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At least 613 records · Page 34Linked to original sources
PubMed1998

Normal intelligence with severe insulin-like growth factor I deficiency due to growth hormone receptor deficiency: a controlled study in a genetically homogeneous population.

Superior school performance was reported for 52 Ecuadorian probands with severe deficiency of insulin-like growth factor I (IGF-I) due to GH receptor deficiency (GHRD) resulting from homozygosity for the E180 splice mutation of the GHR. In contrast, subnormal intelligence was reported in a study of 18 genetically heterogeneous Israeli patients, attributed to frequent hypoglycemia or IGF-I dependence of brain development. This study is the first controlled evaluation of the intellectual ability of patients with GHRD. We compared the intelligence of 18 patients of school age (mean +/- SD age, 11.5 +/- 2.8 yr), 42 of their relatives (11.5 +/- 2.8 yr), and 28 community controls (10.0 +/- 0.8 yr), using a battery of intelligence tests that have been validated in cross-cultural research, designed to minimize the effects of physical size, motor coordination, and cultural background. Because all patients had the same GHR mutation, for which the carrier state could be determined, this study also investigated whether heterozygosity for mutation of the GHR among unaffected relatives is associated with intelligence. The intellectual ability of the patients with GHRD was not significantly different from that of their relatives (P > 0.05) on the psychometric tests of intelligence and was comparable to that of the community controls on the chronometric tests. Homozygosity or heterozygosity for the mutation in the GHR gene common to Ecuadorian patients was unrelated to intelligence (P > 0.05). These results indicate that the gene defect causing GHRD is not related to intelligence in the Ecuadorian population. They also indicate that GH-induced IGF-I production is not required for normal brain growth in utero or for postnatal intellectual development.

Adolescent↗
PubMed1993

Cognitive skills in achondroplasia.

Increased intracranial pressure and ventricular and subarachnoidal dilatation are common manifestations in achondroplasia. They rarely lead to major neurologic and/or psychomotor deficits and neurosurgical intervention is seldom needed. The present study was undertaken to detect signs of minor cerebral dysfunction and discuss possibilities of their prevention. Thirty children with achondroplasia were compared to 3 control groups: their next-born sibs, 30 children with other forms of dwarfism, and 30 children with normal height. Early development was assessed by means of questionnaires. Cognitive skills were evaluated with the German version of the Cognitive Abilities Test and the Lorge-Thorndike Intelligence Test. Personality data were tested using standardized neuroticism, extraversion, and anxiety scales. Children with achondroplasia had more frequent histories of delayed motor development, retarded speech development, and lower school grades in language-related specialties. Psychometric testing disclosed total and subtest scores in the population-based normal range. In comparison with their sibs and matched controls children with achondroplasia had significantly lower total scores mainly caused by low scores in the subtest "verbal comprehension." We conclude that verbal comprehension is significantly impaired in children with achondroplasia. This partial deficiency is probably related to frequent middle ear infections and resulting conductive hearing loss. Hypotonia with delayed oropharyngeal muscle coordination and parental response to an altered, more infantile instinctive releasing pattern may be contributing factors.

Achondroplasia↗
PubMed1993

Results of parenchymal and angiographic magnetic resonance imaging and neuropsychological testing of children after stroke as neonates.

We describe the long-term follow up of infants after neonatal stroke of the middle cerebral artery (MCA). Stroke was diagnosed by CT scan in eight full-term neonates. Three dimensional (volume) magnetic resonance angiography (MRA) is a noninvasive technique that images the arterial vessels without contrast agents. All patients, aged from 1.5 to 8.4 years, were investigated by MRI and MRA and by neuropsychological tests. Cognitive development was investigated by intelligence tests, tests of visual perception, motor and language development. Out of the eight patients, seven had a retarded mental and motor development, and 50% of the children were treated for epilepsy. Seven patients had a spastic hemiparesis. Seven out of eight children showed major cognitive deficits. In all patients, MRI revealed clear parenchymal defects with variable distribution patterns. MRA studies showed abnormalities corresponding to the expected vascular distribution. Children with complications at delivery, with seizures, and an interruption of the main stem of MCA as demonstrated on MRA had the least favourable long-term follow up prognosis with severe cognitive delays.

