SEARCH · Search PubMed
Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
An eight-year-old female cat developed a skin neurofibroma. The cytogenetic evaluation of the tumour cells showed the presence of a high percentage (16.4 per cent) of trisomic cells. The trisomy concerned chromosome number D2.
From 1975 to 1988 seventeen patients with neurofibromatosis type 1 and a disfiguring facial plexiform neurofibroma (FPN) were investigated. The FPN was left-sided in 13 patients. It was orbital/periorbital in 4, lower facial in 7 and involved the whole face in 6 subjects. Neuroimaging (n = 13) revealed a tumor (of optic pathways or basal ganglia) in 8, an ipsilateral middle cranial fossa arachnoid cyst in 2, multiple areas of high signal intensity (in T2-weighted magnetic resonance imaging) in 1, and normal findings in 2 patients. In NF-1 patients with FPN there seems to be a high incidence of intracranial tumors and possibly of arachnoid cysts. Our observation has to be confirmed in a larger patient series.
Peroneal nerve palsy developed in a patient with T cell-type acute lymphoblastic leukemia (ALL) is reported. In the fifth month after starting of chemotherapy against ALL, the patient, a 7-year-old girl, developed drop foot on the left. Three possibilities were considered as its pathogenesis; (1) VCR neuropathy, (2) neurotoxicity of intrathecal MTX, (3) leukemic invasion to the spinal canal. However, there was no evidence of leukemic invasion in any lumbar taps, and no improvement was obtained by cessation of VCR and intrathecal MTX. Examination by CT scan revealed tumors in the intervertebral (L5-S2) region, which was diagnosed to be neurofibromas by biopsy. The tumors compressed the left peroneal nerve and neurotoxicity of antineoplastic agents for ALL could be the cause of her drop foot.
We describe a benign diffuse neurofibroma of the pylorus, unassociated with von Recklinghausen's neurofibromatosis, which was a cause of pyloric stenosis; epigastric discomfort, vomiting, and weight loss of 60 lb were the most prominent symptoms. Partial gastrectomy resulted in a cure. The literature on nerve-sheath tumors of the stomach is reviewed.
A solitary duodenal neurofibroma located very closely to the papilla and causing intestinal bleeding could be demonstrated by endoscopy and sonography in a 53 year old female. ERP showed narrowing of the proximal segment of the pancreatic main duct. The diagnosis was confirmed at surgery, in addition it was found, that the choledochus was incarcerated by the tumor as well. A duodeno-hemipancreatectomy after Whipple was performed, because of the localization of the tumor.
The authors described a 22-year-old female patient in whom a neurofibroma had been removed at the age of 13 years (laminectomy L1, 2, 3), and 9 years later psammoma was removed by laminectomy Th7, 8, 9). Both tumours developed outside the cord and were removed radically. The patient without complaints and without neurological deficit returned to work.
An 8-month-old girl had ipsilateral ptosis, proptosis, and glaucoma caused by a massive left-sided plexiform neurofibroma. The tumor extended from the cavernous sinus into the orbit, involving the optic nerve, extraocular muscles, and eyelid. Although the prognosis in such cases is considered very poor, most of the mass was excised by a radical neurosurgical and ophthalmologic procedure. Today, the patient remains asymptomatic with no further neurologic defects. This case is unusual in that the glaucoma developed prior to clinically evident eyelid involvement.
In a 24-year-old male melanin synthesis was demonstrated in a neurofibroma by light and electron microscopy. Although it is unclear whether the tumor cells are pigment-synthesizing Schwann cells or whether they originate from a coexisting melanocytic tumor, this tumor again demonstrates the close relationship between peripheral nerve sheath tumors and melanocytic malformations, as for example cellular blue nevi.
We report on a 49-year-old female patient suffering from Pacinian neurofibroma on her right middle finger. The microscopical findings of this rare neoplasm are discussed in detail.
A case of oesophageal neurofibroma is reported; its low incidence among the benign tumours of the oesophagus is pointed out. The clinical, radiologic and histologic features of this very rare tumour are described.
