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At least 595 records · Page 33Linked to original sources
PubMed1996

Therapeutic delivery of calcitonin to inhibit external inflammatory root resorption. II. Influence of calcitonin binding to root mineral.

Experimentally-induced external inflammatory tooth-root resorption can be inhibited by therapeutic doses of calcitonin. Such doses can be delivered by an intrinsically slow diffusion pathway, from a reservoir in endodontically-debrided root canals, via the dentinal tubules. While the kinetics of this journey have been followed in an earlier report, the binding characteristics of calcitonin to the tooth mineral, which will be responsible, in part, for these kinetics, have not been reported before. The current study examines the binding potential of calcitonin to root mineral and addresses the potential role of non-specific binding proteins. A modified Scatchard plot indicated that a simple non-reactive type of ligand binding exists between calcitonin and root mineral, represented by a small number of identical binding sites. This interaction is both strong and reversible. Furthermore, it appears to be time-dependent with more time being required for the residual ligands to interact with the diminishing numbers of free calcitonin-binding sites. While preloaded [125I]-calcitonin could be incompletely (75-91%) displaced from dental-root material by non-radioactive calcitonin, its release was slow over 23 h. Calcitonin was four times as effective as bovine-serum albumin in competing for common "calcitonin binding sites" on macerated dental-root material. Thus, even in the presence of extraneous protein, calcitonin will bind tightly but reversibly to tooth-root material, making it a good candidate for therapeutically protracted delivery to external root surfaces from root canals.

Adolescent↗
PubMed2005

Treatment of invasive cervical resorption with MTA: case report.

This paper presents a case report of a maxillary lateral incisor affected by invasive cervical resorption. The tooth was submitted to a 21-day treatment with calcium hydroxide followed by root canal filling. The area of resorption was sealed with MTA followed by glass ionomer cement and restored with composite resin. Two-year radiographic follow-up showed stability of the resorption site and normal coronal colour and depth of gingival sulcus.

Adult↗
PubMed2000

Localization of cathepsin D in human odontoclasts. a light and electron microscopical immunocytochemical study.

Odontoclasts are dentine and cementum resorbing cells whose relationship to bone resorbing osteoclasts is not clear. Like osteoclasts, they possess different cathepsins which are involved in mineralized tissue degradation during the tooth root resorption process in deciduous teeth. Whether cathepsin D, which in osteoclasts probably functions as an activator of other cathepsins, can be found in odontoclasts, has, however, not been investigated before. In order to determine its occurrence and localization, cathepsin D immunocytochemistry was applied to paraffin-embedded sections from 30 human deciduous tooth roots undergoing resorption. Using immunogold postembedding immunocytochemsitry on LR-Gold embedded specimens, the distribution of cathepsin D was investigated at the ultrastructural level. We identified tartrate-resistent acid phosphatase-positive mono- and multinuclear odontoclasts near and on the periodontal surfaces of tooth roots. Nearly all of these cells showed cytoplasmic granular cathepsin D immunoreactivity. At the electron microscopical level, gold labelling was seen on vacuoles and vesicles of the odontoclasts, which were identified as secondary lysosomes and phagosomes. Extracellularly it was seen along the ruffled border and in neighboured resorption areas of dentine and cementum. These findings indicate that cathepsin D is secreted into the resorbing area of human odontoclasts in order to participate in degradation of mineralized tooth matrix, but may also function as an activator of other proteases in lysosomal organelles.

Cathepsin D↗
PubMed2004

Immunohistochemical localization of alphavbeta3 integrin receptor during experimental tooth movement.

During orthodontic treatment, multinucleated clast cells carry out the resorption of mineralized tissues. Adhesion of clast cells to the mineralized tissues is mediated by transmembrane cell-surface glycoproteins called integrins, specifically by the alphavbeta3 integrin, which plays an important role in the process of bone resorption. The role of the alphavbeta3 integrin in bone resorption leading to osteoporosis has been demonstrated, but its role in alveolar bone and root resorption during orthodontic tooth movement is unknown. This study examined the expression of the alphavbeta3 integrin during experimental tooth movement. Tooth movement was achieved in 16 male Sprague-Dawley rats (each weighing 120-200 g) with elastic bands between their maxillary first and second molars. The molar-bearing segments were dissected and processed for histologic and immunohistochemical examination. The expression of alphavbeta3 integrin was examined with 2 primary antibodies: a polyclonal anti-alphav integrin subunit antibody and a polyclonal anti-beta3 integrin subunit antibody. Negative controls were similarly processed but without incubation with primary antibodies. The alphavbeta3 integrin was expressed both by osteoclasts associated with alveolar bone resorption and by odontoclasts associated with root resorption during experimental tooth movement. Furthermore, the beta3 integrin subunit was expressed by the epithelial rests of Malassez in the periodontal ligament. Negative controls did not show immunolabeling. The alphavbeta3 integrin adhesion receptor is expressed during experimental tooth movement and might be involved in the process of mineralized tissue resorption and the functions of the epithelial rests of Malassez.

Alveolar Process↗
PubMed1989

[Histological study on root resorption of upper permanent incisor].

In the permanent tooth, physiological root resorption does not occur, but inflammatory resorption occurs due to the orthodontic force, ectopic eruption of neighboring tooth and others. In this study, the morphological and histological investigation of the root resorption of the upper permanent incisors caused by the ectopic eruption of the canine was carried out. The left central incisor and lateral incisor from a 12-year-old female were examined. The roots were resorbed almost completely, and in part the resorption extended into the enamel. The results were as follows: 1. In the resorbed dentine, two types of resorption lacuna were observed. One was in direct contact with resorption tissue and the other was repaired with cementum-like tissue. 2. In the resorption lacuna, no odontoclast was recognized. 3. The pulp tissue was normal and the internal resorption was not seen. 4. On the wall of the root canal connected with root resorption, a large amount of hard tissue was formed, and on the external surface of the root, secondary cementum was formed on the primary cementum. 5. Under the scanning electron microscope, the clear dentine tubules in the resorption lacuna, the shallow, unclear resorption lacuna with deposition of the hard tissue and the various steps between them were observed.

