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At least 595 records · Page 33Linked to original sources
PubMed1990

[One step forward, one step back. Research policy in the 1990's--a link in a historical sequence].

A description is presented of the major problems in Danish research in the nineteen nineties, including internationalization, competition, concentration, training of research workers, transparency, connections with the surrounding community and ability of drawing conclusions. Elements in the Danish research system and the research policy are described. Connections are then made with the situations at the end of the nineteen sixties and beginning of the nineteen seventies when the new research council established a considerable part of the basis upon which we build today. Finally, freedom in research and the responsibilities of research and research workers for the community are mentioned.

Denmark↗
PubMed1990

[The evaluation of dry chemical laboratory methods. Their value within the framework of step-by-step diagnosis in general medicine].

In a prospective study involving eleven general practices, dry-chemical laboratory methods were compared with wet-chemical methods in the establishment of the diagnosis. The study included 658 patients in whom defined liver disease, lipid metabolic disturbances, diabetes mellitus or hyperuricemia were clinically suspected. In the "dry chemistry" group, between 12 and 29% fewer basic examinations (ESR, Hb, erythrocytes, leukocytes) were performed than in the "wet chemistry" group. In addition the number of analyses per patient in the so-called search program and among the subsequently requested laboratory analyses were also lower by about 21% in the "dry chemistry" group. This indicates that through the use of "dry chemistry", laboratory examinations can be used with greater selectivity. A further advantage of "dry chemistry" is the appreciably shorter time required to establish and report the diagnosis.

Clinical Laboratory Techniques↗
PubMedDate not supplied

Prophylaxis of fatal pulmonary embolism in general surgery using low-molecular weight heparin Cy 216: a multicentre, double-blind, randomized, controlled, clinical trial versus placebo (STEP). STEP-Study Group.

The effectiveness of low-molecular weight heparin CY 216 in the prophylaxis of fatal pulmonary embolism in patients undergoing general surgery was assessed in a multicentre, double-blind, randomized, clinical trial against placebo. A total of 4,498 patients aged over 40 undergoing general surgery were enrolled in the 18 centres which took part in the trial. Patients received a single daily subcutaneous injection of 7,500 anti-Xa units I.C. of CY 216 or placebo two hours before surgery, 12 hours after the initial injection and then daily for at least seven days. A post-mortem examination had to be carried out in every patient who died. The two groups of patients were well-matched for age, sex, type of disease, site and duration of operation as well as for incidence of risk factors which could predispose to the development of thromboembolism. Twenty-six deaths were recorded and validated: eight (0.36%) in the CY 216 group and 18 (0.80%) in the placebo group (p less than 0.05). At the post-mortem examination, carried out in 23 patients (88.5%), two deaths were found to be directly due to pulmonary embolism (0.09%) in the CY 216 group and four (0.18%) in the placebo group. Pulmonary embolism contributed to death in four other placebo-treated patients. Pulmonary or extrapulmonary thromboembolism was a significantly less frequent direct cause of death (p less than 0.05) in the CY 216 group (two pulmonary embolisms) than in the placebo group (four pulmonary embolisms, one acute myocardial infarction, one disseminated intravascular coagulation, two ischemic cerebral strokes).(ABSTRACT TRUNCATED AT 250 WORDS)

Double-Blind Method↗
PubMed1989

Methods for purification of Rickettsia prowazekii separated from the host tissue: a step-by-step comparison.

Two methods for purification of Rickettsia prowazekii strains E, E Vir, and Breinl grown in chick embryo yolk sacs are described. These methods combine either differential centrifugation or sucrose mix, centrifugation through sucrose cushion, 10 mmol/l MgCl2 treatment, filtration through a glass filter AP-20 and 2 cycles of verografin discontinuous density gradient centrifugation. The purification procedure including sucrose mix allowed to recover about 38-42% biologically active rickettsiae, a yield which was by 10% higher than that obtained by the method beginning at differential centrifugation. The rickettsiae free of host cell components preserved their infectious activity. The obtained biomass was suitable for immunological and biological characterization of Rickettsia prowazekii and for isolation of its total DNA.

Animals↗