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At least 613 records · Page 34Linked to original sources
PubMed1985

Measurement of total IgE antibody levels in lacrimal fluid of patients suffering from atopic and non-atopic eye disorders. Evidence for local IgE production in atopic eye disorders?

Total IgE levels in lacrimal fluid of patients suffering from different eye disorders were quantitatively measured by a modification of the paper radio immuno sorbent test (PRIST). The geometric mean values for patients with atopic conjunctivitis, patients with keratoconjunctivitis vernalis, and patients with asthma without conjunctivitis differed significantly from those for control persons and those for patients without atopic conjunctivitis. Besides lacrimal fluid IgE levels, serum IgE levels as well as lacrimal fluid and serum albumin levels were measured. From these values the local IgE production was calculated. Although there seemed a good correlation between the level of lacrimal fluid IgE and the amount of local IgE production, the results suggest that local IgE production in lacrimal fluid is not restricted to patients with atopic eye disorders only.

Adolescent↗
PubMed1995

A case of one eye with gelatinous drop-like corneal dystrophy and the other eye with band-shaped spheroidal corneal degeneration.

The first case of gelatinous drop-like corneal dystrophy in one eye and band-shaped spheroidal corneal degeneration in the other eye was reported. She was a member of Japanese family with gelatinous drop-like corneal dystrophy. A close association between gelatinous drop-like corneal dystrophy and band-shaped spheroidal corneal degeneration was suggested.

Adult↗
PubMed2003

Intravitreal triamcinolone acetonide injection in blind painful eyes. Intraocular steroids as a treatment for blind painful red eyes.

PURPOSE: Phthisis bulbi results from different ocular conditions. We evaluated intravitreal triamcinolone acetonide as a treatment option in blind painful eyes. METHODS: Thirty-one patients with unilateral phthisis were randomly divided into two groups. Group A received 0.3 ml (12.5 mg) triamcinolone acetonide intravitreally and Group B 0.3 ml balanced salt solution after retrobulbar anesthesia. Treatment success was assessed by subjective response to pain and clinically by biomicroscopic evaluation of conjunctival congestion. Tonometry was done before and after treatment. Follow-ups were at 24 hours, 3 weeks, 3 and 6 months, and 1 and 2 years. RESULTS: Throughout the two-year follow-up, only two patients in Group A reported pain after the procedure and were retreated, one at week 4 and the other at week 7. Conjunctival congestion was significantly lower in Group A. Two patients with hypotony before treatment had normal tension after triamcinolone. All Group B patients were reinjected with triamcinolone because pain continued after balanced salt solution injection. No severe complications were found. CONCLUSIONS: Intravitreal triamcinolone acetonide may be effective and safe for treating blind painful eyes.

Adolescent↗
PubMed2003

Measuring eye aberrations with Hartmann-Shack wave-front sensors: should the irradiance distribution across the eye pupil be taken into account?

A usual approximation in Hartmann-Shack aberrometry is that the centroid displacements are proportional to the spatial averages of the wave-front slopes at the sampling subapertures. However, these spatial averages are actually weighted by the local irradiance distribution across each microlens. The irradiance across the eye pupil is not uniform in usual reflectometric aberrometers, which is due to several factors including retinal scattering and cone waveguiding directionality. It is shown that neglecting this fact in usual least-squares reconstruction procedures gives rise to a biased estimation of the aberration coefficients. The magnitude of this bias depends on the actual irradiance distribution across the eye pupil, the mode being estimated, the detailed modal composition of the aberrated wave front, and the geometry of the wave-front sampling array. Order-of-magnitude calculations suggest that this bias may well be in the range 5%-10% for relatively smooth irradiance distributions. The systematic nature of this error makes it advisable to check for its presence and, if required, to compensate for it by an adequate choice of the least-squares reconstruction matrix.

Humans↗
PubMed1976

Inability to wink an eye and eye dominance.

Data from 56 subjects in Grades 4 to 12 only able to wink one eye indicated that the non-winking eye was used as the dominant one in tests on monocular and binocular sighting.

Achievement↗
PubMed2000

Are better eye movements an advantage in ball games? A study of prosaccadic and antisaccadic eye movements.

The aim of this study was to compare prosaccadic and antisaccadic eye movements of experts in ball sports and controls. In the prosaccadic and antisaccadic task, subjects made saccades respectively towards and away from a suddenly appearing stimulus. By means of infrared-oculography, we compared horizontal eye movements of experts (n=18) and controls (n=20). Experts had shorter overall saccadic latencies, but significantly shorter latencies occurred only on the antisaccade task, not on the prosaccade task. Our findings seem to support the concept that prosaccades and antisaccades have different underlying mechanisms and that expertise in ball games mainly improves antisaccadic performance in terms of latency and variability.

Adult↗
PubMed1990

Medicare program; payment for outpatient surgery at eye specialty hospitals and eye and ear specialty hospitals--HCFA. Final rule.

