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At least 613 records · Page 34Linked to original sources

Adenocarcinoma of the renal pelvis. Report of two cases, one with simultaneous transitional cell carcinoma of the bladder.

Mucinous adenocarcinoma of the renal pelvis is a very rare condition and represents less than 1% of renal pelvic tumors. Hydronephrosis of long duration, stones and inflammation are frequently associated with these tumors. We report 2 cases. In 1 of them, adenocarcinoma of the renal pelvis, pyelolithiasis and transitional carcinoma of the bladder were present simultaneously. The other patient had a history of abdominoperineal resection for rectal cancer 10 years prior to the renal tumor.

Adenocarcinoma↗

Metastasis of renal cell carcinoma to the contralateral renal pelvis.

Extremely rarely renal cell carcinoma metastasizes to the contralateral renal pelvis or ureter. The present report concerns a case where a metastatic tumor could be successfully removed from the left renal pelvis 3 years after right nephrectomy for the primary tumor. A review of the literature revealed this to be only the fourth such case documented.

Carcinoma, Renal Cell↗

Adenocarcinoma of the renal pelvis. A report of two cases.

Two cases of intestinal-type adenocarcinoma of the renal pelvis (ARP) in 48- and 63-year-old females are presented. Both had a previous history of urinary obstructive disease, one secondary to staghorn calculus and the other to postirradiation stenosis following treatment for carcinoma of the cervix. Immunohistochemical findings revealed marked positivity to epithelial membrane antigen and focal positivity to cytokeratins and carcinoembryonic antigen. Chronic irritation of the renal pelvis plays an important role in the pathogenesis of ARP. In one of our cases of multicentric origin, the synergistic effect of pelvic irradiation and cyclophosphamide chemotherapy in a patient with a previous squamous cell carcinoma of the cervix, may be responsible for the pathogenesis of the ARP.

Adenocarcinoma↗

Renal pelvis rupture after blunt abdominal trauma.

A 45-year-old male patient presented with rupture of the left renal pelvis after blunt abdominal trauma. The patient had preexisting bilateral megaureters with secondary obstruction of the pyeloureteral junction. The underlying disease was a persisting type III posterior urethral valve. Diagnosis of renal pelvis rupture and the underlying malformation was achieved sonographically and by abdominal CT scan. The left kidney was exposed at the time of admission and a pyeloplasty according to Anderson-Hynes was carried out. Secondarily the urethral valve was resected.

Abdominal Injuries↗

Transvaginal color and pulsed Doppler ultrasound evidence of hemodynamics of the female pelvis.

Transvaginal color and pulsed Doppler ultrasound examinations were made on 40 patients to assess hemodynamics in the pelvis. Use of a special probe for transvaginal scanning led to superb simultaneous visualization of structures and blood flow, and we noted various events, even in the small, deep and/or peripheral vessels. Some but not all of the observations were in agreement with the results obtained using transabdominal color and pulsed Doppler ultrasound. We propose that transvaginal color and pulsed Doppler ultrasound be considered for routine use to determine physiological and pathological events in the female pelvis.

Color↗

Effect of indomethacin on unilateral obstructed renal pelvis and on ureteral peristalsis. Experimental study in awake sheep.

An experimental model to study the physiology of the obstructed kidney in awake sheep is described. Unilaterally, a kidney was obstructed, and the pressure in the renal pelvis was measured before and after intravenous injection of indomethacin. This experiment study on awake sheep enabled us to compare the clinical behavior of the animal with the recorded objective data, to demonstrate the rapid decrease in pressure in the obstructed renal pelvis. In addition, we observed a decrease in ureteral peristalsis frequency following the injection of indomethacin.

Abdomen↗

Renal pelvis reconstruction with a free peritoneal patch.

The authors report on the use of a patch of peritoneum in the reconstruction of the renal pelvis. Four successful cases are reported. This leads to the use of such a technique in the reconstruction of the pelvis whenever repair by simple apposition of the margins is impossible.

Adult↗

Pacemaker localization in the renal pelvis of the unicalyceal kidney. In vitro study in the rabbit.

To determine the precise localization of the pacemaker in the renal pelvis of the unicalyceal rabbit kidney, the spontaneous activity of muscle strip preparations was investigated in vitro. (1) The highest frequency of spontaneous contractions was found in the most intrarenal part of the renal pelvis. (2) The frequency diminished from the most intrarenal parts to the pyeloureteral junction. (3) No spontaneous activity was observed in ureter preparations; even adrenaline, noradrenaline, acetylcholine and oxytocin did not start any contraction. In the pyeloureteral system the cells with the highest spontaneous frequency will act as a pacemaker. Cells with a less frequent activity can only work as secondary or latent pacemakers.

Acetylcholine↗

Increased pelvic vein thrombi in cryptogenic stroke: results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) study.

