Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “HAND DERMATOSES”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 613 records · Page 34Linked to original sources
PubMed1983

Evaluation of tonsillectomy as a treatment for pustulosis palmaris et plantaris.

One hundred and twenty-four cases of pustulosis palmaris et plantaris (PPP) were studied by questionnaire survey to evaluate the effectiveness of tonsillectomy as treatment. We found that tonsillectomy as a method of treatment for PPP showed a significantly high rate of cure, against which other methods of treatment, e.g. corticosteroid therapy, PUVA therapy and so on, were compared. The examination, by means of Kaplan-Meier's method, showed a 59.2% cure rate for patients one year after tonsillectomy and 71.8% 2 years after the operation. When patients are older than 60 years, the prognosis is good, regardless of the method of treatment.

Adolescent↗
PubMed1983

Morphological and immunological studies on pustulosis palmaris et plantaris, especially on its focal infection theory.

The deposition of immunoglobulins and complement was examined in skin lesions of pustulosis palmaris et plantaris by applying a direct-immunofluorescence technique. Linear deposition of IgG and C3 was demonstrated in the horny layer in 5 cases out of 10. The antikeratinlayer antibody was measured using the sera of patients with PPP, and elevated levels were recorded in patients with a maximum ratio of 1:80. Light and electron-microscopical examinations revealed a structure similar to the epidermal keratin layer of the tonsillar epidermis and phagocytosis of the structure by macrophages. This is an interesting finding in view of the antigen of the epidermal keratin layer.

Adult↗
PubMed1983

Pustulosis palmaris et plantaris due to tonsillar focal infections. From the analysis of long-term observed cases.

We studied the effects of tonsillectomy in patients with pustulosis palmaris et plantaris (PPP) and suspected of having focal tonsillar infections which could still be observed more than one year after tonsillectomy. The rate of healing with tonsillectomy, including 6 cases with remarkable effect, was 76%. The clinical findings from which we expect an effect of tonsillectomy are (a) late onset PPP and early tonsillectomy, (b) tonsils with grade I hypertrophy, oozing of pus, and localized dark-redness on the anterior palatine arches, (c) anamnestic tonsillitis, and (d) positive results both at tonsillar provocation and negation tests. From the analyses of pre- and postoperative clinical examinations we found that the preoperative values of serum complement (C3), and neutrophils, lymphocytes and eosinophils in peripheral blood were significantly depressed in the effectively treated group, compared with the 'ineffective' group or the control group.

Adult↗
PubMed1983

Conceptual understanding of pustulosis palmaris et plantaris as an immune complex disease due to focal tonsillar infections.

The relationship between pustulosis palmaris et plantaris (PPP) and immune complexes was studied in 17 patients who underwent tonsillectomy. By means of the Clq-binding test, immune complexes were detected in a considerable number of sera from these patients. Patients with a high serum level of immune complexes which decreased following tonsillectomy were found to benefit by a remarkable improvement in their skin lesions. There was a close association between the degree of improvement in skin lesions following tonsillectomy, and the changes in circulating immune complex levels after tonsillectomy. Immunofluorescence showed that all 6 patients with PPP tested had deposits of IgG, IgM, IgA or C3 in their skin lesions. These results suggest that PPP may be an immune complex disease, and that it may be closely associated with the tonsil as a focus for the release of antigens or immune complexes.

Adolescent↗
PubMed1983

Pustulosis palmaris et plantaris. With reference to the cross-reactivity between tonsillar epithelium antigen and skin antigen.

Though it is well known that pustulosis palmaris et plantaris (PPP) is one of skin diseases caused by focal infection of the tonsils, its etiology remains unknown. The purpose of this study was to elucidate the role of the tonsils in the pathogenesis of PPP, by using histological and immunological techniques. Our findings were as follows: The common histological findings in tonsillar lacunae of patients with PPP were pus plugs, pronounced infiltration of polymorphonuclear cells and mononuclear cells, desquamation of keratinized squamous cells, uneven thickness of the epithelium, and inflammation of the subepithelial area. By applying Arthur's method, skin extracts of sole (S) and epithelial extracts of tonsillar lacunae (T) were prepared as antigens for rabbit immunization. Cross-reactivity between skin extract of sole and epithelial extract of tonsils was tested using the Ouchterlony technique. Anti-T antisera reacted to both T and S. Anti-S antisera reacted similarly to T and S. Direct and indirect immunofluorescence studies using anti-T and anti-S antisera revealed positive staining either in the lacunal epithelium of tonsil or in the corneous, granular and papillary layers of sole. As regards the pathogenesis, it is suggested that the antigenic modification of tonsillar epithelium caused by various stimuli produces cells and/or antibodies so as to challenge against skins.

