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Stereotactic localization and resection of intracranial tumors.

Stereotaxis has existed since the early 1900s, originating in Western Europe. Its practice was originally limited to isolation of nerve tracts, drainage of superficial abscesses and early attempts at psychosurgery. Today, with stereotactic-compatible imaging techniques and equipment, many types of intracranial lesions can be precisely localized and resected. Stereotactic approaches to therapy, including aggressive surgical resection, have become the treatments of choice for many types of potentially devastating lesions. A case study illustrates a stereotactic resection procedure, as well as the nursing plan of care and implications for the neuroscience nurse.

Adult↗

[Women under the knife--another history of surgery].

UNLABELLED: During the 19th century, surgery developed from management of lesions mainly on the surface of the body to operative treatment within the body as well as, at the same time, from a handicraft to a scientific discipline based on pathological anatomy. In the 1860s, ovariectomy became the 'key operation' in supervening traditional boundaries. The increasing safety of surgical intervention soon led to unspecifically indicated operations on normal organs within the female abdomen, aiming at curing 'typically female mental abnormalities', i.e. a kind of psychosurgery. This is still occasionally found today. The operative management of normal situations has even increased in gynaecology (hysterectomy) and obstetrics (caesarean section) in the 1970s and 1980s. Traditional medical ethos has therefore not been able to prevent it. Another new field, plastic and aesthetic surgery, had its specific ethical problems, which were well recognised as early as 1900. Because of the relative frequency of goitres and their operative treatment, after 1883 women came to the fore of the concepts of internal secretion, organ transplantation, and physiological surgery. IN CONCLUSION: In view of cultural and gender history, socio-cultural factors have been at least as decisive as medico-scientific 'facts' for the frequency of some of the operations performed on women. These operations have, in turn, accelerated the progress in surgery and medicine in general.

Europe↗

Bilateral stereotactic amygdalotomy for self-mutilation disorder. Case report and review of the literature.

Bilateral stereotactic amygdalotomy for the management of patients with severe aggressive behavior disturbances was first introduced by Hideki Narabayashi in 1961. Since then, more than 500 cases have been reported in scientific literature, with a variety of cited behavior improvement rates. The advances of psychopharmacology along with the existent skepticism of the medical community in regards to psychosurgery have resulted in a dramatic decrease in the number of amygdalotomies performed worldwide. In our current communication, we report a case of bilateral stereotactic amygdalotomy for a medically refractory self-mutilation disorder. We also review the pertinent literature with an emphasis on the selection of the most appropriate anatomical targets, the procedure-related complications and the outcomes of this occasionally helpful procedure.

Adult↗

Use of the Horsley-Clarke stereotactic frame in humans.

It is well known that the Horsley-Clarke frame (HCF) was developed and engineered by the British physicians Robert Henry Clarke and Victor Horsley in 1906 for use in animals. It is less appreciated that the HCF was also used by the Frederic Gibbs group in 1947 for studies of human epileptics. Subcortical depth electrodes were placed using the relationship between external landmarks and intracranial structures and confirmed by pneumoencephalography. Events leading to the development of the HCF and its subsequent use in humans for depth recordings, and lesion production in the treatment of epilepsy, movement disorders, and psychosurgery are discussed.

Animals↗

Age disorientation in chronic schizophrenia is not associated with pre-morbid intellectual impairment or past physical treatment.

Forty-two long-stay hospital patients with chronic schizophrenia were divided into age and sex-matched groups with and without temporal disorientation, and assessed for premorbid academic performance and past physical treatment. The schooling of schizophrenic patients who had cognitive impairment, as identified by gross temporal disorientation, did not differ from those who were cognitively intact. The groups did not differ in past history of ECT, insulin coma, neuroleptic treatment, or psychosurgery. Patients with age disorientation were on lower mean doses of neuroleptic or anticholinergic medication. Gross cognitive impairment thus appears to occur in the course of the disease and is not due to physical treatment.

Adolescent↗

Suicide as an outcome for mental disorders. A meta-analysis.