Child↗
PubMed1992

[Histological study of the change of pulp tissue during shedding of the deciduous tooth].

To understand the pulp change of root resorption of human deciduous teeth from a histological point of view, one hundred and twenty specimens were collected for study. The teeth (caries-free) were extracted for occlusal reason or because they exhibited various degrees of mobility and discomfort. The extent of root resorption was classified into five grades: Res. i, Res. 1/4, Res. 1/2, Res. 3/4 and Res. Co., according to Moorrees et al. and Haavikko. All teeth were fixed in 10% formalin (pH 7.2) immediately after extraction for 3-7 days. They were then decalcified for 14 days in 5% formic acid-sodium citrate, sectioned serially at 7 microns and stained with hematoxylin and eosin, Masson's stain, and silver impregnated stain. All sections were examined under a light microscope. The results obtained were as follows: 1. While the root was resorbed more than one half way, some normal pulp was replaced by the connective tissue as in inflammation. Internal resorption could be seen. 2. By the time deciduous root resorption was essential as complete, normal pulp tissue was no longer present. 3. Because the nerve degenerated during initial tooth resorption, there was no evidence that deciduous root resorption was under nervous control. 4. The present observation suggests that in addition to odontoclasts, several other cells such as fibroblast-like cells and macrophages, were actively involved in root resorption during the shedding of deciduous teeth.

Child↗
PubMed1988

An 'invisible' supernumerary tooth.

A case is reported of an unerupted maxillary supernumerary tooth, apparently undergoing resorption, which was not visible on extra-oral radiographs, but was clearly visible on an intra-oral occlusal radiograph.

Adult↗
PubMed1999

Management of an avulsed primary incisor.

The case describes the management of an avulsed maxillary central primary incisor of a 3 1/2-year-old girl. The tooth was retained in the oral cavity for 30 min. After replantation it was splinted for 17 days. At day 11 the root canal was completely instrumented and obturated with a calcium hydroxide paste. The 1-year follow-up documented no pathologic clinical or radiographic findings. One and a half years after the trauma the tooth was extracted since a fistula and extensive external inflammatory resorption had developed. The permanent successor erupted along with its neighboring central incisor without any complications 6 months later. Conventional approaches for treating avulsed permanent teeth could also be applied to avulsed primary incisors to preserve them for a certain period without the additional risk of damaging their developing permanent successors.

Child, Preschool↗
PubMed2005

The fate of a mid-root fracture: a case report.

The present report describes a case of a mid-root fracture in a maxillary central incisor of a 19-year-old patient. The fractured tooth was splinted with composite that was removed only 3 years later, as the patient did not appear for follow-up examinations. At this time, the radiographs revealed a normal periodontal ligament, rounding of the borders of the fragments and pulp obliteration of both fragments. Eight years later, the tooth was clinically normal and blurred calcification of the root canal was disclosed radiographically. After 13.5 years the patient complained of tooth mobility and radiographic examination revealed an advanced cervical root resorption. As no conservative approach was possible at this stage, the patient was referred to a prosthodontist for esthetic rehabilitation.

Adult↗
PubMed2005

Bilateral maxillary periodontal ligament hamartoma in a dog.

A 12.5-year-old dog was presented for severe periodontal disease and bilateral maxillary enlargement. Radiographs of the maxilla showedgeneralized root resorption, ankylosis, and rarefaction of bone with focal radiodense areas. Surgical tooth extraction of multiple maxillary teeth and bilateral incisional biopsies of the periodontal tissue and maxilla in the region of the maxillary fourth premolars were performed. Histopathologic examination showed features typical of fully differentiated periodontal ligament with abundant cementum/alveolar lining bone and sparce odontogenic epithelial cell rests. Histopathology in conjunction with radiographic and clinical signs suggested a diagnosis of bilateral periodontal ligament hamartoma. Examination 3-months postoperatively indicated uncomplicated healing of the extraction and biopsy sites with no resolution of the maxillary enlargement.

Animals↗
PubMed1995

Retention of teeth with reduced root length through use of a resin-bonded splint: a case report.

Orthodontic relapse and tooth migration are commonly observed in patients with severe postorthodontic root resorption. If conventional removable retention is not adequate, fixed splint retention is necessary. Proponents of flexible splints suggest that the difference in mobility between natural teeth and the rigid systems is responsible for the loss of cement seal in the rigid systems. Proponents of rigid splints suggest that the flexibility that allows physiologic movement of the teeth also contributes to fatigue and subsequent failure of the material in the flexible splint systems. A clinical technique for increasing retention, consequently improving the prognosis of a resin-bonded fixed splint, is described.

Adolescent↗
PubMed1990

Inflammatory resorption caused by an adjacent necrotic tooth.

A case history is presented with a large periapical lesion and a perforating resorption defect on a cuspid. Endodontic therapy was performed, presuming that the necrotic cuspid caused the inflammatory response. No radiographic healing was evident 18 months after endodontic therapy. Considerable healing was demonstrated 6 months later, following the extraction of an adjacent tooth with prior root canal therapy. It was concluded that the failing root canal therapy of the extracted tooth was the primary factor leading to the inflammatory lesion, the resorptive perforation of the adjacent tooth, and its pulpal necrosis. It has not been reported prior that inflammatory resorption can result from the pulpal necrosis of an adjacent tooth.

Adult↗