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At least 613 records · Page 34Linked to original sources
PubMed1977

Defective platelet lipid peroxidation in myeloproliferative disorders: a possible defect of prostaglandin synthesis.

Platelet lipid peroxidation induced by the sulphydryl blocking reagent n-ethylmaleimide [NEM] was measured by production of malonyldialdehyde [MDA]. Lipid peroxidation was decreased in five of 10 patients with proven myeloproliferative disease. The low levels of lipid peroxidation correlated well with in vitro and in vivo tests of platelet function and the bleeding and bruising problems. The reduction in lipid peroxidation with NEM may be due to one or more of the following: [i] an aged platelet population; [ii] an abnormal cell line; [iii] a reduction of the cyclo-oxygenase enzyme activity in the platelet prostaglandin synthetic pathway; [iv] a reduction of the substrate for platelet prostaglandin synthesis, Arachidonic acid; and [v] an abnormality of phospholipase A activation.

Blood Platelet Disorders↗
PubMed1990

Semen anomalies due to voiding defects of the ampullo-vesicular tract. Infertility due to ampullo-vesicular voiding defects.

Anatomical (congenital or postinflammatory) or functional anomalies of the uroseminal intersection can induce a voiding dysfunction of the deferential ampullae and seminal vesicles, leading to infertility. In case of azoospermia or OAT-syndrome with poor semen volume and decreased vesicular markers, some clinical history and examination data can cause suspect of one of such anomalies. The transrectal ultrasonographic findings of anechoic area(s) inside the prostate and/or seminal vesicle (even after recent ejaculation), the peculiar vasovesiculographic pictures (especially after ejaculation following the contrast medium injection into the vasa deferentia), plus the evaluation of the "deferential-ampullary sperm reserve", will permit a detailed diagnosis of the voiding dysfunction of the uroseminal crossing. A successful appropriate treatment of these pathologies can be done. Ultrasonically-guided transrectal puncture, or transurethral incision upstream of (or resection of) the ejaculatory duct orifices, or prolonged sexual abstinence, or artificial spermatocele of the vas deferens, or sperm recovering from urine for GIFT or IVF/ET after washing-out of the seminal tract by vas puncture are all methods, which can be selectively used depending on the individual case, to treat these forms of infertility. The authors present some paradigmatic clinical cases, and report that this pathology presumably occurs in up to 9% of non-selected infertile patient population.

Adult↗