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At least 613 records · Page 34Linked to original sources
PubMed1997

Gordon Holmes, the cortical retina, and the wounds of war. The seventh Charles B. Snyder Lecture.

By the turn of the 20th century, localization of function in the cerebral cortex of the brain had advanced considerably, but a relatively vague idea only existed that human vision was represented in the vicinity of the calcarine cortex. World War I produced a large number of isolated missile wounds of the brain. Their study yielded a complete topographical mapping of the visual field in the primary cortical vision center, and is a basis of our modern interpretation of visual fields. This map has been recently modified by MRI studies to show that the magnification of the central retinal projection onto the cerebral cortex to be even greater than previously thought. Many names are associated with the story of how war led to this knowledge. This essay refers to Harvey Cushing, William Osler, Tatsui Inouye, and most particularly to the career and contributions of the British neurologist Gordon Holmes.

Brain Mapping↗
PubMed1997

Albert Einstein and his mentor Max Talmey. The seventh Charles B. Snyder Lecture.

While he was a student at the Munich medical school, Max Talmey strongly influenced the education of Albert Einstein. Their association occurred during five years of Einstein's second decade. They lost contact for many years after each left Munich. Talmey emigrated to the United States and practiced medicine, mainly ophthalmology, in New York City. He made significant contributions to medicine, to the popularization of Einstein's work, and to the development of international languages. The relationship of Talmey and Einstein was rekindled when Einstein visited and later moved to the United States.

Famous Persons↗
PubMedDate not supplied

Whitaker Lecture 1996: microcirculation, biomedical engineering, and artificial blood.

The development of artificial blood requires the understanding of how blood behaves at the level of the microcirculation. A number of measuring systems have recently become available that allow analysis of the transport properties of blood and the microvessels in terms of pressure, flow, the dynamics of their diameter changes, and the rate and manner of oxygen delivery. Findings from this technology have led to the development of an analytical framework with which to assess the consequences of altering the physical properties of blood and to verify quantitatively theoretical predictions. Results show that blood viscosity and oxygen-carrying capacity are directly related, and must be jointly modified in a prescribed manner to maintain tissue oxygen delivery. The use of optical techniques to assess flow and oxygen delivery in experimental animal models show that the consumption of oxygen by the microvessel wall is an important determinant of tissue oxygenation. Furthermore, the viscosity of blood and/or the mixture of blood and an artificial substitute must achieve a viscosity that is close to normal. Low blood viscosity is not necessarily beneficial, unless blood flow velocity rises to maintain the shear stress at the wall needed for the generation of local vasodilators. Manipulating physical properties of currently available modified hemoglobins by mixing them with conventional plasma expanders yield fluids that may provide optimal blood replacements.

Biomedical Engineering↗
PubMedDate not supplied

Images from Waves--photoelastic modelling of bones. 8th Samuel Haughton Lecture, Bioengineering Section of Royal Academy of Medicine in Ireland. January 2002.

BACKGROUND: This paper cites the development of the principles of photoelastic stress analysis, contemporary to the life of Samuel Haughton. Subsequent studies of bone and joint replacements are discussed, with reference to hypotheses regarding bone, including the coincidence of trabecular structure with principal stresses. Issues regarding assumptions of homogeneous and isotropic properties in photoelastic modelling are acknowledged. AIM: Awareness of photoelastic methods is often through the visual appeal of the coloured fringe patterns. The aim of this paper is to complement this awareness by demonstration of the quantitative analyses that may be conducted through biomechanical examples. METHODS: Examples of new pseudo three-dimensional model analyses are presented together with a method for photoelastic study of cancellous bone, which entails novel procedures for preparation of replicate models and for optical evaluation of fringes. CONCLUSION: Photoelastic analysis offers novel solutions to studies in biomechanics, which are facilitated by contemporary modelling materials.

Animals↗
PubMed2001

Friedrich Miescher Prize awardee lecture review. A conserved family of nuclear export receptors mediates the exit of messenger RNA to the cytoplasm.

The distinguishing feature of eukaryotic cells is the segregation of RNA biogenesis and DNA replication in the nucleus, separate from the cytoplasmic machinery for protein synthesis. As a consequence, messenger RNAs (mRNAs) and all cytoplasmic RNAs from nuclear origin need to be transported from their site of synthesis in the nucleus to their final cytoplasmic destination. Nuclear export occurs through nuclear pore complexes (NPCs) and is mediated by saturable transport receptors, which shuttle between the nucleus and cytoplasm. The past years have seen great progress in the characterization of the mRNA export pathway and the identification of proteins involved in this process. A novel family of nuclear export receptors (the NXF family), distinct from the well-characterized family of importin beta-like proteins, has been implicated in the export of mRNA to the cytoplasm.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMed2004

Visualising insulin secretion. The Minkowski Lecture 2004.

Insulin secretion from pancreatic islet beta cells is a tightly regulated process, under the close control of blood glucose concentrations, neural inputs and circulating hormones. Defects in glucose-triggered insulin secretion, possibly exacerbated by a decrease in beta cell mass, are ultimately responsible for the development of type 2 diabetes. A full understanding of the mechanisms by which glucose and other nutrients trigger insulin secretion will probably be essential to allow for the development of new therapies of type 2 diabetes and for the derivation of "artificial" beta cells from embryonic stem cells as a treatment for type 1 diabetes. I focus here on recent developments in our understanding of beta cell glucose sensing, achieved in part through the development of recombinant targeted probes (luciferase, green fluorescent protein) that allow islet beta cell metabolism and Ca(2+) handling to be imaged in situ in the intact islet with single cell resolution. Combined with classical biochemistry, these techniques show that the beta cell is uniquely poised, thanks to the expression of low levels of lactate dehydrogenase and plasma membrane lactate/monocarboxylate transporters, to channel glucose carbons towards oxidative metabolism, ATP synthesis and inhibition of AMP-activated protein kinase, a newly defined regulator of insulin release. I also discuss the molecular basis of the recruitment of secretory vesicles to the cell surface, analysed by the use of new imaging techniques including total internal reflection of fluorescence, as well as the "nanomechanics" of the exocytotic event itself.

Animals↗
PubMed2005

Prediction, progression and prevention of diabetic nephropathy. The Minkowski Lecture 2005.

Diabetic nephropathy is a major problem for patients and health care systems. The costs of treatment remain high. To confront the ongoing challenge, we need to identify individuals at high risk for initiation and progression of this devastating complication. Risk factors include genetic markers; constitutional factors such as low birthweight; haemodynamic factors, including activation of the RAS system and hypertension; metabolic factors such as glycaemia; and additional factors such as urinary AER and smoking. Modifiable risk factors should be treated aggressively. Potential new markers of risk include indices of increased inflammation, changes in coagulation, endothelial dysfunction, growth factors and cytokines. Application of such markers may in time improve risk assessment and allow new treatment targets to be identified. Interventions that aim to achieve strict glycaemic control and blockade of the renin-angiotensin system have been shown to be effective in clinical trials and are feasible in clinical practice. The 'natural history' of diabetic nephropathy can be transformed if these strategies of intensive screening and care are applied, leading both to a lower incidence of diabetic nephropathy and to an improved outcome, with survival exceeding 20 years from onset of overt proteinuria.

Biomarkers↗