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At least 613 records · Page 34Linked to original sources
PubMed2001

Fan effects reveal position-specific numerical concepts.

We examined associative interference (i.e., fan) effects to determine if the numerical concepts mediating numerical fact retrieval can be position specific. Participants memorized 15 "diamond arithmetic" facts (e.g., 3 [symbol: see text] 5 = 97; Whalen, 1997) involving five different operands. Ignoring operand position (i.e., left vs. right), each operand appeared equally often across items (i.e., position-independent fan was constant). In contrast, position-specific fan values varied across items (e.g., 2 appeared five times as the left operand, but once in the right position; 3 appeared four times as the left operand, and twice as the right operand, etc). Thus, we expect a fan effect only if the concepts activated by arithmetic operands are position specific. Results indicated that position-specific fan was an excellent predictor of trials to criterion, error rate, and latency. The concepts mediating number fact retrieval can be position specific.

Adolescent↗
PubMed2003

Adults' understanding of inversion concepts: how does performance on addition and subtraction inversion problems compare to performance on multiplication and division inversion problems?

Problems of the form a + b - b have been used to assess conceptual understanding of the relationship between addition and subtraction. No study has investigated the same relationship between multiplication and division on problems of the form d x e / e. In both types of inversion problems, no calculation is required if the inverse relationship between the operations is understood. Adult participants solved addition/subtraction and multiplication/division inversion (e.g., 9 x 22 / 22) and standard (e.g., 2 + 27 - 28) problems. Participants started to use the inversion strategy earlier and more frequently on addition/subtraction problems. Participants took longer to solve both types of multiplication/division problems. Overall, conceptual understanding of the relationship between multiplication and division was not as strong as that between addition and subtraction. One explanation for this difference in performance is that the operation of division is more weakly represented and understood than the other operations and that this weakness affects performance on problems of the form d x e / e.

Adolescent↗
PubMed1990

Conditional discrimination of series containing either two or three rewarded trials.

Series of trials differing only in the number of rewarded trials (2R or 3R series) were used to test rats' ability to learn conditional numerical discriminations. Although the series were conditionally related to initially non-numerical situations, the rats successfully learned the discrimination. It is concluded that these discriminations can plausibly be conceptualized as conditional counting. A pair of transfer tests given after the discriminations were well established suggested that, under these conditions, numerical information will overshadow other non-numerical sources of discrimination made relevant by the transfer shifts.

Animals↗
PubMed2003

A sense of life: computational and experimental investigations with models of biochemical and evolutionary processes.

We collaborate in a research program aimed at creating a rigorous framework, experimental infrastructure, and computational environment for understanding, experimenting with, manipulating, and modifying a diverse set of fundamental biological processes at multiple scales and spatio-temporal modes. The novelty of our research is based on an approach that (i) requires coevolution of experimental science and theoretical techniques and (ii) exploits a certain universality in biology guided by a parsimonious model of evolutionary mechanisms operating at the genomic level and manifesting at the proteomic, transcriptomic, phylogenic, and other higher levels. Our current program in "systems biology" endeavors to marry large-scale biological experiments with the tools to ponder and reason about large, complex, and subtle natural systems. To achieve this ambitious goal, ideas and concepts are combined from many different fields: biological experimentation, applied mathematical modeling, computational reasoning schemes, and large-scale numerical and symbolic simulations. From a biological viewpoint, the basic issues are many: (i) understanding common and shared structural motifs among biological processes; (ii) modeling biological noise due to interactions among a small number of key molecules or loss of synchrony; (iii) explaining the robustness of these systems in spite of such noise; and (iv) cataloging multistatic behavior and adaptation exhibited by many biological processes.

Animals↗
PubMed2003

Pair hidden Markov models on tree structures.

MOTIVATION: Computationally identifying non-coding RNA regions on the genome has much scope for investigation and is essentially harder than gene-finding problems for protein-coding regions. Since comparative sequence analysis is effective for non-coding RNA detection, efficient computational methods are expected for structural alignments of RNA sequences. On the other hand, Hidden Markov Models (HMMs) have played important roles for modeling and analysing biological sequences. Especially, the concept of Pair HMMs (PHMMs) have been examined extensively as mathematical models for alignments and gene finding. RESULTS: We propose the pair HMMs on tree structures (PHMMTSs), which is an extension of PHMMs defined on alignments of trees and provides a unifying framework and an automata-theoretic model for alignments of trees, structural alignments and pair stochastic context-free grammars. By structural alignment, we mean a pairwise alignment to align an unfolded RNA sequence into an RNA sequence of known secondary structure. First, we extend the notion of PHMMs defined on alignments of 'linear' sequences to pair stochastic tree automata, called PHMMTSs, defined on alignments of 'trees'. The PHMMTSs provide various types of alignments of trees such as affine-gap alignments of trees and an automata-theoretic model for alignment of trees. Second, based on the observation that a secondary structure of RNA can be represented by a tree, we apply PHMMTSs to the problem of structural alignments of RNAs. We modify PHMMTSs so that it takes as input a pair of a 'linear' sequence and a 'tree' representing a secondary structure of RNA to produce a structural alignment. Further, the PHMMTSs with input of a pair of two linear sequences is mathematically equal to the pair stochastic context-free grammars. We demonstrate some computational experiments to show the effectiveness of our method for structural alignments, and discuss a complexity issue of PHMMTSs.

