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At least 613 records · Page 34Linked to original sources
PubMed2004

[Clinical evaluation of the INJEX system, a local anesthesia system without needles: a comfort evaluation study].

UNLABELLED: The use of needless local anaesthesia systems in dentistry can be of a help in treating needle phobia patients. The aim of this comfort study was to compare a classical local infiltration anaesthesia with a needle-free system. INJEX (ROSCH AG Germany). A split mouth design study was performed. All patients in this study needed 2 restorations. In order to receive objective information on both systems needle-phobia patients were banned. Therefore the first restoration was performed with the classical system (with needle) and the well-acceptance was evaluated. The second restoration was done with the needle-free system. Both patient and dental practitioner performed an evaluation after each treatment. Evaluation by the patient was given by a questionnaire on the comfort of the treatment using Faces Pain Scale, Lickert Scale and a modified version of the Abbreviated Acceptability Rating Profile. By the dental practitioner the comfort of the treatment and the amount of local anaesthesia needed was evaluated. The study was approved by the ethical committee of Ghent University Hospital Belgium. CONCLUSION: The INJEX system can be a valuable alternative to use in paediatric dentistry, although non needle phobia patients in this study did not preferred the needle free INJEX system above the classical local injection.

Adolescent↗
PubMedDate not supplied

Children's preferences concerning the physical appearance of dental injectors.

PURPOSE: This pilot study was carried out to assess how the physical appearance of dental injectors influenced children's choice. METHODS: The study group consisted of 34 randomly selected children (17 boys, 17 girls) between the ages of 7 and 11 (mean age=8.6 +/- 1.4), who had been registered for treatment at the School of Dentistry, Marmara University. A combination of tests-the Children's Fear Survey Schedule-Dental Subscale (CFSS-DS), Venham Picture Test (VPT), and facial image scale (FIS)-were used to assess the multi-dimensional character of children's dental anxiety. Dental injectors (Wand, Citoject, traditional metal injector [MI], and plastic injector [PI]) were displayed on a tray and introduced to the children. The children were asked to consider which injectors they would choose "if their tooth had to be put to sleep," and their preferences were noted starting with their first choice. RESULTS: The children's first choice was: (1) the Wand (56%); (2) PI (29%); (3) Citoject (12%); and (4) MI (3%). The anxious children (n= 13) preferred the Wand with significantly higher ratings (Wand=84%; Citoject=8%; MI=8%; PI=0%). CONCLUSION: The physical appearance of dental injectors is important to children and even more important for children who are anxious.

Alloys↗
PubMed1991

[The characteristics of the reactogenicity and immunological activity of a new cholera bivalent chemical vaccine based on the results of controlled trials].

The reactogenic properties and immunological potency of modified cholera chemical vaccine (choleragen-toxoid + O-antigens Inaba and Ogawa) were tested in 278 volunteers aged 18 years and over in comparison with those of a commercial batch of monovalent cholera vaccine (choleragen-toxoid + O-antigen Inaba). The cholera vaccine, enriched with O-antigen Ogawa, was found to be safe; vaccination with this vaccine was not accompanied by the development of systemic and local reactions whose frequency and intensity met the requirements for the reactogenic properties of commercial cholera vaccine. The immunological potency of the bivalent vaccine with respect to strain Inaba was not inferior to that of the commercial vaccine; at the same time in persons immunized with the new preparation the titers of vibriocidal antibodies to strain of serovar Inaba were five-fold higher. The conclusion on the expediency of using cholera chemical vaccine enriched with O-antigen Ogawa was made.

Adult↗
PubMedDate not supplied

Antityphoid and antitetanic intradermal vaccination of chronic neuropsychic patients in a typhoid fever outbreak.

Intradermal immunization of 229 chronic neuropsychic patients in Gura Ocnitzei Sanatorium, Dîmbovitza County, where a typhoid fever outbreak burst, was performed with a freeze-dried typhoid vaccine, suspended in purified and concentrated tetanic anatoxin. Adverse reactions were minimal and immunologic response, evaluated by laboratory tests, was good, reaching the level of that obtained as a result of classic vaccination methods (subcutaneous antityphoid and intramuscular anti-tetanic). Both after vaccination and also booster O and H agglutinating titers increased 4-7 times and anti-S. typhi. seroprotecting effect reached and maintained a high level. Moreover, antityphoid vaccination permitted epidemic focus limiting and its complete extinguishing after booster. Antitetanic vaccination resulted in protecting titers settlement (greater than or equal to 0.01 IU/ml) in all previously non-protected persons (1/3 of all subjects) and in the increase of protecting titers, existing before vaccination in the other persons.

