Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Toe Phalanges”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 613 records · Page 34Linked to original sources
PubMed2005

Skeletal segments of the human pollical and hallucal rays: comparison and analysis of their intrinsic proportions.

Since in humans, the first digital ray has a different functional significance in the hand and in the foot, the comparison of the pollical and hallucal rays seems interesting in order to evaluate the influence of specific evolutionary functional factors and biomechanical constraints. The objective of this study was to provide original and detailed data on the intrinsic proportions of the three segments of the human pollical and hallucal rays (metacarpal or metatarsal bone, proximal phalanx, and distal phalanx) in order to allow a quantitative comparison of their relative development. No similar data evaluated from three-dimensional approaches (volumetric or ponderal) seem to be available in the literature. The material consisted of 77 skeletons of the pollical ray and 77 skeletons of the hallucal ray of normal adult individuals. The ponderal approach was used. The first metapodial represented a mean of 57.17% for the pollical ray and 68.48% for the hallucal ray, whereas the phalanges respectively represented 42.83% and 31.52%. The intrinsic phalangeal proportions were almost identical for the pollex and for the hallux (respectively, 71.76% and 72.88% for the proximal phalanx; and 28.24% and 27.12% for the distal phalanx). Since these intrinsic proportions are the reflection of biological, functional and evolutionary constraints, these data seem of interest for the analysis of the functional significance of these rays, for the characterization of malformative syndromes in clinical practice, for reference in comparative morphology, and for the interpretation of hominid fossil bones.

Biological Evolution↗
PubMed1976

Hereditary index finger polydactyly: phenotypic, radiological, dermatoglyphic, and genetic findings in a large family.

Index finger polydactyly in a Turkish family is reported. The transmission of the malformation fits the pattern of regular autosomal dominant inheritance. Some of the affected individuals had one or two phalanges on their first digits, but all had triphalangeal second fingers. Subjects with polydactyly had very interesting dermatoglyphs, such as an extra a triradius under the super-numerary index finger, the proximal radiant of this triradius (an extra A-line) ending on the radial border of the hand, and arch tibials in the hallucal areas. The carpal bones, beginning with os multangulum majus, or alternatively with the extra one were articulated with two metacarpals. A similar finding was found in the feet.

Dermatoglyphics↗
PubMed2000

The Weil osteotomy of the lesser metatarsals: a clinical and pedobarographic follow-up study.

The clinical results with pedobarographic analysis were assessed in 32 patients (59 metatarsals) who underwent a distal metatarsal shortening (Weil) osteotomy for either intractable plantar keratoses or chronically dislocated lesser metatarsal phalangeal joints. All patients had increased pressure under the involved metatarsal heads. Thirty three of the 59 metatarsophalangeal (MTP) joints were chronically dislocated. At an average follow-up of 30 months, patients rated the result as excellent or good for 32 of the 37 feet (86%). The mean preoperative AOFAS score was 59 (maximum 100), which improved to 81 post-operatively. This difference is significant: p = 0.00001 (with t-test). Comparison of the pre and post-operative pedobarographic measurements showed a significant decreased load under the affected metatarsal heads (p = 0.05). A complete disappearance of the callus was noted under 44 operated metatarsals (75%) and partial disappearance under 12 metatarsals (20%). Two symptomatic transfer lesions occurred under an adjacent metatarsal head. Recurrent dislocations occurred in 5 joints (15%). While metatarsophalangeal joint range of motion was significantly diminished, toe strength was maintained. Average metatarsal shortening was 5.9 mm with no nonunions, delayed unions, or malunions. The Weil shortening osteotomy is a simple and reliable procedure which can effectively reduce the load under the lesser metatarsophalangeal joints and is helpful for the reduction of dorsally dislocated MTP joints.

Adult↗
PubMed1980

Silastic arthroplasty of the first metatarso-phalangeal joint.

Twenty-nine patients were operated on for painful conditions of the first metatarso-phalangeal joint using Swanson's implant arthroplasty. In three cases the implant had to be removed. An analysis was made of the remaining 26 cases 4 to 6 years postoperatively based on a clinical and radiographic review. The results were deemed favourable and comparable to those attained by successful resections or osteotomies. The relatively high incidence of reactive bone changes, plus implant breakage in five cases, makes long-term results more uncertain.

