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At least 613 records · Page 34Linked to original sources
PubMed1978

[Treatment of mycosis fungoides by PUVAtherapy. Report on 18 cases (author's transl)].

A group of 18 patients with mycosis fungoides (M.F.) was treated by PUVAtherapy. According to VanScott classification, they have been set in:--5 parapsoriasis in large plaques = 5 stages I;--6 stages II;--3 stages III;--2 stages IV;--1Sézary syndrom.--1 erythrodermia. There was complete clearing of 12 patients (66 p. 100); 2 patients (11 p. 100) improved cutaneous lesions without a complete clearing, and there was no response to treatment for 3 patients (22 p. 100) (1 with erythrodermia, 1 with Sézary syndrom and 1 stage IV, and 1 forsaking). The method applied here was different in several points: orally administered methoxalen were given according to the body area (mg/m2) and some of the patients had twice a day puvatherapy. Puvatherapy seems to be the least dangerous and most effective treatment for the patients in the early stages of mycosis fongoides (I, II) and nitrogen mustard, electron therapy, corticoids and even mono- or polychimiotherapy could be associated to puvatherapy, if necessary, for the stages III and IV.

Aged↗
PubMed1983

Granulomatous mycosis fungoides. A 14-year follow-up of a case.

This is a 14-year follow-up of a patient with granulomatous mycosis fungoides. The patient has had nodular lesions of mycosis fungoides for more than 30 years, an unusually long survival for the nodular form of the disease that is often quickly fatal. The role of the granulomatous inflammatory response in his survival is speculated upon.

Follow-Up Studies↗
PubMed1981

Mycosis fungoides in the maxillary sinus and oral cavity: report of two cases.

Two cases of biopsy-proven mycosis fungoides are described. Case 1 appears to be the first reported instance of mycosis fungoides in the maxillary sinus. Case 2 involves persistently recurring lesions within the oral cavity, which appear to have been placed in a long-term remission by a full course of cobalt irradiation therapy to the entire oral cavity.

Aged↗
PubMed1982

[Topical application of ACNU for the treatment of mycosis fungoides].

The effects of topical chemotherapy of 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) on the lesions of mycosis fungoides were evaluated in 7 patients, ranging in age from 44 to 79 years old. Either 0.2% or 0.4% concentration of ACNU, in ointment and ethanol was used. 0.4% ACNU ethanol solution was effective in bringing the plaque lesions under satisfactory control with a complete clearance. ACNU was painted two to three times a week with a maximum dose of 50mg. Irritation and erosion of the applied areas were the major side effects, which were however, controlled by topical steroid ointment. No serious side effects of marrow and liver function were found even when ACNU was applied as long as 40 months (total ACNU dose: 16 gm). Histologically the cleared lesions revealed the thinning of epidermis, almost complete loss of lymphocytic infiltrates and fibrosis of dermis which was density infiltrated by lymphocytes prior to the ACNU therapy. Thus, topical chemotherapy of ACNU appears to be encouraged for modifying the plaque lesions of mycosis fungoides.

Administration, Topical↗
PubMed1980

[Topical, intratumor and intravenous nitrogen mustard in the treatment of mycosis fungoides (author's transl)].

Topical nitrogen mustard (NH2) is recommended in mycosis fungoides stages 1 or 2 (eczematous premycotic phase and plaque stage), intratumor infiltration in stage 3 (tumor stage) and intravenous administration in stages 4 and 5 (widespread disease). Following these criteria ten patients with mycosis fungoides have been treated with NH2. Six cases were included in stages 1 or 2 and complete remission was achieved in four of them. Therapy had to discontinued in one case due to allergic hypersensitivity. The remaining patient experienced clinical improvement after 27 months of continued treatment. There were three patients in stages 4 and 5 and all their plaques disappeared after topical NH2, but tumor regression was completely achieved in one case adn partially in the remaining two. A case with Sezary's syndrome was treated in addition with chlorambucil. Association of newer palliative measures (topical NH2, high energy electron beam therapy, nitrosourea derivatives) offer a hope of cure for patients in stages 1 or 2. Tumor stage requires systemic chemotherapeutic agents (chlorambucil tablets and intravenous nitrogen mustard).

Administration, Topical↗
PubMed1982

The treatment of mycosis fungoides with ointment-based mechlorethamine.

