Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Inhalation Exposure”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 613 records · Page 34Linked to original sources
PubMed1983

Concentration-dependent behavioral changes in mice following short-term inhalation exposure to various industrial solvents.

Mice were exposed during a 4-hr period to various concentrations of 13 aliphatic or aromatic solvents which affect primarily the central nervous system (CNS). The test compounds were benzyl chloride, butyl alcohol, chlorobenzene, cyclohexanone, 1,2-dichloroethylene, diisobutyl ketone, isopropyl acetate, methyl ethyl ketone, styrene, tetrachloroethylene, 1,1,1-trichloroethane, toluene, and ortho-xylene. After exposure, measurements were made to see whether these neurotoxicants would decrease the immobility developed in a "behavioral despair" swimming test. Each chemical was shown to reduce the total duration of immobility measured over a 3-min period in a concentration-related manner. The systematic determination of the atmospheric concentrations responsible for a 50% decrease in immobility (ID50) permitted classification of the solvents in terms of their relative potencies. The possibility of using such experimental data as tentative guidelines for setting safe levels of work exposure to the neurotoxicants was suggested, considering the existence of quantitative relationships between the ID50 values and the current occupational standards.

Animals↗
PubMed1987

Experimental sensitization to subtilisin. II. Production of specific antibodies following inhalation exposure of guinea pigs.

We have previously reported the development of pulmonary sensitivity in guinea pigs exposed for 5 consecutive days to bacterial subtilisin in concentrations ranging from 1.9 to 15.0 mg proteolytic enzyme/m3. Animals exposed to lesser concentrations of 0.0083 and 0.041 mg/m3 failed to demonstrate this sensitivity. In the same study, animals exposed for 11 weeks to a subtilisin concentration of 0.00068 mg/m3 followed by 6 weeks to 0.0051 mg/m3 failed to demonstrate pulmonary sensitivity. We report here the antibody response in these animals. Both an enzyme-linked immunosorbent assay and a latex agglutination assay were developed for antibody detection. A concentration-related antibody response was detected in animals which had received acute subtilisin exposures of 0.0083 to 1.9 mg/m3. Antibody titers were not increased further upon exposure to higher subtilisin concentrations. A single 3-hr exposure to 1.9 mg/m3 resulted in the same antibody response as that produced following 5 days of exposure to the same concentration. The cumulative 17-week exposure of 1.12 mg/m3 X hr subtilisin resulted in 36% (9 of 25) of the animals producing significant levels of IgG or IgM antibodies. None of these animals demonstrated pulmonary sensitivity. These results indicate that the circulating antibody titer reflected antigen exposure levels and occurred at exposures below those necessary for production of pulmonary sensitivity.

Animals↗