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The evolution of the sensitivity to fosfomycin over the past two years.

The sensitivity of 1,823 bacteriological strains of differing types is shown (E. coli, Klebsiella-Enterobacter-Serratia, Proteus-Providence, Pseudomonas, Salmonella-Shigella-Citrobacter, Haemophilus, Staphylococcus and Streptococcus); all of clinical origin, isolated during March and April, 1975. The methods used were series of double dilutions in Mueller-Hinton agar and the disc-plate method (weight of 50 mug). A comparative study is made of the sensitivity between a part of the present strains (1,725) and another group of 1,664 germs, isolated and observed in January and February, 1973. Some variations are observed which, on general lines, do not seem to be significant, except for Klebsiella-Enterobacter and Serratia.

Anti-Bacterial Agents↗

cis-Diamminedichloroplatinum (CDDP)-fosfomycin (FOM) combination in lung cancer patients with respect to the peripheral T lymphocyte subsets.

An antibiotic FOM was found to be preventive of the side effect of an antineoplastic drug CDDP on the peripheral T lymphocytes in lung cancer patients. Whereas finding a significant decrease in T3+ cells (p less than 0.01) and T4+ subset (p less than 0.05) with CDDP alone, the initial levels of these cell populations were kept unchanged in combination with FOM. T8+ subset showed no substantial change. A protective effect of FOM on T4+ subset was suggested to be an additional aspect of its action at least in combination with CDDP.

Aged↗

Fosfomycin--friend or foe?

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Antineoplastic Combined Chemotherapy Protocols↗