Antibodies↗
PubMed1983

Tonsil and pustulosis palmaris et plantaris. Mainly in respect of complement.

Since the tonsil is one of the immunological organs, a concept whereby the relation between the tonsil and pustulosis palmaris et plantaris (hereafter abbreviated PPP) can be explained by a specific immunological mechanism, has been favoured. It must be pointed out, however, that there have been a considerable number of clinical findings which are irreconcilable with this concept. The present authors have therefore observed the relationship between the tonsil and PPP, from the point of view of non-specific in vivo factors, such as complements and endotoxins. This theory of the authors was motivated by the clinical fact that the serum complement titres of some patients with PPP were changed by performing the tonsillar provocation test, and that in such cases their skin rashes were aggravated after provocation. Thereafter, the distribution of the complemental components in the tonsillar tissue was examined with the immunofluorescence technique and it was found that they were localized mainly in the epithelium of the tonsillar crypt. In other words, the region where the complement system in the tonsillar tissue is active is the crypt. It was further found that the lacunar debris in the tonsillar crypt possesses a strong complement-activating activity. In particular, it was discovered that the action is stronger in bacteria and endotoxins within the lacunar debris. In recent years, the activation of complements associated with the surface layer of the skin has been emphatically considered to be the mechanism causing the onset of aseptic pustules in patients with PPP.(ABSTRACT TRUNCATED AT 250 WORDS)

Bacteria↗
PubMed1983

Studies on experimental exanthema in rabbits by means of recurrent systemic sensitization.

To explore the relationship between the tonsils and pustulosis palmaris et plantaris, the author performed several experiments. Since, in the pustulosis palmaris et plantaris abscess, many pleomorphic leukocytes are seen histologically, in order to provoke this condition, sensitized lymphocytes isolated from sensitized rabbits were transferred intravenously. To localize the site of immunological reaction on the skin, extracts were used from cutaneous abscesses elicited by intracutaneous injection of BCE, CA, and PPD, emulsified with FCA. The results were as follows: (1) exanthema was demonstrated in 4 out of 28 rabbits; (2) the antigens that caused exanthema were BCE and CA; (3) the sites on which exanthema appeared were the footpads of both fore- and hindlimbs, in one rabbit only, and in the others, the footpads of hindlimbs; (4) as the predominant cause of the exanthema, the relationship between immune complex and sensitized lymphocytes was suspected.

Abscess↗
PubMed1983

Immunological study of pustulosis palmaris et plantaris. Blastoid transformation of tonsil and peripheral blood lymphocytes by stimulation with human skin extract.

The experiment was performed in order to approach the question whether denatured epithelial debris in the tonsillar crypts could be an antigenic substance which might be responsible for inducing autoallergic reactions in the skin. Identical antigenicity of the tonsillar epithelium and of the skin was determined by immunofluorescence study. Then heat-denatured skin extract was used as a model system for studying the antigenicity of denatured epithelial debris. A blastoid transformation study of tonsil and peripheral blood lymphocytes obtained from patients with pustulosis palmaris et plantaris and control individuals was carried out by stimulating with heat-denatured skin extract. Tonsil lymphocytes responded well to skin extract, but peripheral blood lymphocytes scarcely responded at all. Skin extract induced transformation of tonsil lymphocytes occurred in the T-cell fraction, but not in the B-cell fraction. The results indicate that denatured tonsillar epithelium can induce an immune response of tonsil lymphocytes as autoantigen, and that the blastogenesis observed was dependent upon T cells.

B-Lymphocytes↗
PubMed1983

Multinucleated giant cells in the palatine tonsil of three patients with pustulosis palmaris et plantaris.

In a histopathological analysis of the palatine tonsils resected in 70 patients (28 adults and 42 children) with persistent angina, several Langhans'-type giant cells without epithelioid granuloma were detected in the serial specimens of all tonsils from 3 adult patients with pustulosis palmaris et plantaris. By contrast, in the tonsils of the other 67 patients, without pustulosis palmaris et plantaris, only a few atypical multinucleated giant cells including those of foreign body type were found, in the serial specimen of 4 cases. On the basis of these results, the appearance of Langhans'-type giant cells in the tonsil should be noted in persistent angina with pustulosis palmaris et plantaris.