BACKGROUND AND PURPOSE: Cryptogenic stroke is associated with an increased prevalence of patent foramen ovale. The Paradoxical Emboli From Large Veins in Ischemic Stroke (PELVIS) study hypothesized that patients with cryptogenic stroke have an increased prevalence of pelvic deep venous thrombosis (DVT). METHODS: At 5 sites, patients 18 to 60 years of age received an MRI venogram (MRV) of the pelvis within 72 hours of new symptom onset. Clinical data were then determined. Radiologists blinded to clinical data later read the scans. RESULTS: The 95 patients who met entry criteria were scanned. Their mean+/-SD age was 46+/-10 years, and time from stroke onset to pelvic MRV scan was 49+/-16 hours. Compared with those with stroke of determined origin (n=49), patients with cryptogenic stroke (n=46) were significantly younger, had a higher prevalence of patent foramen ovale (61% versus 19%), and had less atherosclerosis risk factors. Cryptogenic patients had more MRV scans with a high probability for pelvic DVT (20%) than patients with stroke of determined origin (4%, P<0.03), with most having an appearance of a chronic DVT. CONCLUSIONS: In this study of young stroke patients evaluated early after stroke, patients with cryptogenic stroke showed differences in several clinical features compared with patients with stroke of determined origin, including increased prevalence of pelvic DVT. The results require confirmation but suggest that paradoxical embolus from the pelvic veins may be the cause of stroke in a subset of patients classified as having cryptogenic stroke.

Adolescent↗

Incidence and pathology of spontaneous renal pelvis transitional cell carcinomas in rats.

Spontaneous transitional cell carcinoma (TCC) originating from renal pelvis is very rare. Metastasis from this tumor having been reported only once previously. Data from control groups of 17 carcinogenicity studies in Sprague-Dawley and 10 carcinogenicity studies in Fischer 344 (F-344) rats were reviewed and evaluated to determine the incidence and pathology of TCC. Renal pelvis TCC were observed in 1 male and 1 female Sprague-Dawley rat and in 1 male F-344 rat. Metastasis from TCC to the lung was observed in 1 male Sprague-Dawley rat. Detailed histopathological features of this tumor are described and discussed.

Animals↗

Urothelial signet-ring cell carcinoma of the renal pelvis with collagenous spherulosis: a case report.

We present a unique case of urothelial carcinoma of the right renal pelvis. It occurred in a 58-year-old woman. The tumor was located in the renal pelvis with extension into the adjacent renal medulla and cortex. Two years after surgical excision the patient is free of recurrence and metastasis. The tumor was well demarcated, without capsule, firm, solid, and whitish on the cut surface. It was 3x4 cm in largest diameter and without signs of necroses and hemorrhages. The tumor did not infiltrate the ureter. Histologically the predominant pattern of the tumor was adenocarcinomatous differentiation, and only very rare foci of urothelial carcinoma composed of typical transitional cells were found. No signs of intestinal type of metaplasia and adenocarcinoma, changes similar to the cystitis cystica or cystitis glandularis, were found in the tumor or in its vicinity. Most of the tumor looked like solid nests composed of cells with intracytoplasmic lumens. The resulting appearance was that of typical signet-ring cell change. These solid nests were usually surrounded by columnar epithelium, which in many areas formed papillary structures. A very striking feature was formation of collagen spherules. Small collagen spherules were often surrounded by a layer of the neoplastic cells so that collagenous rosettes were formed. In some areas these collagenous spherules clustered together so that they formed areas of collagenous spherulosis. The collagen in the spherules reacted positively with collagen IV. Ultrastructurally these spherules were formed by basal membrane-like material. Intracytoplasmic lumens of the signet-ring cell change were endowed by slender microvilli at ultrastructural level.

Carcinoma, Signet Ring Cell↗

Computed tomography-guided salvage brachytherapy of recurrent large nonresectable familial colo-rectal cancer in the pelvis: case report.

Here we present the first reported case of three-dimensional CT-guided salvage brachytherapy of recurring colorectal cancer in the pelvis after failed radiation therapy, total colectomy, and chemotherapy. Initial CEA was 67.0 ng/mL and tumor volume 93 cm3 with no metastasis outside the pelvis. A total of 333 seeds of Iodine-125 were delivered to the entire target, with dosage of 150 to 200 Gy as calculated by post-implant CT dosimetry with Varian MMS software. CEA 12 months after implant decreased to 5.7 ng/mL. Clinical and biochemical results are encouraging; however long-term data in a greater universe of patients are required.

Adenocarcinoma↗

Parasymphyseal and associated insufficiency fractures of the pelvis and sacrum.