The use of topical mechlorethamine hydrochloride in the treatment of skin disease has been restricted because of the frequent development of contact dermatitis. A series of 24 patients with mycosis fungoides in stages 1A (eight patients), 1B (15 patients), and 2 (one patient) were treated with ointment-based mechlorethamine, prepared by an anhydrous method. This preparation was therapeutically effective. Complete clearing occurred in 15 of 18 patients with active disease over evaluation periods of up to 27 months, and one patient had partial clearing. Two patients showed a partial relapse during their evaluation periods. The incidence of contact dermatitis was very low: 8% in individuals with a history of hypersensitivity to mechlorethamine and 0% in patients being exposed to the medication for the first time. This new preparation has been shown to be effective therapy for mycosis fungoides. Patient use is associated with minimal side effects.

Administration, Topical↗
PubMed1982

Hyperkeratosis in mycosis fungoides.

A case of mycosis fungoides with hyperkeratotic changes of the nails, palms, and soles is presented. Although these features have been reported in the older literature, most contemporary authors neglect to mention this interesting cutaneous change in mycosis fungoides.

Antineoplastic Agents↗
PubMed1982

Widespread cutaneous candidiasis and tinea infection masking mycosis fungoides.

A 71-year-old female with a widespread double mycotic infection caused by C. Albicans and T. rubrum was discovered to be suffering from mycosis fungoides. Clinically she was found to have large, polycyclic erythematous plaques with scaly, slightly infiltrated borders, covering almost all areas of the glabrous skin, and also involving the scalp (with no hair penetration), the soles and palms, toe-webs, finger and toe nails; there was also perleche and oral thrush. Cultures yielded C. albicans from most of the skin lesions, from the scalp, mouth, finger nails and urine and stool specimens, and T. rubrum from intermingled skin specimens, from the palms and soles and toe-nails. Blood culture was negative as were intracutaneous tests with fungal antigens and tuberculin. Histological examination confirmed the fungal invasion of the horny layer and at the same time revealed an underlying pathologic picture of mycosis fungoides, the lesions having been masked by the mycotic eruption. Intensive cytostatic and antifungal therapy led to a transient improvement but shortly thereafter there was a relapse of the fungal and lymphoproliferative manifestations and the patient died in septic shock.

Aged↗
PubMed1981

[Alternations of dermal lymphocytes in mycosis fungoides, a study with the scanning electron microscope (author's transl)].

Isolated dermal lymphocytes from the infiltrate of mycosis fungoides show on scanning electron microscopic examination following characteristics, which differ from normal lymphocyte surface: loss of the round cell shape, increase of absolute length of microvilli, increase of lymphocytes with smooth surface and mitoses. These alterations concern all immunologic subpopulations and may indicate a stimulation of the whole dermal infiltrate in mycosis fungoides.

Cell Membrane↗
PubMed1981

Clinicopathologic correlations in Alibert-type mycosis fungoides.

Five cases of mycosis fungoides of the Alibert type were studied by taking multiple biopsy specimens at different stages of the disease. Large hyperchromatic, slightly irregular mononuclear cells are the most frequent cells. Ultrastructurally, the cells were only slightly convoluted, had prominent heterochromatin banding at the nuclear membrane, and unremarkable cytoplasmic organelles. Highly convoluted cerebriform nucleated cells were few. Large regular vesicular histiocytes were prominent in the early stages. Ultrastructurally, the cells showed evenly distributed euchromatin. Epidermotrophism was equally as important as Pautrier's abscess as a hallmark of the disease. Stereologic techniques comparing the infiltrate with regard to size and convolution of cells in all stages of mycosis fungoides with infiltrates seen in a variety of benign dermatoses showed no statistically significant differences.

Aged↗
PubMed1980

Familial mycosis fungoides revisited.

Familial examples of mycosis fungoides are rarely seen; to my knowledge, only two carefully documented examples have been reported. This report uniquely involves a father and daughter. The disease onset in the daughter occurred 24 years after the father's death from mycosis fungoides.

Aged↗
PubMed1994

The role of total skin electron beam radiation therapy in the management of mycosis fungoides.

Total skin electron therapy is a complex method of delivering superficial radiation therapy to the entire skin surface. It is an effective means of treating cutaneous malignancies which involve large surface areas of the skin. Mycosis fungoides is the most common malignancy treated in this manner. Understanding the rational and technique of total skin electron beam therapy, the characteristics of mycosis fungoides, and nursing interventions for related patient problems will enable dermatology nurses to better educate patients afflicted with MF who may be undergoing or considering radiation therapy.