Twenty patients with neurofibromas of the head and neck have been observed for periods ranging from ten to 25 years. Seventeen patients had classical von Recklinghausen's disease. Of these, ten showed recurrence or appearance of new lesions after surgical resection, whether it was done during childhood or adulthood. While there is no known means of curing or even arresting neurofibromatosis, it is desirable to remove, as completely as possible, tumors which are deforming or symptomatic. Subsequent operations are often necessary to keep pace with the growth of the tumors. However, surgical resection, incomplete and imperfect as it may be, is extremely useful in improving the appearance, comfort and quality of life of these unfortunate patients.
In a 66-year-old woman, a large solitary neurofibroma arising in the right infraorbital nerve extended into the maxillary antrum and the orbit. Following extirpation of this rare tumor, bony defects of the right orbital floor and inferior orbital rim were repaired with a biplanar supramid implant.
Epicranial plexiform neurofibroma is a rare presentation of neurofibromatosis. Two such cases are presented in which epicranial tumors constituted isolated manifestations of the disease except for skin pigmentation. Tumor development began at two and three months of age respectively; one case showed a calvarian bony defect associated with the tumor.
A case of neurofibroma of the median nerve at the wrist is reported. An operation to resect 15 cm of the nerve was performed; no transplant was substituted. No motor or sensory paralysis was noted, either directly after the operation or at follow up after nine years. Injection of procaine into the ulnar nerve at the epitrochlear groove demonstrated complete compensation, by means of anastomoses between the two nerves at the upper third of the forearm. It is assumed that the type of lesion (circumscribed neurofibromatosis) beginning in infancy or childhood, had some influence in giving rise to this substitution.
A female aged 22 died 13 hours after having given birth to a live mature fetus. On autopsy, bilateral phoechromyocytomas, a mucosal neurofibroma of the tongue and a solid medulary carcinoma of the thyroid with amyloid associated with Hashimoto's lymphocytic thyroiditis were detected. After parturition, there occurred bleeding into the left-side pheochromocytoma followed by a release of phenyl alkylamines into the circulation. This resulted in fatal peripheral circulatory failure.
Case report of an endothoracic neurofibroma of the left vagus nerve, presenting as an anterior mediastinal mass in a 62 years old man without other signs of Recklinghausen's disease. Rarity of such cases is noted. Previously published sixty one reports are studied. Only four are localised in anterior mediastinum. The authors emphasize absence of specific signs of vagal involvement, importance for diagnosis of surgical extirpation, and mildness of post operative course.
The surgical approach to the jugular foramen has been considered to be very difficult and troublesome, because of the location in which important structures, such as the internal jugular vein, internal carotid artery and lower cranial nerves, converge in the narrow deep space. A case of huge neurofibroma, which extended from the tentorium cerebelli through the dilated jugular foramen to the level of the vertebral body of C3 was presented. A 12-year-old girl was admitted with complaints of visual disturbance and palsy of the V-XII cranial nerves of the left side. Plain skull film showed prominent widening of the cranial sutures and enlargement of the sella turcica. Horizontal CT scan with contrast showed symmetrical ventricular dilatation and a heterogeneously enhanced mass, which was situated mainly in the left CP angle. Coronal CT scan with contrast revealed a huge mass and enlarged jugular foramen, through which the tumor extended to the level of the vertebral body of C3. Occlusion of the sigmoid sinus and the internal jugular vein of the left side was noticed in the vertebral angiography. Two-stage approach, the first one for removal of the intracranial tumor and the second one for extracranial tumor, was performed for its huge tumor. Several authors have reported excellent surgical approaches for the tumors situated in the jugular foramen. By our approach, modifying Gardner's original one, a wide operative field was obtained to remove the tumor around the jugular foramen with success. Our approach for the jugular foramen was described with illustrations.
Two cases of storiform neurofibroma were examined electronmicroscopically. Their pigment was identified as melanin both by histochemical methods and by the presence of melanosomes. In one case moreover another pigment of lysosomal location was found.