis, with most patients split into two groups, one experiencing rapid and the other slower progression. CONCLUSIONS: SVI is not associated with a uniformly poor prognosis. Rather, tumors can be substratified by pathologic parameters into groups with differing prognoses based on routine histologic examination.

Adenocarcinoma↗

Prognostic-factors-based risk-stratification model for invasive urothelial carcinoma of the urinary bladder in Taiwan.

Objectives. To develop a prognostic-factors-based predictive model for invasive urothelial carcinoma of the urinary bladder derived from statistical comparison of clinical characteristics.Methods. The medical records for patients with invasive urinary bladder urothelial carcinoma were reviewed. Clinical data for age, sex, serum lactate dehydrogenase, creatinine, albumin, alkaline phosphatase, alanine aminotransferase, total bilirubin and hemoglobin levels, white blood cell and platelet counts, positive urine cytology, Eastern Cooperative Oncology Group performance status score, tumor size, histologic grading, T stage, presence of lymph node metastases, squamous differentiation, hydronephrosis, prostatic involvement, Charlson comorbidity index, surgical procedures, and adjuvant chemotherapy status were recorded. Univariate and multivariate analyses were performed to test independent factors for prediction of survival and disease recurrence.Results. After univariate and multivariate analyses, six independent prognostic factors were found: T stage, grading, prostatic involvement, Eastern Cooperative Oncology Group performance status score, and pretreatment serum creatinine and albumin levels. A scoring system was developed on the basis the relative risk associated with the proposed prognostic factors and patients were stratified into three groups according to their scores, with statistically significant prognostic differences revealed for each of the between-group comparisons. Independent factors affecting recurrence-free survival and best predicted disease recurrence were pretreatment serum creatinine, T stage, and surgical procedure.Conclusions. This prognostic-factors-based risk-stratification model for invasive urothelial carcinoma of the urinary bladder may help clinicians predict outcome and select the most appropriate therapeutic modalities. The incidence of recurrent disease is significantly higher for patients with poor renal function before treatment or advanced T stage and those undergoing transurethral tumor resection instead of radical cystectomy.

Aged↗

Risk stratification in patients with chest pain.

This article reviews the role of exercise testing in the assessment of patients with suspected coronary disease. To accomplish this, four major topics are considered: the general concept of risk stratification; the estimation of outcomes using data from the initial evaluation of the patient; diagnostic assessment with the exercise test; and prognostic assessment with the exercise test. This review focuses on the standard treadmill exercise test.

Chest Pain↗

Analysis of 5 years of bacteraemias: importance of stratification of microbial susceptibilities by source of patients.

Many factors need to be considered when selecting empiric antimicrobial treatment for infections; foremost are the principal pathogens causing the diagnosed infection and their antimicrobial susceptibility patterns. These susceptibilities are location specific. This study analyses blood cultures of a 5-year period (1990-94) at a 550 bed community hospital and stratifies antimicrobial susceptibilities by source of patients. Data included: date of culture, patient location, number of positive bottles with the same organism over a period of 2 weeks and results of susceptibility testing. Positive cultures from patients in the Emergency Department were deemed to reflect community-acquired strains: positive cultures from patients in the Intensive Care Unit were considered nosocomial organisms. During the study period 52055 blood cultures were drawn; 5652 (11%) from 2742 patients grew at least one organism, excluding skin contaminants. Organisms cultured most frequently were: Enterobacteriaceae: 1162 patients (42%); Staphylococcus aureus: 442 (16%); Enterococcus; 429 (16%); and Pseudomonas: 196 (7%). Antimicrobial susceptibility percentages of Enterobacteriaceae from Emergency Room patients (n = 370) were significantly greater to all tested antimicrobials than from ICC patients (n = 161) (P < 0.001). Overall, 143 isolates of S. aureus from 442 patients (32%) were methicillin resistant (MR); stratification by department revealed a range of 20/142 (14%) MR in community acquired strains to 49/67 (73%) from ICU patients (P < 0.001). Detailed tables with antimicrobial susceptibilities according to strains, and stratified by source of patients are presented. When selecting empiric antimicrobial therapy for patients with bacterial infections, it is crucially important to physicians to have access to antimicrobial susceptibility percentages, stratified by source of patients.

Anti-Bacterial Agents↗

Prognostication and risk stratification by assessment of left atrioventricular plane displacement in patients with myocardial infarction.