Humans↗
PubMed1994

Epidemiology of mycosis fungoides.

Study of the epidemiology of mycosis fungoides has been hampered by methodologic issues. Mycosis fungoides does appear to be increasing in frequency more rapidly than lymphoma in general. There is substantial geographic variation, as well as variation by race and gender. Analytic studies have not demonstrated additional risk factors.

Adult↗
PubMed1994

Topical carmustine (BCNU) for patch/plaque mycosis fungoides.

This article summarizes experience with topical carmustine (BCNU) solution in 172 patients with patch/plaque stage mycosis fungoides. At 36 months 92% of stage-T1 (less than 10% skin involvement) and 64% of stage-T2 (10% or more skin involvement) patients were either in complete or partial remission. The most frequent side effect was an erythematous reaction which was followed by a benign-type telangiectasia in some patients. No secondary skin cancers were seen. Bone marrow depression was uncommon. Topical BCNU is an effective treatment for patch/plaque stage mycosis fungoides.

Administration, Topical↗
PubMed1993

HTLV-I-related retroviral markers in Hungarian patients with mycosis fungoides.

Cell and serum samples from 7 Hungarian patients with mycosis fungoides were examined for the presence of HTLV-I-related DNA sequences and antibodies recognizing HTLV-I antigens. DNA sequences distantly related to the proviral DNA of HTLV-I were shown by Southern blot hybridization in 3 patients. Serum samples from these patients contained antibodies reactive with the internal core polypeptides of HTLV-I and HTLV-II, but not with the env gene encoded type-specific HTLV antigens. Restriction enzyme analysis with EcoRI, PstI, BamHI and SacI revealed structural similarity of the provirus(es) integrated in the DNA of mycosis fungoides cells to HTLV-I but not to HTLV-II. Data suggest that these proviruses and HTLV-I are similar to each other along gag and pol regions.

DNA, Viral↗
PubMed1995

[Mycosis fungoides in the child. Three cases].

INTRODUCTION: Cutaneous lymphoma is unusual in children but according to data in the literature, approximated 5 p. 100 of the cases observed would begin in childhood. CASE REPORT: We retrospectively studied 3 cases of mycosis fungoides where the first manifestations occurred before 10 years of age. In one of the patients, the diagnosis was not definitively confirmed until adulthood. DISCUSSION: Diagnosis in these forms which begin in childhood is usually achieved after a long delay. Clinically, these lymphomas form a homogeneous group. In approximately 15 p. 100, guttate parapsoriasis occurs before mycosis fungoides. Biopsy is indicated if the lesions change in aspect or become atypical. The most frequent presentation in children or young adults is vitiligoid hypo-pigmented macules. Histologically, childhood forms do not differ from the adult forms and also respond to local treatment as in adults. Prospective studies conducted conjointly by paediatricians and dermatologists would be needed to describe the natural history of these cutaneous lymphomas in light of progression to aggressive lymphoma of Hodgkin's disease described in certain cases.

Antigens, CD↗
PubMed1996

Mycosis fungoides associated with unusual epidermal hyperplasia.

A 58-year-old white woman presented with widespread pruritic brownish plaques and hyperpigmented flexural lesions with a velvety appearance. On histopathological examination, the macules were diagnostic of mycosis fungoides, plaque stage, and the flexural lesions showed epidermal hyperplasia with a seborrhoeic keratosis-like appearance. There was intense mucin deposition and marked reduction of elastic fibres in the papillary dermis, as well as a moderately dense dermal lymphoid infiltrate composed of CD4+ T cells with occasional atypia and focal epidermotropism. The clinical and pathological manifestations of cutaneous T-cell lymphomas, including mycosis fungoides (MF), may show considerable variation. Apart from the three classic stages, a number of unusual clinical presentations and a broad spectrum of histopathological findings have been reported in the literature. In this report, a case of MF, plaque stage, with flexural lesions clinically reminiscent of (pseudo)acanthosis nigricans is presented. On histopathological examination, there was epidermal hyperplasia with a seborrhoeic keratosis-like appearance, with intense deposition of mucin and marked reduction of elastic fibres in the papillary dermis, together with a lymphoid infiltrate composed mainly of CD4+ cells with occasional atypia and epidermotropism. Cytokines produced by the lymphocytes in the infiltrate might account for the epithelial and dermal changes that characterize this peculiar variant of MF.

Female↗