Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Thyroid Function Tests”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 595 records · Page 33Linked to original sources
PubMed1989

Alterations in thyroid function tests in major depression.

Most clinically euthyroid patients with acute or chronic nonthyroid illness have abnormal thyroid function which is called the euthyroid sick syndrome. To assess the euthyroid sick syndrome in depression, we examined levels of total thyroxine (TT4), total triiodothyronine (TT3), T3 uptake (T3U) by radio-immunoassay and thyrotropin (TSH) by immunoradiometric assay in a group of 46 patients with major depression (diagnosed according to DSM-III), 44 normal control subjects and 39 schizophrenics. As compared with the normal controls and schizophrenics, depressed patients showed the following significant differences: a reduction of the mean TT3 level by 26% (89.6 +/- 26.9 ng/dl versus 121 +/- 21.4 ng/dl, p less than 0.05), an increase in the mean T3U level by 6% (35.4 +/- 4.1 versus 33.1 +/- 3.0%, p less than 0.05), and a rise in the mean FT4I level by 15% (2.96 +/- 0.59 versus 2.50 +/- 0.40, p less than 0.05). However, both the mean TSH and TT4 levels in depressed patients were not significantly different from those in normal subjects and schizophrenics, though there was a trend toward high mean TT4 levels in depressed patients. Among the 46 depressed patients who had normal basal TSH levels, 7(15%), 3(6%) and 11 (23%) had the low T3 syndrome, low T3 plus low T4 syndrome and high T4 syndrome, respectively. The clinical implication of the low T3 or/and T4 low syndrome was discussed. All the abnormal thyroid indices in the 21 depressed patients were normalized after recovery of depression. These findings suggest that the euthyroid sick syndrome in depression might be a state-dependent phenomenon.

Adult↗
PubMed1990

The use and limitations of a chemiluminescent thyrotropin assay as a single thyroid function test in an out-patient endocrine clinic.

A chemiluminescent TSH assay (detection limit, less than 0.01 mU/L) allows for accurate measurement of subnormal TSH concentrations. We retrospectively analyzed serum TSH and the free T4 (fT4) index of 460 consecutive endocrine clinic visits to determine the usefulness of TSH measurements alone in the assessment of thyroid function. Additionally, case histories were presented nonconsecutively to one of us (TSH alone or TSH with fT4) to determine if knowledge of the fT4 level would alter management. Of hypothyroid patients on replacement therapy (n = 127), 60% had concordant fT4 and TSH, 14% had subnormal TSH with normal fT4, 18% had high TSH with normal fT4, and 4% normal TSH with high fT4; only 4% were managed differently when the fT4 level was known in addition to TSH. Of the patients receiving suppressive therapy with TSH levels above 0.05 mU/L (n = 81), only 4% were managed differently when fT4 was known; 4% had high fT4. With TSH levels below 0.05 mU/L (n = 64), knowledge of fT4 was felt to be necessary for management in all cases; 53% had high fT4. Twenty-three of 46 (50%) patients being treated for hyperthyroidism had discordant TSH and fT4, including 7 patients with low TSH and low fT4. Two of 21 (10%) patients screened with pituitary/hypothalamic disease had discordant TSH and fT4, and 4 of 9 (44%) patients treated with L-T4 for secondary hypothyroidism had subnormal TSH. Knowledge of fT4 was felt to be necessary in all these cases. We conclude that TSH alone is sufficient for screening and monitoring L-T4 replacement or suppression therapy if TSH levels are above 0.05 mU/L. These patients account for the majority of visits to our endocrine clinic. TSH alone is misleading in pituitary disease and during the treatment of hyperthyroidism. fT4 is needed if TSH levels are less than 0.05 mU/L to assess the degree of hyperthyroidism.

Aged↗
PubMed1990

Tests of thyroid function: update in the diagnosis and management of thyroid disease.

Current thyroid function tests give the clinician powerful tools for the accurate assessment of thyroid status in the majority of patients encountered. There are, however, a small number of clinical situations in which there appear to be inconsistencies in the interrelationship of the thyroid function tests and/or in which they are apparently inappropriate to the clinical status of the patient. In most instances, there is a rational explanation for these observed alterations. The application of this information should allow clinicians to further refine their diagnostic accuracy and thereby enable them to proceed with an appropriate therapeutic or management program.

Adult↗
PubMed1979

Tables to estimate total binding capacity of thyroxine-binding globulin from the in vitro thyroid function tests.

Equations for an estimate of the total binding capacity of serum thyroxine-binding globulin (TBG-TC) were developed relating this parameter to serum thyroxine concentration (T4) and in vitro uptake (T3U). This extimate demonstrated a highly significant, positive correlation with TBG-TC as measured by electrophoresis in ten normal subjectdividuals with altered TBG-TC but without thyroid dysfunction (ten normal pregnant women, ten healthy women receiving anovulatories, ten nephrotics, and ten patients with severe malnutrition). True-positive (sensitivity) and true-negative (specificity) ratios were calculated for total and free T4 in serum, T3U, Free T4 Index, and both measured and calculated TBG-TC. False-positive results for free T4 index (12%) were due to altered TBG-TC. In such cases, 93% were recognized by the calculated TBG-TC from the calues of the invitro tests. It is concluded that this estimates should be added to the in vitro thyroid tests for their proper interpretation in cases where altered TBG-TC could be misleading. This estimate applies only to the particular in vitro testing system used herein.

Anovulation↗