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High-resolution computed tomography of the middle ear and mastoid. Part I: Normal radioanatomy including normal variations.

The use of high-resolution computed tomography (CT) to examine the middle ear and mastoid is discussed. Exceptional detail of the viscera of the middle ear was attained in almost all cooperative patients with proper technique. Important anatomical structures are illustrated and discussed, and the appropriate projection for depicting specific structures is emphasized. Normal variations, preoperative knowledge of which is important to the otologic surgeon, are also illustrated.

Ear Ossicles↗

Long-term outcome of Ménière's disease: endolymphatic mastoid shunt versus natural history.

This retrospective study evaluates the outcome of 38 patients with intractable Ménière's disease with a minimum of 7 years follow-up. Twenty underwent endolymphatic-mastoid shunt (EMS) and 18 were offered surgery but declined (natural history, NH, group). At the last control, 85% of the patients who were operated on (EMS group) and 74% of the NH patients had complete or substantial control of vertigo. The difference between the two groups was not significant. However, it was significant at 2 and 4 years follow-up. At 2 years, EMS patients had complete or substantial control of vertigo in 65% of the cases, at 4 and 6 years in 85% of the cases. Only 32 % of the NH patients had complete or substantial control of vertigo at 2 years. This percentage rose to 50% at 4 years and to 74% at 6 years. Hearing results in the two groups were not significantly different. Tinnitus disappeared or decreased in 56% of the EMS patients and in 18% of the NH patients. Sixty-seven percent of the EMS patients and 29% of the NH patients reported that their aural fullness was abolished. In conclusion, over the years, approximately 8 out of 10 of our patients with Ménière's disease achieved complete or substantial control of vertigo; however, this reduction was observed earlier in EMS patients than in those who declined surgery.

Adult↗

Neurofibroma in the mastoid segment of the facial canal.

Neural tissue-derived facial nerve tumours usually present as neurinomas. We describe the extremely rare occurrence of a histologically verified neurofibroma primarily arising in the mastoid segment of the facial canal in a patient not fulfilling diagnostic criteria for neurofibromatosis. The tumour showed evidence of perineural growth into the jugular foramen, as suggested by cross-sectional imaging and intraoperative findings.

Facial Nerve Diseases↗

Pharmacokinetics of flomoxef in mucosal tissue of the middle ear and mastoid following intravenous administration in humans.

The pharmacokinetics of flomoxef in serum and in the mucosal tissue of the middle ear and mastoid were studied in 9 patients undergoing tympanoplasties. All patients received 1 g of flomoxef intravenously. Flomoxef levels in serum and in mucosal tissue were determined by a bioassay method. The peak value of mean concentrations of flomoxef in the mucosal tissue was 30.3 +/- 11.7 micrograms/ml at 10 min after the administrations. Pharmacokinetic analyses showed that the concentration of flomoxef in the mucosal tissue was over 1.56 micrograms/ml (which is the MIC90 for the common pathogens of otitis media) for more than 2 h and decreased parallel with serum concentration with a half-life of about 40 min.

Adolescent↗

Study of the distribution of oral ciprofloxacin into the mucosa of the middle ear and the cortical bone of the mastoid process.

This multicentre study evaluates the distribution of ciprofloxacin into the tissue structures of the middle ear following multiple dosing of one 500 mg tablet every 12 h. The samples were taken perioperatively from adult patients due to undergo surgery for chronic otitis. Administration of ciprofloxacin was instigated 9 days prior to the operation. The samples were taken at different intervals after the last dose in order to evaluate variations in concentration with time. The average peak concentrations recorded and the time taken to reach these concentrations were as follows: middle ear mucosa (n = 16): 5.54 +/- 3.46 micrograms/g (3-4 h): cortical bone of the mastoid process (n = 21): 1.07 +/- 1.29 micrograms/g (4 h). The measurements carried out 12 h after the last dose show that concentrations of ciprofloxacin in the middle ear mucosa were still at least as high as the minimum inhibitory concentration for this antibiotic for most of the pathogens implicated in acute exacerbations of chronic otitis. These results suggest that, administered as an oral dose of 500 mg every 12 h, ciprofloxacin may be an effective agent for the treatment of chronic suppurative otitis. These results now need to be backed up by clinical trials.

Administration, Oral↗

Brain herniation into the mastoid in a normal hearing ear.

A cluster of right temporal lobe abscesses in a 40-year-old male originated from an endaural brain hernia affecting the mastoid only, without direct contact with the ossicular chain. In infancy, antrotomy had been performed. Otologic signs were sparse, hearing was normal. Computed tomography of the temporal bone showed homogenous clouding of the retrotympanal spaces and a defect of the tegmen antri. Treatment consisted of transmastoid débridement, reduction and duraplasty with fascia lata.

Adult↗

Bezold's abscess following chronic mastoiditis in a newborn.

Despite the availability of antibiotics, acute otitis media can still lead to major complications. Bezold's abscesses are very rare complications and are usually found only in adults with well-pneumatized mastoid bones. We present the case of a 10-week-old newborn with a Bezold's abscess. It is stressed that acute otitis media can be silent and undetected in infants and can lead to major complications such as Bezold's abscess.

Abscess↗

Mastoid and middle ear cavity obliteration for control of otitis media.

Total soft tissue obliteration of the mastoid-middle ear cavity and primary closure of the external auditory meatus were employed in six patients to control chronic suppurative otitis media. Previously, all these patients had unsuccessful surgery and all but one had profound loss of cochlear function. Thorough removal of cholesteatoma, granulation tissue, and ear canal skin is necessary before total obliteration can be performed safely. Wound healing was complete by one to two weeks postoperatively and all patients have been asymptomatic for two to seven years.

