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At least 613 records · Page 34Linked to original sources
PubMed1992

Therapeutic options for erythroderma.

In this work we will discuss some of the dilemmas and therapeutic options in the treatment of patients with erythroderma. We will mention treatment modalities for psoriatic erythroderma and review briefly one illustrative case in which a new experimental approach was utilized.

Adult↗
PubMed1990

[Skin lymphoma morbidity over a 10-year period (based on data from the Rostov-on-Don Skin Clinic)].

The author analyzes the incidence of skin lymphomas and the manifestations of this condition in the patients treated in the dermatologic center of Rostov-on-Don in 1979-1987. There were 14 patients with primary reticulosis of the skin, 11 ones with mycosis fungoides, 1 with reticulosarcomatosis, 2 with lympholeukemia, and 16 with psoriasis en plaques. Each group of patients is characterized in detail. Comparative analysis of the morphologic forms of lymphomas of the skin has detected the differences in the course of each process. Analysis of the cases with skin lymphomas calls for further studies and improvement of the methods of treatment of this patient population.

Humans↗
PubMed1987

Clonal T-cell populations in pityriasis lichenoides et varioliformis acuta (Mucha-Habermann disease).

Patients with the skin disorder pityriasis lichenoides et varioliformis acuta (PLEVA) develop recurrent, self-healing papulonecrotic lesions that contain infiltrates of cytologically and antigenically normal T lymphocytes. DNA extracted from the lesions of 3 patients with PLEVA was analyzed for rearrangement of beta-T-cell receptor genes for the purpose of assessing the clonality of T lymphocytes within the tissues of this disease. Lesions from all 3 cases showed clonal gene rearrangements. In each of 2 cases from which two separate lesions were biopsied, identical rearrangements were found in specimens from both sites. DNA from a variety of inflammatory lesions obtained from patients with other types of skin diseases failed to show detectable rearrangements of beta-T-cell receptor genes. These results suggest that PLEVA represents a T-cell lymphoproliferative process, rather than an inflammatory disorder, as had been previously thought.

DNA Restriction Enzymes↗
PubMedDate not supplied

[Mucha-Habermann disease. Description of a case in childhood].

The authors report a case of Mucha-Habermann disease in childhood. Mucha-Habermann disease is not a very well known, though not infrequent, disease. It is characterized by recurrent erythematous-papular-vesicular skin lesions associated with arthralgia or arthritis or large joints. Prognosis is generally favourable although an evolution towards Pityriasis Lichenoides Chronica and/or Mycosis Fungoides is possible. There are not specific laboratory findings for this form. Diagnosis is essentially based on histology showing an immunopathogenetic vasculitis. At the present time there is not a safe therapy for the disease; there are however indications for the use of Erythromycin and we followed these in our therapy with positive results.

Arthritis↗
PubMed1985

[Treatment of mycosis fungoides with Zovirax (acyclovir). Study of 2 patients].

We report on two female patients suffering from mycosis fungoides, tumorous type but without systemic involvement, who have been treated with 400 mg Zovirax (Acyclovir) 3 times daily (about 15 mg/kg/day) for 12 days. The follow-up period amounted to 11 and 14 days, respectively. This therapy did not result in regression of the disease; one patient even showed progression of her skin tumors.

Acyclovir↗