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At least 613 records · Page 34Linked to original sources
PubMed1993

Transvaginal color and pulsed Doppler assessment of adnexal tumor vascularity.

The objective of the study was assessment of the adnexal tumor vascularization with transvaginal color and pulsed Doppler sonography. Vessel location, its arrangement, and pulsed Doppler waveform characteristics were used to distinguish benign from malignant vascularity. The study was designed as a retrospective one in which sonographic and personal records of 254 women were investigated. The significance between ultrasonic results was analyzed by difference between group means and pooled estimate of variance. Results showed that peripheral and pericystical location with single vessel displayed and resistance index above 0.40 were highly associated with benign ovarian lesions. Blood vessels located in the centar, septum, and papillary projection of the tumor with diffuse dispersed vascular arrangement and resistance index below 0.41 were highly correlated with malignancy. There were no statistically significant differences in blood flow velocities observed at different vascular locations and vessel arrangement between benign and malignant ovarian masses. In conclusion, in addition to resistance index analysis of blood flow, vascular arrangement and location are important for accurate discrimination of benign from malignant ovarian lesions.

Adnexa Uteri↗
PubMed1999

The significance of adnexal involvement in endometrial carcinoma.

OBJECTIVE: To evaluate the prognostic significance of and predictive factors for adnexal involvement (AI) in patients with endometrial carcinoma. METHODS: We retrospectively reviewed the pathological features and outcomes of endometrial carcinoma patients. The prognostic significance of AI was examined by univariate and multivariate analyses. Median follow-up was 30.7 months. RESULTS: Of the 382 cases reviewed, 40 (10.5%) had AI. Patients with AI had a worse 5-year disease-free (DFS) survival (73.1 vs 37.1%, P < 0.0001) than patients without AI. However, patients with AI had multiple adverse features, including high grade disease, lymphovascular invasion, and additional sites of extrauterine disease. After controlling for these factors on multivariate analysis, AI lost its prognostic significance (P = 0.56). The 12 AI patients without other extrauterine disease had a favorable outcome (5-year DFS of 70.9%). Factors predictive of AI on logistic regression were metastatic disease, positive peritoneal washings, cervical involvement, and unfavorable histology. CONCLUSION: Endometrial carcinoma patients with AI have relatively poor prognoses. However, AI per se has little, if any, independent prognostic significance. The poor outcomes seen in these patients appear to result from the preponderance of other adverse pathologic factors.

Adnexa Uteri↗
PubMed1982

Effect of the active tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on hair follicular growth and development of hair anlage tumors in the mouse skin: a comparison with human adnexal lesions.

Effect of the active tumor promoter, TPA, on the induction of hair follicular growth and possible neoplasia was studied histologically in normal nd precancerous mouse skin. Biweekly application of TPA resulted in nevoid proliferation of hair follicles, decreased the latent period of tumor induction, and increased the number of carcinomas of hair follicular origin in mice pretreated with MCA. The experimental tumor induction data was compared with human adnexal tumors of hair follicular origin. Similar types of animal and human lesions could be attributed to the promoter effect alone or to the dual influence of a carcinogen and promoter.

Animals↗
PubMed1995

Uterine adenofibroma presenting as a cystic adnexal mass.

Uterine adenofibroma is a form of mixed mesodermal tumor in which both the epithelial and stromal components are benign. Almost all previously reported cases have been confined to the endometrium or endocervical mucosa. Our patient presented with a cystic adnexal mass and had a hysterectomy.

Adenofibroma↗
PubMed1992

Molecular-genetic analysis of ocular adnexal benign lymphoid hyperplasias by a two-step polymerase-chain-reaction.

Twelve biopsied ocular adnexal benign lymphoid hyperplasias (OABLH) satisfying benign histological criteria were investigated for clonal immunoglobulin (Ig) heavy-chain gene rearrangement by means of a two-step polymerase chain reaction (PCR) method using formalin-fixed and paraffin-embedded tissue. Of the 12, 4 (33%) demonstrated clear single bands of the rearranged gene for the Ig heavy-chain, of between 100 and 150 base pairs. The selected cases were all free of malignant lymphoma and all of the lesions were small (2 x 2-22 x 6 mm; median 4.5 x 3 mm). Histopathological and cytological features were not essentially different between monoclonal and non-monoclonal examples. Immunohistochemistry was of little benefit in separating the two. It is concluded that OABLH demonstrating a benign clinical course frequently contain monoclonal B cell populations suggesting a continuous progressive spectrum of lesions in B cell neoplasia. In addition, the significance of molecular-genetic analysis for OABLH and the utility of the two-step PCR method should be emphasized.