Cerebral Arteries↗
PubMed1987

Psychiatric interviews and psychological tests as predictors of medical students' success.

Psychiatric interviews carried out during the first year of four medical school classes of the University of Chicago School of Medicine (now Pritzker School of Medicine) during 1946 through 1949 were found to be statistically significant in predicting the students' graduation. However, the number of "false negatives" was high; that is, a large number of students predicted not to graduate did graduate. Psychological tests--consisting of personality, interest, and intelligence tests--were not statistically significant in predicting graduation. Neither the interviews nor the tests correctly predicted the students' mental or physical health or their occupational or marital adjustment as of 1982, as measured by replies to a questionnaire from more than 90 percent of the students in the original study who could be located. There is some subjective evidence that moderate degrees of anxiety, immaturity, and compulsivity are not associated with failure to complete medical school but that passivity, withdrawal, and weak motivation are. Although psychiatric interviewing of applicants is not now feasible because of legal restrictions, some of the findings of the study reported here may be useful for admission interviewers and as a basis for further research.

Achievement↗
PubMed1992

Acoustical changes of loudly spoken speech and their effects on speech recognition in hearing-impaired listeners.

The level of speech is usually increased in conversations with unaided hearing-impaired listeners. However, the speaker may talk at conversational levels to aided hearing-impaired persons. In this case, the level of speech is electronically increased by the hearing aid. In the present study, the acoustical changes of loudly spoken speech and their effects on speech recognition were investigated in 20 patients with sensorineural hearing loss. Eight test words of the German Speech Intelligibility Test ('Freiburger Sprachtest') were recorded at original levels of 60 and 75 dB SPL by a male speaker. Both recordings were presented to hearing-impaired subjects at a playback level of 75 dB SPL. Thus, the level of the 60 dB SPL recording was increased electronically by 15 dB. For the 75 dB SPL recording, playback and recording levels were identical. The average whole-word score was 49% for the 60 dB SPL recording and 39% for the 75 dB SPL recording. This difference was statistically significant (0.002 less than P less than 0.005). The results of the speech recognition ability tests could be explained by the acoustical changes of the loudly spoken speech. In the 75 dB SPL recording, the levels of voiceless fricatives, nasals and plosives were significantly lower than in the 60 dB SPL recording. Spectrally, the fundamental frequency was increased and the configuration of the first formant was altered in the 75 dB SPL recording. The significance of the findings for clinical speech audiometry and hearing aid evaluation is discussed.

Acoustic Stimulation↗
PubMed1976

Evaluating the ability of aircrew personnel to hear speech in their operational environments.

High-quality tape recordings were constructed of single, double, and triple word test items from the six monosyllabic work lists of the Modified Rhyme Test (MRT), a multiple-choice intelligibility test. The test workd were incorporated in a carrier phrase somewhat analogous to typical aircraft radio messages. The recorded lists were mixed with shaped noise and played back to a group of listeners at three speech-to-noise ratios. The regular closed-response format of the MRT was utilized for all three types of test items. There was little difference in overall listener performance for the single, double, and triple word test items. Because of their more representative message length and decreased testing time, the triple word test items will be utilized in subsequent data-gathering studies directed toward the development of an efficient reliable test for assessing the ability of aircrew personnel to hear speech in their operational environments.

Adaptation, Physiological↗
PubMed1990

[Speech intelligibility in tongue and mouth-floor cancer patients who received surgical excisions after induction therapy].

Speech intelligibility has been investigated in 40 patients who had received a glossotomy because of tongue and/or mouth floor carcinomas after preoperative induction therapy. The results are summarized below. 1. Speech was clearer and better understood in intelligibility tests than by tests of single sounds. 2. Speech intelligibility was impaired in 12 patients. The impairment degree was mild (slight difficulty in understanding the spoken content) in 9 cases, where as the speech in the remaining patients was moderately or severely impaired. 3. Hardly any speech impairment resulted when the tongue resection was limited to the ipsilateral 1/3 of the tongue, where as the impairment was greater in cases who received a glossotomy over that limit. 4. Tongue mobility was related to speech intelligibility, and conservation of the tongue tip appeared important. 5. Aggressive induction therapy made limited surgical extirpation possible, and many patients speech functions were well preserved by conservative surgery. Together with good local control, aggressive induction therapy seemed to be beneficial for tongue and mouth-floor carcinomas.