BACKGROUND: Mean left atrioventricular plane displacement is strongly related to prognosis in patients with heart failure. We aimed to examine its value for prognostication and risk stratification in patients hospitalised for acute myocardial infarction. METHODS AND RESULTS: Left atrioventricular plane displacement was assessed by echocardiography in 271 consecutive patients with acute myocardial infarction. Mean prospective follow-up was 628 days. Atrioventricular plane displacement was readily assessed in all patients and was significantly lower in patients who died (n=41, 15.1%) compared to the survivors: 8.2(5.6) v. 10.0(5.5) mm, P<0.0001. Overall mortality was 31.3% in the lowest quartile with regard to atrioventricular plane displacement (<8.00 mm) and 10.1% in the combined upper three quartiles. Thus, the hazard ratio for an atrioventricular plane displacement <8.0 mm compared to 8 mm or more was 3.1, P=0.0001. The combined mortality/heart failure hospitalisation incidence was 43.8% in the lowest and 14.6% in the combined upper three quartiles: Risk ratio 3.0, P<0.0001. In multivariate analysis, including age and history of atrial fibrillation, left atrioventricular plane displacement was an independent prognostic marker. CONCLUSION: In post-myocardial infarction patients, echocardiographic assessment of atrioventricular plane displacement showed a strong, independent prognostic value. Determination of left atrioventricular plane displacement can be readily performed in virtually all patients, and may in clinical practice facilitate identification of high-risk patients.

Aged↗

Percent achieved of predicted peak exercise oxygen uptake and kinetics of recovery of oxygen uptake after exercise for risk stratification in chronic heart failure.

To investigate whether percent achieved of predicted peak exercise oxygen uptake (%VO2max) and recovery of oxygen consumption after exercise may provide prognostic information in chronic heart failure (CHF), we prospectively studied 196 patients with mild to moderate CHF. The following variables were examined: age, etiology of CHF, functional class, ejection fraction (EF), peak exercise oxygen uptake normalized for body weight (VO2max), %VO2max, time to reach 50% of the peak oxygen uptake after exercise (T1/2VO2max), presence of nonsustained ventricular tachycardia (NSVT) and inability to take ACE-inhibitors. VO2max was the most powerful predictor of cardiac death (P<0.0001). Other independent predictors of death were EF, T1/2VO2max, NSVT and inability to take ACE-inhibitors. The discriminatory accuracy of VO2max for cardiac death was not significantly greater than that of %VO2max. In conclusion, the determination of %VO2max does not enhance risk stratification in CHF whereas the kinetics of oxygen consumption after exercise can provide prognostic information.

Exercise Test↗

Early risk stratification of unstable angina/non-Q myocardial infarction: biochemical markers of coronary thrombosis.

Coronary thrombosis is an important determinant of prognosis in patients with acute coronary syndromes (ACS). However, the identification of patients at high-risk for progression of coronary thrombosis is difficult partly because we currently lack clinically meaningful laboratory methods for its detection. The most promising approaches involve the measurement in plasma of markers of fibrin formation and degradation. Thrombin activity, as reflected by plasma or urine concentrations of fibrinopeptide A, is increased in patients with ACS and is associated with adverse outcome. However, the use of fibrinopeptide A as a marker of fibrin formation is limited by the very short half-life of the compound, by artifact due to sample acquisition, and by extremely long turnaround times. To overcome these limitations, measurement of soluble fibrin has been proposed. We have recently explored the prognostic value of a new fibrin-specific ELISA assay for soluble fibrin in patients with ACS and found that patients with the highest levels had a 2-fold increased risk of early and late cardiac events. Increases in plasma concentrations of cross-linked fibrin degradation products (XL-FDPs), which reflect increased fibrin turn-over, are a marker of risk for complications of myocardial infarction. However, until recently, assays for XL-FDPs lacked specificity, because they did not distinguish between fibrin and fibrinogen degradation products. Recently, fibrin-specific ELISAs have been described and a rapid whole blood assay for D-dimer has been developed. We recently validated the prognostic value of this whole blood agglutination assay in patients with ACS. These results suggest that: (1) The detection of significant activation of the coagulation and/or fibrinolytic system may be important for rapid risk stratification of patients with ACS; (2) patients with biochemical evidence of ongoing coronary thrombosis may particularly benefit from aggressive antithrombotic strategies; (3) sequential measurement of these markers may be useful to guide antithrombotic treatment during the unstable phase of coronary artery disease.

Angina, Unstable↗

Development and prospective validation of a risk stratification system for patients with syncope in the emergency department: the OESIL risk score.