In accordance with section 4068(a) of the Omnibus Budget Reconciliation Act of 1987, this final rule revises the payment provisions concerning outpatient hospital services furnished in connection with ambulatory surgical procedures for certain qualified eye specialty hospitals and eye and ear specialty hospitals. It establishes that, for cost reporting periods beginning on or after October 1, 1988 and before October 1, 1990, the blended payment amount applicable to these hospitals remains at 75 percent of the hospital-specific amount and 25 percent of the ambulatory surgical center amount.

Ambulatory Surgical Procedures↗
PubMed2000

Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Herpetic Eye Disease Study Group.

OBJECTIVES: To investigate the effect of oral acyclovir therapy for recurrences of herpes simplex virus (HSV) epithelial keratitis and stromal keratitis and to determine if certain patients derive differential benefit. DESIGN: This randomized, double-masked clinical trial enrolled 703 immunocompetent patients with prior HSV eye disease within the preceding year; assigned 357 patients to receive oral acyclovir, 800 mg/d, and 346 to receive placebo; and followed up patients during a 12-month treatment period for the development of HSV eye disease. RESULTS: The cumulative probability of a recurrence of any type of ocular HSV disease during the 1-year treatment period was 19% in the acyclovir group compared with 32% in the placebo group. Sixteen patients in the acyclovir group and 30 in the placebo group had more than 1 recurrence. A benefit was seen for preventing both epithelial keratitis (rate ratio, 0.62; 95% confidence interval, 0.39-0.97) and stromal keratitis (rate ratio, 0. 57; 95% confidence interval, 0.36-0.89). Although a relative benefit of treatment on preventing any type of recurrence was present in most subgroups, the magnitude of absolute benefit was greatest among patients with the highest number of prior episodes of ocular HSV disease. The benefit in preventing stromal keratitis was seen solely among patients with a history of stromal keratitis. CONCLUSIONS: Long-term suppressive oral acyclovir therapy reduces the rate of recurrent HSV epithelial keratitis and stromal keratitis. Acyclovir's benefit is greatest for patients who have experienced prior HSV stromal keratitis. Arch Ophthalmol. 2000;118:1030-1036

Acyclovir↗
PubMed2000

Incidence of nd:Yag capsulotomy after lens implantation of an Acrylic IOL in one eye and a Silicone IOL in the other eye of the same patient: a preliminary study.

We retrospectively reviewed the charts of 40 patients who underwent an uneventful phacoemulsification in both eyes and had an Acrylic IOL (AcrySof) implanted in one eye and a Silicone IOL (SI 30/S 140) in the other. A subset of 18 patients had a mean follow up of 1 1/2 year. In the Acrylic group 1 patient (5.5%) underwent a posterior Yag-capsulotomy. In the Silicone group 6 patients (30%) underwent a Yag-capsulotomy. (2 anterior--4 posterior) (p = 0.04) Acrylic IOL's were associated with a significantly reduced incidence rate of Yag-capsulotomy compared with silicone IOL's after 1 1/2 years.

Biocompatible Materials↗
PubMedDate not supplied

The dorsal compound eye of simuliid flies: an eye specialized for the detection of small, rapidly moving objects.

The highly specialized dorsal compound eye of male Simuliids is especially adapted to detect during flight the females which are very small animals (1X3 mm). At dawn, the eye functions close to the physical limit imposed by the quantum fluctuations of light. In birght illuminations, light-qauntum noise is not a limiting factor as can be shown by behavioural experiments.

Animals↗
PubMed1992

The reliability of eye movement quantitative evaluation. I. Saccadic eye movements.

We adopted the estimate of the intraclass coefficient of reliability, R, to evaluate the reliability of saccadic eye movements quantitative analysis. At a one-week interval we recorded refixative saccadic eye movements twice from fifteen healthy subjects by means of the binocular electrooculographic technique. R was computed for the constants and the slopes of the amplitude/duration and the amplitude/peak velocity relationships, for the mean precision values and for the mean latency values adjusted for subject's age. Our data demonstrated that the reliability of saccade parameters is fairly good for the amplitude/peak velocity relationship, good for the precision and very good for the amplitude/duration relationship. Finally, we believe that the normal variability values we obtained can be usefully employed in neurophysiological longitudinal studies not only in normal subjects, but also in pathological condition provided the more reliable parameters and the more adequate strategies to compute normal variability values are chosen.

Adult↗
PubMed1992

The reliability of eye movement quantitative evaluation. II. Smooth pursuit eye movements.

We adopted the estimate of the intraclass coefficient of reliability, R, to evaluate the reliability of smooth pursuit eye movement quantitative analysis. At a one-week interval, we recorded twice smooth pursuit eye movements from fifteen healthy subjects by means of the binocular electrooculographic technique. R was computed for the constant and the slope of the target velocity/gain relationships. R values were rated good for the slope and excellent for the constant. Finally, we computed for each parameter the maximum variability value according to two differing methods; on the basis of the within-subjects mean square values, we defined the normal range of biological test-retest variability for the two parameters.

