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At least 613 records · Page 34Linked to original sources
PubMed1986

METAMOD: software for steady-state modelling and control analysis of metabolic pathways on the BBC microcomputer.

METAMOD, a BBC microcomputer-based software package for steady-state modelling and control analysis of model metabolic pathways, is described, The package consists of two programs. METADEF allows the user to define the pathway in terms of reactions, rate equations and initial concentrations of metabolites. METACAL uses one of two algorithms to calculate the steady-state concentrations and fluxes. One algorithm uses the current ratio of production and consumption rates of variable metabolites to adjust iteratively their concentrations in such a way that they converge towards the steady state. The other algorithm solves the roots of the system equations by means of a quasi-Newtonian procedure. Control analysis allows the calculation of elasticity, control and response coefficients, by means of finite difference approximation. METAMOD is interactive and easy to use, and suitable for teaching and research purposes.

Algorithms↗
PubMed1986

A demonstration of pharmacokinetics and physiological modelling using a microcomputer for data capture and analysis.

We describe a simple and inexpensive demonstration of mass transport and exchange using dye clearance from a hydrodynamic model. A microcomputer was used for data acquisition and storage, non-linear least squares curve fitting, compartmental analysis and parameter estimation. The system is useful for demonstrating the indicator-dilution technique for fluid volume measurement and compartmental analysis in pharmacokinetics.

Algorithms↗
PubMed1987

Microcomputer package for statistical analysis of microbial populations.

We have developed a Pascal system to compare microbial populations from different ecological sites using microcomputers. The values calculated are: the coverage value and its standard error, the minimum similarity and the geometric similarity between two biological samples, and the Lambda test consisting of calculating the ratio of the mean similarity between two subsets by the mean similarity within subsets. This system is written for Apple II, IBM or compatible computers, but it can work for any computer which can use CP/M, if the programs are recompiled for such a system.

Algorithms↗
PubMed1988

BBC microcomputer controlled field inversion gel electrophoresis.

Agarose gel electrophoresis to separate DNA molecules is a widely used technique in molecular biology but there is an upper limit to the sizes that can be resolved. Pulsed field techniques have extended this limit but require expensive equipment. Here we describe a home-made control unit to interface conventional electrophoresis equipment to a BBC microcomputer for the purposes of field inversion gel electrophoresis.

Electrophoresis↗
PubMed1988

Matrix algebra routines for the Acorn Archimedes microcomputer: example applications.

A set of matrix algebra routines have been written, as BASICV procedures, for the Acorn Archimedes microcomputer. It is shown that these procedures are executed so quickly that programs, which require matrix algebra computations, can be written in interpreted BASIC. Two example applications, reciprocal averaging and principal components analysis, are demonstrated.

Computers↗
PubMed1989

Fast and sensitive multiple sequence alignments on a microcomputer.

A strategy is described for the rapid alignment of many long nucleic acid or protein sequences on a microcomputer. The program described can handle up to 100 sequences of 1200 residues each. The approach is based on progressively aligning sequences according to the branching order in an initial phylogenetic tree. The results obtained using the package appear to be as sensitive as those from any other available method.

Algorithms↗
PubMed1989

TEFOOL/2: a program for theoretical drug design on microcomputers.

TEFOOL/2, a program written in BASIC, is presented in this paper. The purpose of TEFOOL/2 is to provide people interested in drug design with an easy-to-handle program where some of the most important techniques in QSAR are included. The program permits the selection of the training series, performs regression calculations and searches for optimum substituents. The latter is achieved by using either a Hansch's strategy or geometrical procedures. The program is interactive and can be implemented on an IBM-PC or compatible microcomputer. Although TEFOOL/2 has been developed for its application in drug design studies, its great flexibility makes it suitable for application to any experimental design or optimization process.

Algorithms↗
PubMed1990

A BASIC microcomputer program for prediction of B and T cell epitopes in proteins.

A BASIC microcomputer program (EPIPLOT) has been developed for predicting B and T cell antigenic sites in proteins from their primary structures. The program calculates and plots flexibility, hydrophilicity and antigenicity profiles using 13 different scales, chosen as those yielding the best predictions on proteins whose antigenic structures are known. T cell epitope prediction is based on published algorithms focused on amphiphilic structures and characteristic sequence patterns. The advantages of joint predictions in locating T cell antigenic sites are also discussed.

Algorithms↗
PubMed1990

Generating precise mechanical stimuli and recording chordotonal organ discharge patterns using a microcomputer.

A computer-controlled system for the investigation of the response properties of the tibio-femoral chordotonal organ in the locust is described. The computer is used to generate small amplitude sinusoidal movements of the tibia via a small servo-controlled motor. The resulting response recorded via a suction electrode is simultaneously detected, processed and stored on disk. Full constructional details for all hardware required are given. The software, developed for a BBC microcomputer, in addition to controlling all the hardware, has graphics and analysis routines enabling the operator to display and manipulate the stored data.

