Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “SENSATION”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 613 records · Page 34Linked to original sources
PubMed2005

Sensation seeking and the use and selection of media materials.

175 individuals recruited from urban universities (n=82) and the surrounding community (120 women, 55 men; 82 18- to 25-yr.-olds, 26 26- to 34-yr.-olds, 44 35- to 50-yr.-olds, 23 50 yr. old or over) completed a sensation seeking scale and measures of the frequency with which they used specific media and selected specific television programming, film, and music genres. Regression analyses showed Sensation Seeking to be associated positively with Movie Theatre Attendance and with the Selection of Urban Music Genres. Sensation Seeking was also associated negatively with Selection of Light Film Genres.

Adolescent↗
PubMedDate not supplied

The effects of nasal anaesthesia upon nasal sensation of airflow.

The effect of nasal anaesthesia upon the sensation of nasal airflow and activity of menthol was investigated in 25 subjects using a visual analogue scale. Nasal anaesthesia was shown to decrease the sensation of nasal airflow, and also decrease the action of menthol in enhancing the sensation of nasal airflow. These differences were shown to be highly significant p less than 0.001. Physiological mechanisms responsible for conveying the subjective appreciation of a nasal airflow stimulus are discussed, and also the site and nature of the sensory nerve endings involved.

Administration, Intranasal↗
PubMed1983

Sensation seeking and drug choice.

Sensation Seeking Scale scores were obtained from two groups of drug program clients: polydrug users and opiate and depressant drug users. The major findings were that polydrug users scored higher in sensation seeking than depressant users, and that this effect was independent of demographic differences between groups. These results suggest that the sensation-seeking motive may be a significant factor for polydrug, but not depressant, abuse patterns.

Adult↗
PubMed1991

[Subclinical swallowing disorder in patients with abnormal sensation in the throat].

Measurement of swallowing pressure was done in 75 patients who complained of abnormal sensation such as obstructive sensation, difficulty in swallowing, etc. in the throat without noticeable cause. Abnormal swallowing pressure curves were observed in 33 patients (44%), and 76% of them showed abnormal elevation of the pressure at the hypopharyngeal or cervical esophageal region. These results indicated that subclinical swallowing disorder, particularly abnormal high swallowing pressure, can be a possible cause of their complaints. The author assumed that abnormal elevation of swallowing pressure is due to hypertonicity of the hypopharyngeal and cervical esophageal muscles. By the animal experiments using dog, a muscle relaxant, eperizone hydrochloride, revealed to change muscle tonus of the hypopharyngoesophageal muscles. Intravenous administration of the drug decreased swallowing pressure and prolonged the relaxation time of the cricopharyngeal muscle. Clinically the muscle relaxant showed to be effective in ameliorating the complaint of the patients with abnormal high swallowing pressure at the hypopharyngeal or cervical esophageal region. Based on the above results, the author proposed that the clinical entity, hypopharyngeal-cervical esophageal hypertonicity, causes a subclinical swallowing disorder leading to the abnormal sensation in the throat.

Adult↗
PubMed2004

Transient receptor potential ion channels and animal sensation: lessons from Drosophila functional research.

Ion channels of the transient receptor potential (TRP) superfamily are non-selective cationic channels with six transmembrane domains. The TRP channel made its first debut as a light-gated Ca2+ channel in Drosophila. Recently, research on animal sensation in Drosophila disclosed other members of the TRP family that are required for touch sensation and hearing as well as the sensation of painful stimuli.

Animals↗
PubMed1995

Assessment of the methods available for testing sensation in leprosy patients in a rural setting.

The aim of this study was to assess the efficacy, practicality and patient understanding of 5 methods used for testing sensation in leprosy patients, in a rural setting. The tests used were the WHO test, cottonwool, pin-prick, monofilaments and the biothesiometer. We concentrated on testing sensation in the hands, and the various tests were carried out on 75 patients and 32 controls, all taken from villagers living at Kindwitwi Leprosy Village, Tanzania. Our results showed that although the WHO test, cottonwool and pin-prick were all easy to use, cheap and well accepted they were not sensitive enough to be of any practical value. We found that the monofilaments, as well as being cheap and easy to use, had great potential value, as the 2-g monofilament could be used as a threshold value (indicative of leprosy, but not diagnostic) for protective sensation with a combined false-positive and false-negative value of only 4%. Finally, the biothesiometer was found to be a precise test that can accurately identify leprosy patients from controls and identify patients at risk of ulceration. It was, however, associated with its own problems, chiefly those of expense and its need of electricity, although we found this latter problem could be easily and relatively cheaply solved by the use of a solar powered recharger (Appendix).

