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Prospective randomized comparison of single-dose versus 1-day cefazolin for prophylaxis in gynecologic surgery.

BACKGROUND: The purpose of this prospective, randomized study was to compare the efficacy of single-dose versus 1-day cefazolin prophylaxis for the prevention of postoperative gynecologic infections. METHODS: From June 2001 to January 2003, 548 patients were randomized to receive either single-dose (1 g of cefazolin intravenously before surgery, 273 patients) or 1-day cefazolin (1 g intravenously before surgery and three more doses every 6 hr after surgery, 275 patients) prophylaxis. RESULTS: A total of 531 (267 patients in the single-dose group and 264 in the 1-day group) completed the study. Only one of 267 (0.37%) patients in the single-dose group developed a trocar wound infection and one of 264 (0.37%) patients in the 1-day group developed a vaginal cuff infection. Had a single dose of prophylactic antibiotics been administered to all patients, the antibiotic cost would have been reduced by 75-80%. CONCLUSIONS: The use of single-dose preoperative cefazolin prophylaxis was as effective as four doses of cefazolin for preventing serious infectious morbidity among our patients. Shortening the duration of antibiotics prophylaxis also reduced medical costs and microorganism resistance.

Adult↗

Applications of intraoperative ultrasound in gynecological surgery.

PURPOSE OF REVIEW: Gynecologists are well trained in office-based ultrasound, but are less experienced in the field of intraoperative ultrasound. Many gynecologic procedures may benefit from the use of real-time ultrasonography. The purpose of this review is to summarize the current use of intraoperative ultrasound in gynecologic procedures. RECENT FINDINGS: Evaluation and assessment of the value of intraoperative ultrasound in gynecological procedures is essentially non-existent. The role of intraoperative ultrasound in gynecology is in its infancy, with anecdotal experience and literature involving predominantly case reports. Intraoperative ultrasound is helpful in laparoscopic myomectomy, particularly when the uterine contour is normal. It is also useful in defining pelvic anatomy in cases of complex reproductive procedures. Intraoperative ultrasound improves precision in characterizing ovarian lesions, particularly in the setting of endometriomas or dermoid cysts. It has been shown to decrease both operative time and complication rates in dilation and curettage procedures. Intraoperative ultrasound reduces recurrence and re-operation rates after hysteroscopy by facilitating more-complete resection of uterine myomas. Ultrasound guidance improves the efficiency of embryo transfer in in-vitro fertilization and could potentially be beneficial in other 'blind' gynecological procedures. SUMMARY: Intraoperative ultrasound appears to be a safe and valuable tool for the gynecologic surgeon. Ultrasound improves visualization of anatomy, reduces complication and re-operation rates, and facilitates completion of more cases via less-invasive endoscopic approaches.

Female↗