Action Potentials↗
PubMed1992

GCWIND: a microcomputer program for identifying open reading frames according to codon positional G+C content.

GCWIND is a microcomputer (IBM-PC compatible) program for the identification of protein-coding open reading frames. The program is similar to the FRAME program, but the latter has only been implemented for a specialized graphics package. The base compositions (%G+C) for each of the three possible reading phases through the DNA sequence are displayed separately, together with the positions of potential translation initiation and termination codons (on the leading and complementary strands), to provide an immediate representation of those regions within the sequence that have coding potential.

Codon↗
PubMed1984

Microcomputer-based anaesthetic record system.

A system, based on the Apple II microcomputer, has been developed to collect cardiovascular data on-line from a non-invasive arterial pressure monitor. Off-line data are entered as far as possible, with a light pen. All information is stored on disc for subsequent analysis. A coloured trend graph can be displayed on the screen. The trend graph and all the information entered off-line can be printed out at the end of the operation to form a complete anaesthetic record.

Anesthesia↗
PubMed1986

Microcomputer-based haemodynamic monitoring during continuous extradural analgesia.

A system for monitoring, recording and storing arterial pressure and heart rate during continuous extradural analgesia has been developed using an Apple II microcomputer and a Dinamap 1846 non-invasive arterial pressure monitor. The administration of local anaesthetic (or vasopressor) was recorded using a light pen. The computer was programmed to recognize this, and to initiate automatically more frequent measurements of heart rate and arterial pressure. The results of a study using this equipment are reported. The commands for computer control of the Dinamap 1846 are described.

Adult↗
PubMed1989

Opportunistic research in general practice using a low cost microcomputer based medical record system as a tool.

A low cost microcomputer-based medical record system was used to facilitate opportunistic research projects in the teaching clinic of the Chinese University of Hong Kong. An example of an actual clinical trial comparing the effectiveness of three methods of teaching breast self-examination to clinic patients was used and the process of setting up the research protocol, the sampling of patients, and the analysis of early results after one and a half years were described. It was found that the sampling bias in opportunistic research was that subjects selected were more likely to be older with more problems, and have a higher attendance rate at the clinic. The bias could be corrected during the analysis of data by stratifying the selected sample into groups of different attendance rates. Another potential sampling bias was due to non-compliance of both the patients and the clinical staff. However, it was found to be possible to obtain useful results from opportunistic research. It was easy to implement this type of research with the help of a computerized medical record system.

Adult↗
PubMed1982

A convenient and adaptable package of DNA sequence analysis programs for microcomputers.

We describe a package of DNA data handling and analysis programs designed for microcomputers. The package is convenient for immediate use by persons with little or no computer experience, and has been optimized by trial in our group for a year. By typing a single command, the user enters a system which asks questions or gives instructions in English. The system will enter, alter, and manage sequence files or a restriction enzyme library. It generates the reverse complement, translates, calculates codon usage, finds restriction sites, finds homologies with various degrees of mismatch, and graphs amino acid composition or base frequencies. A number of options for data handling and printing can be used to produce figures for publication. The package will be available in ANSI Standard FORTRAN for use with virtually any FORTRAN compiler.

Amino Acid Sequence↗
PubMed1984

Graphic display of nucleic acid structure by a microcomputer.

A microcomputer program for the display of a three dimensional structure of a nucleic acid and a protein has been developed. This program can generate a wire model and a ball and stick model on a color CRT display. The phosphate atoms on the backbone, backbone, bases and all atoms can be respectively displayed. Rotation and enlargement of a partial structure is easily accomplished.

Computers↗
PubMed1984

Microcomputer programs for back translation of protein to DNA sequences and analysis of ambiguous DNA sequences.

Three computer programs are described which may be used to translate a DNA sequence into a protein sequence, back translate the protein sequence into an ambiguous DNA sequence, and then do pattern searching in the ambiguous sequence. The programs are written in the C programming language, have been compiled to run on a microcomputer under the CP/M 80 operating system, and may be copied in binary format through a modem. They are also to become available for the IBM/PC.

Amino Acid Sequence↗
PubMed1986

A collection of programs for nucleic acid and protein analysis, written in FORTRAN 77 for IBM-PC compatible microcomputers.

We have developed a collection of programs for manipulation and analysis of nucleotide and protein sequences. The package was written in Fortran 77 on a Sirius1/Victor microcomputer which can be easily implemented on a large variety of other computers. Some of the programs have already been adapted for use on a Vax 11. Our aim was to develop programs consisting of small, comprehensible and well documented units that have very fast execution times and are comfortably interactive. The package is therefore suitable for individual modifications, even with little understanding of computer languages.

Amino Acid Sequence↗