BACKGROUND: Mental disorders have a strong association with suicide. This meta-analysis, or statistical overview, of the literature gives an estimate of the suicide risk of the common mental disorders. METHOD: We searched the medical literature to find reports on the mortality of mental disorders. English language reports were located on MEDLINE (1966-1993) with the search terms mental disorders', 'brain injury', 'eating disorders', 'epilepsy', 'suicide attempt', 'psychosurgery', with 'mortality' and 'follow-up studies', and from the reference lists of these reports. We abstracted 249 reports with two years or more follow-up and less than 10% loss of subjects, and compared observed numbers of suicides with those expected. A standardised mortality ratio (SMR) was calculated for each disorder. RESULTS: Of 44 disorders considered, 36 have a significantly raised SMR for suicide, five have a raised SMR which fails to reach significance, one SMR is not raised and for two entries the SMR could not be calculated. CONCLUSIONS: If these results can be generalised then virtually all mental disorders have an increased risk of suicide excepting mental retardation and dementia. The suicide risk is highest for functional and lowest for organic disorders with substance misuse disorders lying between. However, within these broad groupings the suicide risk varies widely.

Ambulatory Care↗

A patient with a resistant major depression disorder treated with deep brain stimulation in the inferior thalamic peduncle.

OBJECTIVE AND IMPORTANCE: The present report explored the effect of electrical stimulation on the inferior thalamic peduncle in a patient with resistant major depression disorder (MDD). CLINICAL PRESENTATION: This report refers to a 49-year-old woman with a history of recurrent episodes of major depression for 20 years (12 episodes and 2 hospitalizations), fulfilling Diagnostic and Statistical Manual of Mental Disorders, 4th edition, revised, criteria for MDD; in addition, the patient met criteria for borderline personality disorder and bulimia. Her longest episode of depression with suicidal ideation began 5 years before surgery. The patient's symptom array responded poorly to different combinations of antidepressants, cognitive therapy, and electroconvulsive therapy, which induced improvement only for short periods of time. Immediately before surgery, her Global Assessment of Functioning score was 20 and her Hamilton Depression Scale score ranged from 33 to 42. The patient was proposed for surgery for MDD. INTERVENTION: The patient had bilateral eight-contact electrodes stereotactically implanted for stimulation of areas at and around the inferior thalamic peduncle. Electrode position was corroborated by unilateral electrical stimulation searching for recruiting responses and regional direct current shifts in the electroencephalogram. Recording electrodes were replaced by tetrapolar electrodes for deep brain stimulation and connected to an internalized stimulation system for continuous bipolar stimulation at 130 Hz, 0.45 milliseconds, 2.5 V. Bimonthly follow-up included psychiatric and neuropsychological evaluations performed over the course of 24 months. After 8 months of ON stimulation, the patient entered a double-blind protocol with stimulators turned OFF. Improvement of depression measured by the Hamilton Depression Scale score was evident after initial placement of electrodes without electrical stimulation. Depression relapsed partially at the end of the first week. Electrical stimulation further improved depression, normalizing depression scores and neuropsychological performance. Patient depression scores ranked between 2 and 8 during 8 months of ON stimulation without antidepressant medication. After stimulation was turned OFF, spontaneous fluctuations in patient symptoms reflected by Hamilton Depression Scale and Global Assessment of Functioning scores were documented; these fluctuations disappeared after stimulation was turned on by Month 20. CONCLUSION: Complicated patients with comorbid conditions are common referrals to psychosurgery services. In this report, we present promising results of electrical stimulation of the inferior thalamic peduncle to treat recurrent unipolar depression in a patient with MDD and borderline personality disorder who responded poorly to treatment.

Deep Brain Stimulation↗

The interaction of delirium and seizures.

The induction of a delirium by medical illness, somatic treatments, or experimental drugs occasionally relieves psychotic, excited, and manic states. An induced delirium is a feature of modern electroconvulsive therapy (ECT), and was a feature of insulin coma therapy and psychosurgery. Case material explores the relationship between psychosis, mania, seizures, and electroencephalogram. From our understanding of the mechanism of ECT in relieving intractable status epilepticus, we suggest a hypothesis for the beneficial interaction between delirium and ECT.

Adolescent↗

The mental patients' rights movement and mental health institutional change.

The mental patients' rights movement has added to the widespread critique of institutional psychiatry and provided leadership in opposing treatment methods such as electroshock, psychosurgery, and overdrugging, which are dangerous and regressive not only to patients, but to the expanded population of non-institutionalized persons as well. The movement has had some success in court cases for democratic rights, such as the right to treatment, the right to refuse treatment, patient labor, and commitment law. At the same time patients' rights demands have been partly coopted by mental health administrators. In a number to cases, mental health officials supported patients' rights litigation because it enabled them to speed up their deinstitutionalization programs. Overall, the conjuncture of the movement with economic impetus toward deinstitutionalization has allowed mental health planners to use the patients' rights issues to justify their essentially fiscal policy. Providers and administrators have set up advocacy offices, posted patients' bills of rights, and incorporated ex-patient representatives on advisory boards. Yet mental health administrators are generally opposed to a broad application of patients' rights.

