Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Pupil Disorders”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 613 records · Page 34Linked to original sources
PubMed1993

Iron mydriasis. Pupillary paresis from occult intraocular foreign body.

Two patients presented with unilateral dilated and poorly reactive pupils and were found to have a previously unsuspected intraocular iron foreign body. Both of them had normal vision and one had normal color of the iris so that the condition was missed by several physicians. The pupils reacted normally to pilocarpine 1% and also showed response to dilute (0.1%) pilocarpine. There was no response to phospholine iodide. These findings indicate that the mydriasis was due to a local siderotic parasympathetic neuropathy of the pupil.

Adult↗
PubMedDate not supplied

SUNCT syndrome: VIII. Pupillary reaction and corneal sensitivity.

SUNCT is a newly described headache characterized by shortlasting, unilateral attacks of a neuralgiform character, accompanied by conjunctival injection and tearing on the symptomatic side. At present, 8 patients have been observed, all males. In the present work, vertical pupillary diameters have been estimated by the binocular, Whittaker infrared pupillometer (Gulf & Western). Measurements have been carried out both during the basal state and after topical, pharmacologic stimulation (by sympathicomimetic agents, i.e. tyramine (2%), OH-amphetamine (1%) and phenylephrine (1%). In the basal state, there was no clear tendency to anisocoria. After sympathicomimetic drugs, there was a tendency to underreaction on the symptomatic side, mainly as regards the indirectly acting ones (OH-amphetamine and tyramine). These two agents should supposedly give similar results, but, nevertheless, the results partly deviated. Phenylephrine did not invariably normalize the symptomatic/non-symptomatic side ratio. Corneal sensitivity was investigated with the Cochet-Bonnet esthesiometer. Two of 6 patients studied outside attack showed moderately lowered values on the symptomatic side. During attack, there seemed to be reduced corneal sensitivity in both patients investigated, in one bilaterally, in the other, on the symptomatic side only.

Administration, Topical↗
PubMed1994

[Neurophthalmological alterations in multiple sclerosis].

With the aim of defining the neuro-ophthalmological alterations in multiple sclerosis, both with respect to visual and oculomotor aspects, we have studied a sample of 100 clinically definite multiple sclerosis patients, all in the remittent phase of the disease. We compared them with a sample of 100 unrelated healthy controls, matched for age and sex. Visuomotor alterations were found in 99%, purely visual alterations in 38%, purely oculomotor alterations in 3%, and mixed alterations in 58% of the MS patients. Comparisons with controls showed significant statistical differences in all the tests used in the study. The neuro-ophthalmological examination in multiple sclerosis permits us to detect subclinical lesions and arrive at a better comprehension of central nervous system involvement in this disease, thereby contributing collaborating to better patient care.

Age of Onset↗
PubMedDate not supplied

Sinus arrhythmia and pupil size in Chiari I malformation: evidence of autonomic dysfunction.

In a prospective study on latent autonomic dysfunction in the Chiari type I malformation, 15 patients were examined for degree of sinus arrhythmia in the supine and the sitting positions with a deep breathing test, and for pupil size and function with electronic pupillometry after sympathicomimetic eyedrop stimulation. The 5 patients with brainstem signs had a marked disturbance of sinus arrhythmia, which was more pronounced in the supine than in the sitting position. The clinical signs suggested a dysfunction of the reflex centers in the medulla rather than of the lower cranial nerves. The patients also tended to have more anisocoria than healthy controls, but no clear-cut pattern existed as to pupil dysfunction. Of the 4 patients with syringomyelia, however, the two with the most extensive cord cavitations had a Horner-like pupil reaction ipsilaterally to a marked hand wasting, indicating a sympathetic lesion at the T1 level of the cord.

Adult↗
PubMed1993

Vitrectomy in ocular trauma. Factors influencing final visual outcome.

The results of vitrectomy in 240 consecutive cases of ocular trauma were reviewed. Of these cases, 71.2% were war injuries. Intraocular foreign bodies were present in 155 eyes, of which 74.8% were metallic and 61.9% ferromagnetic. Multivariate analysis identified the prognostic factors predictive of poor visual outcome, which included: (1) presence of an afferent pupillary defect; (2) double perforating injuries; and (3) presence of intraocular foreign bodies. Association of vitreous hemorrhage with intraocular foreign bodies was predictive of a poor prognosis. Eyes with foreign bodies retained in the anterior segment and vitreous had a better prognosis than those with foreign bodies embedded in the retina. Timing of vitrectomy and type of trauma had no significant effect on the final visual results. Prophylactic scleral buckling reduced the incidence of retinal detachment after surgery. Injuries confined to the cornea had a better prognosis than scleral injuries.

Adolescent↗
PubMed1987

Binocular VEP summation in infants and adults with abnormal binocular histories.

Visual evoked potentials (VEPs) were recorded under binocular and monocular viewing conditions in 19 2- to 10-month-old infants, 19 stereodeficient adults, and 12 normal adults. VEPs were elicited by medium contrast, phase-alternated checkerboards with check sizes ranging from 10-52 min of arc. Binocular VEP summation was defined as the percentage by which the binocular VEP amplitude exceeded the mean of the two monocular VEP amplitudes. In the stereonormal adults, binocular VEP summation was significantly greater than zero and significantly less than 100%. In the stereodeficient adults, binocular VEP summation was not significantly greater than zero. These findings support the hypothesis that the magnitude of binocular VEP summation reflects the activation of binocular cortical neurons. However, binocular VEP summation in the infants averaged approximately 95%. Moreover, infants under 5 months of age, many younger than the reported age of onset for stereopsis, showed binocular VEP summation of nearly 145%. The significantly higher level of binocular VEP summation in the infants was the result of much larger binocular VEP amplitudes, while monocular VEP amplitudes were equivalent to those of stereonormal and stereodeficient adults. These results support the hypothesis that VEP amplitude is mediated by two independent pools of monocular cortical neurons and that binocular VEP amplitude in stereonormal and stereodeficient adults saturates at a lower level than in infants. Thus, it is hypothesized that binocular VEP summation is not representative of the activation of binocular cortical neurons.