Humans↗
PubMed2000

Cortical processing of human somatic and visceral sensation.

Somatic sensation can be localized precisely, whereas localization of visceral sensation is vague, possibly reflecting differences in the pattern of somatic and visceral input to the cerebral cortex. We used functional magnetic resonance imaging to study the cortical processing of sensation arising from the proximal (somatic) and distal (visceral) esophagus in six healthy male subjects. Esophageal stimulation was performed by phasic distension of a 2 cm balloon at 0.5 Hz. For each esophageal region, five separate 30 sec periods of nonpainful distension were alternated with five periods of similar duration without distension. Gradient echoplanar images depicting bold contrast were acquired using a 1.5 T GE scanner. Distension of the proximal esophagus was localized precisely to the upper chest and was represented in the trunk region of the left primary somatosensory cortex. In contrast, distension of the distal esophagus was perceived diffusely over the lower chest and was represented bilaterally at the junction of the primary and secondary somatosensory cortices. Different activation patterns were also observed in the anterior cingulate gyrus with the proximal esophagus being represented in the right midanterior cingulate cortex (BA 24) and the distal esophagus in the perigenual area (BA32). Differences in the activation of the dorsolateral prefrontal cortex and cerebellum were also observed for the two esophageal regions. These findings suggest that cortical specialization in the sensory-discriminative, affective, and cognitive areas of the cortex accounts for the perceptual differences observed between the two sensory modalities.

Adult↗
PubMed2000

Subjective sensation of heaviness in gout patients.

The main objective of the treatment of gout is to protect the major organs. Almost all gout patients require medication throughout their lives. Gout patients are asymptomatic during intercritical periods, even if they are not receiving antihyperuricemic drugs. Some patients, therefore, misinterpret that their gout is cured and may cease taking medication of their own accord. Thirty-two gout patients who had received continuous treatment with antihyperuricemic drugs for more than 3 months were selected. The sensation of heaviness was relieved by antihyperuricemic drugs in 14 (44%) of 32 patients. The heaviness did not exist or change in the other patients. Benzbromarone, probenecid, and allopurinol were found to be effective. The sensation of heaviness occurred after increased physical activity in 10 of 14 patients. Of 14 patients, 12 did not notice that the sensation of heaviness was relieved by antihyperuricemic drugs. Two hypotheses for the cause of heaviness are considered. One is mild gouty neuropathy, the other low-grade inflammation. A proper understanding that this symptom is relieved by antihyperuricemic drugs may serve as additional motivation for gout patients to take their medication regularly.

Adult↗
PubMedDate not supplied

Epigastric sensations as an unusual manifestation of adult absence epilepsy.

We report the case of a 39-year-old woman with onset of daily epigastric sensations associated with brief episodes of unresponsive blank stare, which have been interpreted as complex partial seizures with occasional secondary generalisation. Phenytoin as monotherapy and in combination with valproate had not been effective. During video-EEG we recorded typical absences with brief 3 second spike, and slow-wave discharges of up to 5 seconds, which were recognized by the patient herself. All absences were preceded by epigastric sensations. There was no indication of focal epilepsy. Monotherapy with valproate substantially decreased the frequency of the absences. In conclusion, this case is peculiar for several reasons: 1) late onset of absence epilepsy, 2) epigastric sensation at onset of absence seizures, 3) recognition of brief "phantom" absences and 4) presumable adverse effects of phenytoin.

Adult↗
PubMed2001

[New development of hair examination! The searching of hair for the terminal residual substance of pleasant sensation].

