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PubMed1996

[Histological study on experimental tooth movement in alveolar bone defects implanted with decalcified bone powder].

Recently, secondary bone grafting for the alveolar cleft of cleft lip and palate patients has carried out generally with the object of connecting the alveolar cleft, of leading the tooth eruption, of control the tooth axis. In this study, the experimental tooth movements to the area were tested and the histological changes were investigated with adult cats. The experimental defects of 2mm in diameter were made at the alveolar bone mesial to the both maxillary first molar. At the experimental side, DBP were stuffed into the defect. Only defects were made at the control side. The tooth were moved for 6 weeks. The restoration of the defect hadn't occurred at the control side after 14 weeks. While appositional bone growth and new bone formation surrounding the DBP were observed, and complete restoration had be already occurred at experimental side after only 8 weeks. In the group which tooth movement were started after 1 week, the existing alveolar bone were bent to mesial at both side. In the group were started after 8 weeks, the existing alveolar bone were bent to mesial at the control side, either. The DBP and new bone were resorbed at the same time at the experimental side.

Alveolar Bone Loss↗
PubMed1997

Monocyte recruitment and expression of monocyte chemoattractant protein-1 are developmentally regulated in remodeling bone in the mouse.

Tooth eruption is defined as the movement of a tooth from its site of development within the alveolar bone to its position of function in the oral cavity. It represents an excellent model to examine osseous metabolism as bone resorption and bone formation occur simultaneously and are spatially separated. Bone resorption occurs in the coronal (occlusal) area, whereas bone formation occurs in the basal area. Monocytes are thought to have a significant role in the regulation of osseous metabolism. The goal of this study was to examine the recruitment of monocytes to bone in C57BL/6J mice that are undergoing developmentally regulated bone remodeling. Monocytes were detected by immunohistochemistry and osteoclasts were counted as bone-associated multi-nucleated, tartrate-resistant acid phosphatase (TRAP)-positive cells. Cell numbers were obtained from histological sections of animals sacrificed daily for 14 days after birth; an image analysis system was used for quantification. The results demonstrated that, immediately after birth, there were relatively few monocytic cells. In the area of bone resorption, the number of monocytes increased with time, reaching peaks at 5 and 9 days, and decreased thereafter. A similar pattern was observed for osteoclasts. In the area of bone formation, there was a time-dependent increase in the number of monocytes. In contrast, the number of osteoclasts in this area was highest at the earliest time points and decreased after day 3. To investigate potential mechanisms for the recruitment of monocytes, expression of monocyte chemoattractant protein (MCP)-1 was assessed. The number of MCP-1-positive cells increased with time and was generally proportional to the recruitment of mononuclear phagocytes. Osteoblasts were the principal bone cell type expressing MCP-1. The results demonstrate that the recruitment of mononuclear cells in the occlusal area is associated with bone resorption. In contrast, recruitment of monocytes in the basal area is associated with bone formation and a decrease in the number of osteoclasts. These results suggest that monocytes have different functional roles in areas of bone formation compared with bone resorption. Furthermore, the expression of MCP-1 is developmentally regulated and may provide a mechanistic basis to explain the recruitment of monocytic cells.

Animals↗