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609 records · Page 34Linked to original sources
PubMed2004

Monophasic synovial sarcoma of hypopharynx: case report and review of the literature.

Synovial sarcoma (SS) is a malignant mesenchymal neoplasm usually involving the lower limbs of young adults. Localization in head-neck district is rare. Histologically, these are characterised by a biphasic or monophasic variant, the latter being more rare and difficult to identify. Immunohistochemistry plays a crucial role in the diagnosis. Cytogenetics also play an important role since both the monophasic and the biphasic forms are characterised by a reciprocal translocation (x;18) (p 11.2;q 11.2). Treatment options include an aggressive surgical approach and radiotherapy, whereas the role of chemotherapy remains to be defined. The case is described of monophasic synovial sarcoma located in the hypopharynx and a review is made of the literature concerning this rare neoplasm.

Adult↗
PubMed2004

Use of solid-phase double-antibody radioimmunoassay to identify species from small skeletal fragments.

Protein radioimmunoassay (pRIA) offers the potential to identify species in small skeletal fragments submitted as forensic evidence. The technique consists of protein extraction followed by a solid-phase double-antibody radioimmunoassay using controls of antisera (raised in rabbits) and radioactive (iodine-125) antibody of rabbit gamma globulin (produced in donkeys). Species determination results from evaluation of radioactivity uptake. To demonstrate the potential of this technique, six known bone samples (three human and three nonhuman, including one from a deer [Odocoileus virginianus]) were submitted for blind analysis. pRIA correctly distinguished the human from the nonhuman samples. Using 200 mg or less of each sample, species of the deer specimen was identified correctly, given the choices of cow, deer, dog, goat, and pig.

Adult↗
PubMed2004

Vertebral artery dissection as a rare cause of vertigo: case report.

Vertebral artery dissection is one of the more frequent cerebral-vascular disorders in the young adult. The initial symptoms rarely consist of vertigo with clinical characteristics of Selective Monolateral Acute Vestibular Deficit Syndrome. The case is described of a patient, who arrived with intense rotatory vertigo associated with neurovegetative symptoms and spontaneous nystagmus, which we initially diagnosed as right neuronitis. About 48 hours later, the symptoms of vertigo disappeared spontaneously, and prevalently nuchal cephalea appeared. Since the symptoms were atypical and the otoneurologic study revealed normal canalar and otholithic function, a cerebral nuclear magnetic resonance, with contrast, was carried out which showed the presence of multiple areas of cerebellar ischaemia, prevalently on the left, and at the level of the right occipital lobe. Study of the patient was completed with an intracranial angio-nuclear magnetic resonance of the neck arteries and cerebral angiography the findings of which were compatible with left vertebral artery dissection. It is important to emphasize, as reported in the literature, that in cases in which atypical evolution of the pathology appears, or instrumental data do not confirm initial suspicions, a more scrupulous study is always necessary in order to find a possible central cause. Among the central causes, it should not be forgotten that multiple small cerebellar strokes (more frequent in elderly patients) and even more rarely also vertebral artery dissection (which is typical of younger patients) may become evident in a clinical picture that is almost identical to that seen in selective monolateral acute vestibular deficit syndrome.

Adult↗
PubMed2004

Dynamical MCG mapping with an atomic vapor magnetometer.

We have developed a magnetometer based on magnetic resonance in cesium vapor optically pumped by resonant laser radiation, which has the sensitivity and bandwidth to record human magnetocardiograms. The device is operated as a first-order gradiometer in a weakly shielded environment and allows us to record 2-dimensional field maps by shifting the subject with respect to a single sensor and making time-sequential measurements. We discuss the magnetometer technique and its performance as well as obtained results, which include a comparison of MCG data recorded with our single channel optical magnetometer with SQUID measurements from a commercial multi-channel device as well as from SQUID reference data. The results obtained so far in the detection of cardiomagnetic signals using the optical magnetometer make us confident that the technique has a high potential to serve as an alternative to SQUID detection.

Body Surface Potential Mapping↗
PubMed1995

The ecology of anthrax spores: tough but not invincible.