Formerly, hair had been analyzed mainly in the field of individual identification. Otherwise, it is known that many substances are accumulated in hair such as metals like arsenic, mercury, alkaloids like caffeine, theophylline, drugs like opiate, stimulants, other drugs and poisons. So, by qualitative and quantitative analysis of such deposits in hair. It is possible to presume one's life manner during recent several months. This is the new development of hair analysis and it is expected that it may be wide of application. The main theme of this paper is hedonics. Nobody dislike hedonic sensation. So, it can be said everybody being living always coveting hedonic sensation. There are many hedonic sensers all over the body, and hedonic sensation transmitted by A10 nerve, so A10 nerve is called the hedonic nerve. Neurotransmitter of this A10 nerve is Dopamine. Dopamine is the endogenous hedonic material. Exogeneous hedonic one is stimulant like Methamphetamine. In this paper, relation between Dopamine, Methamphetamine and Tyramine, thought to be the terminal product from two formers is examined in the aspect of hair analysis. Catecholamines including Dopamine are made of Tyrosine. They have a Benzene-ring. Compounds with a Benzene-ring made of Tyrosine are relatively rare, but all of them have very strong action. Tyramine is made of Tyrosine, too. So the structure of Tyramine is essentially resemble to Dopamine, and the skeletal structure of Methamphetamine is identical to Dopamine, so the action is identical, too. Normally, excessive release of Dopamine in brain is controlled by the negative feedback of GABA system. But extrinsic stimulus as Methamphetamine put balance of the homeostasis between Dopamine system and GABA system in to disorder, and long term administration of Methamphetamine makes long remaining degeneration of synapse of Dopamine nerve. So, abnormal state of excess releasing of Dopamine happens easily. And the morbid state named stimulant psychosis occur. The volume of Tyramine in hair changes correlatively with the volume of released Dopamine in brain. Therefore it is suggested that quantitative analysis of Tyramine in hair enable to estimate the changes of Dopamine released in brain.

Amphetamine↗
PubMed1992

[Quantification of the gnostic sensitivity via measurement of the vibration threshold and of finger tip sensation].

OBJECTIVE: Quantification of vibration perception and fingertip sensation in routine neurological examination. SETTING: Neurological Clinic, University Hospital, Groningen, the Netherlands. DESIGN: Prospective, controlled investigation. METHODS: Vibration perception and fingertip sensation were quantified in a large group of normal control persons of various ages and in neurological patients and compared with the usual sensory tests at routine neurological examination. The vibration perception limit was measured with a biothesiometer without accelerometer, the fingertip sensation with a device for two-point discrimination slightly modified according to Renfrew ('Renfrew meter'). Concordance of the tests was studied by calculating kappa values. RESULTS: The normal values of both sensory qualities had a log-normal distribution and increased with age. The values obtained with the Renfrew meter correlated well with those of the two-point discrimination and stereognosis but were systematically higher than those indicated by Renfrew. CONCLUSION: Both methods appear useful at routine neurological examination if certain measuring precautions are taken.

Adolescent↗
PubMed1992

[Role of psychological factors as a determinant of the hypercapnic ventilatory response and dyspnea sensation].

We examined, in 38 healthy adult subjects (male 15, female 23), the relationship between psychological background as assessed by manifest anxiety scale test and Yatabe-Guillford test, and the hypercapnic ventilatory response (HCVR), which was tested twice with and without inspiratory resistive loading (17 cmH2O/L/sec). In addition, we attempted to evaluate the possible role of psychological factors in dyspnea sensation felt during HCVR, which was simultaneously assessed by visual analogue scaling (VAS). The slope value of HCVR was positively correlated with the social extraversion score in the male group (r = 0.55, p less than 0.05) only when the test was conducted without resistive loading. In the female group, it was positively correlated with emotional instability in both conditions (r = 0.46, p less than 0.05) without resistive loading and r = 0.47, p less than 0.05 with resistive loading). With respect to dyspnea sensation, manifest anxiety score alone had a positive correlation with VAS score evaluated in relation to ventilation only in the male group (r = 0.61, p less than 0.05). From these findings, we conclude that psychological factors may play a role as a determinant of HCVR, regardless of the presence of inspiratory resistive loading, as well as a determinant of the sensation of dyspnea during HCVR.

Adult↗
PubMedDate not supplied

The sensation of pulmonary dyspnea in school-age children.