AIMS: Aim of the present study was the development and the subsequent validation of a simple risk classification system for patients presenting with syncope to the emergency departments. METHODS AND RESULTS: A group of 270 consecutive patients (145 females, mean age 59.5 years) presenting with syncope to the emergency departments of six community hospitals of the Lazio region of Italy was used as a derivation cohort for the development of the risk classification system. Data from the baseline clinical history, physical examination and electrocardiogram were used to identify independent predictors of total mortality within the first 12 months after the initial evaluation. Multivariate analysis allowed the recognition of the following predictors of mortality: (1) age >65 years; (2) cardiovascular disease in clinical history; (3) syncope without prodromes; and (4) abnormal electrocardiogram. The OESIL (Osservatorio Epidemiologico sulla Sincope nel Lazio) score was calculated by the simple arithmetic sum of the number of predictors present in every single patient. Mortality increased significantly as the score increased in the derivation cohort (0% for a score of 0, 0.8% for 1 point; 19.6% for 2 points; 34.7% for 3 points; 57.1% for 4 points; p<0,0001 for trend). A similar pattern of increasing mortality with increasing score was prospectively confirmed in a second validation cohort of 328 consecutive patients (178 females; mean age, 57.5 years). CONCLUSIONS: Clinical and electrocardiographic data available at presentation to the emergency department can be used for the risk stratification of patients with syncope. The OESIL risk score may represent a simple prognostication tool that could be usefully employed for the triage and management of patients with syncope in emergency departments.

Cohort Studies↗

Use of troponin T and creatine kinase-MB subunit levels for risk stratification of emergency department patients with possible myocardial ischemia.

STUDY OBJECTIVES: To evaluate and compare the utility of measurement of troponin T and the creatine kinase MB subunit (CK-MB) for risk stratification of ED patients with possible myocardial ischemia. METHODS: Prospective observational study of ED patients with symptoms of possible myocardial ischemia with early, single sample serologic testing for cardiac troponin T and CK-MB using an identity-unlinked process. Chart review (ED, inpatient, outpatient), and telephone and mail surveys identified adverse events (AEs) during the 14 days following enrollment. AEs recorded included death, respiratory or cardiac arrest, myocardial infarction (MI), atrial and ventricular arrhythmias, pulmonary edema, conduction disturbances, and recurrent angina. Measures of the predictive ability for AEs were calculated for troponin T, CK-MB, and a combined troponin T/CK-MB index (defined as positive if either troponin T or CK-MB levels exceeded threshold values). RESULTS: Among 292 study patients, 45 (15.4%) experienced at least one AE, including seven deaths and 12 MIs. The troponin T result was positive in 34 patients, and the CK-MB result was positive in 15 patients; 6 patients had positive results for both markers and 43 patients had a positive combined troponin T/CK-MB index. Odds ratios (ORs) for occurrence of AEs among all patients were 4.4 (1.8 to 10.2), 10.0 (3.0 to 36.0), and 4.5 (2.0 to 9.8) for troponin T, CK-MB and the troponin T/CK-MB index, respectively. Both markers were individually predictive of AEs (troponin T = 4.3; CK-MB = 7.5) among all those with chest pain. Only the CK-MB level was significantly predictive of AEs among those presenting with symptoms other than chest pain (OR = 24.3 [1.1, 1448]), whereas only the troponin T level was significantly predictive among patients representing a disposition dilemma for the emergency physician (OR = 5.7 [1.4, 20.7]). When compared, the ORs for troponin T and CK-MB were not significantly different for any patient subgroup. The troponin T/CK-MB index did not have a higher prognostic value than either troponin T or CK-MB alone in any subgroup studied. CONCLUSION: A positive test result for either troponin T or CK-MB in the ED successfully identified patients at significantly higher risk of adverse events during the 2 weeks following their ED visit. The two markers may complement each other in that each appears to have prognostic ability among a unique patient subgroup. ED marker measurement can provide useful prognostic information for patients with a broad spectrum of presentations consistent with possible myocardial ischemia.

Adult↗

[Surgical stratification of renal carcinoma with extension into inferior vena cava].

Renal cell carcinoma with inferior vena cava thrombus is relatively uncommon and complicates radical nefrectomy. During the past twenty years our hospital have substantially contributed to the surgical stratification of renal cell carcinoma with extension into inferior vena cava through different techniques. The reason for this article is to discuss the mote efficient and appropiate surgical technique for this pathology. We believe that the diagnosis of vena caval invasion and level of tumoral extension is based on radiological examinations and it is crucial for the success of the surgery. We consider that the use of vena caval filter applied preoperatively could prevent the risk of thromboembolism during and after the surgery. The use of prosthetic grafts is unusual, because the long standing obstruction caused by the tumor thrombus will develope extensive collateral circulation which works as a natural veno-venous bypass. Finally, we try to avoid the use of veno-venous and cardiopulmonar bypass with or without complete hypothermic circulatory arrest due to the high association with adverse outcomes and mortality.

Carcinoma, Renal Cell↗