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The metaphysics of brain death.

The dominant conception of brain death as the death of the whole brain constitutes an unstable compromise between the view that a person ceases to exist when she irreversibly loses the capacity for consciousness and the view that a human organism dies only when it ceases to function in an integrated way. I argue that no single criterion of death captures the importance we attribute both to the loss of the capacity for consciousness and to the loss of functioning of the organism as a whole. This is because the person or self is one thing and the human organism is another. We require a separate account of death for each. Only if we systematically distinguish between persons and human organisms will we be able to provide plausible accounts both of the conditions of our ceasing to exist and of when it is that we begin to exist. This paper, in short, argues for a form of mind-body dualism and draws out some of its implications for various practical moral problems.

Beginning of Human Life↗

The relation between attained adult height and the metaphyseal lesions in hypophosphataemic vitamin-D resistant rickets.

In 13 young adult patients (5 men and 8 women) adult height was correlated with the average rachitic activity on radiographs of the wrist, taken at intervals during childhood. To this end the rachitic activity was classified into 4 different, clearly distinguishable stages according to its severity. The coefficient of correlation between adult height (expressed as standard deviation score) and the average rachitic activity or score was -0.796 (p less than 0.01), indicating that adult height varied inversely with the severity of the disease. The regression equation between adult height (y) and the rachitic score (x) was: y = -1.53x + 0.90; the SEy was 0.76. Although the coefficient of correlation was highly significant, this value for SEy indicated that much of the observed variation was due to other factors, apart from the rachitic process.

Adult↗

Sibs with mental retardation, supraorbital sclerosis, and metaphyseal dysplasia: frontometaphyseal dysplasia, craniometaphyseal dysplasia, or a new syndrome?

A brother and sister are presented with unusual facies, bilateral mixed hearing loss, mental retardation, and widespread radiological abnormalities. The clinical and radiological evidence for and against the two most likely diagnoses of frontometaphyseal dysplasia and craniometaphyseal dysplasia is considered.

Abnormalities, Multiple↗

Metaphyseal giant-cell tumor in a girl of 14.

A case of giant-cell tumor in the radial metaphysis of a 14-year-old girl is reported. 3.5% of these tumors are detected in patients younger than 15 years of age, when closure of the cartilaginous growth plate occurs. A significant number of the 14% of giant-cell tumors detected in patients younger than 20 may originate in a metaphysis during adolescence and become symptomatic only after long bone epiphyseal involvement.

Adolescent↗