Adolescent↗
PubMed1979

[The role of chlamydiae in male urethro-adnexitis (author's transl)].

Chlamydiae belonging to Subgroup A occur in both the normal male urethra and in patients with urethro-adnexitis, which means that Chlamydiae must be attributed with a significant pathogenetic role in certain cases of abacterial urethroadnexitis. Susceptibility to erythromycin therapy confirms this.

Adult↗
PubMed1979

[Clinical significance of arteriovenous shunt malformations in the uterine and adnexal region (author's transl)].

This case report describes and discusses the entity of arteriovenous shunt malformations in the uterine and adnexal region. The diagnostic measurements and clinical importance of this disease is also outlined. The condition is rare, but should be considered in cases of severe hemorrhage when routine investigations have been normal. For the first time bloodgas-analytic measurements showing the extent of the shunting have been performed with such a disease.

Adnexa Uteri↗
PubMed1993

The risk of malignancy with an apparently simple adnexal cyst on ultrasound.

We received data of 144 patients, who had been operated upon in the 2nd Department of Obstetrics and Gynecology in Vienna because of persisting sonographically detected "simple" adnexal cysts. Only 3 cysts were malignant (one of them borderline). All three patients were postmenopausal. The mean diameter of the malignant cysts were 7, 11 and 18 cm, respectively. 82 sonographically simple cysts were histologically benign. We found 27 cysts associated with chronic pelvic sepsis (hydrosalpinx and pseudocysts), 22 were benign cystadenomas and 10 were endometriotic.

Adult↗
PubMed2005

A microcystic adnexal carcinoma in the auditory canal 15 years after radiotherapy of a 12-year-old boy with nasopharynx carcinoma.

BACKGROUND: Radiogenic malignancies require cure of the primary disease and a prolonged survival. The introduction of high-volt technology in the 1950s and 1960s made radical radiotherapy feasible and successful in terms of higher cure rates and longer survival. We are already in a time when a higher number of patients with radiogenic secondary malignancies must be expected. CASE REPORT: A 12-year-old boy is reported who suffered from an advanced nasopharynx carcinoma and was treated with radical irradiation in 1983. 15 years later he developed a rare microcystic adnexal carcinoma of the auditory canal inside the volume of the target dose. The secondary malignant neoplasm was resected and required another radiation treatment (1 Gy b.i.d.) due to involved margins. DISCUSSION AND LITERATURE REVIEW: The entity of microcystic carcinoma is discussed with a review of the literature on biology, diagnosis, and treatment.

Carcinoma↗
PubMed2007

The tale and molecular trail of a disseminated ocular adnexal malt lymphoma.

PURPOSE: To report a case of a MALT lymphoma of the eyelid, which recurred in several sites over a time period of 14 years, and where the identical B-cell clone could be demonstrated in most samples using polymerase chain reaction (PCR) and GeneScan analysis. METHODS: Clinical, histologic, immunohistochemical, PCR and GeneScan analysis findings are presented. RESULTS: A 58-year-old woman presented with a swelling of the left lower lid. Excisional biopsy of the tumour revealed a low-grade malignant B-cell Non-Hodgkin lymphoma (NHL) of MALT type. Despite localized radiochemotherapy, the patient developed recurrences occurring in the pharynx, in the right orbit, in the skin of the right foot, and in the bone marrow 1, 7, 11 and 14 years, respectively, after establishment of the first diagnosis. PCR for a rearrangement of the immunoglobulin heavy chains (IgH) and GeneScan analysis of the samples produced amplificates identical in size at most sites, indicating derivation from the same B-cell clone. CONCLUSIONS: It is generally assumed that ocular adnexal MALT lymphoma is associated with an indolent clinical course. Using IgH-PCR and GeneScan analysis, we demonstrate that the current case illustrates that these lymphomas do indeed require regular control examinations following treatment, as they often recur and disseminate in some patients in an unpredictable manner.

Biomarkers, Tumor↗
PubMed1982

Intralesional corticosteroid injection for infantile adnexal hemangioma.

I treated ten patients who had adnexal hemangioma with intralesional injections of corticosteroid. A marked and lasting regression of the hemangioma occurred in eight of the patients and one had a moderate response. This treatment also proved effective in preventing amblyopia in infants who had large hemangiomas that occluded the visual axis, and often resulted in a reversal of the astigmatism induced by these tumors. There were no complications. The advantages of intralesional corticosteroid injection include ease of administration, speed of action, apparent freedom from adverse side effects, and repeatability.

Adrenal Cortex Hormones↗
PubMed1983

Identification of T lymphocytes in ocular adnexal neoplasms by hybridoma monoclonal antibodies.