Adult↗
PubMed1996

A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse.

Using gene targeting in mice, we have undertaken a systematic mutational analysis of the homeobox-containing 5' HoxD genes. In particular, we have characterized the limb defects observed in mice with independent targeted disruptions of hoxd-12 and hoxd-13. Animals defective for hoxd-12 are viable, fertile, and appear outwardly normal yet have minor autopodal defects in the forelimb which include a reduction in the bone length of metacarpals and phalanges, and a malformation of the distal carpal bone d4. The limb phenotypes observed in hoxd-13 mutant mice are more extensive, including strong reductions in length, complete absences, or improper segmentations of many metacarpal and phalangeal bones. Additionally, the d4 carpal bone is not properly formed and often produces an extra rudimentary digit. To examine the genetic interactions between the 5' HoxD genes, we bred these mutant strains with each other and with our previously characterized hoxd-11 mouse to produce a series of trans-heterozygotes. Skeletal analyses of these mice reveal that these genes interact in the formation of the vertebrate limb, since the trans-heterozygotes display phenotypes not present in the individual heterozygotes, including more severe carpal, metacarpal and phalangeal defects. Some of these phenotypes appear to be accounted for by a delay in the ossification events in the autopod, which lead to either the failure of fusion or the elimination of cartilaginous elements. Characteristically, these mutations lead to the overall truncation of digits II and V on the forelimb. Additionally, some trans-animals show the growth of an extra postaxial digit VI, which is composed of a bony element resembling a phalange. The results demonstrate that these genes interact in the formation of the limb. In addition to the previously characterized paralogous interactions, a multitude of interactions between Hox genes is used to finely sculpt the forelimb. The 5' Hox genes could therefore act as a major permissive genetic milieu that has been exploited by evolutionary adaptation to form the tetrapod limbs.

Animals↗
PubMed2002

New Sivapithecus postcranial specimens from the Siwaliks of Pakistan.

Several new postcranial elements of Sivapithecus from the Siwaliks of Pakistan are described. These include a distal femur from the U-level of the Dhok Pathan Formation, a navicular from the Chinji Formation, and seven manual and pedal phalanges from the Nagri Formation. The functional morphology of these elements adds new detail to the reconstruction of Sivapithecus positional behavior. Femoral cross-sectional geometry indicates that the shaft was adapted to support mediolaterally directed loading. Femoral condylar asymmetry and a broad but shallow trochlea are distinctly ape-like, revealing capabilities for both rotation and withstanding eccentric loading in the knee. The navicular is characterized by features relating to a broad mid-tarsus and broad distal articulations for the cuneiforms. It also lacks a navicular tubercle as in Pongo. These features suggest that the foot was capable of a powerful grip on large supports, with an inversion/supination capability that would permit foot placement in a variety of positions. The morphology of the new phalanges, including evidence for a relatively large pollex, similarly suggests powerful grasping, consistent with prior evidence from the hallux and tarsus. The functional features of the new specimens permit refinement of previous interpretations of Sivapithecus positional capabilities. They suggest a locomotor repertoire dominated by pronograde activities and also such antipronograde activities as vertical climbing and clambering, but not by antipronograde suspensory activities as practiced by extant apes.

Animals↗
PubMed2003

A new dominant branchiogenic-deafness syndrome with internal auditory canal hypoplasia and abnormal extremities.

Two sibs from one Lebanese family presented with congenital hearing loss, meatal atresia, preauricular tags and pits, branchial cysts or fistulae, strabismus, difficulty in opening the mouth wide enough, abnormal fifth fingers, somewhat short stature, and learning disability and patchy skin depigmentation in one. Temporal bone abnormalities identified on computed tomography included atresia of the external auditory canal with reduction in size of the middle ear, malformed ossicles, and unilateral internal auditory canal hypoplasia. Hand radiographs showed pointed phalanges of the 5th fingers with osseous erosions. Their father, his sister, and his half-brother had unilateral auricular pits and/or branchial cysts. Results of all laboratory investigations including sequencing of the EYA1 gene were normal. Differential diagnosis is discussed and the possibility of the report of a new autosomal dominant type of branchiogenic-deafness syndrome with variable expressivity is raised.