Bacillus anthracis is the causative agent of anthrax, a serious and often fatal disease of wild and domestic animals. Central to the persistence of anthrax in an area is the ability of B. anthracis to form long-lasting, highly resistant spores. Understanding the ecology of anthrax spores is essential if one hopes to control epidemics. Studies on the ecology of anthrax have found a correlation between the disease and specific soil factors, such as alkaline pH, high moisture, and high organic content. Researchers initially suggested that these factors influenced vegetative anthrax bacilli. However, subsequent research has shown that vegetative cells of B. anthracis have very specific nutrient and physiological requirements and are unlikely to survive outside a host. Review of the properties of spores of B. anthracis and other Bacillus species suggests that the specific soil factors linked to epidemic areas reflect important environmental conditions that aid the anthrax spores in causing epidemics. Specifically, high levels of calcium in the soil may help to maintain spore vitality for prolonged periods, thereby increasing the chance of spores encountering and infecting a new host. Cycles of runoff and evaporation may collect spores dispersed from previous epidemics into storage areas, thereby concentrating them. Uptake of large doses of viable spores from storage areas by susceptible animals, via altered feeding or breeding behavior, may then allow the bacterium to establish infection and cause a new epidemic. Literature search for this review was done by scanning the Life Sciences Collection 1982-1994 using the keywords "anthrax" and "calcium and spore."

Animals↗
PubMedDate not supplied

[Value of TC99m-Nanocolloid spect in diagnosis and follow-up of necrotizing external otitis].

Necrotizing external otitis (NEO), or malignant external otitis, a severe penetrating infection of the ear canal and the temporal bone, which occurs almost exclusively in diabetic or immunodepressed elderly patients, is caused in most cases by Pseudomonas aeruginosa while Staphylococcus epidermidis and Aspergillus fumigatus have been described as other possible agents. Recently bone scintigraphy, carried out above all employing SPECT, has been considered an important tool in diagnosis and follow-up of NEO. Many Authors confirm the role taken by Technetium99m-methylene-diphosphonate (MDP) and Gallium67-citrate bone scanning. Benecke suggested that response to therapy could be monitored with Ga67 or In111 scans. Two cases of NEO in which diagnosis and follow-up were made using Tc99m-nanocolloid (NC) SPECT are presented in this paper. The Authors discuss the advantages of this latter radiotracer, compared to those obtained with Ga67-citrate, in the follow-up evaluation of therapy efficacy. Tc99m-NC, in fact, is a better inflammation index in that its fixation on bone tissue is determined by the permeability of the basal membrane of vessels. Furthermore, with Tc99m-NC antibiotic therapy may be continued as long as necessary. Bone scintigraphy with other radiotracers may infact result positive for a long period after disease remission in that their fixation is linked to the one remodelling process.

Aged↗
PubMedDate not supplied

Changes in some properties of the aurochs heart pyruvate dehydrogenase complex induced by its partial phosphorylation.

Comparative studies on the properties of the dephosphorylated and partially phosphorylated (to 35% activity reduction) pyruvate dehydrogenase complex (PDC) from aurochs heart muscle have been made. Data have been obtained indicating that the partial phosphorylation of PDC abolishes the kinetic attributes of a positive cooperativity of the pyruvate binding sites (nH = 1.5) featuring at low substrate concentrations. In addition, the partially phosphorylated PDC is inactivated slower at 50 degrees C.

Animals↗
PubMed1995

An investigation of the kinase activity of aurochs heart pyruvate dehydrogenase complex.

The purified aurochs heart pyruvate dehydrogenase complex (PDC) saturated to approximation 60% with endogenous thiamine pyrophosphate (TPP), was slowly and incompletely inactivated by its kinase in the presence of ATP. Exogenous TPP or ADP, but not pyruvate, strongly inhibited the kinase activity. The kinetic properties of the aurochs heart PDC kinase suggested the occurrence of two active sites each with different affinities for ATP (K'm - 1.7 microM, K''m = 48 microM).

Adenosine Triphosphate↗