Adult↗

Quantitative histology of the mucous membrane of the accessory nasal sinus and mastoid cavities.

The mucous membranes of the accessory nasal sinuses and of the mastoid labyrinth were measured in undecalcified, plastic-embedded specimens from nonpathologic postmortem cases. Epithelial thicknesses, lamina propria thicknesses and the ratio of nuclear to total cell area of the epithelia are presented for these organs to provide a quantitative basis for dosimetric calculations of alpha-emitting radionuclides. These data will be of value for studies in populations at risk for head carcinomas from the intake of radium and related nuclides.

Adult↗

Labyrinthine fistula in chronic mastoiditis.

A series of 79 otic capsule fistulae occurring in 792 consecutive cases of chronic mastoiditis undergoing mastoidectomy was analyzed. The incidence (10%) is the same as in other large series, the primary difference being the location of the fistula. In all series cited, 90% of fistulae were in the lateral semicircular canal whereas in this series the comparable incidence was 75%. The 20 (25%) fistulae located in areas other than the lateral semicircular canal enabled us to document a method of "reading" the fistula test preoperatively to establish its precise location. Eye responses to the test and the fistula site were entirely consonant with the physiology of the vestibular system. The location of the fistula, in other words, can be reliably predicted by the eye movement. Clinicopathologic correlates are cited.

Chronic Disease↗

Thermal hazards in mastoid surgery: an evaluation of instruments and irrigation techniques.

Study of the mechanical properties of three commonly used mastoid drills disclosed major differences in their power and potential for heat production. Based on available information regarding heat tolerance of neural tissue, all drills were found capable of producing hazardous temperature elevations. After testing several irrigation techniques, continuous and copious suction irrigation was found to be most effective in preventing bone heating.

Biomechanical Phenomena↗

Surgical procedure for the mastoid cavity problem.

When the mastoid cavity infection is the result of breakdown of the skin lining, the cavity should be obliterated. Many types of material have been used, but postauricular tissue has been most effective. Instead of a pedicled flap, a free graft of tissue is recommended because it allows better placement of the graft deep into the cavity. It undergoes a more uniform contracture and does not tend to pull out of the depths of the cavity. The principle of obliteration is not only to obliterate the cavity but also to bring a layer of vascularized subcutaneous tissue between the skin lining and the bone.

Bone Diseases↗

Prolonged ventilation of the middle ear and mastoid cavities: technical considerations.

Chronic eustachian tube dysfunction contributes to many chronic middle ear diseases and to early and late surgical failures. Furthermore, surgeons may overlook air passage obstructions from the mesotympanum to the mastoid cavity. To date, long-term ventilation of the middle ear is the most practical technique of bypassing stubborn eustachian tube and middle ear ventilatory malfunctions. I present the techniques used to overcome and bypass tubal and intratympanic obstructions in 8% of operated ears in the past 6 years.

Ear Diseases↗

Hypercellularity of the mastoid as a cause of spontaneous pneumocephalus.

In this paper two cases are reported in which spontaneous entry of air into the head appears to have occurred through a hypercellular mastoid air cell system. In both these cases forceful sneezing and nose blowing were considered contributory factors. They underwent surgical repair of the bony defects which, combined with less vigorous nose blowing, has affected a successful repair. The aetiology of pneumocephalus is discussed and a review of the pertinent literature is also presented.

Adolescent↗

Adenomatous tumors of the middle ear and mastoid.

Three cases of middle ear and mastoid neoplasms are reported as "adenomatous tumors" since in their search of the literature the authors did not find any previously described lesions with a similar histologic appearance and benign biologic behavior. Microscopically, all three tumors are similarly composed of solid cords and nests of closely-packed small cells having an epithelial appearance. Two distinct cell types are present: cuboidal cells, arranged in a rudimentary gland-like pattern, and angular cells forming irregular nests with no distinct pattern. All three tumors developed in patients in their 20's, over a period of months with minimal symptoms; yet in all of the lesions the tympanic membrane was intact at the time of initial examination. None of the neoplasms was diagnosed preoperatively, and, once removed, all three tumors were pathologic enigmas and therapeutic problems in view of the initial and subsequent consultant pathologic opinions; nevertheless, total local excision with preservation of the tympanic membrane would appear to be safe treatment in these cases. The term "adenomatous tumor" is applied to these three neoplasms because: 1. a true glandular epithelial origin warranting the term adenoma or adenocarcinoma cannot be proven; and 2. the biologic behavior and prognosis is not necessarily reflected by the histologic appearance. A more specific term reflecting the origin and behavior of these tumors does not appear possible without the study of further cases.

Adenocarcinoma↗

Surgical management of brain tissue herniation into the middle ear and mastoid.

In the well pneumatized temporal bone, the temporal lobe of the brain is separated from the middle ear and mastoid process by a thin layer of bone known as the tegmen. Congenital defects, infection, and trauma can alter this structure in such a way that cerebral tissue herniates into the ear. This unusual condition may precipitate numerous otologic problems such as hearing loss, trapped squamous epithelium, and the potential for meningitis or encephalitis. The purpose of this paper is to define the problem as well as discuss the diagnosis and surgical management. The authors feel this should be a team effort, in many cases employing the assistance of a neurosurgeon, as the repair must often be intradural. Case histories and an extensive review of the literature are to be included.

Adult↗