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PubMed1988

Mutants of translational components that alter reading frame by two steps forward or one step back.

External suppressors, sufS, of a -1 frameshift mutant cause ribosomes to shift into the -1 frame when reading the sequence CAG GGA GUG. The resulting product is not Gln-Gly-Val but Gln-Gly-Ser with Ser being encoded by the underlined AGU. The alleles investigated are approximately 2% efficient in causing frameshifting. Two other suppressors, hopR and hopE of the same -1 frameshift mutant, cause some ribosomes reading the sequence GUG UG to decode a single amino acid, Val, from the five nucleotides. The possibility is considered that peptidyl-tRNA(Val) dissociates from the mRNA, but re-pairs in a triplet manner after the mRNA slips forward by two bases.

Amino Acid Sequence↗
PubMed1988

[Possibilities of the control of arterial hypertension using the step-by-step schedule of long-term treatment with antihypertensive drugs. The Working Group on the Study of New Drugs for the Prevention of Arterial Hypertension].

The results of therapy of 186 patients with stable arterial hypertension were described. Intervals in therapy for 3 mos and more were recorded in 5.9% of the patients. Monotherapy with one randomly chosen drug turned out possible for one year in 40.9% of the patients. In a group analysis a total antihypertensive effect (complete or partial) was noted in 93.5% of the patients. An individual analysis showed that a stable antihypertensive effect (over 6 mos running for one year) was achieved in 17.7%. A stable and prolonged intermittent effect (for 6 mos during one year with and without interruptions) was achieved in 46.2%. Regular control with relation to AH initial type was recommended: in 3 mos for a mild type, in 1.5 mos for a moderate type, in 0.5 mos in a severe type.

Academies and Institutes↗