Adult↗
PubMed1991

The needleless syringe: efficacy of anesthesia and patient preference in child dental patients.

Delivery of local anesthesia in dentistry is primarily by way of a needle-tipped syringe. This procedure, when used on children, is often stressful and sometimes painful for the patient. The Syrijet is an instrument which delivers anesthesia without the use of a needle. This is accomplished by delivering the anesthetic solution under high compressive forces. The subjects were thirty-four children ranging in age between 5 and 15 years, on whom forty-five dental procedures were completed. There was a statistically significant difference in favor of the instrument, with twenty-five subjects reporting a preference for it. The instrument was completely successful in providing anesthesia in thirty-six of the forty-five procedures.

Adolescent↗
PubMed1990

[Treatment of patients with corticoid-dependent bronchial asthma by step-by-step intra-pulmonary administration of glucocorticoids].

The efficacy of a local step-by-step intrapulmonary and systemic administration of glucocorticosteroids (GCS) in 61 patients with corticoid dependent bronchial asthma was studied. A significantly earlier normalization of the basic clinical symptoms of exacerbation of the disease and an improvement of the external respiration function were revealed in the main group of patients, as compared to the controls. The method of a local step-by-step intrapulmonary administration of GCS made it possible to increase the treatment efficacy by bringing down the GCS dosage required to maintain++ remission and excluding complications caused during intrapulmonary injection of drugs to patients with corticoid dependent bronchial asthma.

Adult↗
PubMed1990

[Individual human personality characteristics as a factor in the etiology of postvaccinal reactions].

Healthy volunteers with quite opposite emotional properties defined by means of Cattell Personality Questionnaires were shown to have essential differences in their postvaccinal reactions. These differences were seemingly caused by psychoemotional tension developing in unstable persons as a result of their perception of vaccination as a threatening factor. The administration of Phenasepam (3 mg) decreased such emotional tension and thus removed negative reactions at the postvaccinal period. The preparation had no influence on the production of protective antibodies to all types of antigens used for immunization.

Adolescent↗
PubMed1991

[Endobronchial drug administration in resuscitation].

The endobronchial application of drugs is recommended during pharmacological reanimation in lack of venous punction possibility. To find out the quantity of the area of resorption after deep endobronchial instillation twelve human corpses had been intubated and methylen-blue was applicated through the tube. A special application kit with a single use ampule was used. The results showed a very good distribution of 100% or 90% in the bronchi principals dexter and sinister. The bronchi lobaris of the right and the left bronchial tree were reached by the injection with an incidence of more than 70%. This proved distribution of the applicated indicator liquid in a patient in horizontal position (no circulation) allows the statement that during reanimation a sufficient pulmonal surface area is reached in both lungs to guarantee a resorption of the drug.

Bronchi↗
PubMed1990

[Comparative study of cibenzoline and flecainide administered via an intravenous route in reducing auricular arrhythmia].

The efficacy of intravenous flecainide and cibenzoline acetate in the reduction of atrial rhythm disorders was compared in two groups of 30 patients. These arrhythmias are divided in 31 atrial fibrillation, 11 tachy-systoles, 18 atrial flutters. Parenteral administration of the anti-arrhythmic drug over a 24 hour-period is preceded by a bolus injection of 1.5 mg/kg of flecainide acetate for group I, and a bolus of 1 mg/kg of cibenzoline for group II. The overall efficacy of the two molecules is comparable (53%) as well as the reduction of the atrial fibrillations (65% vs 57%). Flecainide acetate seems more effective in treating effectively atrial tachycardias (66.6% vs 40%), and cibenzoline is more effective in the treatment of atrial flutters (54% vs 14%). The functional, electrical and haemodynamic tolerance has always been good in both group, except in 2 patients, because of the indirect pro-arrhythmic effect of cibenzoline. We are concluding that the efficacy of both molecules is satisfactory and we advocate their use, as first intention, in recent and idiopathic atrial fibrillation; it seems that cibenzoline is more effective on ischemic cardiopathies and flecainide acetate is more effective on valvular cardiopathies. Nevertheless, the possible indirect pro-arrhythmic effect, sometimes poorly tolerated in the first minutes following administration of the bolus, only on organized atrial rhythm disorder, leads us to advocate the prescription of these two drugs when attempts of transesophageal or endocardiac atrial stimulation have failed.