Adult↗
PubMed1988

Immunological studies on the relation between tonsil and pustulosis palmaris et plantaris.

In order to clarify the relationship between the tonsils and pustulosis palmaris et plantaris (PPP), immunological investigations were performed focusing on keratin and antikeratin antibody. As materials, the tonsils, plantar skins and peripheral blood from the patients with PPP undergoing tonsillectomy were used. The results were summarized as follows: 1) Common keratin polypeptides reacting with monoclonal anti-keratin antibody were found both in the tonsillar epithelium and in the plantar skin. 2) High molecular weight keratin polypeptides were predominant in the tonsillar epithelium of the patients with PPP as in the plantar skin. 3) The antikeratin antibody titers in the sera of the patients with PPP were on a high level, and tended to decrease after tonsillectomy. 4) The antibody in the sera of the patients with PPP reacted with 67, 63 and 56 kd bands of keratin polypeptides. 5) The antikeratin antibody titers in the culture medium of the patients with PPP, especially in the tonsillar lymphocyte cultures, were on a high level. These results suggest the possibility that the keratin of the tonsillar epithelium and the antikeratin antibody in the serum may play an important role for pustule formation.

Antibodies↗
PubMed1988

Participation of autonomic nerve in tonsillar focal infection.

Participation of the autonomic nerve in tonsillar focal infection was investigated by measuring neurotransmitters, receptors and microvibration. In focal infection patients, the volume of norepinephrine in the tonsil increased significantly and the number of a-adrenergic receptors decreased. These findings suggest that the focally infected tonsil exhibits a high degree of sympathetic nerve activity. The ratio of N-type in microvibration decreased systematically, which indicates some imbalance or immaturity of the autonomic nervous system in focal infection patients. Based on this data, the production mechanism of tonsillar focal infection was speculated from the point of view of the autonomic nerve.

Autonomic Nervous System↗
PubMed1988

Skeletal disease, arthro-osteitis, in adult patients with pustulosis palmoplantaris.

A follow-up study of 13 patients with pustulosis palmoplantaris (PPP) and skeletal disease is reported. A prolonged and fluctuating course occurred in all patients. Nine patients had anterior chest wall involvement with erosions or ankylosis of the sternoclavicular, first sternocostal and/or manubriosternal joint together with sclerosis and often hyperostosis of adjacent bones, ossification/calcification of the first costal cartilage, and in 7 patients of the costoclavicular ligament. Spinal involvement in the form of spondylodiscitis, sclerosis of vertebral bodies, syndesmophytes, paravertebral ossifications and/or spondyloarthritis occurred in 11 patients, three of whom also had involvement of the sacroiliac joints. One patient had sclerosis of a pubic and ischial bone. Peripheral arthritis or tenosynovitis occurred in 5 patients, two of whom had signs of enthesopathy, and one also erosions. The presence of a distinct PPP syndrome is suggested.

Adult↗
PubMed2004

[Optimal dosages and cycles of itraconazole pulse therapy for onychomycosis].

OBJECTIVE: To compare the international standard regimen of itraconazole pulse therapy with low daily-dose pulse therapies, which are widely conducted in Japan. DESIGN: Randomized, double-blind, parallel-group comparative study. PATIENTS: 186 patients with a big toenail showing onychomycosis symptoms such as opacity. INTERVENTION: Patients were assigned to Group I (200 mg/d, 3 cycles), Group II (200 mg/d, 6 cycles) or Group III (400 mg/d, 3 cycles). All received itraconazole orally. MAIN OUTCOME MEASURE: Cure or complete response - assessment based on improvement in the opacity ratio and microscopic examination. RESULTS: The clinical response rates (cure plus complete response) at week 24 were Group I: 14.9%; Group II: 25.5%; Group III: 32.7%. At week 48, 17 patients were cured in Group III - up from 3 at week 24. At week 48 the area under the nail plate concentration-time curves (AUC) was: Group I: 6,084 +/- 3,696 ng h/g; Group II: 10,448 +/- 6,980 ng h/g; Group III: 24,189 +/- 15,157 ng h/g. There was no difference among the three groups in the incidence of adverse drug reactions. CONCLUSIONS: The clinical response rates demonstrated that the pulse therapy of 400 mg/d itraconazole for 3 cycles was most effective. The significantly higher Group III AUC (week 48) suggests that, when the same total amount of itraconazole is administered, this drug remains in nail plates longer following pulse therapy with a higher daily dose. It was also suggested that clinical efficacy correlated with the duration of the presence of itraconazole.

Antifungal Agents↗