Attitude of Health Personnel↗

Marxism, social psychology, and the sociology of mental health.

The political activism of the 1960s brought with it activism in the mental health field, broadly defined as antipsychiatry. Included in this social phenomenon are R.D. Laing and his colleagues, mental patients' rights activists, movements against psycho-technological abuses such as psychosurgery, Marxist and radical critiques of mainstream psychiatric practices, and feminist therapy. Some aspects of this broad movement have been influenced or even directed by Marxist perspectives. When Marxist influences have not predominated, antipsychiatric points of view still have much affinity with Marxism. This broad-based criticism of mental health practices and ideologies not only influences the mental health field, but also affects general Marxist social theory, adding to traditional Marxism a concern with feminist issues and the politics of personal and family life. This article explores the progress made by these antipsychiatric perspectives, and examines their limitations as well. Four schools of thought in Marxist psychology--Freudo-Marxism, orthodox-economist Marxism, see Marxist medical model, and "ideology-critique"--are explored to see how they can contribute to the further production of Marxist psychological theory and practice.

Delivery of Health Care↗

[Surgical treatment of epilepsy in Denmark a century ago].

Surgery for epilepsy in Denmark has been slowed down officially the larst decade. The reason for that is suggested to be an unfortunate combination of this kind of surgery with psychosurgery. Other European countries have been given much more credit to modern scientific development. In that concept it is worth to mention that Denmark in reality started epilepsy surgery in the Nordic countries a century ago Cooperation between the first epileptologist F. K. Hallager and the skilled surgeron P. W. Heiberg made that possible. In the period 1883 to 1900 they together treated 4 patients with nontraumatic epilepsy with primary good results.

Denmark↗

The Origins of Electroconvulsive Therapy (ECT).

Prior to the 1930s, the prime mode of treatment for psychiatric outpatients was psychoanalysis. Little could be done for inpatients, other than provide sedation and social support. In the 1930s, four major somatotherapies, all interventionist in technique, were developed: insulin coma therapy, Metrazol convulsive therapy, lobotomy (psychosurgery), and electroconvulsive therapy (ECT), the only one of these therapies still in use today. This paper focuses on the development of ECT by Ugo Cerletti and Lucio Bini at the Clinic for Nervous and Mental Disorders in Rome in 1938. The first electroshock treatment with humans is discussed in detail and the export of ECT to North America is described. Fifty years after the first treatment, ECT remains a controversial method of psychiatric treatment.

Journal Article↗

Pharmacotherapy of obsessive compulsive disorder.

The authors briefly review studies of the efficacy of potent serotonin reuptake inhibitors (SRIs) (e.g., clomipramine, fluvoxamine) in obsessive compulsive disorder (OCD) and compare the use of antidepressants in the treatment of depression and OCD. They propose an algorithm for those patients with OCD who fail to respond to an adequate trial with a potent SRI and discuss the promise and limitations of adding tryptophan, fenfluramine, lithium, buspirone, or a neuroleptic to ongoing SRI therapy. Other biological approaches (e.g., ECT, psychosurgery) are considered in terms of their narrowly defined roles in the treatment of patients with SRI-resistant OCD.

1-Naphthylamine↗

From Rogers to Rivers: the rights of the mentally ill to refuse medication.

Many individuals with mental illness wish to avoid psychotropic drugs, a type of treatment that may relieve their symptoms only at the risk of unpleasant, even permanent, side effects. In marked contrast to the widely-held view that most patients may refuse any treatment and that even patients with mental illness may reject other psychoactive interventions such as electroconvulsive therapy and psychosurgery, the courts and legislatures have been slow to recognize any right to refuse psychotropic drugs. This Article demonstrates that many of the justifications offered for forcing patients to take unwanted medications are inadequate and that unless treatment refusals are reviewed outside mental institutions, patients' rights will rarely receive appropriate deference. The author analyzes the federal and state litigation to determine whether the courts have fashioned meaningful relief for the mentally ill. The Article concludes that two recent United States Supreme Court decisions have made it impossible for the federal courts to provide adequate protection. By contrast, several state courts have responded to the needs and rights of patients with mental illness.

Federal Government↗

Study of disturbed tryptophan metabolism in depressive illness.

