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At least 613 records · Page 34Linked to original sources
PubMed1991

[The parasitism characteristics of the causative agent of melioidosis in the host cells].

The electron microscopic study of the damaged areas of the lungs, liver, spleen and lymph nodes of guinea pigs infected with two P. pseudomallei virulent strains C-141 and 100 has revealed that this organism is a facultative intracellular parasite and exhibits tropism to reticuloendothelial cells of the body, parasitizing both in "professional" phagocytes (mononuclear, phagocytes, polymorphonuclear leukocytes) and "nonprofessional" phagocytes (capillary endotheliocytes, splenic and lymph-node reticulocytes). In the course of their intracellular development P. pseudomallei have been shown to form capsules protecting the pathogens from the unfavorable action of the protective mechanisms of the host cells.

Acute Disease↗
PubMed1991

[The role of the surface antigens of Pseudomonas pseudomallei in the pathogenesis of melioidosis].

As established with the use of electron-immunochemical techniques, glycoprotein antigen 6 is the outer membrane component of P. pseudomallei cell wall, while glycoprotein antigen 8 is localized on the cell surface as a capsule-like formation. Antigen 6 plays no perceptible role in the realization of the pathogenic properties of the infective agent, but serves as a reliable sign in the differentiation of P. pseudomallei strains into serovars. Subcultures, defective in the synthesis of antigen 8, have sharply reduced virulence for laboratory animals. As revealed in this study, the pathogenetic action of antigen 8 is linked with its pronounced antiphagocytic function. Thus, antigen 8 is considered to be one of the key pathogenicity factors of P. pseudomallei.

Animals↗
PubMed1989

[Antigenic properties of the electrophoretic fractions of the causative agent of melioidosis].

Antisera to the antigens of 5 fractions, isolated as the result of the separation of P. pseudomallei aqueous saline extract by continuous electrophoresis in the vertical block of granulated gel, have been obtained. Immunoelectrophoresis with the use of P. pseudomallei aqueous saline extract has revealed that antisera to electrophoretic fractions contain antibodies mainly to the antigens of the corresponding fractions, which shows that this technique ensures the effective separation of P. pseudomallei biopolymers by their electrophoretic motility and molecular weight. These antisera differ in their species specificity. Thus, antisera to antigens with anode motility have been found to contain antibodies mainly to P. pseudomallei antigens and antisera to electroneutral antigens or to those with cathode motility, to P. pseudomallei and P. mallei antigens.

Animals↗