Adult↗
PubMed1993

[Standardized analysis of visual spatial perception. Construction of the procedure and applications].

Assessment of visuo-spatial perception (VS) in brain-damaged patients. So far, no comprehensive methods for reliable assessment of visuo-spatial deficits after brain damage have been described. The tests usually applied are subtests of intelligence tests, paper-pencil tests or visual-constructive tests which also require motor and planning abilities. Almost all these methods are unsuitable for measuring therapeutic changes and do not reveal specific impairments. The computational method presented here (VS) is suitable for the quantitative assessment of visuo-spatial functions, e.g. subjective visual vertical and horizontal; orientation, length, distance, form and position discrimination as well as line bisection. It can easily be installed on an IBM compatible PC. A clinical standard examination can be performed within 20-30 minutes including numerical and graphical analysis of the results. The method is sensitive for measuring therapeutic changes. Moreover, it offers a wide range of experimental task manipulations for more sophisticated experimental tests.

Attention↗
PubMed1976

Relations between twins' similarity of appearance and behavioral similarity: testing an assumption.

Questionnaires rating twins' physical similarity and similarity of dress were obtained from the parents of 121 identical and 70 same-sex fraternal twin pairs. Within-pair difference scores on several behavioral measures (two intelligence tests, two perceptual tests, one reading test, one test of speech articulation, and one personality inventory) were correlated with the twins' scores for physical similarity and similarity of dress. The correlations revealed no systematic relation between the similarity of appearance and the similarity of behaviors for either the identical twin pairs or the same-sex fraternal twin pairs. The assumption that twins' behaviors are more alike because they are more similar in appearance does not seem warranted.

Body Height↗
PubMed1982

Vocabulary deficit and abstraction impairment in hospitalized alcoholics.

The use of a standard intelligence test for detecting cognitive impairment has been re-examined in a cohort of 506 hospitalized alcoholics. The value of Vocabulary scores as indicators of original intelligence was tested by formulating the hypothesis that Vocabulary scores would remain constant despite increasing degrees of alcohol-induced cerebral dysfunction. Subjects were assigned to non-dysfunctional, minimal and severe dysfunctional groups on the basis of psychometric testing and their Wechsler Vocabulary scores categorized as either 'abstract' 'concrete' or 'wrong'. Significant linear deficits in Vocabulary score and loss of abstract ability correlated with increasing dysfunction, irrespective of age but with greater frequency in females.

Adult↗
PubMed1989

Development of the Speech Intelligibility Rating (SIR) test for hearing aid comparisons.

The Speech Intelligibility Rating (SIR) Test has been developed for use in clinical comparisons of hearing aid conditions. After listening to a short passage of connected speech, subjects generate a rating proportional to its intelligibility using an equal-appearing interval scale from 0 to 10. Before test passages are presented, the signal-to-babble ratio (SBR) is adjusted to a level that elicits intelligibility ratings of 7-8 for a "setup" passage. Then, with SBR held constant, three or more test passages are rated and the results averaged for each aided condition. This paper describes the generation of recorded test materials and their investigation using normally hearing listeners. Based on these data, a critical difference of about 2 scale intervals is recommended. A future paper will deal with results for hearing-impaired subjects.

Hearing Aids↗
PubMed1978

Use of the Leiter International Performance Scale with adult aphasics.

Considered whether the Leiter International Performances Scales (LIPS), a general intelligence test used successfully with Ss age 2-18, can be adapted for use with aphasic adults. Six aphasic adults and 6 matched controls were given the Reitan Indians Screening Test of Aphasia and the LIPS. Results showed that the aphasic sample had total test scores comparable with the control group; however, the aphasic group required approximately 66% more time than the controls to complete the test. It was concluded that further work is merited based on the following results: (1) the test provided a sufficient range of difficulty so that each S errored on at least one-fourth of the test items; (2) the test could be given to the adult aphasics within a feasible time frame; (3) the aphasic adults were able to work with the test materials despite visual defects and hemiparesis of the dominant side; (4) feasible modifications can be made in the test.

