Effects of human mast cell tryptase on the kinetics of blood clotting.
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Blood Coagulation↗
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Results for “Tryptases”
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Massive extracellular tryptase from activated bladder mast cells in interstitial cystitis.
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Biopsy↗
Elevated serum tryptase in exercise-induced anaphylaxis.
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Adolescent↗
A simple method to evaluate basophil tryptase after allergen challenge in vitro.
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Allergens↗
Levels of tryptase, chymase, and Fc epsilon RI alpha messenger RNA in human skin are unchanged after IgE-dependent stimulation of cutaneous mast cells in vivo.
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Allergens↗
Increased postmortem serum mast cell tryptase in a fatal anaphylactoid reaction to nonionic radiocontrast medium.
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Aged↗
Hymenoptera stings and serum tryptase.
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Anaphylaxis↗
Clinical utility of tryptase levels in systemic mastocytosis and associated hematologic disorders.
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Anaphylaxis↗
Improved diagnosis of anaphylactoid reactions by measurement of serum tryptase and urinary methylhistamine.
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Anaphylaxis↗
Dibasic inhibitors of human mast cell tryptase. Part 3: identification of a series of potent and selective inhibitors containing the benzamidine functionality.
A survey of charged groups and linkers for a series of symmetrical and unsymmetrical dibasic inhibitors is described, leading to several classes of potent and selective inhibitors. In particular, the benzamidine functionality was identified as the most potent charged group investigated.
Benzamidines↗
Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G.
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Animals↗
Anaphylaxis during negative penicillin skin prick testing confirmed by elevated serum tryptase.
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Adult↗
Tryptase-positive mast cells predict clinical outcome of patients with early B-cell chronic lymphocytic leukemia.
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Humans↗
Tryptase-positive mast cells correlate positively with bone marrow angiogenesis in B-cell chronic lymphocytic leukemia.
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Bone Marrow↗
The kininogenase activity of human mast cell tryptase.
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Amino Acid Sequence↗
Proteinase-activated receptors: a growing family of heptahelical receptors for thrombin, trypsin and tryptase.
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Amino Acid Sequence↗
Mast cell tryptase and its role in tissue remodelling.
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Cell Division↗
Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma.
BACKGROUND: The importance of angiogenesis in melanoma has been controversial and is not homogeneous. Mast cell density (MCD) is highly correlated with the extent of both normal and pathological angiogenesis, such as that in chronic inflammatory diseases and tumours. METHODS: We evaluated the prognostic significance of tumour microvascular density (MVD) and MCD in 25 advanced melanoma patients after resection and a 4-5-year follow up: 48% of the patients were alive and free of metastases (good prognostic subgroup); 16% had developed regional nodal metastases (intermediate prognostic subgroup); and 36% had died (poor prognostic subgroup). Tissues samples were investigated immunohistochemically to count microvessels and mast cells with an antifactor VIII and an antitryptase antibody, respectively. RESULTS: Immunohistological staining showed a higher number of microvessels and mast cells in melanoma lesions of poor prognosis as compared with intermediate prognosis and with good prognosis, respectively. CONCLUSIONS: These data agree with those showing a close relationship between MCD and angiogenesis during tumour progression and demonstrate, for the first time, a prognostic significance of MCD in human melanoma.
Adult↗