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At least 613 records · Page 34Linked to original sources
PubMed1989

Nuclear magnetic resonance spectra of heparin in admixture with dermatan sulfate and other glycosaminoglycans. 2-D spectra of the chondroitin sulfates.

Characteristics of the 1H-n.m.r. spectra of heparin admixed with other glycosaminoglycans are described with respect to the identification of the latter as possible contaminants of pharmaceutical heparins. Chemical shift differences are sufficiently large, particularly with the aid of resolution enhancement, to allow for the detection of dermatan sulfate, chondroitin 4- or 6-sulfate, hyaluronic acid, or heparan sulfate as a minor constituent in the presence of heparin. The acetamidomethyl resonance region (delta 1.95-2.15) is especially useful in this context, both for identification and quantitative estimation. Whereas dermatan sulfate is a common contaminant of pharmaceutical heparin preparations, in some instances comprising 10-15 percent of the polymer mixture, the other glycosaminoglycans, by contrast, were not detected in such preparations. Two-dimensional heterocorrelation and homo-correlation n.m.r. experiments have provided 1H- and 13C-chemical shift data that complete or verify (or both) previous information available for heparin, dermatan sulfate, and chondroitin 4- and 6-sulfates (chondroitins A and C).

Animals↗
PubMed1995

Second-order derivative spectrophotometric assay for imipramine hydrochloride and diazepam in pure admixtures and in dosage forms.

The determination of imipramine HCl and diazepam in tablets by derivative spectrophotometry is described. The drugs in combined preparations have been quantified using the second-order derivative spectra of their solutions in 0.1 M HCl. The method has been applied to pure drug mixtures as well as commercial preparations and was found to be precise and reproducible. Compliance of Beer's Law was observed in the concentration range of 10-70 micrograms ml-1 for imipramine HCl and 2-8 micrograms ml-1 for diazepam. Lower limits of detection at the 95% confidence level were 1.96 micrograms ml-1 for imipramine HCl and 0.21 microgram ml-1 for diazepam.

Diazepam↗
PubMed2005

Pathological consequences from the infusion of unstable lipid emulsion admixtures in guinea pigs.

The pathophysiologic effects of infusing unstable lipid emulsions are unclear, but these were shown to cause reticuloendothelial system (RES) dysfunction in animals and humans. We investigated the effects of unstable lipid emulsions in RES organs defined by two levels of the percent fat >5 microm (percentage of fat, PFAT>5 microm) in a guinea pig model. Two identical injectable lipid emulsions with differing (stable versus unstable) PFAT >5 microm levels, were infused for over 24h into two groups of animals (n=5/group). The PFAT>5 microm concentration was measured before and at the end of the infusion to ascertain the dose range of enlarged fat globules in each group. Animals were euthanized and specimens from the upper, middle and lower lung, and a single liver sample were examined histologically and for micromolar concentrations of malondialdehyde (MDA) per gram (micromol(-1)g) of wet tissue. The PFAT>5 microm concentrations pre-infusion were 0.004+/-0.001 and 2.418+/-0.273 for the stable and unstable injectable lipid emulsions respectively. At 24 h, the PFAT>5 microm level increased in both the groups (stable: 0.161+/-0.008; unstable: 7.861+/-0.291). MDA concentrations were significantly higher in the lungs of animals receiving the unstable (47.2+/-26.2 micromol(-1)g) versus stable (32.4+/-11.2 micromol(-1)g) injectable lipid emulsions (P=0.033), but was not different for the liver specimens (stable: 16.9+/-7.6 micromol(-1)g versus unstable: 17.7+/-2.2 micromol(-1)g, P=0.944). These preliminary data suggest that infusion of unstable injectable lipid emulsions has pathological consequences showing greater evidence of oxidative stress in the lungs.

Animals↗
PubMed2006

Allele frequencies for 15 autosomal STR loci and admixture estimates in Puerto Rican Americans.

Allelic frequencies of 15 short tandem repeats (STR) markers (CSF1PO, FGA, THO1, TPOX, VWA, D3S11358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, D19S433 and D2S1338) were determined using the AmpFl STR Identifiler PCR Amplification Kit in Puerto Rican American individuals (N=205) from Massachusetts. The FGA, D18S51 and D2S1338 loci had a high power of discrimination (PD) with values of 0.967, 0.965 and 0.961, respectively. Significant deviations from the Hardy-Weinberg (HW) equilibrium were not detected. An important genetic contribution of Caucasian European (76.4%) was detected in Puerto Rican Americans. However, comparative analysis between Puerto Rican American and other neighboring populations from United States mainly with African and Caucasian Americans, revealed significant differences in the distribution of STR markers. Our results are important for future comparative genetic studies of different American ethnic groups, in particular a cultural group called Hispanic-Americans and should be helpful for forensic and paternity testing.

DNA Fingerprinting↗
PubMed2006

Archaic admixture in the human genome.

One of the enduring questions in the evolution of our species surrounds the fate of 'archaic' forms of Homo. Did Neanderthals go extinct without interbreeding with modern humans 25-40 thousand years ago or are their genes present among modern-day Europeans? Recent work suggests that Neanderthals and an as yet unidentified archaic African population contributed to at least 5% of the modern European and West African gene pools, respectively. Extensive sequencing of Neanderthal and other archaic human nuclear DNA has the potential to answer this question definitively within the next few years.

Animals↗
PubMed2006

High durability cementitious material with mineral admixtures and carbonation curing.

Nuclear waste repositories need highly durable cementitious materials to function for over thousands of years while resisting leaching and degradation. The durability of cementitious material can be effectively improved by reducing permeability and by changing cement hydrates to a less soluble matrix. This paper describes the properties of carbonated new cementitious materials containing belite-rich cement and gamma-2CaO.SiO2 as main components. In addition, the long-term leaching properties are investigated and compared with ordinary Portland cement by using a predictive leaching model.

Carbon↗
PubMed2004

An unusual admixture of neoplastic and metaplastic lesions of the female genital tract in the Peutz-Jeghers Syndrome.

BACKGROUND: Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant condition with variable penetrance characterized by gastrointestinal hamartomatous polyps and mucocutaneous pigmentation. Patients with PJS have an increased risk for breast, gastrointestinal and female genital tract cancers. CASE: Multiple genital tract neoplasms in a 41-year-old Italian woman with PJS are described. The patient presented with abdominal pain due to intussusception. A CT scan of the abdomen also showed a left adnexal mass, diagnosed as ovarian mixed serous and mucinous borderline tumor. An ovarian microscopic sex cord tumor with annular tubules (SCTAT) was incidentally diagnosed together with a minimal deviation mucinous adenocarcinoma of the uterine cervix. Also areas of typical hyperplasia of the tubal mucosa with mucinous metaplasia were found. CONCLUSION: This appears to be one of the rare cases reported in literature in which PJS is complicated by multiple and contemporaneous genital tract tumors and rare histological findings. The clinical significance of recurrence of these unusual genital tract tumors and histological alterations in PJS patients is reviewed.

Adult↗