Abnormalities, Multiple↗
PubMed2004

Vascular supplies differ in regenerating and nonregenerating amputated rodent digits.

Bone regenerates following amputation through the level of the nail, but bone is capped following amputation through more proximal levels. Because osteogenesis requires an ample blood supply, we postulated that a restricted vascular supply might be correlated with restricted regenerative ability at proximal levels. More than 40 rats and mice were injected with ink or resin to visualize vascular supplies of intact, regenerating, and nonregenerating rat and mouse digits. Ink-injected specimens were viewed as histological sections or cleared whole mounts. Partially digested resin casts were viewed using scanning electron microscopy. Contrary to our hypothesis, prior to amputation, proximal sites are more vascular than distal sites. At both proximal and distal levels, endosteal and periosteal vascular systems are evident. However, in proximal phalanges, additional subcutaneous and dermal layers encircle the bone. Beneath the distal nail, these layers are absent, and a single layer of vessels provides both periosteal and cutaneous supplies. After amputation at both levels, new vessels sprout profusely in osteogenic areas of both endosteum and periosteum. However, at proximal levels, the additional hypodermal and dermal vessels contribute to a vascular plexus that, paradoxically, may impair bone regrowth by contributing to the formation of dermal scar rather than bone.

Acrylic Resins↗
PubMed2006

Does a bone deformity of the distal phalanx undergo remodeling after removal of a congenital ectopic nail?: A case with periodic radiographic follow-up.

BACKGROUND: Congenital ectopic nails are rare and are characterized by the presence of nail-like tissue mainly at the tip of a finger or toe. OBJECTIVE: Although the accompanying bone deformity might undergo remodeling after removal of the ectopic nail, it remains unknown whether complete bone remodeling can be eventually achieved, and whether such remodeling is necessary to improve the final cosmetic appearance of the concerned fingertip. METHODS AND RESULTS: Follow-up with periodic radiographic examination for 1 year after surgery in a child with congenital ectopic nail revealed no bone remodeling, despite the satisfactory cosmetic result. CONCLUSION: We conclude that residual bone deformity does not affect the final appearance.

Bone Diseases↗
PubMed1989

[Type C hereditary brachydactyly].

We report 2 generations with type C hereditary brachydactyly of dominant autosomal inheritance of variable expressiveness. The most characteristic data was the shortening of the middle phalanges of the second, third and fifth finger as well as the first metacarpal. Short stature was observed in three of the patients studied. The goal of this study was aimed at stimulating GH pharmacologically and determining its 24 h physiologic secretion, as well as somatomedin C levels. All the determinations were within the normal range. The deficient growth shown by these patients is a constitutional growth delay, possibly an expression of type C brachydactyly.

Child, Preschool↗
PubMed1980

[The diagnosis of early changes in the phalanges in primary and secondary hyperparathyroidism by a direct radiological magnification technique].

A comparative study of direct radiological magnification technique was made of 22 patients with primary hyperparathyroidism, 15 patients with secondary hyperparathyroidism, and 17 patients without changes in bone structure. Only regarding the summation of all radiologically visible changes in bone structure, a hyperparathyroidism can be suspected. The differential diagnosis of primary and secondary hyperparathyroidism is mostly impossible. Furthermore we were able to demonstrate that early discrete changes in bone structure are more easily diagnosed in magnification technique than in standard technique. Therefore we regard the direct radiological magnification technique as an adequate method for patients, in whom hyperparathyroidism is suspected.

Bone and Bones↗
PubMed1992

Identical phalangeal defects induced by phenytoin and nifedipine suggest fetal hypoxia and vascular disruption behind phenytoin teratogenicity.