Eleven post-menopausal women presenting with a parasymphyseal insufficiency fracture of the pubis are reported. The plain radiographs showed delayed healing with a mixed lytic and sclerotic area developed at the fracture site simulating a malignant lesion. Aetiological factors included post-menopausal osteoporosis, rheumatoid arthritis and steroid therapy, previous hip replacement and pelvic radiotherapy. Ten patients had concomitant fractures of the pelvis, including nine with sacral fractures. These were all initially missed on presentation because of the subtle radiographic signs of a longitudinal band of sclerosis, usually bilaterally, in the sacral ala. Bone scanning was shown to be the most sensitive technique in detecting the sacral fractures by demonstrating increased uptake in the sacral ala as well as the other fractures of the pelvis. Computed tomography in three cases was helpful in confirming the presence of fractures and excluding the possibility of malignancy.

Aged↗

[Studies on the in vivo pacemaker potentials of the canine renal pelvis].

In vivo pacemaker potentials of canine renal pelvis were able to be recorded by our new method. Potentials recorded at the pelvicalyceal region of canine renal pelvis in vivo had two phasic slow rising wave form that had duration of 0.2 sec, amplitude of 20 microV and discharge interval of about 5 sec. Furthermore, the discharge interval of ureter EMGs was a integral multiple of that of pacemaker potentials. In diuretic state by intravenous administration of furosemide, pacemaker potentials showed no change in wave form and discharge interval. However, ureter EMGs occurred more frequently to correspond to pacemaker potentials one to one. Noradrenaline and isoproterenol had no action on pacemaker potentials. To the contrary, ureter EMGs were increased by noradrenaline and were decreased by isoproterenol. Acetylcholine had a great variety of action on both pacemaker potentials and ureter EMGs. These results suggest that the pelvicalyceal region as thought to be the pacemaker of ureteral peristalsis is controlled under the influence of parasympathetic nerve system and the ureter is controlled under the influence of both sympathetic and parasympathetic nerve systems.

Acetylcholine↗

Pseudo-Meigs' syndrome associated to renal pelvis tumor.

INTRODUCTION: Pseudo-Meigs' syndrome is associated with tumors different from the benign ovary tumor, but it has never been described in association to transitional cell carcinoma. CASE REPORT: A female 73 year-old patient presenting pleural effusion nonmetastatic associated with renal pelvis transitional cell carcinoma that resolved and did not recur after radical nephroureterectomy. COMMENTS: Renal pelvis transitional cell carcinoma can result in the Pseudo-Meigs' syndrome. Although being a rare clinical entity, the identification of such syndrome can result in an accurate diagnosis, leading to an efficient surgical treatment, without comorbidity for the patient.

Aged↗

Effect of dobutamine on adenylate cyclase activity in rabbit renal pelvis and ureter.

The adenylate cyclase activity in the rabbit renal pelvis and ureter was measured by the method of Salomon et al. (1974). The dobutamine-induced increase of adenylate cyclase activity is more prominent in the renal pelvis including the pacemaker region than in the ureter that is non-pacemaker region in the upper urinary tract. Therefore, it is thought that the pacemaker region is different from other regions in the upper urinary tract with regard to responses to dobutamine.

Adenylyl Cyclases↗

Properties of spontaneous electrical activity in smooth muscle of the guinea-pig renal pelvis.

In the guinea-pig renal pelvis, most smooth muscle cells examined (>90%), using a conventional microelectrode, had a resting membrane potential of about -50 mV and produced spontaneous action potentials with initial fast spikes and following plateau potentials. The remainder (<10%) had a resting membrane potential of about -40 mV and produced periodical depolarization with slow rising and falling phases. Experiments were carried out to investigate the properties of spontaneous action potentials. The potentials were abolished by nifedipine, suggesting a possible contribution of voltage-gated Ca(2+) channels to the generation of these potentials. Niflumic acid and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), inhibitors of Ca(2+)-activated Cl(-) channels, showed different effects on the spontaneous action potentials, and the former but not the latter inhibited the activities, raised the question of an involvement of Cl(-) channels in the generation of these activities. Depleting internal Ca(2+) stores directly with caffeine or indirectly by inhibiting Ca(2+)-ATPase at the internal membrane with cyclopiazonic acid (CPA) prevented the generation of spontaneous activity. Chelating intracellular Ca(2+) by 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) increased the amplitude of the spike component of spontaneous activity. Indomethacin inhibited the spontaneous activity, whereas prostaglandin F(2 alpha) enhanced it. The results indicate that in smooth muscle of the renal pelvis, the generation of spontaneous activity is causally related to the activation of voltage-gated Ca(2+) channels through which the influx of Ca(2+) may trigger the release of Ca(2+) from the internal stores to activate a set of ion channels at the membrane. Endogenous prostaglandins may be involved in the initiation of spontaneous activity.

Animals↗