The purpose of this investigation was to describe the sensation of dyspnea in a sample of 39 school-age children with asthma and to identify strategies used to cope with the symptom. In addition, three methods to measure dyspnea intensity in children were tested and compared. Breathing on a "bad breathing day" was used as a proxy variable to represent dyspnea. The most frequent description of how breathing feels on a bad day was "it is hard to breathe." Words chosen most frequently from a checklist of sensations were "wheezy," "short of breath," "tight," and physical sensations such as "throwing up," "hurting," and "stuffiness." The children's feelings on a bad breathing day were categorized as negative moods or emotions, a wish for change, or physical symptoms. Ratings of breathing on "good", "bad," and "usual breathing" days on word descriptor, visual analogue, and color scales provided evidence of concurrent validity for the three measures of dyspnea intensity. The most frequent strategies used to cope with dyspnea were medications, change in position, decreased activity, fluids, relaxation, distraction, and social support. The findings were very similar to those previously described for an adult sample.

Adaptation, Psychological↗
PubMed1988

Aesthesiometry: quantification of cutaneous pressure sensation in diabetic peripheral neuropathy.

The Semmes-Weinstein pressure aesthesiometer, which measures cutaneous pressure sensation, was used for quantifying sensory loss in diabetic peripheral neuropathy. Eighty subjects comprising four groups were tested: nondiabetic controls (Group C); non-neuropathic, diabetic controls (Group DC); diabetic subjects with neuropathy and without a history of pedal ulcerations (Group DN); and, diabetic subjects with a history of or active pedal ulceration (Group DU). Cutaneous pressure sensation of 10 dorsal and plantar sites on the foot were tested, using a method of interval comparison modeled after the two-alternative forced choice algorithm. The sensitivity threshold level was defined as the lightest probe in which the subject accurately chose the correct interval in at least 2 out of 3 trials. The mean sensitivity threshold level for Group DC was not significantly increased (p greater than .05) compared to Group C. In contrast, patients with neuropathy (Group DN or DU) showed a significantly higher mean sensitivity threshold (p less than .001) than either Group C or DC. In addition, this technique demonstrated that patients in Group DU had a mean sensitivity threshold that was statistically higher (p less than .001) than Group DN, although both groups of patients had symptomatic neuropathy. This study provides a direct demonstration that decreased sensation of pressure occurs in the feet of diabetic patients with a history of ulceration. The best discrimination between groups is obtained by requiring that three of the six plantar forefoot sites have a sensitivity threshold level of greater than 5.07 log (0.1 mg) force as the risk discriminator level. Semmes-Weinstein aesthesiometry should now be tested in a prospective study to demonstrate its effectiveness in determining those patients at great risk of developing foot ulcers.

Adult↗
PubMed1987

Corneal sensation in retinal detachment surgery.

We compared the rate of recovery of corneal sensation in two randomly selected groups of patients with rhegmatogenous retinal detachment whose eyes were otherwise healthy. One of the groups underwent removal of the epithelium and, and the other was characterized by nonremoval of the epithelium. The corneal sensations were measured serially with an esthesiometer. The return of corneal sensation occurred sooner in the nonremoval group than in the removal group in the early postoperative period, but at three months, the difference was negligible.

Cornea↗
PubMed1986

Effect of vibration on force sensation in fatigued muscle.

Nine subjects did repeated maximal voluntary contractions (MVCs) of the right knee extensors to induce fatigue. At regular intervals during this process, they matched the force of a 50% MVC in the fatiguing right muscle with a contraction of the unfatigued left muscle that felt like the same force. Perturbations in force sensation were achieved by applying high-frequency vibration (160 Hz) to the patellar tendon of the fatigued muscle during one of a pair of 50% MVCs. The neural drive to the muscle was monitored from the surface electromyogram. Cycles of 10 fatiguing contractions followed by 2 matching contractions were repeated until the subjects could no longer produce 50% of the initial MVC or until they chose to stop. On the average, MVC force fell to 68% of its initial value by the end of 50 fatiguing contractions; almost all of the force loss occurred after completing the first 20 contractions. Maximal electromyograms declined proportionally, and percutaneous shocks delivered during fatiguing contractions did not produce a measurable twitch. This indicated that there was no central fatigue and that force loss was due to failure of the contractile apparatus. In the non-vibrated trials, force sensation increased as a mirror image of force loss. Vibration increased force sensation in the fresh muscle but the effect of vibration disappeared in fatiguing contractions. These data suggest that the sensory analog of muscular fatigue is not necessarily a consequence of alterations in peripheral receptors but may also reside in the central nervous system.

Action Potentials↗