Adult↗
PubMed1990

Double-blind group comparative study of 2% nedocromil sodium eye drops with placebo eye drops in the treatment of seasonal allergic conjunctivitis.

A multicenter double-blind group comparative study was carried out in 126 patients, 64 of whom received 2% nedocromil sodium eye drops, and 62 placebo eyedrops twice each day for the treatment of seasonal allergic conjunctivitis to birch pollen. The patients were evaluated at 2 week intervals for clinical signs of conjunctivitis and kept daily diary records of eye symptoms (0-4 severity scales) and concomitant therapy. Diary trends favored active treatment, and reached significance for excessive lacrimation (P less than .05) during peak pollen challenge. Clinic assessments showed the same directional trend and final opinions of treatment efficacy were significantly in favor of nedocromil sodium (P = .003, patients; P = .006, clinicians). In addition, the placebo group used significantly more topical (P less than .05) and oral (P less than .01) concomitant antihistamine therapy. Nedocromil sodium and placebo treatments were equally acceptable and well tolerated. The results show that 2% nedocromil sodium used topically twice each day is an effective therapy for seasonal allergic conjunctivitis.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1997

Subcortical input to the smooth and saccadic eye movement subregions of the frontal eye field in Cebus monkey.

We have recently identified two functional subregions in the frontal eye field (FEF) of the Cebus monkey, a smooth eye movement subregion (FEFsem) and a saccadic subregion (FEFsac). The thalamic input to these two subregions was studied and quantified to gain more information about the influence of the cerebellum and basal ganglia on the oculomotor control mechanisms of the cerebral cortex. A recent study using transneuronal transport of virus demonstrated that there are neurons in the basal ganglia and cerebellum that project to the FEFsac with only a single intervening synapse (Lunch et al., 1994). In the present study, we concentrated on the thalamic input to the FEFsem to define possible basal ganglia-thalamus-cortex and cerebellum-thalamus-cortex channels of information flow to the FEFsem. We localized the functional subregions using low threshold microstimulation, and retrogradely transported fluorescent tracers were then placed into the FEFsem and FEFsac. The neurons that project to the FEFsem are distributed in (1) the rostral portion of the ventral lateral nucleus, pars caudalis, (2) the caudal portion of the ventral lateral nucleus, pars caudalis, (3) the mediodorsal nucleus, (4) the ventral anterior nucleus, pars parvocellularis, and (5) the ventral anterior nucleus, pars magnocellularis. In contrast, the large majority of neurons that project to the FEFsac are located in the paralaminar region of the mediodorsal nucleus. The FEFsac and FEFsem thus each receive neural input from both basal ganglia-receiving and cerebellar-receiving cell groups in the thalamus, but each receives input from a unique combination of thalamic nuclei.

Animals↗
PubMed2000

Psychological stress and other potential triggers for recurrences of herpes simplex virus eye infections. Herpetic Eye Disease Study Group.

OBJECTIVE: To assess psychological stress and other factors as possible triggers of ocular herpes simplex virus (HSV) recurrences. DESIGN: A prospective cohort study nested in a randomized, placebo-controlled, clinical trial. SETTING: Fifty-eight community-based or university sites. PARTICIPANTS: Immunocompetent adults (N = 308), aged 18 years or older, with a documented history of ocular HSV disease in the prior year and observed for up to 15 months. EXPOSURE VARIABLES: Psychological stress, systemic infection, sunlight exposure, menstrual period, contact lens wear, and eye injury recorded on a weekly log. The exposure period was considered to be the week before symptomatic onset of a recurrence. MAIN OUTCOME MEASURE: The first documented recurrence of ocular HSV disease, with exclusion of cases in which the exposure week log was completed late after the onset of symptoms. RESULTS: Thirty-three participants experienced a study outcome meeting these criteria. Higher levels of psychological stress were not associated with an increased risk of recurrence (rate ratio, 0.58; 95% confidence interval, 0.32-1.05; P =.07). No association was found between any of the other exposure variables and recurrence. When an analysis was performed including only the recurrences (n = 26) for which the exposure week log was completed late and after symptom onset, there was a clear indication of retrospective overreporting of high stress (P =.03) and systemic infection (P =.01). Not excluding these cases could have produced incorrect conclusions due to recall bias. CONCLUSIONS: Psychological stress does not appear to be a trigger of recurrences of ocular HSV disease. If not accounted for, recall bias can substantially overestimate the importance of factors that do not have a causal association with HSV infection.

Cohort Studies↗
PubMed1991

A retrospective analysis of primary eye cancer at the University of Alabama at Birmingham 1958-1988. Part I: Eye and orbital cancer.

Records of 99 patients with 100 primary eye cancers seen at the University of Alabama Hospital for the years 1958-1988 were reviewed. Three ocular cancers were found to predominate: 1) choroidal melanoma, 2) retinoblastoma, and 3) squamous cell carcinoma. Epidemiologic distribution of the population is presented and compared to that of tumors commonly seen in general ophthalmic practice.

Adolescent↗