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Results for “Diffusion of Innovation”

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At least 613 records · Page 34Linked to original sources
PubMed2001

Successful diffusible brachytherapy (dBT) of a progressive low-grade astrocytoma using the locally injected peptidic vector and somatostatin analogue [90Y]-DOTA0-D-Phe1-Tyr3-octreotide (DOTATOC).

We present the therapeutic effect of diffusible brachytherapy (dBT), an innovative approach for the management of symptomatic low grade gliomas [1]. This protocol uses a radiolabelled small diffusible peptidic vector which is a somatostatin analogue to target somatostatin type 2 (sst-2) receptors. The stable radioconjugate [90Y]-DOTA0-D-Phe1-Tyr3-octreotide (DOTATOC) is repeatedly injected via catheters placed into the resection cavity or into tumour nodules. We report on the four year follow-up after initiation of dBT to treat progressive disease in a patient with a complex eleven year history of fibrillary low-grade astrocytoma. The radiopharmakon was not only locally injected into the resection cavity following debulking surgery, but also administered by slow infusion technique to target recurrent and infiltrative tumour zones in the subventricular region around the inferior and posterior horns. In conclusion, peptidic vector based dBT was found to be safe, of mild and transitory toxicity, and effective in long-term tumour control.

Adult↗
PubMed1981

Medical resistance to innovation.

A certain amount of resistance to new ideas is normal and functional in science providing the innovations have a means of being tested. A number of differences between medicine and pure science are noted which can result in some medical innovations being ignored or rejected without an adequate assessment. Historical and current instances of resistance to innovation are given. Social-organizational factors in medicine appear to favor the acceptance of theoretically glamorous, pharmaceutical, and high technology innovations over simpler and less profitable ones.

Ascorbic Acid↗
PubMed1996

Creating the vision: the role of the chief nurse executive in bringing innovations to client service delivery.

The chief nurse officer brings the value-adding contribution of client partner to the executive management team. The nurse executive contributes professional nursing's client-centered, health-enabling approach to care delivery to assist organizations in developing new client and community services. The single most important leadership-challenge presented to nurse administrators, leaders, and managers is the ability to articulate a vision of client-centered care, demonstrate the costs and benefits of service innovations, and effectively shape organizational cultures to achieve innovations in service delivery.

Delivery of Health Care, Integrated↗
PubMed1998

How to get your best practices on the Web.

The Best Practice Network, founded by 13 nursing organizations, is a forum for sharing information among health care professionals. One of the network's main projects has been the development of a Web site offering free, easy access to best practice ideas. The Web site offers tips on everyday innovations, discussion groups, and a place to post best practice ideas.

Benchmarking↗
PubMed1998

Information technology, best practices, and care management: Part I.

Web-enabled technologies are swiftly becoming popular in all walks of life--health care included. New health care applications are blossoming every week, creations that promise to drastically change the efficiency of managed care systems. In this first installment of a two-part series, the author describes some of the innovative changes that are occurring today.

Benchmarking↗
PubMed1982

Public policy and pharmaceutical innovation.

Historically, new drug introductions have played a central role in medical progress and the availability of cost-effective therapies. Nevertheless, public policy toward pharmaceuticals has been characterized in recent times by increasingly stringent regulatory controls, shorter effective patent terms, and increased encouragement of generic product usage. This has had an adverse effect on the incentives and capabilities of firms to undertake new drug research and development activity. The industry has experienced sharply rising research and development costs, declining annual new drug introductions, and fewer independent sources of drug development. This paper considers the effects of government regulatory policies on the pharmaceutical innovation process from several related perspectives. It also examines the merits of current public policy proposals designed to stimulate drug innovation including patent restoration and various regulatory reform measures.

Diffusion of Innovation↗
PubMed2003

Images of health technology in national and local strategies.

OBJECTIVES: This paper examines the potential of various models relating technology to society and institutional structures to inform health policy. Among the models discussed are various versions of technological determinism, social constructivism, actor network theory and critical theory. METHODS: The paper considers recent developments in policy and strategy that aim to shape the way the UK's National Health Service (NHS) integrates Information and Communication Technologies (ICTs) into health care and considers what these alternative models highlight or emphasise, and how they might influence the activities of setting local implementation strategies. RESULTS AND CONCLUSIONS: Contemporary ICTs are often presented as having a particular relevance and power in reforming or transforming the delivery of health care. Understanding how such technologies might be conceived of, implemented and become an integral part of some future health care system is an important and challenging task that requires innovative theoretical treatments.

Computer Communication Networks↗