We performed indirect immunofluorescence with the OKT series of hybridoma monoclonal antibodies in order to determine the total number of T cells and their subset distribution, that is, the percentages of helper (OKT3+T4+T8-) and suppressor/cytotoxic (OKT3+T4-T8+) T cells, in 28 ocular adnexal lymphoid neoplasms. OKT3+T4+ (helper) T cells vastly predominated in each of ten benign, polyclonal ocular lymphoid proliferations. The helper-suppressor T-cell ratio (T4-8) ranged from 2.5 to 8.2 (mean, 5.4) in these ten cases. In comparison, the mean T4-T8 ratio in 24 benign reactive lymph nodes was 3.4. These findings strongly suggested that the polyclonal ocular lymphoid proliferations represent a T-cell antigen-dependent response characterized by a proliferation of helper T cells, which in turn drive B cells to proliferate and to differentiate, eventually resulting in the formation of a clinically detectable tumor. The mean T4-T8 ratio was 2.3 in 18 ocular and in 16 nodal monoclonal B-cell proliferations, suggesting that the benign T cells in these proliferations represent a residual cell population rather than a distinctive subset originating in response to the B-cell neoplasm.

Antibodies, Monoclonal↗
PubMed1988

Evolution of cystic and adnexal tumors identified by echography.

The authors present their experience in detecting volume and echostructure alterations of the ovary in 14,525 women examined echographically and clinically. They analyzed 499 adnexal tumors and observed after clinical follow-up and echography that 60.6% of the cystic-septa tumors had involuted spontaneously. Percentage of spontaneous resolution was higher in small-diameter tumors, avoiding unnecessary surgery.

Adenoma↗
PubMed1988

Occurrence of epidermal growth factor receptors in human adnexal tumors and their prognostic value in advanced ovarian carcinomas.

Ninety-eight different malignant adnexal tumors were analyzed for the presence of epidermal growth factor (EGF)-specific binding sites and binding parameters were calculated by Scatchard plot analysis [G. Scatchard, Ann. N.Y. Acad. Sci. 51, 660-672 (1949)]. Thirty-four biopsies were EGF receptor (EGF-R) positive with dissociation constants (KD) of 0.5-12 X 10(-9) M and binding capacities (Bmax) of 2-250 fmol/mg. One tumor had a KD of 60 X 10(-9) M and a Bmax of 1660 fmol/mg. The correlation of EGF-R status with clinical parameters showed no significant differences in primary, metastatic, or recurrent tumors, histological subtype, tumor differentiation, and tumor residual after primary surgery. As an inverse correlation, EGF-R-positive tumors are 39% and EGF-R-negative tumors 60% progesterone receptor positive. A response to chemotherapy was noticed in 50% of EGF-R-positive ovarian carcinomas with a mean survival time of patients of 28 months. The response rate of EGF-R negative ovarian carcinomas was 12% with a mean survival time of 16 months. Regarding the treatment schedule the major differences were noticed in the cis-platinum plus cyclophosphamide treatment group. These results suggest that the biology of ovarian carcinomas is influenced by growth factors and their receptors, which can be used as prognostic factors.

Adnexa Uteri↗
PubMedDate not supplied

The direction of bladder displacement by adnexal masses.

Impression on the bladder, or its displacement, indicates the presence of a mass or mass effect. The direction of the displacement aids in the formulation of an appropriate differential diagnosis. We present for discussion two cases in which preoperative lateral bladder displacement was attributed to adnexal masses. When the anatomy of the paravesical spaces is reviewed, it is apparent that lateral bladder displacement is generally not compatible with such masses.

Adnexa Uteri↗
PubMed2005

Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery.

BACKGROUND: Microcystic adnexal carcinoma (MAC) is reported to have a high rate of recurrence with standard wide local excision. OBJECTIVE: To report a large series of patients with MAC treated with Mohs micrographic surgery (MMS). METHODS: This prospective, multi-center case series included all patients in Australia treated with MMS for MAC, who were monitored by the Skin and Cancer Foundation between 1993 and 2002. RESULTS: There were 44 cases; most of them (90.9%) were located in the head and neck area. In 31.8% of cases it was a recurrent tumor. In 32.5% of cases the tumor was initially misdiagnosed as basal cell carcinoma or squamous cell carcinoma. Perineural invasion was recorded in 17.5% of cases; most of them (85.7%) were previously recurrent tumors. There was only one case of recurrence (5%) out of 20 patients who completed a 5 year follow-up period after MMS. CONCLUSION: The low 5-year recurrence rate of MAC with MMS emphasizes the importance of margin-controlled excision.

Adolescent↗