Adult↗
PubMed1990

[Enoximone: hemodynamic effect in patients with cardiac insufficiency].

Enoximone, a phosphodiesterase inhibitor, is a positive inotropic agent with direct vasodilator properties. Its acute effects after I.V. administration and the possibility of oral relay were studied in 14 patients (13 men and 1 woman), 40 to 78 years of age (mean 61 years) with Stage IV cardiac failure (NYHA Classification). Eleven patients had dilated cardiomyopathy, 2 had ischemic heart disease and 1 a dilated hypertrophic cardiomyopathy. The haemodynamic inclusion criteria were: cardiac index less than or equal to 2.2 l/mn/m2 and pulmonary capillary pressure greater than or equal to 18 mmHg. Patients with cardiogenic shock and severe renal or hepatic failure were excluded. The drug was administered as a bolus of 1 mg/kg followed by a continuous infusion of 5 to 15 g/kg/mn (average 8.9 +/- 2.6 for 7 to 72 hours; average 27 +/- 16 hours). Haemodynamic effects of I.V. administration: no change in heart rate, slight lowering of blood pressure, very significant reduction in right atrial and pulmonary capillary pressures, of pulmonary artery pressures, of arteriolo-capillary and systemic resistances and marked increase in cardiac output. General tolerance was excellent with no clinical secondary effects and no signs of hepatic, renal or haematological (platelets) toxicity. Cardiac tolerance was also excellent, no aggravation of preexisting arrhythmias. There was no immediate mortality. Oral relay was undertaken in 14 patients with a daily dose of 300 mg in 12 cases, 400 mg in 1 case and 500 mg in 1 case. Six patients underwent control haemodynamic evaluation on the 8th day: there were no signs of the haemodynamic improvement obtained by I.V. administration.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1990

[Treatment of chronic cardiac insufficiency with intravenous bolus enoximone. Study of a pharmacokinetic-hemodynamic relation].

The aim of this study was to evaluate the efficacy and pharmacokinetics of enoximone administered as an intravenous bolus in 12 patients (mean age 62 years) with severe chronic congestive cardiac failure (Stage IV of the NYHA) due to ischemic (N = 6) or idiopathic (N = 6) cardiomyopathy. The haemodynamic parameters and plasma concentrations of enoximone and its metabolite were measured 15, 30, 60, 90, 120 minutes, 4 and 6 hours, after IV bolus of enoximone 1 mg/kg in 10 minutes. Enoximone increased the cardiac index by an average of 37 p. 100 (1.92 +/- 0.3 to 2.63 +/- 0.35 l/mn/m2; p less than 0.001); pulmonary artery diastolic pressures fell by 33 p. 100 (p less than 0.01). Systemic arterial resistances decreased by 23 p. 100 (p less than 0.05). No significant changes in heart rate or blood pressure were observed. The peak effect was recorded between the 15th and 30th minute. The pharmacokinetic study showed the half life of enoximone to be 2.2 +/- 0.78 hours, the area under the curve to be 2,818 +/- 953, the volume of distribution to be 69.6 +/- 24 l and the total clearance to be 22.8 +/- 8.5 l/hour. The half life of the metabolite was 4.45 +/- 1.05 hours. There was a significant correlation between the percentage increase in cardiac index and peak enoximone concentration (r = 0.91; p less than 0.001). In conclusion, an IV bolus of enoximone is an effective treatment for chronic cardiac failure. The haemodynamic response was related to the peak enoximone plasma concentration.

Aged↗
PubMed1990

[Current patterns of the use of heparin in angiography].

All members and fellows of the Society of Cardiovascular and Interventional Radiology were surveyed to determine current patterns of heparin use in angiography. Five hundred responses (68%) were received. In general, significant differences exist across the United States in the mean heparin dose for angiography, mean dose for angioplasty, heparin concentration in flush solutions, and, especially, frequency with which heparin is mixed with nonionic contrast media. Few respondents routinely use systemic (bolus) heparinization for angiography. Heparin concentration in flush solutions varies from 0 IU/L to 12,000 IU/L. Eleven percent of respondents mix heparin with nonionic contrast agents, at a median dose of 5 IU/mL. Results of this survey reveal patterns of practice but do not represent a standard of practice. Protocols for heparin use should be based on experimental evidence, and heparin dosage must be individualized for each procedure and each patient. Large-scale, prospective studies of the merits of systemic heparinization and of mixing heparin with nonionic contrast agents are needed.

Adult↗