Algorithms↗
PubMedDate not supplied

Prospects for development of a transmission blocking vaccine against Schistosoma japonicum.

Despite intensive long-term control programmes, schistosomiasis japonica remains a serious public health problem in China and the Philippines. The termination of mass praziquantel-treatment has seen a dramatic recent rebound in both its prevalence and associated morbidity. Schistosomiasis japonica is a zoonosis but, despite complicating control efforts, this feature provides a practical method for attacking Schistosoma japonicum through development and deployment of a transmission blocking veterinary vaccine. A recently completed bovine drug intervention trial and mathematical modelling of the transmission of S. japonicum underpin the concept that such a vaccine, targeting water buffalo, would have major implications for future integrated schistosomiasis control in China. A major block to success is the low ceiling efficacy achieved with current vaccine molecules. To solve this challenge, an antigen discovery pipeline needs to be established for identification of new vaccine targets that induce greater potency than the current anti-S. japonicum candidate vaccines. Excretory-secretory products and molecules exposed on epithelial surfaces (including receptors) which interact directly with the host immune system warrant especial attention. Extensive schistosome genomics programmes currently underway coupled with new advances in proteomics and microarray technology provide an unparalleled opportunity to identify new molecules exploitable as vaccine targets. These will then need to be produced in quantity and rigorously tested first in the laboratory and then the field. If a transmission blocking veterinary vaccine developed for bovines can be put into practice in combination with other control strategies such as human chemotherapy, elimination of S. japonicum from China may be achievable.

Animals↗
PubMed1995

Motivational styles in English and mathematics among children identified as having special educational needs.

This study is concerned with the identification, development and prevalence of three different motivational styles: learned helplessness, self-worth motivation and mastery orientation in two National Curriculum core subjects: English and mathematics. These three motivational styles are concerned with the ways in which children respond in the face of difficult and challenging educational tasks. Using Craske's (1988) procedures, a total of 437 children in their first year of secondary school (aged 11-12) were categorised into one of the three motivational styles. Children with special educational needs were identified using a battery of cognitive ability tests (Thorndike, Hagen & France, 1986). This study compares the prevalence of each motivational style in English and mathematics in children of different abilities and presents empirical support for the view that learned helplessness and self-worth motivation are more prevalent among children identified as having special educational needs. Further analyses indicate that: overall, learned helplessness and self-worth motivation are more prevalent in English than mathematics; learned helplessness is more prevalent among girls and self-worth motivation among boys in mathematics. Implications for teachers in developing teaching strategies which foster mastery orientation in their children are discussed.

Adolescent↗
PubMed2004

Language and the origin of numerical concepts.

Reports of research with the Pirahã and Mundurukú Amazonian Indians of Brazil lend themselves to discussions of the role of language in the origin of numerical concepts. The research findings indicate that, whether or not humans have an extensive counting list, they share with nonverbal animals a language-independent representation of number, with limited, scale-invariant precision. What causal role, then, does knowledge of the language of counting serve? We consider the strong Whorfian proposal, that of linguistic determinism; the weak Whorfian hypothesis, that language influences how we think; and that the "language of thought" maps to spoken language or symbol systems.

Animals↗
PubMed2005

A brief conceptual tutorial on multilevel analysis in social epidemiology: investigating contextual phenomena in different groups of people.

STUDY OBJECTIVE: (1) To provide a didactic and conceptual (rather than mathematical) link between multilevel regression analysis (MLRA) and social epidemiological concepts. (2) To develop an epidemiological vision of MLRA focused on measures of health variation and clustering of individual health status within areas, which is useful to operationalise the notion of "contextual phenomenon". The paper shows how to investigate (1) whether there is clustering within neighbourhoods, (2) to which extent neighbourhood level differences are explained by the individual composition of the neighbourhoods, (3) whether the contextual phenomenon differs in magnitude for different groups of people, and whether neighbourhood context modifies individual level associations, and (4) whether variations in health status are dependent on individual level characteristics. DESIGN AND PARTICIPANTS: Simulated data are used on systolic blood pressure (SBP), age, body mass index (BMI), and antihypertensive medication (AHM) ascribed to 25 000 subjects in 39 neighbourhoods of an imaginary city. Rather than assessing neighbourhood variables, the paper concentrated on SBP variance between individuals and neighbourhoods as a function of individual BMI. RESULTS: The variance partition coefficient (VPC) showed that clustering of SBP within neighbourhoods was greater for people with a higher BMI. The composition of the neighbourhoods with respect to age, AHM use, and BMI explained about one fourth of the neighbourhood differences in SBP. Neighbourhood context modified the individual level association between BMI and SBP. Individual level differences in SBP within neighbourhoods were larger for people with a higher BMI. CONCLUSIONS: Statistical measures of multilevel variations can effectively quantify contextual effects in different groups of people, which is a relevant issue for understanding health inequalities.