In previous experimental studies in rabbits, we have shown that vasodilating drugs (including nifedipine) cause distal digital defects. These defects were preceded by edema, hemorrhage, and finally necrosis of the developed cartilage in the phalanges. The underlying mechanism is most likely a fetal hypoxic response, secondary to maternal hypotension and decreased uteroplacental blood flow. Since phenytoin is known to cause distal digital defects both in man and rabbits, we decided to compare the defects provoked by oral administration of phenytoin (100 mg/kg) versus nifedipine (8.3 mg/kg) to New Zealand White rabbits on days 6-18 of gestation. In order to investigate phase-specificity, phenytoin (150 mg/kg) was given on days 14-17. The result of single dose administration on day 16 of phenytoin (300 mg/kg) versus nifedipine (33.2 mg/kg) was also studied. In this latter experiment maternal heart rate was measured up to 21 hours after phenytoin administration. Phenytoin induced digital defects identical with those produced by nifedipine and caused marked maternal cardiodepression. The defects consisted of a reduction, absence, or abnormal structure of the distal phalanges. The distal phalanx of the fourth digit on the hindpaw was the first to be affected, with inclusion of other phalanges, both on the hind- and forepaws, with increasing dose. The sensitive period for induction and histological appearance of these defects was identical for phenytoin and nifedipine. These results suggest that vascular disruption due to a fetal hypoxic response lies behind phenytoin teratogenicity, as has been shown for vasodilators. A cardiodepressive action on the maternal and fetal hearts, possibly in combination with decreased uteroplacental blood flow, is discussed as a probable factor behind phenytoin teratogenicity.

Abnormalities, Drug-Induced↗
PubMed1991

[Progression towards dislocations of foot bone lesions in leprosy].

From a series of 211 tarsal, medio-tarsal and metatarso-phalangeal dislocations, the authors, after having recalled the lesion mechanism, adopted a classification and gave a place to preventive conservative surgery in 52 cases. The early forms can have early limited arthrodesia. The developed lesions present indications of arthrodesia--isolated reconstruction or associated to spongy or cortico-spongy bone grafts. The late forms impose amputation even when the forefoot seems of good bone quality because the metatarsal-phalangial stiffness is the cause for the failure of the Wladimiroff-Mickulicz interventions.

Amputation, Surgical↗
PubMed1990

Characteristics of the limb malformations induced by maternal exposure to cadmium in the mouse.

Single doses of 2,3,4,6,8,10, and 15 mg/kg of cadmium chloride were administered (SC) to groups of MF1 mice on one of days 7 to 12 of gestation. Fetuses collected on day 18 were observed for limb malformations, and alizarin red-S stained skeletons were examined for their skeletal bases. Ectrodactyly, postaxial polydactyly, syndactyly, brachydactyly, adactyly, phocomelia, meromelia, and malrotation of the limbs were detected in a significant number of fetuses. Days 7 to 10 were greatly susceptible for induction of these malformations. Postaxial ectrodactyly was more frequent in the forepaws, and sidedness was not significant. Preaxial ectrodactyly preferentially affected the left hindpaws in the 9th-day treatment group. Postaxial polydactyly was predominently right sided and mostly involved the forepaws. Day 8 was particularly susceptible for induction of adactyly. Malrotation of the limbs together with edema and caudal narrowing resulted in a 'penguin-like' appearance. Ossification of the long bones, the carpals, tarsals, and phalanges were affected. Even those limbs that were not externally malformed had skeletal dysgenesis. Limb buds examined histologically at midgestation showed scanty and poorly organized mesenchyme, extensive elaboration of marginal sinsus, reduced thickness of the apical ectodermal ridge (AER), and discontinuous basement membrane. It is speculated that such histologic alterations at early stages of development could have contributed to the defective morphogenesis of limbs in this animal model.

Abnormalities, Drug-Induced↗
PubMed1986

Improved ankle-foot system for above-knee amputees.