The evidence for disturbances of tryptophan and 5-hydroxytryptamine in depression and for various mechanisms by which such disturbances could occur is discussed. Two recent relevant studies in the author's laboratory are described: a) non-esterified fatty acid and total and free tryptophan were determined in plasmas of psychiatric patients unselected with respect to psychiatric diagnosis before and after a stress situation. Retarded patients had significantly low total and free tryptophan values which correlated negatively with agitation. Total tryptophan fell significantly after stress in the non-retarded subjects. The only biochemical abnormality significantly associated with a diagnosis of primary depression was the rise of plasma non-esterified fatty acid after stress. Thus tryptophan abnormalities were associated more with psychiatric rating scores than with diagnoses. b) Determinations on plasma and lumbar and ventricular CSF from psychiatric patients undergoing psychosurgery indicate that low plasma free tryptophan concentrations are associated with decreased 5HT turnover in the central nervous system.

Depression↗

Legal issues in psychiatric treatment.

This paper has presented a discussion of the three overlapping phases in the regulation of psychiatric treatment: consent, patients' rights, and physicians' duties. The concepts of consent are relatively well defined. Still, the courts sometimes utilize the rubric of consent to decide difficult cases (e.g., Clites). One can predict that litigation attempting to further define the specific aspects of consent for high-risk therapies will continue. Because of the court's decision in Youngberg, one can also predict that there will be more litigation as to the constituents of constitutionally-adequate treatment. Given the court's dicta in that case, about deferring to professional judgment, it is impossible to know how these cases will fare if and when they are reviewed by the Supreme Court. Given the court's decisions in Mills and Rennie, it is unlikely that the Supreme Court will be ruling on a broad constitutionally-based right to refuse treatment for some time. The most active interface of psychiatry and law is that detailing physicians' duties. In terms of dangerousness, the majority of cases require that psychiatrists attempt to protect victims, or classes of victims, when they believe that dangerous conduct is apt to occur. Still unclear is the extent to which the courts will inquire specifically into the clinical decision-making process to determine whether the physician "reasonably should have known" that the patient was dangerous. Also unclear is the extent to which the courts will find that physicians owe a duty to an ill-defined class. Still, a reasonable guess would be that other courts will find Lipari persuasive. Finally, with regard to specific treatment modalities, it is evident that physicians are being required to practice with an extra measure of care and caution when prescribing neuroleptics, ECT, or psychosurgery. One final note: Too often, physicians have been leery of the political process. Since many decisions with great impact on patients and practitioners are political, this author would urge physicians to engage in that process to secure more reasonable and more equitable medical regulation.

Antipsychotic Agents↗

[Therapeutic strategy in cancer pain].

Surgical and pharmacological management of cancer pain is described and discussed according to the physiopathological mechanisms underlying this complex syndrome. The therapeutic approach is planned in three mayor phases which may be employed alone or in combination, following an accurate evaluation of the pathophysiology and the clinical pattern in every single patient. The first phase includes multifocal pharmacological therapy by nonnarcotic drugs in order to affect at different levels the physiopathological mechanisms of cancer pain. The second phase is indicated when nonnarcotic drugs cannot achieve complete pain relief; neurosurgical procedures (nerve blocks, rhizotomies, cordotomies, ecc...) are employed in this phase. The pharmacological treatment must be continued and associated to surgery. The third phase includes hypophysectomy, deep brain stimulation, psychosurgery and/or narcotic drug therapy, which are the last step in management of terminal cancer pain when all treatments have been ineffective. The results of this therapeutic program in 188 patients affected by pain of malignant origin are reported and discussed.

Analgesics, Opioid↗

Biological approaches to treatment-resistant obsessive compulsive disorder.

Biological approaches to the patient with treatment-resistant obsessive compulsive disorder are briefly reviewed. The most commonly employed strategy involves combining a potent serotonin reuptake inhibitor (SRI) (e.g., clomipramine or fluvoxamine) with another medication that may exert effects on the brain serotonin system. Open-label reports regarding the addition of tryptophan, fenfluramine, lithium, or buspirone to ongoing SRI therapy of obsessive compulsive disorder are encouraging. However, the anti-obsessive compulsive efficacy of SRI-lithium and SRI-buspirone combination therapy has not been confirmed in recent controlled trials. Preliminary evidence suggests that addition of neuroleptic may benefit SRI-refractory obsessive compulsive disorder patients who have a comorbid chronic tic disorder. Other biological approaches (e.g., electroconvulsive therapy and psychosurgery) are considered in terms of their narrowly defined roles in the treatment of patients with SRI-resistant obsessive compulsive disorder. Finally, an algorithm is proposed for those patients with obsessive compulsive disorder who fail to respond to an adequate trial with a potent SRI.

Behavior Therapy↗