Adult↗
PubMed2004

Gaussian processes for machine learning.

Gaussian processes (GPs) are natural generalisations of multivariate Gaussian random variables to infinite (countably or continuous) index sets. GPs have been applied in a large number of fields to a diverse range of ends, and very many deep theoretical analyses of various properties are available. This paper gives an introduction to Gaussian processes on a fairly elementary level with special emphasis on characteristics relevant in machine learning. It draws explicit connections to branches such as spline smoothing models and support vector machines in which similar ideas have been investigated. Gaussian process models are routinely used to solve hard machine learning problems. They are attractive because of their flexible non-parametric nature and computational simplicity. Treated within a Bayesian framework, very powerful statistical methods can be implemented which offer valid estimates of uncertainties in our predictions and generic model selection procedures cast as nonlinear optimization problems. Their main drawback of heavy computational scaling has recently been alleviated by the introduction of generic sparse approximations.13,78,31 The mathematical literature on GPs is large and often uses deep concepts which are not required to fully understand most machine learning applications. In this tutorial paper, we aim to present characteristics of GPs relevant to machine learning and to show up precise connections to other "kernel machines" popular in the community. Our focus is on a simple presentation, but references to more detailed sources are provided.

Algorithms↗
PubMed1991

Applications of fractal analysis to physiology.

This review describes approaches to the analysis of fractal properties of physiological observations. Fractals are useful to describe the natural irregularity of physiological systems because their irregularity is not truly random and can be demonstrated to have spatial or temporal correlation. The concepts of fractal analysis are introduced from intuitive, visual, and mathematical perspectives. The regional heterogeneities of pulmonary and myocardial flows are discussed as applications of spatial fractal analysis, and methods for estimating a fractal dimension from physiological data are presented. Although the methods used for fractal analyses of physiological data are still under development and will require additional validation, they appear to have great potential for the study of physiology at scales of resolution ranging from the microcirculation to the intact organism.

Animals↗
PubMed2004

An expressive three-mode principal components model for gender recognition.

We present a three-mode expressive-feature model for recognizing gender (female, male) from point-light displays of walking people. Prototype female and male walkers are initially decomposed into a subspace of their three-mode components (posture, time, and gender). We then apply a weight factor to each point-light trajectory in the basis representation to enable adaptive, context-based gender estimations. The weight values are automatically learned from labeled training data. We present experiments using physical (actual) and perceived (from perceptual experiments) gender labels to train and test the system. Results with 40 walkers demonstrate greater than 90% recognition for both physically and perceptually labeled training examples. The approach has a greater flexibility over standard squared-error gender estimation to successfully adapt to different matching contexts.

Adult↗
PubMed1998

The self-portrait in adulthood and aging.

Ninety-eight participants aged thirty to eighty-five, drew a self-portrait in which the depiction of face features and limb extremities was studied. Statistical multivariate analysis permitted to describe three classes of drawings with different modes of representation of hands and face features. The representation of the hands was problematic in most of the participants regardless of age. There was a relation between age and not representing the face features: 17 percent of the participants over sixty-five did not represent the face features vs. none of the younger participants. Results are discussed from a psychoanalytic perspective. The difficulties in representing the hands are discussed in relation to castration. The absence of face features in the portraits of some elderly drawers could indicate a minimal age-related defect of the network which establishes that the real mouth and eyes are both symbolic body orifices and imaginary face features. The comments made by some drawers strongly suggest that this absence may also represent an incapacity to face the losses imposed by aging.

Adult↗
PubMed2000

Overall self-confidence, self-confidence in mathematics, and sex-role stereotyping in relation to salivary free testosterone in university women.

This study investigated in 40 young university women the possible relationships between levels of testosterone and specific measures of overall self-confidence and self-confidence in approaching mathematics. Correlations of -.43 and -.49 with each measure of self-confidence, respectively, and level of testosterone were found in the portion of the sample displaying normal ovulatory function. There was no correlation (r=.02) between the measures of mathematics and overall self-confidence. 19 women did not display normal ovulatory function. The only significant result for the full sample was a significant correlation of -.73 between scores on the Bem Sex Role Inventory Masculinity and overall self-confidence. The reasons for the high anovulatory percentage are not clear, nor are the associations which anovulation might have with either hormonal levels or the personality characteristics in question.

Adolescent↗
PubMed2006

Applying principles of development to help at-risk preschoolers develop numeracy.

In a yoked control design, multicultural Head Start 4-year-olds played numerous games involving either numeracy or the oddity principle and insertions into series. Children showed better mastery of oddity and insertions after playing games directed at those two concepts. Numeracy scores on the McCarthy Scales of Children's Abilities (D. McCarthy, 1972) were equivalent for children who played numeracy games and children who played oddity and insertion games. These results are consistent with other research indicating that the understanding of oddity relations and that of insertions are key transitional thinking abilities that support numeracy at the preschool-kindergarten interface.

Child Development↗