Above-knee amputees were studied while wearing a prosthesis containing either a standard or a modified single axis foot. The modified foot allowed 12-15 degrees of dorsiflexion and reduced stiffness in the area of the metatarsal-phalangeal (MTP) joint. The amputees were allowed to vary the stiffness at the two joints to obtain what "felt best." The amputees agreed that in comparison to the standard single-axis foot, the modified foot: a) offered a more comfortable gait while walking on level ground; b) made walking up inclines easier; c) affected knee stability while walking on declines; and d) made foot placement on stairs and ladders more critical due to potential knee instability. As well as qualitative reactions, changes in the gait cycle were measured quantitatively for different speeds and inclinations of walking on a treadmill. Measurements from normal subjects matched by age and sex were used for control purposes. All participants wore soft-soled shoes. The amputees selected a stiffness that allowed a degree of dorsiflexion which precisely matched on average that of the normal subjects. In contrast, they selected a stiffness at the MTP joint which allowed very little flexion of the toes. Significant changes also occurred in the pattern of hip movements, so that they became much more symmetrical on the two sides, although substantial differences remained between the hip movements of the amputees and the normal subjects. If modifications in the ankle joint can be coupled with improvements in the knee joint to prevent potential instability, a much improved gait should be possible for above-knee amputees.

Adult↗
PubMed1977

Inhibition and axial deviation of limb regeneration in the newt by means of a digit implanted into the amputated limb.

This research was designed to follow up the observation of Thornton and Kraemer ('51) that regressed, denervated limbs of Ambystoma larvae will not regenerate upon reinnervation if all digits on the limbs were not completely resorbed. The object of this experiment was to determine whether the presence of an apical structure, protruding past the amputation surface, would affect the regenerative process. Both forearms of adult newts were amputated midway between the elbow and the wrist. One limb served as a normal regeneration control, and in the other limb the third digit from the removed hand was implanted in place of the removed radius, so that the three distal phalangeal segments protruded past the plane of amputation. Blastema formation in the experimental limbs was delayed by several weeks as compared with control limbs. Approximately one third of the experimental limbs did not regenerate. The regenerates that did form were strongly deviated (45-90 degrees) radially from the longitudinal axis of the limb. Experimental analysis showed that the delay in regeneration is due largely to the projecting part of the digit. The radial deviation of the regenerates is not due to the digital implant, but rather to the removal of the radius. Trauma alone does not account for this phenomenon.

Ambystoma↗
PubMed1997

Attribution of foot bones to sex and population groups.

Although cranial and pelvic bones are the preferred skeletal material used by forensic anthropologists to assign unknown individuals to their most probable sex and population (racial) groups, these remains may be unavailable. This paper presents models for classification using metatarsals, proximal pedal phalanges, and the first distal phalanx of the foot. Measurements include lengths and mediolateral and dorsoplantar widths of these foot bones. Four samples of 40 individuals each (black and white males and females) comprise the dataset. Models were developed separately for right and left sides. Three models are provided for each side: a metatarsal model, a proximal phalangeal model, and a combination model involving selected metatarsal and phalangeal measurements. A stepwise discriminant procedure was used for variable selection, with some highly correlated (r > 0.85) variables subsequently removed. The metatarsal models correctly assign approximately 77-84% of individuals to their correct sex and population groups; proximal phalangeal models yield correct assignments in 70-72% of cases, and the combination models give correct classifications in 87% of cases. Models exchanging variables selected from one side for corresponding variables on the other show discriminating power ranging from approximately 67-86%. More conservative "jackknife" estimates give correct assignments in 64-82% of cases. When these models are used for classification of sex alone, 86.2-93.7% ("jackknife" range, 84.3-91.2%) of cases are correctly classified; for race alone, 78.6-96.2% ("jackknife" range, 75.5-92.4%).

Adult↗
PubMed1998

Radiographic assessment of equine interphalangeal joints asymmetry: articular impact of phalangeal rotations (Part I).

This study is part of a work to develop a radiographic method that defines objectively the individual conformation of an equine digit and its appropriate trimming. The authors used isolated distal limbs on a rotation support to study the influence of induced foot rotations on several angles measured from specific radiographs. The results of this work enabled the authors to quantify the rotation of the proximal phalanx compared to the distal, and to determine exactly the possible rotation in the distal interphalangeal joint. It was also observed that, faced with a forced rotation of the foot, the digit responded by a hoof plastic deformity, a distal interphalangeal intra-articular rotation and asymmetrical interphalangeal compressions.

Animals↗