Adult↗
PubMed1994

[Pupillary blockage after intracapsular cataract extraction in the adult apropos of 4 cases].

Intra capsular extraction is the most employed surgical technics for the treatment of senile cataract in developing countries. Nevertheless complications are usual, among them the pupillary block. The authors notified in 365 intra capsular cataract extractions, executed during 8 months, 4 cases of pupillary block occurred after operation without incident. The 3 cases had favorable evolution after an average of 4 days with medical treatment. 1 case had unfavorable evolution to aphakic glaucoma in spite of medical and surgical treatment. They point out in the necessity of strict post operative supervision and early treatment.

Adult↗
PubMed1996

Multi-layered perceptron as a model for the pupillary pathway.

Derived from models of neural networks, a model for the pupillary pathway is introduced that can easily be handled computationally and analytically. To model the binocular pupillary reactions we use a feed-forward network, namely, a multi-layered perception. It is possible to calculate the pupillary reactions analytically as a function of the light stimuli of the retinal hemifields, on the one hand, and the set of neural couplings between the neural layers, on the other. Several lesions, e.g., lesions of the intercalated neurons between the afferent and efferent pupillary pathways, can be simulated within the model and the corresponding pupillary reactions such as anisocoria or relative afferent pupillary defects (RAPD) can be calculated analytically. Due to its neural network structure the model described herein can easily be extended to much more complex pupillary pathways while remaining calculable computationally and analytically.

Humans↗
PubMed1995

Relative afferent pupillary defect and edge light pupil cycle time in the early differentiation of central retinal vein occlusion.

A total of 37 patients of unilateral fresh central retinal vein occlusion (CRVO) of less than one month duration were examined and re-evaluated after 8 weeks. All eyes with relative afferent pupillary defect (RAPD) < or = 0.6 log units with edge light pupil cycle time (ELPCT) of 925 +/- 94 ms, visual acuity > or = 6/60 with minimal field defects proved to be of nonischemic CRVO, while eyes with RAPD > or = 0.9 log units with ELPCT of 4005 +/- 712 ms, visual acuity 3/60 with marked field defects proved to be of ischemic CRVO with evidence of retinal ischemia on fluorescein angiography. RAPD and ELPCT were found to be extremely reliable indicators for early differentiation of ischemic from nonischemic CRVO and the values remained stable over a period of time. The electroretinography (ERG) correlated well with these parameters.

Afferent Pathways↗
PubMed1996

Autonomic and sensorimotor neuropathy in patients with systemic lupus erythematosus and systemic sclerosis.

OBJECTIVE: To determine and compare the prevalence and degree of autonomic (ANP) and sensorimotor neuropathy (SNP) in patients with systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). METHODS: Thirty-one patients with SLE and 19 with SSc were investigated. Pupillary ANP was assessed by pupillometry, cardiovascular ANP using a standardized test battery, and SNP by a standardized clinical examination. RESULTS: In patients with SLE (SSc), 26% (10.5%) had a pathological pupillary latency time and 6.5% (13.7%) had an abnormal maximal pupillary area (p for the difference between latency time and maximal pupillary area in SLE = 0.040). Thus, patients with SLE had more often lesions of the pupillary parasympathetic portion of the autonomic nervous system. Overall prevalence of ANP was not different between the 2 groups; 29.0% in SLE and 21.1% in SSc for pupillary ANP and 9.7 and 15.7% for cardiovascular ANP, respectively. Overall prevalence of SNP was 6.5% in SLE and 21.1% in SSc. Disease activity was correlated with ANP (p = 0.008) and SNP (p = 0.020) in SLE. Kidney involvement was associated with more severe ANP in patients with SSc (p = 0.031). Duration of the disease did not correlate with any type of neuropathy. CONCLUSION: ANP and SNP are often present in SLE and SSc. SLE and SSc differ in the pattern of ANP and SNP, which indicates that different structures and neuropathogenic mechanisms may be involved. Patients with SLE had severe pupillary ANP, probably a sign of central nervous system involvement.

Adult↗
PubMedDate not supplied

[Adie's tonic pupil].

Explore the source record for details and available documents.

Adie Syndrome↗
PubMed1996

Measurement of pupillary unrest in eyestrain.

Using a computer-assisted infrared optometer with a pupillometer, we studied pupillary unrest in 20 eyes of 20 patients suffering from eyestrain, and 20 eyes of normal controls. The eyestrain patient group had smaller mean pupil area than the control group (29 mm2 vs 38 mm2; P < 0.01); showed prominent pupillary unrest, and had an increased mean coefficient of variation (CV) of the pupil area (9.2% vs 3.4%; P < 0.001). Long-duration waves of pupillary unrest (> 1 second) were frequently recorded in this group, but not in the control group. The patient group also had a significantly higher dark focus of accommodation than the control group (1.1 D vs 0.4 D; P < 0.01). These findings suggest that abnormal parasympathetic excitation of the iris and/or ciliary muscle may be a factor in the etiology of eyestrain.

Accommodation, Ocular↗