Adult↗
PubMed2002

Intelligence and cognitive function in children and adolescents with spinal muscular atrophy.

Spinal muscular atrophy is a chronic disease characterised by loss of motor function. The aim of the study was to analyse cognitive functions in a large group of patients with spinal muscular atrophy. It was hypothesised that their intelligence is comparable to controls, but not above average as previously postulated. Ninety-six children and adolescents with spinal muscular atrophy I-III, aged 6.0-18.11 years, 45 non-affected siblings and 59 healthy, matched controls were examined with one- (CPM/SPM), as well as multi-dimensional intelligence tests (Kaufman-ABC; Wechsler tests). The mean IQ measured with the CPM/SPM tests was 109.6 for the spinal muscular atrophy group, 107.3 for the sibs and 104.1 for the healthy controls (no significant difference). In the older children and adolescents (SPM only) the mean IQ was significantly higher for the spinal muscular atrophy patients (109.6) than for the controls (95.4). The standard score in the 'mental processing composite' scale of the Kaufman-ABC was identical in the spinal muscular atrophy group and controls (103.8). The cognitive profile was relatively homogeneous. However, the older children and adolescents did have a significantly higher verbal IQ (113.8) than controls (104.6) in the Wechsler tests. There were no significant differences in any of the tests among different grades of severity (spinal muscular atrophy types I-III). It can be concluded that children and adolescents with spinal muscular atrophy have a general intelligence in the normal range. By adolescence, environmentally mediated aspects of intelligence are higher in patients with spinal muscular atrophy. It could be speculated that the development of cognitive skills and knowledge is a creative way to compensate the many restrictions due to their physical handicap.

Adolescent↗
PubMed2000

Performance of black and white South African children on the Wechsler Intelligence Scale for Children--Revised and the Kaufman Assessment Battery.

The validity of traditional intelligence tests for cultural groups that differ from those for whom the tests were normed has come under scrutiny. This is particularly the case for the previously disadvantaged black majority in South Africa. The Kaufman Assessment Battery for Children (K-ABC) is reportedly a relatively nondiscriminatory test of intellectual functioning. This study compared the performance of 21 black and 35 white third-grade South African children on the K-ABC and the Wechsler Intelligence Scale--Revised (WISC-R) at two schools for children with learning problems. While the WISC-R Verbal and Full Scale IQ of black children were significantly lower than that of whites, there was no significant difference between these groups on the K-ABC. Teachers' ratings for white and black pupils were acceptably concordant with students' performance on the K-ABC but not on the WISC-R. Support is provided for the usefulness of the K-ABC as a relatively nondiscriminatory alternative to the WISC-R for South African children.

Black or African American↗
PubMed1999

Family size and intelligence revisited: the role of emotional intelligence.

Studies examining the link between family size and intelligence have consistently found a negative relationship. Children born into larger families tend to score lower on intelligence tests than children raised in smaller families. One recurrent but unexplained finding is that the relation between intelligence and number of siblings is consistently significant for verbal intelligence but inconsistent for nonverbal intelligence. Here, we conceptualize emotional intelligence as one facet of nonverbal intelligence. The research develops a measure of emotional intelligence and uses it to test the hypothesis that emotional intelligence is positively correlated with family size. The results, based upon a sample of graduate students, support the hypothesized relationship. Implications for the study of family size and intelligence, for refining the conceptualizations and measures of nonverbal intelligence, and for leadership theory, are discussed.

Adult↗
PubMed2000

Intelligence and event-related potentials for young female human volunteer apolipoprotein E epsilon4 and non-epsilon4 carriers.

The apolipoprotein E (APOE) epsilon4 allele is associated with late-onset Alzheimer's disease and cognitive function in aging normal populations. To study the effect of the presence of the epsilon4 allele on cognitive function, we compared intelligence-test scores and component values for event-related potentials for epsilon4 and non-epsilon4 carriers in a group of 134 young females. The results demonstrate modest increases in performance intelligence quotient (IQ) and N100 amplitude for epsilon4 carriers (P=0.038 and 0.068, respectively). Our findings suggest that cognitive impairment, associated with the presence of the epsilon4 allele, is age-dependent and thus not probable for young women. The higher performance IQ scores demonstrated for epsilon4 carriers require further exploration.

Adult↗